BRPI0721950A2 - indolopiridinas como inibidores da proteína de fuso de cinesina - Google Patents

indolopiridinas como inibidores da proteína de fuso de cinesina

Info

Publication number
BRPI0721950A2
BRPI0721950A2 BRPI0721950A BRPI0721950A BRPI0721950A2 BR PI0721950 A2 BRPI0721950 A2 BR PI0721950A2 BR PI0721950 A BRPI0721950 A BR PI0721950A BR PI0721950 A BRPI0721950 A BR PI0721950A BR PI0721950 A2 BRPI0721950 A2 BR PI0721950A2
Authority
BR
Brazil
Prior art keywords
indolopyridines
inhibitors
spindle protein
kinesin spindle
kinesin
Prior art date
Application number
BRPI0721950A
Other languages
English (en)
Inventor
Jürgen Braunger
Matthias Vennemann
Petra Gimmnich
Thomas Bär
Original Assignee
4Sc Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4Sc Ag filed Critical 4Sc Ag
Publication of BRPI0721950A2 publication Critical patent/BRPI0721950A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0721950A 2007-08-22 2007-08-22 indolopiridinas como inibidores da proteína de fuso de cinesina BRPI0721950A2 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2007/058748 WO2009024190A1 (en) 2007-08-22 2007-08-22 Indolopyridines as inhibitors of the kinesin spindle protein (eg5 )

Publications (1)

Publication Number Publication Date
BRPI0721950A2 true BRPI0721950A2 (pt) 2015-09-29

Family

ID=39283894

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0721950A BRPI0721950A2 (pt) 2007-08-22 2007-08-22 indolopiridinas como inibidores da proteína de fuso de cinesina

Country Status (7)

Country Link
US (1) US20110027226A1 (pt)
EP (1) EP2178875A1 (pt)
JP (1) JP2010536807A (pt)
AU (1) AU2007358076A1 (pt)
BR (1) BRPI0721950A2 (pt)
CA (1) CA2697246A1 (pt)
WO (1) WO2009024190A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8012976B2 (en) 2008-08-06 2011-09-06 Biomarin Pharmaceutical Inc. Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP)
US8541403B2 (en) 2010-02-03 2013-09-24 Biomarin Pharmaceutical Inc. Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) for use in treatment of diseases associated with a PTEN deficiency
DK2533640T3 (en) 2010-02-08 2017-01-23 Medivation Technologies Inc METHODS OF SYNTHESIS OF DIHYDROPYRIDOPHTHALAZINE DERIVATIVES
PL2630146T3 (pl) 2010-10-21 2020-11-02 Medivation Technologies Llc Krystaliczna sól tosylanowa (8S,9R)-5-fluoro-8-(4-fluorofenylo)-9-(1-metylo-1H-1,2,4-triazol-5-ilo)-8,9-dihydro-2H-pirydo[4,3,2-de]ftalazyno-3(7H)-onu
ES2818977T3 (es) * 2011-10-25 2021-04-14 Janssen Pharmaceutica Nv Método para obtener cristales de sal de meglumina de ácido 1-(5,6-dicloro-1H-benzo[d]imidazol-2-il)-1H-pirazol-4-carboxílico
EA201790290A1 (ru) * 2014-07-31 2017-07-31 Медивэйшн Текнолоджиз, Инк. Формерные соли (2s,3s)-метил 7-фтор-2-(4-фторфенил)-3-(1-метил-1h-1,2,4-триазол-5-ил)-4-оксо-1,2,3,4-тетрагидрохинолин-5-карбоксилата и способы их получения
CN110464722B (zh) * 2019-06-06 2023-05-23 暨南大学 一类小分子化合物或其药学上可接受的盐在制备抗肿瘤转移药物中的应用
FR3112145A1 (fr) * 2020-07-03 2022-01-07 Nanotracks Diagnostics Derives uree de macrolides polyeniques, composes chimiques particuliers susceptibles d’etre utilises pour obtenir ces derives uree, compositions les contenant et utilisations
WO2022003181A1 (fr) * 2020-07-03 2022-01-06 Nanotracks Diagnostics Derivés urée de l'amphotéricine amb, compositions les contenant et leurs utilisations, dérivés isocyanate d'alkyle omega-aminés et leur utilisation pour obtenir lesdits dérivés urée

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9514473D0 (en) * 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
US6890933B1 (en) * 2000-02-24 2005-05-10 President And Fellows Of Harvard College Kinesin inhibitors
MXPA06010542A (es) * 2004-03-15 2007-03-28 Ptc Therapeutics Inc Derivados de carbolina tetra-ciclica para la inhibicion de angiogenesis.
JP2008509971A (ja) * 2004-08-18 2008-04-03 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｅｇ５キネシンのインヒビターとして使用するためのベンゾチエノピリジン

Also Published As

Publication number Publication date
CA2697246A1 (en) 2009-02-26
US20110027226A1 (en) 2011-02-03
AU2007358076A1 (en) 2009-02-26
WO2009024190A1 (en) 2009-02-26
EP2178875A1 (en) 2010-04-28
JP2010536807A (ja) 2010-12-02

Similar Documents

Publication Publication Date Title
BRPI0716477A2 (pt) Derivados heteroarila como inibidores de quinase protéica
BRPI0911228A2 (pt) compostos e composições como inibidores de proteínas quinase
BRPI0908849A2 (pt) Composto e composições como c-kit e inibidores de pdgfr quinase
BRPI0819606A2 (pt) amino triazóis como inobidores de pi3k
CR10400A (es) Derivados de lactamas de ciclohexilpirazol como inhibidores de 11-beta -hidroxiesteroide deshidrogenasa 1
BRPI1015238A2 (pt) diamidas de azetidilina como inibidores de monoaciglicerol lipase
BRPI0913879A2 (pt) fenilpirazinonas como inibidores de quinase
DK2117523T3 (da) Inhibitorer af AKT-aktivitet
BRPI0811516A2 (pt) Compostos e composições como inibidores de c-kit e pdgfr cinase
ES2598358T8 (es) Derivados de quinolina como inhibidores de PI3K quinasa
BR112012001325A2 (pt) tratamento de distúrbios do fígado com inibidaores de pi3k
BRPI0912668A2 (pt) composto e composições como inibidores de quinase
BRPI0811065A2 (pt) Indazóis 5-heteroaril substituídos como inibidores de quinase
BRPI0914652A2 (pt) compostos e composições como inibidores de quinase
BR112012004448A2 (pt) "compostos e composições como inibidores de proteína cinase"
BRPI0920135A2 (pt) imidazopiridazinacarbonitrilos úteis como inibidores de quinase
BRPI0719797A2 (pt) compostos e composições como inibidores de proteína cinase
EP2192838A4 (en) HETEROCYCLIC NEKROPTOSIS HEMMER
BRPI0913580A2 (pt) pirrolopiridinas como inibidores de quinase
BRPI0812825A2 (pt) Derivados ftalazinona como inibidores de parp-1
BRPI0920053A2 (pt) pirazolilaminopiridinas como inibidores da fak
BRPI0719389A2 (pt) Derivados de hidantoína utilizados como inibidores de mmp
BRPI1011046A2 (pt) derivados de isoquinolin-1 (2h)-ona como inibidores de parp-i
EP2083864A4 (en) ANTAGONISTS OF PCSK9
DOP2011000397A (es) Nuevos derivados de fenilimidazol como inhibidores de la enzima pde10a

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.