BRPI0719955A2 - Processo para síntese de derivados de fenóxi diaminopirimidina - Google Patents

Processo para síntese de derivados de fenóxi diaminopirimidina

Info

Publication number: BRPI0719955A2
Authority: BR; Brazil
Prior art keywords: phenomy; diaminopyrimidine; synthesis; derivatives; phenomy derivatives
Prior art date: 2006-10-04

Application number

BRPI0719955-4A2A

Other languages

English (en)

Inventor

Charles Alois Dvorak

Keena Lynn Green

Gary R Lee

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-10-04

Filing date

2007-09-24

Publication date

2014-04-29

2007-09-24 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2014-04-29 Publication of BRPI0719955A2 publication Critical patent/BRPI0719955A2/pt

2024-01-09 Publication of BRPI0719955B1 publication Critical patent/BRPI0719955B1/pt

Links

230000015572 biosynthetic process Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
YAAWASYJIRZXSZ-UHFFFAOYSA-N pyrimidine-2,4-diamine Chemical compound NC1=CC=NC(N)=N1 YAAWASYJIRZXSZ-UHFFFAOYSA-N 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Reproductive Health (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Pyridine Compounds (AREA)

BRPI0719955-4A 2006-10-04 2007-09-24 Processo para síntese de derivados de fenóxi diaminopirimidina BRPI0719955B1 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US84920306P	2006-10-04	2006-10-04
US60/849,203		2006-10-04
PCT/EP2007/060095 WO2008040652A1 (en)	2006-10-04	2007-09-24	Process for synthesis of phenoxy diaminopyrimidine derivatives

Publications (2)

Publication Number	Publication Date
BRPI0719955A2 true BRPI0719955A2 (pt)	2014-04-29
BRPI0719955B1 BRPI0719955B1 (pt)	2024-01-09

Family

ID=39004835

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0719955-4A BRPI0719955B1 (pt)	2006-10-04	2007-09-24	Processo para síntese de derivados de fenóxi diaminopirimidina

Country Status (15)

Country	Link
US (3)	US8003788B2 (pt)
EP (2)	EP2343281B1 (pt)
JP (2)	JP5128603B2 (pt)
KR (1)	KR101176701B1 (pt)
CN (2)	CN102432548A (pt)
AU (1)	AU2007304280B2 (pt)
BR (1)	BRPI0719955B1 (pt)
CA (1)	CA2664305C (pt)
DK (1)	DK2343281T3 (pt)
ES (2)	ES2461595T3 (pt)
IL (3)	IL197639A (pt)
MX (1)	MX2009003257A (pt)
PL (1)	PL2343281T3 (pt)
SI (1)	SI2343281T1 (pt)
WO (1)	WO2008040652A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2007304280B2 (en) *	2006-10-04	2013-01-31	F. Hoffmann-La Roche Ag	Process for synthesis of phenoxy diaminopyrimidine derivatives
AU2014308606B2 (en) *	2013-08-23	2017-08-03	Afferent Pharmaceuticals Inc.	Diaminopyrimidine P2X3 and P2X 2/3 receptor modulators for treatment of acute, sub-acute or chronic cough
CN105085847B (zh) *	2014-05-23	2018-05-04	中国科学院宁波材料技术与工程研究所	一种磺酰胺化芳香族聚合物、其制备方法及应用
US10195198B2 (en)	2014-07-03	2019-02-05	Afferent Pharmaceuticals, Inc.	Methods and compositions for treating diseases and conditions
DK3355889T3 (da) *	2015-09-29	2023-05-15	Afferent Pharmaceuticals Inc	Diaminopyrimidin-p2x3- og p2x2/3-receptormodulatorer til anvendelse i behandling af hoste
AU2017237929B2 (en)	2016-03-25	2021-04-15	Afferent Pharmaceuticals Inc.	Pyrimidines and variants thereof, and uses therefor
CN110087654A (zh) *	2016-12-20	2019-08-02	传入制药公司	P2x3拮抗剂的结晶盐和多晶型物
EP3784242A4 (en) *	2018-04-23	2021-12-22	Merck Sharp & Dohme Corp.	NEW PROCESS FOR PREPARING A PHENOXYDIAMINOPYRIMIDINE COMPOUND
BR112021021600A2 (pt)	2019-04-30	2022-01-04	Beijing Tide Pharmaceutical Co Ltd	Método para tratamento de tosse usando composto de diaminopirimidina
CN111635368B (zh) *	2020-06-12	2021-06-29	东莞市东阳光仿制药研发有限公司	一种胺化合物的制备方法
WO2022060945A1 (en)	2020-09-17	2022-03-24	Teva Pharmaceuticals International Gmbh	Solid state forms of gefapixant and process for preparation thereof
CN113336680B (zh) *	2021-06-04	2023-10-03	寿光永康化学工业有限公司	一种磺胺的绿色工艺合成方法
CN113801097B (zh) *	2021-09-27	2022-11-22	成都施贝康生物医药科技有限公司	二氢嘧啶类化合物、其制备方法及用途
CN113773300B (zh) *	2021-09-27	2022-10-11	成都施贝康生物医药科技有限公司	磺酰胺类化合物、其制备方法及用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3117721B2 (ja) *	1994-11-24	2000-12-18	エフ・ホフマン−ラロシュアーゲー	新規なベンジルピリミジン類
AUPQ968700A0 (en) *	2000-08-28	2000-09-21	Intreat Pty Limited	Treatment of urinary incontinence
WO2004011466A1 (ja) *	2002-07-29	2004-02-05	Sumitomo Chemical Takeda Agro Company, Limited	イミダゾ［１，２−ｂ］ピリダジン類の新規な製造法
CA2557372C (en) *	2004-03-05	2013-01-08	F. Hoffmann-La Roche Ag	Diaminopyrimidines as p2x3 and p2x2/3 antagonists
SE0401716D0 (sv) *	2004-07-02	2004-07-02	Astrazeneca Ab	New compounds
WO2006020830A2 (en) *	2004-08-12	2006-02-23	Amgen Inc.	Bisaryl-sulfonamides
JP4246207B2 (ja) *	2005-02-21	2009-04-02	住友化学株式会社	除草剤組成物
CN101300012B (zh) *	2005-09-01	2011-09-14	弗·哈夫曼-拉罗切有限公司	作为p2x3和p2x2/3调节剂的二氨基嘧啶类化合物在制备治疗呼吸系统疾病的药物中的应用
WO2007025898A1 (en) *	2005-09-01	2007-03-08	F. Hoffmann-La Roche Ag	Process for synthesis of aryloxy diaminopyrimidines
AU2007304280B2 (en) *	2006-10-04	2013-01-31	F. Hoffmann-La Roche Ag	Process for synthesis of phenoxy diaminopyrimidine derivatives
WO2008104474A1 (en) *	2007-02-28	2008-09-04	F. Hoffmann-La Roche Ag	Diaminopyrimidines

