BRPI0718996A2 - Síntese de peptídio em fase sólida com boc e fmoc. - Google Patents

Síntese de peptídio em fase sólida com boc e fmoc.

Info

Publication number
BRPI0718996A2
BRPI0718996A2 BRPI0718996-6A2A BRPI0718996A BRPI0718996A2 BR PI0718996 A2 BRPI0718996 A2 BR PI0718996A2 BR PI0718996 A BRPI0718996 A BR PI0718996A BR PI0718996 A2 BRPI0718996 A2 BR PI0718996A2
Authority
BR
Brazil
Prior art keywords
fmoc
boc
synthesis
solid phase
phase peptide
Prior art date
Application number
BRPI0718996-6A2A
Other languages
English (en)
Inventor
Catherine Fiona Dalton
John Stuart Eynon
Steven Allen Jackson
Gary Alexander Siwruk
Original Assignee
Ipsen Mfg Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipsen Mfg Ireland Ltd filed Critical Ipsen Mfg Ireland Ltd
Publication of BRPI0718996A2 publication Critical patent/BRPI0718996A2/pt
Publication of BRPI0718996B1 publication Critical patent/BRPI0718996B1/pt
Publication of BRPI0718996B8 publication Critical patent/BRPI0718996B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/003—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by transforming the C-terminal amino acid to amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0718996A 2006-11-21 2007-08-31 método para a preparação de um peptídio da fórmula h-d-?-nal-[cys-tyr-d-trp-lys-val-cys]-thr-nh2 ou h-d-?-nal-cys(acm)-tyr-d-trp-lys-val-cys(acm)-thr BRPI0718996B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IE20060841A IE20060841A1 (en) 2006-11-21 2006-11-21 Boc and fmoc solid phase peptide synthesis
PCT/IE2007/000080 WO2008062391A2 (en) 2006-11-21 2007-08-31 Boc and fmoc solid phase peptide synthesis

Publications (3)

Publication Number Publication Date
BRPI0718996A2 true BRPI0718996A2 (pt) 2014-02-18
BRPI0718996B1 BRPI0718996B1 (pt) 2019-08-27
BRPI0718996B8 BRPI0718996B8 (pt) 2021-05-25

Family

ID=39430143

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0718996A BRPI0718996B8 (pt) 2006-11-21 2007-08-31 método para a preparação de um peptídio da fórmula h-d-?-nal-[cys-tyr-d-trp-lys-val-cys]-thr-nh2 ou h-d-?-nal-cys(acm)-tyr-d-trp-lys-val-cys(acm)-thr

Country Status (21)

Country Link
US (3) US8383770B2 (pt)
EP (1) EP2084176B1 (pt)
JP (3) JP5281581B2 (pt)
KR (1) KR101237561B1 (pt)
CN (2) CN101541824A (pt)
AU (1) AU2007323057B2 (pt)
BR (1) BRPI0718996B8 (pt)
CA (1) CA2670209C (pt)
DK (1) DK2084176T3 (pt)
ES (1) ES2682103T3 (pt)
HK (1) HK1209433A1 (pt)
HU (1) HUE038926T2 (pt)
IE (2) IE20060841A1 (pt)
IL (2) IL198451A0 (pt)
MX (1) MX2009005377A (pt)
NO (1) NO344798B1 (pt)
NZ (1) NZ577395A (pt)
PL (1) PL2084176T3 (pt)
PT (1) PT2084176T (pt)
RU (1) RU2439075C2 (pt)
WO (1) WO2008062391A2 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1737889E (pt) 2004-10-19 2010-12-13 Lonza Ag Método para síntese de péptidos em fase sólida
IE20060841A1 (en) * 2006-11-21 2008-05-28 Ipsen Mfg Ireland Ltd Boc and fmoc solid phase peptide synthesis
CN101628929B (zh) * 2009-08-27 2014-09-17 中国人民解放军防化学院 一种固相合成侧链保护肽链的新方法
CN102286078A (zh) * 2011-07-13 2011-12-21 中国药科大学 一种多肽hm-3的制备方法
EP2664374A1 (en) * 2012-05-15 2013-11-20 F. Hoffmann-La Roche AG Lysin-glutamic acid dipeptide derivatives
CN108697770B (zh) 2015-12-21 2023-08-01 得克萨斯技术大学联合体 用于溶液相gap肽合成的系统和方法
WO2017212390A1 (en) * 2016-06-06 2017-12-14 Emcure Pharmaceuticals Ltd, Process for lanreotide acetate preparation
CN108059667B (zh) * 2018-02-10 2018-11-13 润辉生物技术（威海）有限公司 一种兰瑞肽的固相合成方法
CN108440654B (zh) * 2018-02-24 2020-09-04 暨南大学 一种抗菌活性环六肽Thermoactinoamide A的合成方法
EP3802554B1 (en) 2018-05-31 2023-12-13 Sederma Method for solution-phase peptide synthesis and protecting strategies therefore
US12024537B2 (en) 2018-05-31 2024-07-02 Sederma Compositions and methods for chemical synthesis
WO2020159837A1 (en) 2019-02-01 2020-08-06 Gap Peptides Llc Synthesis strategy for gap protecting group
EP4326735A1 (en) 2021-04-23 2024-02-28 Sederma Compositions for chemical synthesis of peptides
WO2023195516A1 (ja) * 2022-04-08 2023-10-12 中外製薬株式会社 ペプチド化合物の製造方法
WO2025089463A1 (ko) * 2023-10-27 2025-05-01 주식회사 엔솔바이오사이언스 펩타이드 정제방법 및 그를 이용하여 정제된 펩타이드
WO2025089467A1 (ko) * 2023-10-27 2025-05-01 주식회사 엔솔바이오사이언스 염형태 변형 펩타이드의 제조방법 및 그를 이용하여 제조된 펩타이드
WO2025089465A1 (ko) * 2023-10-27 2025-05-01 주식회사 엔솔바이오사이언스 펩타이드 제조방법 및 그를 이용하여 제조된 펩타이드

