BRPI0714671B8 - Preparação de (2r,3r)-3-(3-metoxifenil)-n,n,2-trimetilpentanamina e compostos intermediários - Google Patents

Preparação de (2r,3r)-3-(3-metoxifenil)-n,n,2-trimetilpentanamina e compostos intermediários

Info

Publication number
BRPI0714671B8
BRPI0714671B8 BRPI0714671A BRPI0714671A BRPI0714671B8 BR PI0714671 B8 BRPI0714671 B8 BR PI0714671B8 BR PI0714671 A BRPI0714671 A BR PI0714671A BR PI0714671 A BRPI0714671 A BR PI0714671A BR PI0714671 B8 BRPI0714671 B8 BR PI0714671B8
Authority
BR
Brazil
Prior art keywords
preparation
trimethylpentanamine
methoxyphenyl
intermediate compounds
relates
Prior art date
Application number
BRPI0714671A
Other languages
English (en)
Inventor
Ferdinand Maria Filliers Walter
Laurent Maria Broeckx Rudy
Original Assignee
Janssen Pharmaceutica Nv
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv, Gruenenthal Gmbh filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0714671A2 publication Critical patent/BRPI0714671A2/pt
Publication of BRPI0714671B1 publication Critical patent/BRPI0714671B1/pt
Publication of BRPI0714671B8 publication Critical patent/BRPI0714671B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
    • C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PREPARAÇÃO DE (2R,3R)-3-(3-METOXIFENIL)-N,N,2-TRIMETILPENTANAMINA. A presente invenção refere-se a um processo melhorado para a preparação de (2R,3R)-3-(3-metoxifenil)-N,N,2-trimetilpentanamina o qual é um intermediário para a preparação do tapentadol analgésico.
BRPI0714671A 2006-07-24 2007-07-23 Preparação de (2r,3r)-3-(3-metoxifenil)-n,n,2-trimetilpentanamina e compostos intermediários BRPI0714671B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06117708 2006-07-24
EP061177085 2006-07-24
PCT/EP2007/057559 WO2008012283A1 (en) 2006-07-24 2007-07-23 Preparation of (2r,3r)-3-(3-methoxyphenyl)-n,n,2-trimethylpentanamine

Publications (3)

Publication Number Publication Date
BRPI0714671A2 BRPI0714671A2 (pt) 2013-05-07
BRPI0714671B1 BRPI0714671B1 (pt) 2020-09-24
BRPI0714671B8 true BRPI0714671B8 (pt) 2023-03-21

Family

ID=37772663

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0714671A BRPI0714671B8 (pt) 2006-07-24 2007-07-23 Preparação de (2r,3r)-3-(3-metoxifenil)-n,n,2-trimetilpentanamina e compostos intermediários

Country Status (21)

Country Link
US (2) US8138376B2 (pt)
EP (1) EP2046726B1 (pt)
JP (1) JP5208933B2 (pt)
KR (1) KR101370398B1 (pt)
CN (1) CN101495447B (pt)
AT (1) ATE455752T1 (pt)
AU (1) AU2007278224C1 (pt)
BR (1) BRPI0714671B8 (pt)
CA (1) CA2656696C (pt)
CY (1) CY1110075T1 (pt)
DE (1) DE602007004494D1 (pt)
DK (1) DK2046726T3 (pt)
EA (1) EA015003B1 (pt)
ES (1) ES2339403T3 (pt)
HR (1) HRP20100197T1 (pt)
IL (1) IL196627A (pt)
MX (1) MX2009000911A (pt)
PL (1) PL2046726T3 (pt)
PT (1) PT2046726E (pt)
SI (1) SI2046726T1 (pt)
WO (1) WO2008012283A1 (pt)

