BRPI0718996A2 - Síntese de peptídio em fase sólida com boc e fmoc. - Google Patents
Síntese de peptídio em fase sólida com boc e fmoc.Info
- Publication number
- BRPI0718996A2 BRPI0718996A2 BRPI0718996-6A2A BRPI0718996A BRPI0718996A2 BR PI0718996 A2 BRPI0718996 A2 BR PI0718996A2 BR PI0718996 A BRPI0718996 A BR PI0718996A BR PI0718996 A2 BRPI0718996 A2 BR PI0718996A2
- Authority
- BR
- Brazil
- Prior art keywords
- fmoc
- boc
- synthesis
- solid phase
- phase peptide
- Prior art date
Links
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 239000007790 solid phase Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/003—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by transforming the C-terminal amino acid to amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE20060841A IE20060841A1 (en) | 2006-11-21 | 2006-11-21 | Boc and fmoc solid phase peptide synthesis |
| PCT/IE2007/000080 WO2008062391A2 (en) | 2006-11-21 | 2007-08-31 | Boc and fmoc solid phase peptide synthesis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0718996A2 true BRPI0718996A2 (pt) | 2014-02-18 |
| BRPI0718996B1 BRPI0718996B1 (pt) | 2019-08-27 |
| BRPI0718996B8 BRPI0718996B8 (pt) | 2021-05-25 |
Family
ID=39430143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0718996A BRPI0718996B8 (pt) | 2006-11-21 | 2007-08-31 | método para a preparação de um peptídio da fórmula h-d-?-nal-[cys-tyr-d-trp-lys-val-cys]-thr-nh2 ou h-d-?-nal-cys(acm)-tyr-d-trp-lys-val-cys(acm)-thr |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US8383770B2 (pt) |
| EP (1) | EP2084176B1 (pt) |
| JP (3) | JP5281581B2 (pt) |
| KR (1) | KR101237561B1 (pt) |
| CN (2) | CN101541824A (pt) |
| AU (1) | AU2007323057B2 (pt) |
| BR (1) | BRPI0718996B8 (pt) |
| CA (1) | CA2670209C (pt) |
| DK (1) | DK2084176T3 (pt) |
| ES (1) | ES2682103T3 (pt) |
| HK (1) | HK1209433A1 (pt) |
| HU (1) | HUE038926T2 (pt) |
| IE (2) | IE20060841A1 (pt) |
| IL (2) | IL198451A0 (pt) |
| MX (1) | MX2009005377A (pt) |
| NO (1) | NO344798B1 (pt) |
| NZ (1) | NZ577395A (pt) |
| PL (1) | PL2084176T3 (pt) |
| PT (1) | PT2084176T (pt) |
| RU (1) | RU2439075C2 (pt) |
| WO (1) | WO2008062391A2 (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101094867B (zh) | 2004-10-19 | 2011-08-24 | 隆萨股份公司 | 用于固相肽合成的方法 |
| IE20060841A1 (en) * | 2006-11-21 | 2008-05-28 | Ipsen Mfg Ireland Ltd | Boc and fmoc solid phase peptide synthesis |
| CN101628929B (zh) * | 2009-08-27 | 2014-09-17 | 中国人民解放军防化学院 | 一种固相合成侧链保护肽链的新方法 |
| CN102286078A (zh) * | 2011-07-13 | 2011-12-21 | 中国药科大学 | 一种多肽hm-3的制备方法 |
| EP2664374A1 (en) * | 2012-05-15 | 2013-11-20 | F. Hoffmann-La Roche AG | Lysin-glutamic acid dipeptide derivatives |
| WO2017112809A1 (en) | 2015-12-21 | 2017-06-29 | Taxas Tech University System | System and method for solution phase gap peptide synthesis |
| WO2017212390A1 (en) * | 2016-06-06 | 2017-12-14 | Emcure Pharmaceuticals Ltd, | Process for lanreotide acetate preparation |
| CN108059667B (zh) * | 2018-02-10 | 2018-11-13 | 润辉生物技术（威海）有限公司 | 一种兰瑞肽的固相合成方法 |
| CN108440654B (zh) * | 2018-02-24 | 2020-09-04 | 暨南大学 | 一种抗菌活性环六肽Thermoactinoamide A的合成方法 |
| US12024537B2 (en) | 2018-05-31 | 2024-07-02 | Sederma | Compositions and methods for chemical synthesis |
| KR102826649B1 (ko) | 2018-05-31 | 2025-06-30 | 쎄데르마 | 용액-상 펩티드의 합성 방법 및 그에 따른 보호 전략 |
| EP3917937A4 (en) | 2019-02-01 | 2022-11-23 | Sederma | SYNTHETIC STRATEGY FOR A SPLIT PROTECTION GROUP |