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4411890A (en) * 1981-04-14 1983-10-25 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4307083A (en) * 1978-10-16 1981-12-22 The Salk Institute For Biological Studies LRF Antagonists
GB8427651D0 (en) * 1984-11-01 1984-12-05 Beecham Group Plc Compounds
RU2043362C1 (ru) * 1991-08-12 1995-09-10 Синтекс (Ю-Эс-Эй) Инк. Способ твердофазного синтеза пептидов
ES2336826T3 (es) * 2005-05-03 2010-04-16 Novetide, Ltd. Procedimientos para la produccion de un peptido que presenta una amida c-terminal.
IE20060841A1 (en) * 2006-11-21 2008-05-28 Ipsen Mfg Ireland Ltd Boc and fmoc solid phase peptide synthesis

Also Published As

Publication number Publication date
DK2084176T3 (en) 2018-08-27
HK1209433A1 (en) 2016-04-01
NZ577395A (en) 2011-10-28
PT2084176T (pt) 2018-08-01
JP2010510304A (ja) 2010-04-02
US9090654B2 (en) 2015-07-28
HUE038926T2 (hu) 2018-12-28
RU2439075C2 (ru) 2012-01-10
EP2084176B1 (en) 2018-05-30
KR101237561B1 (ko) 2013-02-27
JP5281581B2 (ja) 2013-09-04
IL198451A0 (en) 2010-02-17
US8383770B2 (en) 2013-02-26
MX2009005377A (es) 2009-09-28
CN104530190A (zh) 2015-04-22
WO2008062391A3 (en) 2008-10-02
RU2009122664A (ru) 2010-12-27
PL2084176T3 (pl) 2018-11-30
IES20070687A2 (en) 2008-05-14
ES2682103T3 (es) 2018-09-18
JP6141367B2 (ja) 2017-06-07
JP2016000749A (ja) 2016-01-07
KR20090100369A (ko) 2009-09-23
AU2007323057A1 (en) 2008-05-29
NO344798B1 (no) 2020-05-04
IL243230A0 (en) 2016-02-29
CA2670209C (en) 2012-04-10
US20150284424A1 (en) 2015-10-08
EP2084176A2 (en) 2009-08-05
AU2007323057B2 (en) 2011-07-28
IE20060841A1 (en) 2008-05-28
US20130338337A1 (en) 2013-12-19
BRPI0718996B1 (pt) 2019-08-27
NO20092247L (no) 2009-08-17
JP2013163693A (ja) 2013-08-22
JP5798149B2 (ja) 2015-10-21
WO2008062391A2 (en) 2008-05-29
US20100160604A1 (en) 2010-06-24
CN101541824A (zh) 2009-09-23
CA2670209A1 (en) 2008-05-29
BRPI0718996B8 (pt) 2021-05-25

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 27/08/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 27/08/2019, OBSERVADAS AS CONDICOES LEGAIS

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 31/08/2007 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF