BRPI0820689A2 - processo de produção de um derivado de indolinona - Google Patents

processo de produção de um derivado de indolinona

Info

Publication number: BRPI0820689A2
Authority: BR; Brazil
Prior art keywords: producing; indolinone derivative; indolinone; derivative
Prior art date: 2007-12-03

Application number

BRPI0820689A

Other languages

English (en)

Inventor

Reichel Carsten

Linz Guenter

Merten Joern

Schnaubelt Jürgen

Schiffers Robert

Schmid Rolf

Renner Svenja

Rall Werner

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-03

Filing date

2008-12-02

Publication date

2019-09-24

2008-12-02 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2019-09-24 Publication of BRPI0820689A2 publication Critical patent/BRPI0820689A2/pt

Links

JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)

BRPI0820689A 2007-12-03 2008-12-02 processo de produção de um derivado de indolinona BRPI0820689A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP07122122		2007-12-03
PCT/EP2008/066580 WO2009071523A1 (en)	2007-12-03	2008-12-02	Process for the manufacture of an indolinone derivative

Publications (1)

Publication Number	Publication Date
BRPI0820689A2 true BRPI0820689A2 (pt)	2019-09-24

Family

ID=40452557

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0820689A BRPI0820689A2 (pt)	2007-12-03	2008-12-02	processo de produção de um derivado de indolinona

Country Status (21)

Country	Link
US (1)	US8304541B2 (pt)
EP (1)	EP2229359B1 (pt)
JP (1)	JP5269907B2 (pt)
KR (1)	KR20100094497A (pt)
CN (1)	CN101883756A (pt)
AR (1)	AR069530A1 (pt)
AU (1)	AU2008333286B2 (pt)
BR (1)	BRPI0820689A2 (pt)
CA (1)	CA2706423A1 (pt)
CL (1)	CL2008003598A1 (pt)
DK (1)	DK2229359T3 (pt)
ES (1)	ES2658091T3 (pt)
HU (1)	HUE036390T2 (pt)
IL (1)	IL205389A (pt)
MX (1)	MX2010005556A (pt)
NZ (1)	NZ585799A (pt)
PL (1)	PL2229359T3 (pt)
RU (1)	RU2525114C2 (pt)
TR (1)	TR201802086T4 (pt)
TW (1)	TWI432424B (pt)
WO (1)	WO2009071523A1 (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
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UY31506A1 (es) *	2007-12-03	2009-08-03		Derivados de indolinona y procedimiento para su preparacion
US20170065529A1 (en)	2015-09-09	2017-03-09	Boehringer Ingelheim International Gmbh	Pharmaceutical dosage form for immediate release of an indolinone derivative
WO2012068441A2 (en)	2010-11-19	2012-05-24	Ratiopharm Gmbh	Intedanib salts and solid state forms thereof
US20140350022A1 (en)	2013-05-10	2014-11-27	Boehringer Ingelheim International Gmbh	Efficacious treatment of NSCLC and predictive clinical marker of the responsiveness of a tumour to a treatment
CN104829596B (zh) *	2014-02-10	2017-02-01	石家庄以岭药业股份有限公司	吡咯取代吲哚酮类衍生物、其制备方法、包含该衍生物的组合物、及其用途
CN104262232B (zh)	2014-09-09	2016-05-04	苏州明锐医药科技有限公司	尼泰达尼的制备方法
CN106008308A (zh) *	2015-03-13	2016-10-12	正大天晴药业集团股份有限公司	尼达尼布乙磺酸盐结晶
WO2016178064A1 (en) *	2015-05-06	2016-11-10	Suven Life Sciences Limited	Polymorph of nintedanib ethanesulphonate, processes and intermediates thereof
CN104844499B (zh) *	2015-06-05	2017-03-08	北京康立生医药技术开发有限公司	一锅法制备尼达尼布的合成方法
CN105126909B (zh) *	2015-07-13	2018-01-23	淮海工学院	固载钯催化剂在4‑苯乙炔基‑3‑硝基苯甲酸甲酯合成中的应用
CN105001143A (zh) *	2015-07-24	2015-10-28	南京正大天晴制药有限公司	一种制备高纯度乙磺酸尼达尼布的方法
CZ308695B6 (cs)	2015-07-29	2021-03-03	Zentiva, K.S.	Způsob přípravy methyl (Z)-3[[4-[methyl[2-(4-methyl-1piperazinyl)acetyl]amino]fenyl]amino]fenylmethylen)-oxindol-6karboxylátu (intedanibu, nintedanibu)
CN106432042A (zh) *	2015-08-13	2017-02-22	南京华威医药科技开发有限公司	尼达尼布乙磺酸水合物的药物新晶型
CN106467500A (zh) *	2015-08-14	2017-03-01	廊坊百瑞化工有限公司	一种一锅煮法合成尼达尼布关键中间体的新方法
WO2017077551A2 (en) *	2015-11-03	2017-05-11	Mylan Laboratories Limited	An amorphous nintedanib esylate and solid dispersion thereof
CN105418483A (zh) *	2015-12-15	2016-03-23	南京艾德凯腾生物医药有限责任公司	一种结晶型乙磺酸尼达尼布的制备方法
CN105461609B (zh) *	2015-12-25	2019-08-23	杭州新博思生物医药有限公司	一种尼达尼布的制备方法
CN105837493B (zh) *	2016-04-08	2018-12-14	东南大学	尼达尼布的合成方法及其中间体
CN109415314A (zh) *	2016-05-19	2019-03-01	上海诚妙医药科技有限公司	尼达尼布的新晶型及其制备方法及其用途
CN106543069A (zh) *	2016-09-20	2017-03-29	北京万全德众医药生物技术有限公司	6‑甲氧基羰基‑2‑氧代二氢吲哚的制备
WO2018068733A1 (zh) *	2016-10-12	2018-04-19	浙江华海药业股份有限公司	尼达尼布及其中间体的制备方法
CN107935909B (zh) *	2016-10-13	2023-03-17	上海科胜药物研发有限公司	一种尼达尼布（nintedanib）及其中间体的合成方法
CN108610308A (zh) *	2016-12-09	2018-10-02	上海奥博生物医药技术有限公司	一锅法制备尼达尼布中间体的方法
EP3597636A4 (en) *	2017-03-14	2020-10-21	Allgenesis Biotherapeutics Inc.	CRYSTALLINE FORMS OF 3-Z- [1- (4- (N - ((4-METHYL-PIPERAZIN-1-YL) -METHYLCARBONYL) -N-METHYL-AMINO) -PHENYLAMINO) -1-PHENYL-METHYLENE] -6 -METHOXYCARBONYL-2-INDOLINONE
CN106841495B (zh) *	2017-04-21	2018-05-11	常州佳德医药科技有限公司	乙磺酸尼达尼布中基因毒性杂质的高灵敏度分析方法
CA3082714A1 (en)	2017-11-17	2019-05-23	Fermion Oy	Synthesis of a 2-indolinone derivative known as intermediate for preparing nintedanib
CN110746378B (zh) *	2018-12-03	2021-11-05	江苏豪森药业集团有限公司	一种胺基中间体的制备方法
CN111004141B (zh) *	2019-12-19	2022-10-04	苏州诚和医药化学有限公司	一种尼达尼布中间体2-氯-n-甲基-n-(4-硝基苯基)乙酰胺合成新方法
WO2022029805A1 (en) *	2020-08-07	2022-02-10	Bdr Lifesciences Private Limited	An improved highly efficient process for the prepration of nintedanib and pharmaceutically acceptable salt thereof
CN115181078B (zh) *	2022-07-27	2024-07-19	安徽修一制药有限公司	一种尼达尼布关键中间体的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SK4032001A3 (en) *	1998-09-25	2001-11-06	Boehringer Ingelheim Pharma	Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes
UA75054C2 (uk)	1999-10-13	2006-03-15	Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг	Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу
DE10233500A1 (de) *	2002-07-24	2004-02-19	Boehringer Ingelheim Pharma Gmbh & Co. Kg	3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel
US7148249B2 (en) *	2002-09-12	2006-12-12	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments

2008
- 2008-12-02 KR KR1020107012140A patent/KR20100094497A/ko not_active Ceased
- 2008-12-02 AU AU2008333286A patent/AU2008333286B2/en not_active Ceased
- 2008-12-02 WO PCT/EP2008/066580 patent/WO2009071523A1/en not_active Ceased
- 2008-12-02 MX MX2010005556A patent/MX2010005556A/es active IP Right Grant
- 2008-12-02 HU HUE08857477A patent/HUE036390T2/hu unknown
- 2008-12-02 TW TW097146810A patent/TWI432424B/zh not_active IP Right Cessation
- 2008-12-02 DK DK08857477.7T patent/DK2229359T3/en active
- 2008-12-02 CA CA2706423A patent/CA2706423A1/en not_active Abandoned
- 2008-12-02 AR ARP080105253A patent/AR069530A1/es unknown
- 2008-12-02 JP JP2010535406A patent/JP5269907B2/ja active Active
- 2008-12-02 PL PL08857477T patent/PL2229359T3/pl unknown
- 2008-12-02 TR TR2018/02086T patent/TR201802086T4/tr unknown
- 2008-12-02 CL CL2008003598A patent/CL2008003598A1/es unknown
- 2008-12-02 US US12/745,796 patent/US8304541B2/en active Active
- 2008-12-02 BR BRPI0820689A patent/BRPI0820689A2/pt not_active IP Right Cessation
- 2008-12-02 RU RU2010126906/04A patent/RU2525114C2/ru not_active IP Right Cessation
- 2008-12-02 ES ES08857477.7T patent/ES2658091T3/es active Active
- 2008-12-02 CN CN2008801190699A patent/CN101883756A/zh active Pending
- 2008-12-02 EP EP08857477.7A patent/EP2229359B1/en active Active
- 2008-12-02 NZ NZ585799A patent/NZ585799A/en not_active IP Right Cessation
2010
- 2010-04-28 IL IL205389A patent/IL205389A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
AR069530A1 (es)	2010-01-27
JP2011504919A (ja)	2011-02-17
IL205389A0 (en)	2010-12-30
RU2525114C2 (ru)	2014-08-10
TW200932739A (en)	2009-08-01
IL205389A (en)	2014-11-30
NZ585799A (en)	2012-04-27
US20110201812A1 (en)	2011-08-18
MX2010005556A (es)	2010-08-11
TWI432424B (zh)	2014-04-01
CN101883756A (zh)	2010-11-10
WO2009071523A1 (en)	2009-06-11
EP2229359A1 (en)	2010-09-22
JP5269907B2 (ja)	2013-08-21
DK2229359T3 (en)	2018-02-05
AU2008333286B2 (en)	2014-08-14
EP2229359B1 (en)	2017-11-29
CA2706423A1 (en)	2009-06-11
AU2008333286A1 (en)	2009-06-11
ES2658091T3 (es)	2018-03-08
HUE036390T2 (hu)	2018-07-30
PL2229359T3 (pl)	2018-04-30
CL2008003598A1 (es)	2010-02-12
RU2010126906A (ru)	2012-01-10
US8304541B2 (en)	2012-11-06
TR201802086T4 (tr)	2018-03-21
KR20100094497A (ko)	2010-08-26

Legal Events

Date	Code	Title	Description
2019-10-01	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2020-01-21	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

Publication	Publication Date	Title
BRPI0820689A2 (pt)	2019-09-24	processo de produção de um derivado de indolinona
PT2155838E (pt)	2014-10-08	Processo de produção de hidrocarbonetos ramificados
PT2155839E (pt)	2014-10-13	Processo de produção de hidrocarbonetos ramificados
LTC3214083I2 (lt)	2022-06-27	Kvinolono junginių gamybos būdas
BRPI0821944A2 (pt)	2015-06-23	Processo
BRPI0919868A2 (pt)	2015-12-15	processo
FI20095140L (fi)	2010-08-14	Menetelmä muokatun selluloosan valmistamiseksi
BRPI0921374A2 (pt)	2015-12-29	processo
BRPI0918022A2 (pt)	2015-11-17	método de produção de derivado de amida
BRPI0910916A2 (pt)	2015-07-28	Processo para a produção de um dianidroaçúcar
PT2165971T (pt)	2016-11-16	Processo de hidrotratamento
BRPI0908725A2 (pt)	2015-07-28	Processo enzimático
DK2029567T3 (da)	2010-11-29	Fremgangsmåde til frembringelse af benzopyran-2-ol-derivater
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