| EP4326735A1 (en) | 2021-04-23 | 2024-02-28 | Sederma | Compositions for chemical synthesis of peptides |
| WO2023195516A1 (ja) * | 2022-04-08 | 2023-10-12 | 中外製薬株式会社 | ペプチド化合物の製造方法 |
| WO2025089465A1 (ko) * | 2023-10-27 | 2025-05-01 | 주식회사 엔솔바이오사이언스 | 펩타이드 제조방법 및 그를 이용하여 제조된 펩타이드 |
| WO2025089463A1 (ko) * | 2023-10-27 | 2025-05-01 | 주식회사 엔솔바이오사이언스 | 펩타이드 정제방법 및 그를 이용하여 정제된 펩타이드 |
| WO2025089467A1 (ko) * | 2023-10-27 | 2025-05-01 | 주식회사 엔솔바이오사이언스 | 염형태 변형 펩타이드의 제조방법 및 그를 이용하여 제조된 펩타이드 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4411890A (en) * | 1981-04-14 | 1983-10-25 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
| US4307083A (en) * | 1978-10-16 | 1981-12-22 | The Salk Institute For Biological Studies | LRF Antagonists |
| GB8427651D0 (en) | 1984-11-01 | 1984-12-05 | Beecham Group Plc | Compounds |
| RU2043362C1 (ru) * | 1991-08-12 | 1995-09-10 | Синтекс (Ю-Эс-Эй) Инк. | Способ твердофазного синтеза пептидов |
| ES2336826T3 (es) * | 2005-05-03 | 2010-04-16 | Novetide, Ltd. | Procedimientos para la produccion de un peptido que presenta una amida c-terminal. |
| IE20060841A1 (en) * | 2006-11-21 | 2008-05-28 | Ipsen Mfg Ireland Ltd | Boc and fmoc solid phase peptide synthesis |
-
2006
- 2006-11-21 IE IE20060841A patent/IE20060841A1/en not_active Application Discontinuation
-
2007
- 2007-08-31 CN CNA2007800430493A patent/CN101541824A/zh active Pending
- 2007-08-31 KR KR1020097012968A patent/KR101237561B1/ko active Active
- 2007-08-31 BR BRPI0718996A patent/BRPI0718996B8/pt active IP Right Grant
- 2007-08-31 RU RU2009122664/04A patent/RU2439075C2/ru active
- 2007-08-31 MX MX2009005377A patent/MX2009005377A/es active IP Right Grant
- 2007-08-31 AU AU2007323057A patent/AU2007323057B2/en active Active
- 2007-08-31 ES ES07805470.7T patent/ES2682103T3/es active Active
- 2007-08-31 JP JP2009537759A patent/JP5281581B2/ja active Active
- 2007-08-31 WO PCT/IE2007/000080 patent/WO2008062391A2/en not_active Ceased
- 2007-08-31 CN CN201410791044.0A patent/CN104530190A/zh active Pending
- 2007-08-31 US US12/312,689 patent/US8383770B2/en active Active
- 2007-08-31 HU HUE07805470A patent/HUE038926T2/hu unknown
- 2007-08-31 CA CA2670209A patent/CA2670209C/en not_active Expired - Fee Related
- 2007-08-31 EP EP07805470.7A patent/EP2084176B1/en active Active
- 2007-08-31 PL PL07805470T patent/PL2084176T3/pl unknown
- 2007-08-31 NZ NZ577395A patent/NZ577395A/en unknown
- 2007-08-31 PT PT78054707T patent/PT2084176T/pt unknown
- 2007-08-31 DK DK07805470.7T patent/DK2084176T3/en active
- 2007-09-25 IE IE20070687A patent/IES20070687A2/en not_active IP Right Cessation
-
2009
- 2009-04-28 IL IL198451A patent/IL198451A0/en active IP Right Grant
- 2009-06-10 NO NO20092247A patent/NO344798B1/no unknown
-
2013
- 2013-01-04 US US13/734,537 patent/US9090654B2/en active Active
- 2013-05-24 JP JP2013109478A patent/JP5798149B2/ja active Active
-
2015
- 2015-06-23 US US14/747,083 patent/US20150284424A1/en not_active Abandoned
- 2015-08-19 JP JP2015161578A patent/JP6141367B2/ja active Active
- 2015-10-14 HK HK15110059.0A patent/HK1209433A1/xx unknown
- 2015-12-24 IL IL243230A patent/IL243230A0/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 27/08/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 27/08/2019, OBSERVADAS AS CONDICOES LEGAIS |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 31/08/2007 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |