BRPI0808828A2 - compostos de dibenzo[b,f][1,4]oxazapina - Google Patents

compostos de dibenzo[b,f][1,4]oxazapina

Info

Publication number: BRPI0808828A2
Authority: BR; Brazil
Prior art keywords: compounds; schizophrenia; depression; dibenzo; psychotic
Prior art date: 2007-03-15

Application number

BRPI0808828A

Other languages

English (en)

Inventor

Rubens Courtney

Becker Cyrus

Adams Jason

Palme Monica

Druzgala Pascal

Original Assignee

Aryx Therapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-03-15

Filing date

2008-03-13

Publication date

2017-05-02

2008-03-13 Application filed by Aryx Therapeutics Inc filed Critical Aryx Therapeutics Inc

2017-05-02 Publication of BRPI0808828A2 publication Critical patent/BRPI0808828A2/pt

2017-11-28 Publication of BRPI0808828A8 publication Critical patent/BRPI0808828A8/pt

Links

150000001875 compounds Chemical class 0.000 title abstract 4
UZVGSSNIUNSOFA-UHFFFAOYSA-N dibenzofuran-1-carboxylic acid Chemical compound O1C2=CC=CC=C2C2=C1C=CC=C2C(=O)O UZVGSSNIUNSOFA-UHFFFAOYSA-N 0.000 title abstract 2
201000000980 schizophrenia Diseases 0.000 abstract 3
208000028017 Psychotic disease Diseases 0.000 abstract 2
206010003805 Autism Diseases 0.000 abstract 1
208000020706 Autistic disease Diseases 0.000 abstract 1
208000020925 Bipolar disease Diseases 0.000 abstract 1
206010012289 Dementia Diseases 0.000 abstract 1
WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 abstract 1
WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 abstract 1
208000012902 Nervous system disease Diseases 0.000 abstract 1
208000025966 Neurological disease Diseases 0.000 abstract 1
206010036069 Polydipsia psychogenic Diseases 0.000 abstract 1
206010039987 Senile psychosis Diseases 0.000 abstract 1
208000028810 Shared psychotic disease Diseases 0.000 abstract 1
208000028552 Treatment-Resistant Depressive disease Diseases 0.000 abstract 1
208000031555 Treatment-Resistant Schizophrenia Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
208000024714 major depressive disease Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
208000030459 obsessive-compulsive personality disease Diseases 0.000 abstract 1
208000007656 osteochondritis dissecans Diseases 0.000 abstract 1
208000000231 psychogenic polydipsia Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
208000019116 sleep disease Diseases 0.000 abstract 1
208000024891 symptom Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

BRPI0808828A 2007-03-15 2008-03-13 Compostos de dibenzo[b,f][1,4]oxazapina BRPI0808828A8 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US89504607P	2007-03-15	2007-03-15
PCT/US2008/056866 WO2008112900A1 (en)	2007-03-15	2008-03-13	Dibenzo[b,f][1,4]oxazapine compounds

Publications (2)

Publication Number	Publication Date
BRPI0808828A2 true BRPI0808828A2 (pt)	2017-05-02
BRPI0808828A8 BRPI0808828A8 (pt)	2017-11-28

Family

ID=39472572

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0808828A BRPI0808828A8 (pt)	2007-03-15	2008-03-13	Compostos de dibenzo[b,f][1,4]oxazapina

Country Status (17)