2007
- 2007-09-24 AU AU2007304280A patent/AU2007304280B2/en active Active
- 2007-09-24 SI SI200731458T patent/SI2343281T1/sl unknown
- 2007-09-24 BR BRPI0719955-4A patent/BRPI0719955B1/pt active IP Right Grant
- 2007-09-24 MX MX2009003257A patent/MX2009003257A/es active IP Right Grant
- 2007-09-24 PL PL10180595T patent/PL2343281T3/pl unknown
- 2007-09-24 EP EP10180595.0A patent/EP2343281B1/en active Active
- 2007-09-24 DK DK10180595.0T patent/DK2343281T3/en active
- 2007-09-24 CN CN2011103315372A patent/CN102432548A/zh active Pending
- 2007-09-24 WO PCT/EP2007/060095 patent/WO2008040652A1/en not_active Ceased
- 2007-09-24 KR KR1020097008196A patent/KR101176701B1/ko active Active
- 2007-09-24 CN CN2007800373077A patent/CN101522641B/zh active Active
- 2007-09-24 JP JP2009530844A patent/JP5128603B2/ja active Active
- 2007-09-24 CA CA2664305A patent/CA2664305C/en active Active
- 2007-09-24 ES ES10180595.0T patent/ES2461595T3/es active Active
- 2007-09-24 EP EP07820502.8A patent/EP2079713B1/en active Active
- 2007-09-24 ES ES07820502.8T patent/ES2466667T3/es active Active
- 2007-10-04 US US11/906,802 patent/US8003788B2/en active Active
2009
- 2009-03-17 IL IL197639A patent/IL197639A/en active IP Right Grant
2011
- 2011-07-12 US US13/181,305 patent/US8580960B2/en active Active
2012
- 2012-09-05 JP JP2012194914A patent/JP5669793B2/ja active Active
2013
- 2013-10-14 US US14/053,362 patent/US9643934B2/en active Active
2014
- 2014-09-09 IL IL234545A patent/IL234545A/en active IP Right Grant
2017
- 2017-09-11 IL IL254426A patent/IL254426A0/en unknown