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TWI401237B (zh) * 2006-07-24 2013-07-11 ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備
CN102002065B (zh) * 2009-09-02 2014-09-10 上海特化医药科技有限公司 他喷他多的制备方法及其中间体
US8288592B2 (en) 2009-09-22 2012-10-16 Actavis Group Ptc Ehf Solid state forms of tapentadol salts
IT1397189B1 (it) * 2009-12-01 2013-01-04 Archimica Srl Nuovo processo per la preparazione di tapentadol e suoi intermedi.
WO2011080736A1 (en) 2009-12-29 2011-07-07 Mapi Pharma Hk Limited Intermediate compounds and processes for the preparation of tapentadol and related compounds
WO2011092719A2 (en) * 2010-02-01 2011-08-04 Ind-Swift Laboratories Limited Process for the preparation of l-phenyl-3-dimethylaminopropane derivatives
US20130096346A1 (en) 2010-03-05 2013-04-18 Actavis Group Ptc Ehf Resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol
WO2011128784A2 (en) 2010-04-05 2011-10-20 Actavis Group Ptc Ehf Novel process for preparing highly pure tapentadol or a pharmaceutically acceptable salt thereof
IT1401109B1 (it) * 2010-07-02 2013-07-12 Archimica Srl Nuovo processo per la preparazione di tapentadol e suoi intermedi.
ES2860676T3 (es) * 2010-07-23 2021-10-05 Gruenenthal Gmbh Sales o cocristales de 3- (3-dimetilamino-1-etil-2-metil-propil) -fenol
US8552219B2 (en) 2010-09-20 2013-10-08 Ind-Swift Laboratories Limited Process for preparing L-phenyl-3-dimethylaminopropane derivative
CN102477016B (zh) * 2010-11-26 2014-12-17 中国医学科学院药物研究所 他喷他多的中间体的合成与应用
CZ2010995A3 (cs) * 2010-12-30 2012-04-11 Zentiva, K.S. Zpusob výroby (2R,3R)-N,N-dimethyl-3-(3-hydroxyfenyl)-2-methylpentylaminu
CZ2010997A3 (cs) * 2010-12-30 2012-02-08 Zentiva, K.S. Zpusob výroby (2R,3R)-N,N-dimethyl-3-(3-hydroxyfenyl)-2-methylpentylaminu (tapentadolu)
CZ2010998A3 (cs) * 2010-12-30 2012-02-08 Zentiva, K.S. Zpusob výroby (2R,3R)-N,N-dimethyl-3-(3-hydroxyfenyl)-2-methylpentylaminu (tapentadolu)
HUP1300623A2 (en) * 2010-12-30 2014-03-28 Zentiva Ks O-substituted (2r,3r)-3-(3-hidroxiphenil)-2-metyil-4-pentenoic acids and a method of obtaining the same
CN102617501A (zh) 2011-01-31 2012-08-01 中国科学院上海药物研究所 取代正戊酰胺类化合物、其制备方法及用途
US9446008B2 (en) 2011-03-04 2016-09-20 Gruenenthal Gmbh Semisolid aqueous pharmaceutical composition containing tapentadol
MX369121B (es) 2011-03-04 2019-10-30 Gruenenthal Gmbh Formulacion farmaceutica acuosa de tapentadol para administracion oral.
MX348831B (es) * 2011-03-04 2017-06-30 Gruenenthal Gmbh Administración parenteral de tapentadol.
CN102206164A (zh) * 2011-04-11 2011-10-05 中国药科大学 一种他喷他多中间体的制备方法
WO2012146978A2 (en) 2011-04-28 2012-11-01 Actavis Group Ptc Ehf A novel process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof
US20130150622A1 (en) 2011-12-12 2013-06-13 Boehringer Ingelheim International Gmbh Stereoselective synthesis of tapentadol and its salts
WO2013120466A1 (en) 2012-02-17 2013-08-22 Zentiva, K.S. A new solid form of tapentadol and a method of its preparation
EP2674414A1 (en) 2012-06-15 2013-12-18 Siegfried AG Method for the preparation of 1-aryl-1-alkyl-3-dialkylaminopropane compounds
CN103159633B (zh) * 2012-07-06 2015-08-12 江苏恩华药业股份有限公司 他喷他多的制备方法及用于制备他喷他多的化合物
IN2013MU03670A (pt) 2013-11-21 2015-07-31 Unimark Remedies Ltd
SI3083551T1 (en) 2013-12-16 2018-04-30 Farma Grs, D.O.O. CRYSTAL FORM INTERMEDIATE TAPENTADOL
CN104725287A (zh) * 2013-12-20 2015-06-24 北京蓝贝望生物医药科技股份有限公司 一种对甲苯磺酸酯的制备方法与应用
CZ307492B6 (cs) 2014-02-04 2018-10-17 Zentiva, K.S. Pevná forma maleátu tapentadolu a způsob její přípravy
TW201642843A (zh) 2015-03-27 2016-12-16 歌林達有限公司 他噴他多腸胃外給藥的穩定製劑
CN106278915A (zh) * 2015-05-19 2017-01-04 重庆圣华曦药业股份有限公司 一种制备他喷他多中间体的方法
CA2991421C (en) 2015-07-10 2019-04-30 Mallinckrodt Llc A two-step process for preparing 3-substituted phenylalkylamines
EP3515412B1 (en) 2016-09-23 2025-04-23 Grünenthal GmbH Stable formulation for parenteral administration of tapentadol
SK812017A3 (sk) * 2017-08-18 2019-03-01 Saneca Pharmaceuticals A. S. Spôsob prípravy tapentadolu a jeho medziproduktov
CN112262121A (zh) 2018-06-15 2021-01-22 法尔玛赞公司 用于制备他喷他多的新方法
EP3947342A4 (en) * 2019-03-28 2022-12-28 Council of Scientific and Industrial Research NEW PROCESS FOR THE MANUFACTURE OF TAPENTADOL AND INTERMEDIATE PRODUCTS FROM IT
EP4116288A1 (en) 2021-07-08 2023-01-11 KRKA, d.d., Novo mesto Racemization of (s) and/or (r)-3-(dimethylamino)-1-(3-methoxyphenyl)-2-methylpropan-1- one and its mixtures
EP4269384A1 (en) 2022-04-26 2023-11-01 KRKA, d.d., Novo mesto Method for crystallizing tapentadol intermediate, tapentadol intermediate of high purity, method of making tapentadol and tapentadol of high purity
CN119191999A (zh) * 2024-11-26 2024-12-27 苏州盛迪亚生物医药有限公司 一种制备他喷他多或其可药用盐的方法
CN119176758B (zh) * 2024-11-26 2025-05-09 苏州盛迪亚生物医药有限公司 一种固载催化制备他喷他多或其可药用盐的方法
CN119192000B (zh) * 2024-11-26 2025-07-15 苏州盛迪亚生物医药有限公司 连续流反应制备他喷他多或其可药用盐的方法

