BRPI0719797A8 - Compostos e composições como inibidores de proteína cinase - Google Patents

Compostos e composições como inibidores de proteína cinase

Info

Publication number
BRPI0719797A8
BRPI0719797A8 BRPI0719797A BRPI0719797A BRPI0719797A8 BR PI0719797 A8 BRPI0719797 A8 BR PI0719797A8 BR PI0719797 A BRPI0719797 A BR PI0719797A BR PI0719797 A BRPI0719797 A BR PI0719797A BR PI0719797 A8 BRPI0719797 A8 BR PI0719797A8
Authority
BR
Brazil
Prior art keywords
compounds
compositions
protein kinase
kinase inhibitors
raf
Prior art date
Application number
BRPI0719797A
Other languages
English (en)
Inventor
A Albaugh Pamela
S Chopiuk Gregory
Ding Qing
Huang Shenlin
Liu Zuosheng
Pan Shifeng
Ren Pingda
Wang Xia
Wang Xing
Xie Yongping
Zhang Chengzhi
Zhang Qiong
Zhang Guobao
Poon Daniel
Renhowe Paul
Sendzik Martin
Original Assignee
Novartis Ag
Irm Llc
Novartis Int Pharmaceutical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38955203&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0719797(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag, Irm Llc, Novartis Int Pharmaceutical Ltd filed Critical Novartis Ag
Publication of BRPI0719797A2 publication Critical patent/BRPI0719797A2/pt
Publication of BRPI0719797A8 publication Critical patent/BRPI0719797A8/pt

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Pulmonology (AREA)
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  • Psychiatry (AREA)
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Abstract

COMPOSTOS E COMPOSIÇÕES COMO INIBIDORES DE PROTEÍNA CINASE. A presente invenção refere se uma nova casse de compostos, composições farmacêuticas que compreendem tais compostos e métodos de l" emprego de tais compostos para tratar ou prevenir doenças ou distúrbios associados à atividade de cinase anormal ou desregulada, particularmente doenças ou distúrbios que envolvem ativação anormal das Abl, ARG, BCR- Abl, BRK, Eph8, Fms, Fyn, KDR, c-Kit, LCK, PDGF-R, b-Raf, c-Raf, SAPK2, ' 10 Src, Tie2 e Trk8 cinases.
BRPI0719797A 2006-10-02 2007-09-24 Compostos e composições como inibidores de proteína cinase BRPI0719797A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82787306P 2006-10-02 2006-10-02
PCT/US2007/079340 WO2008042639A1 (en) 2006-10-02 2007-09-24 Compounds and compositions as protein kinase inhibitors

Publications (2)

Publication Number Publication Date
BRPI0719797A2 BRPI0719797A2 (pt) 2017-10-24
BRPI0719797A8 true BRPI0719797A8 (pt) 2017-12-26

Family

ID=38955203

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0719797A BRPI0719797A8 (pt) 2006-10-02 2007-09-24 Compostos e composições como inibidores de proteína cinase

Country Status (22)

Country Link
US (1) US8202876B2 (pt)
EP (1) EP2057146A1 (pt)
JP (1) JP5153777B2 (pt)
KR (1) KR101101675B1 (pt)
CN (2) CN103739595A (pt)
AR (1) AR063099A1 (pt)
AU (1) AU2007305016B2 (pt)
BR (1) BRPI0719797A8 (pt)
CA (1) CA2663366C (pt)
CL (1) CL2007002836A1 (pt)
CO (1) CO6180440A2 (pt)
CR (1) CR10670A (pt)
EA (1) EA015751B1 (pt)
IL (1) IL197724A0 (pt)
MA (1) MA30772B1 (pt)
MX (1) MX2009003456A (pt)
NO (1) NO20091759L (pt)
PE (1) PE20080828A1 (pt)
SM (1) SMAP200900020A (pt)
TN (1) TN2009000105A1 (pt)
TW (1) TW200823200A (pt)
WO (1) WO2008042639A1 (pt)

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