Country	Link
US (2)	US8093237B2 (pt)
EP (1)	EP2137180B1 (pt)
JP (1)	JP5421787B2 (pt)
KR (1)	KR101521951B1 (pt)
CN (2)	CN101641350B (pt)
AT (1)	ATE548367T1 (pt)
AU (1)	AU2008225014B2 (pt)
BR (1)	BRPI0808828A8 (pt)
CA (1)	CA2678897C (pt)
DK (1)	DK2137180T3 (pt)
ES (1)	ES2384036T3 (pt)
IL (1)	IL200250A (pt)
MX (1)	MX2009009535A (pt)
RU (1)	RU2469033C2 (pt)
TW (1)	TWI421079B (pt)
WO (1)	WO2008112900A1 (pt)
ZA (1)	ZA200906573B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT2729474T (pt) *	2011-07-08	2018-06-05	Lilly Co Eli	Compostos (tieno[2,3-b][1,5]benzoxazepin-4-il)piperazin-1-ilo tendo actividade dual como agonistas inversos de h1/antagonistas de 5-ht2a
CN106749219A (zh) *	2015-11-20	2017-05-31	江苏恩华药业股份有限公司	一种内酰胺类衍生物及其应用
WO2019173761A1 (en)	2018-03-09	2019-09-12	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	C-abl tyrosine kinase inhibitory compound embodiments and methods of making and using the same
US12466819B2 (en)	2019-12-13	2025-11-11	712 North Inc.	Tricyclic compounds with OMA1/OPA1 modulatory properties
WO2023064768A1 (en) *	2021-10-11	2023-04-20	Baylor College Of Medicine	G-protein-coupled receptor regulators and methods of use thereof
TWI820605B (zh) *	2022-02-18	2023-11-01	國立臺灣大學	抗菌化合物、其製備方法及其用途
CN117164526A (zh) *	2022-05-27	2023-12-05	苏州泽璟生物制药股份有限公司	2-(哌嗪-2-基)乙腈类衍生物及其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA979441A (en) *	1967-02-27	1975-12-09	American Cyanamid Company	11-(piperazinyl) dibenz (b,f) (1,4) oxazepines and analogous thiazepines
US3683084A (en) *	1969-02-06	1972-08-08	Jean Schmutz	Basically substituted heterocycles as anti-emetics
DE4127849A1 (de) *	1991-08-22	1993-02-25	Merck Patent Gmbh	Benzodioxanderivate
US5602124A (en) *	1994-12-12	1997-02-11	Allelix Biopharmaceuticals, Inc.	5-HT2 receptor ligands
IL117798A (en) *	1995-04-07	2001-11-25	Schering Plough Corp	Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
JPH0940662A (ja) *	1995-05-24	1997-02-10	Kyowa Hakko Kogyo Co Ltd	三環式化合物
WO2003082877A1 (en)	2002-03-28	2003-10-09	Eli Lilly And Company	Piperazine substituted aryl benzodiazepines and their use as dopamine receptor antagonists for the treatment of psychotic disorders
DK1546134T3 (da)	2002-08-05	2007-09-10	Lilly Co Eli	Piperazinsubstituerede arylbenzodiazepiner
AU2003290079A1 (en)	2002-12-20	2004-07-14	Basf Aktiengesellschaft	Pesticidal dibenzo(hetero)azepine derivatives
EP1664063A1 (en) *	2003-09-09	2006-06-07	Eli Lilly And Company	Substituted piperazines of azepines, oxazepines, and thiazepines
CA2550735A1 (en) *	2003-12-22	2005-07-14	Acadia Pharmaceuticals Inc.	Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
DK1804804T3 (da) *	2004-09-21	2012-02-20	Hypnion Inc	3-[4-(dibenzo[b,f][1,4]oxazepin-11-yl)-piperazin-1-yl]-2,2-dimethylpropansyre til anvendelse ved behandlingen af søvnforstyrrelser

2008
- 2008-03-13 BR BRPI0808828A patent/BRPI0808828A8/pt not_active IP Right Cessation
- 2008-03-13 CN CN2008800085093A patent/CN101641350B/zh not_active Expired - Fee Related
- 2008-03-13 ES ES08732129T patent/ES2384036T3/es active Active
- 2008-03-13 AT AT08732129T patent/ATE548367T1/de active
- 2008-03-13 RU RU2009138039/04A patent/RU2469033C2/ru not_active IP Right Cessation
- 2008-03-13 KR KR1020097021464A patent/KR101521951B1/ko not_active Expired - Fee Related
- 2008-03-13 US US12/047,858 patent/US8093237B2/en not_active Expired - Fee Related
- 2008-03-13 CN CN2012103913667A patent/CN103214473A/zh active Pending
- 2008-03-13 CA CA2678897A patent/CA2678897C/en not_active Expired - Fee Related
- 2008-03-13 JP JP2009553781A patent/JP5421787B2/ja not_active Expired - Fee Related
- 2008-03-13 EP EP08732129A patent/EP2137180B1/en not_active Not-in-force
- 2008-03-13 MX MX2009009535A patent/MX2009009535A/es active IP Right Grant
- 2008-03-13 WO PCT/US2008/056866 patent/WO2008112900A1/en not_active Ceased
- 2008-03-13 AU AU2008225014A patent/AU2008225014B2/en not_active Ceased
- 2008-03-13 DK DK08732129.5T patent/DK2137180T3/da active
- 2008-03-14 TW TW097109258A patent/TWI421079B/zh not_active IP Right Cessation
2009
- 2009-08-05 IL IL200250A patent/IL200250A/en not_active IP Right Cessation
- 2009-09-21 ZA ZA2009/06573A patent/ZA200906573B/en unknown
2011
- 2011-12-12 US US13/323,183 patent/US20120178738A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20080255088A1 (en)	2008-10-16
AU2008225014A1 (en)	2008-09-18
ATE548367T1 (de)	2012-03-15
DK2137180T3 (da)	2012-07-02
RU2009138039A (ru)	2011-04-20
US20120178738A1 (en)	2012-07-12
CA2678897C (en)	2015-10-20
CN101641350B (zh)	2012-11-28
WO2008112900A1 (en)	2008-09-18
JP5421787B2 (ja)	2014-02-19
KR20090119999A (ko)	2009-11-23
TW200904449A (en)	2009-02-01
US8093237B2 (en)	2012-01-10
BRPI0808828A8 (pt)	2017-11-28
ES2384036T9 (es)	2013-10-14
EP2137180B1 (en)	2012-03-07
EP2137180A1 (en)	2009-12-30
CN103214473A (zh)	2013-07-24
MX2009009535A (es)	2009-09-16
RU2469033C2 (ru)	2012-12-10
KR101521951B1 (ko)	2015-05-20
ZA200906573B (en)	2011-11-30
JP2010521486A (ja)	2010-06-24
TWI421079B (zh)	2014-01-01
CA2678897A1 (en)	2008-09-18
AU2008225014B2 (en)	2014-12-11
IL200250A0 (en)	2010-04-29
IL200250A (en)	2014-12-31
ES2384036T3 (es)	2012-06-28
CN101641350A (zh)	2010-02-03