Also Published As

Publication number	Publication date
US20140045871A1 (en)	2014-02-13
PL2343281T3 (pl)	2014-08-29
IL234545A (en)	2017-10-31
WO2008040652A1 (en)	2008-04-10
AU2007304280B2 (en)	2013-01-31
AU2007304280A1 (en)	2008-04-10
IL254426A0 (en)	2017-11-30
SI2343281T1 (sl)	2014-06-30
CA2664305A1 (en)	2008-04-10
CA2664305C (en)	2016-06-07
CN102432548A (zh)	2012-05-02
US8580960B2 (en)	2013-11-12
EP2079713A1 (en)	2009-07-22
US8003788B2 (en)	2011-08-23
KR20090055043A (ko)	2009-06-01
IL197639A (en)	2015-02-26
US9643934B2 (en)	2017-05-09
JP5669793B2 (ja)	2015-02-18
EP2343281A1 (en)	2011-07-13
US20080086004A1 (en)	2008-04-10
MX2009003257A (es)	2009-04-07
EP2343281B1 (en)	2014-03-05
ES2466667T3 (es)	2014-06-10
JP5128603B2 (ja)	2013-01-23
DK2343281T3 (en)	2014-03-24
JP2013010780A (ja)	2013-01-17
JP2010505790A (ja)	2010-02-25
CN101522641B (zh)	2012-07-04
IL197639A0 (en)	2009-12-24
EP2079713B1 (en)	2014-04-16
CN101522641A (zh)	2009-09-02
BRPI0719955B1 (pt)	2024-01-09
US20110269961A1 (en)	2011-11-03
ES2461595T3 (es)	2014-05-20
KR101176701B1 (ko)	2012-08-23

Legal Events

Date	Code	Title	Description
2018-04-24	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2020-06-23	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]	Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.
2020-09-29	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2020-10-27	B06U	Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
2021-02-02	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2021-05-18	B09B	Patent application refused [chapter 9.2 patent gazette]
2021-07-20	B12B	Appeal against refusal [chapter 12.2 patent gazette]
2024-01-09	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/09/2007, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.

Publication	Publication Date	Title
BRPI0719955A2 (pt)	2014-04-29	Processo para síntese de derivados de fenóxi diaminopirimidina
BRPI0819602A2 (pt)	2015-05-05	Processo para produzir gás de síntese de amônia
BRPI0814327A2 (pt)	2015-01-20	Processo para produzir gás de síntese de amônia
BRPI0910689A2 (pt)	2016-11-01	processo de síntese de rna por via química
BRPI0819659A2 (pt)	2015-05-26	Processo para produção de álcool
BRPI0816258A2 (pt)	2017-05-02	processo para a preparação de compostos úteis como inibidores de sglt
PT2155838E (pt)	2014-10-08	Processo de produção de hidrocarbonetos ramificados
BRPI0820689A2 (pt)	2019-09-24	processo de produção de um derivado de indolinona
BRPI0807626A2 (pt)	2014-11-25	Processo para a síntese de compostos de 2-aminotiazol como inibidores de quinase
BRPI0718440A2 (pt)	2013-11-19	Processo de preparo de halogenetos de n-alquinaltrexona
CR10562A (es)	2009-03-20	Nuevos derivados de piridazina
ES2380489T8 (es)	2012-06-22	Proceso para la síntesis de compuestos orgánicos
PT2155839E (pt)	2014-10-13	Processo de produção de hidrocarbonetos ramificados
BRPI0814457A2 (pt)	2015-01-06	Derivados de imidazolona, composições farmacêuticas, utilização de derivados de imidazolona, e, processo de síntese de derivados de imidazolona
EP2019118A4 (en)	2011-09-07	METHOD FOR SYNTHETIZING THYMOSINS
BRPI0816911A2 (pt)	2015-03-17	Processo para preparação de 4-aminobut-2-enolidas
DK2029567T3 (da)	2010-11-29	Fremgangsmåde til frembringelse af benzopyran-2-ol-derivater
BRPI0814012A2 (pt)	2015-02-03	Processo para produção de (met)acrilatos
BRPI0910545A2 (pt)	2015-09-29	processo contínuo para fazer composições farmacêuticas
BRPI0813960A2 (pt)	2015-01-06	Processo para produção de biarilas
BRPI0813788A2 (pt)	2014-12-30	Processo para preparação de metacrilato de alila
BRPI0910675A2 (pt)	2015-08-11	Processo para preparação de intermediários de naftalen-2-ilpirazol-3-ona úteis na síntese dos inibidores de receptores sigma
BRPI0915177A2 (pt)	2016-04-26	processo para fazer 2-amino-tiazolonas substituídas
BRPI0821837A2 (pt)	2015-06-16	Processo para a preparação de 6-substituídas-1-(2h)-isoquinolinonas
BRPI0913644A2 (pt)	2015-11-24	processo para a prepração de derivados de pirimidina substituída.