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JPS60188333A (ja) * 1984-03-07 1985-09-25 Ihara Chem Ind Co Ltd ハロゲン化ベンゼン類の製造方法
DE4426245A1 (de) * 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
DE19609847A1 (de) * 1996-03-13 1997-09-18 Gruenenthal Gmbh Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe
ES2278664T3 (es) * 2000-09-14 2007-08-16 Firmenich Sa Utilizacion de esteres insaturados como ingredientes perfumantes.
DE10326097A1 (de) * 2003-06-06 2005-01-05 Grünenthal GmbH Verfahren zur Herstellung von Dimethyl-(3-aryl-butyl)-aminverbindungen
DE10328316A1 (de) * 2003-06-23 2005-01-20 Grünenthal GmbH Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe
TWI401237B (zh) * 2006-07-24 2013-07-11 ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備

Also Published As

Publication number Publication date
CN101495447B (zh) 2013-05-29
AU2007278224A1 (en) 2008-01-31
PT2046726E (pt) 2010-04-15
HRP20100197T1 (hr) 2010-05-31
IL196627A0 (en) 2009-11-18
HK1134280A1 (en) 2010-04-23
ATE455752T1 (de) 2010-02-15
KR20090033444A (ko) 2009-04-03
US8138376B2 (en) 2012-03-20
JP5208933B2 (ja) 2013-06-12
JP2009544658A (ja) 2009-12-17
SI2046726T1 (sl) 2010-05-31
US8440863B2 (en) 2013-05-14
AU2007278224C1 (en) 2012-06-21
DK2046726T3 (da) 2010-05-10
WO2008012283A1 (en) 2008-01-31
EA200970147A1 (ru) 2009-08-28
CA2656696C (en) 2013-06-11
BRPI0714671B1 (pt) 2020-09-24
CA2656696A1 (en) 2008-01-31
MX2009000911A (es) 2009-02-04
CY1110075T1 (el) 2015-01-14
BRPI0714671A2 (pt) 2013-05-07
EP2046726A1 (en) 2009-04-15
EA015003B1 (ru) 2011-04-29
IL196627A (en) 2013-06-27
DE602007004494D1 (de) 2010-03-11
EP2046726B1 (en) 2010-01-20
KR101370398B1 (ko) 2014-03-05
US20090312578A1 (en) 2009-12-17
AU2007278224B2 (en) 2011-09-15
US20120142970A1 (en) 2012-06-07
ES2339403T3 (es) 2010-05-19
CN101495447A (zh) 2009-07-29
PL2046726T3 (pl) 2010-06-30

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Legal Events

Date Code Title Description
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 24/09/2020, OBSERVADAS AS CONDICOES LEGAIS.

B25A Requested transfer of rights approved

Owner name: GRUENENTHAL GMBH (DE)