Legal Events

Date	Code	Title	Description
2017-09-26	B25A	Requested transfer of rights approved	Owner name: ALPINE BIOSCIENCES, INC. (US)
2017-10-03	B25B	Requested transfer of rights rejected	Owner name: ALPINE BIOSCIENCES, INC. (US)
2017-10-10	B25D	Requested change of name of applicant approved	Owner name: ALPINE BIOSCIENCES, INC. (US)
2017-10-24	B25A	Requested transfer of rights approved	Owner name: ALPINE BIOSCIENCES, INC. (US)
2017-11-28	B25D	Requested change of name of applicant approved	Owner name: PROTOCELL THERAPEUTICS INC. (US)
2018-01-09	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2018-05-02	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]
2021-07-13	B350	Update of information on the portal [chapter 15.35 patent gazette]

Publication	Publication Date	Title
ZA200906573B (en)	2011-11-30	Dibenzo[1,4]oxazapine compounds
PH12012501122A1 (en)	2012-10-29	Pteridinones as inhibitors of polo-like kinase
MA35285B1 (fr)	2014-07-03	Indazoles
NO20090166L (no)	2009-03-12	Amino-imidazoloner og deres anvendelse som et medikament for behandling av kognitiv svekkelse, Alzheimers sykdom, neurodegenerering og demens
PH12013501556A1 (en)	2017-10-25	IMIDAZO[5,1-f][1,2,4]TRIAZINES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
CY1119326T1 (el)	2018-02-14	Φαινυλο-3-αζα-δικυκλο[3.1.0]εξ-3-υλο-μεθανονες και η χρηση αυτων ως φαρμακο
MX2010007683A (es)	2010-10-25	Derivados heterociclicos fusionados y metodos de uso como inhibidores de c-met.
TW201129562A (en)	2011-09-01	Iminothiadiazine dioxide compounds as BACE inhibitors, compositions, and their use
MY167135A (en)	2018-08-13	Fused heterocyclic derivatives and methods of use
UY30408A1 (es)	2008-01-31	Derivados sustituidos del acetato de 8-(4-metoxifenil)-2,3,4,8-tetrahidroimidazo-[1,5-a]-pirimidin-6-amina, composiciones farmacéuticas y aplicaciones
MX2009011830A (es)	2009-11-13	Compuestos amino-heterociclicos.
MX2009013885A (es)	2010-01-27	Derivados de quinolina fusionados utiles como moduladores de acido gamma-aminobutirico.
TW200734311A (en)	2007-09-16	New compounds
MX2010001486A (es)	2010-03-01	Derivados de tetrahidropiridin carboxamida como antagonistas de trpvl.
MA33407B1 (fr)	2012-07-03	Composes bicycliques et tricycliques servant d'inhibiteurs de kat ii
IL205045A (en)	2015-08-31	Piperidinyl and piperazine derivatives, preparations containing them and their uses
MX2009010727A (es)	2009-10-26	Heterociclos como antagonistas de orexina.
NZ593279A (en)	2013-03-28	Aroylamino - and heteroaroylamino-substituted piperidines as glyt-1 inhibitors
EA200870492A1 (ru)	2009-04-28	N-оксиды производных пиридилметилпиперазина и - пиперидина
UA86873C2 (en)	2009-05-25	SUBSTITUTED ARYL 1,4-PYRAZlNE DERIVATIVES
IL184439A0 (en)	2007-10-31	2,5-disubstituted phenyl methanone derivatives as glycine transporter 1
ATE407126T1 (de)	2008-09-15	Herstellung von (s)-4-fluormethyl-dihydro-furan-2-on
DE602006007483D1 (pt)	2009-08-06
IL202282A0 (en)	2010-06-16	Prolinamide-tetrazole derivatives as nk3 receptor antagonists
TH125488A (pt)	2013-07-17