BRPI0809326B8 - métodos de preparação de microesfera de liberação controlada contendo exendina com camada de revestimento, composição e microesfera - Google Patents

métodos de preparação de microesfera de liberação controlada contendo exendina com camada de revestimento, composição e microesfera

Info

Publication number
BRPI0809326B8
BRPI0809326B8 BRPI0809326A BRPI0809326A BRPI0809326B8 BR PI0809326 B8 BRPI0809326 B8 BR PI0809326B8 BR PI0809326 A BRPI0809326 A BR PI0809326A BR PI0809326 A BRPI0809326 A BR PI0809326A BR PI0809326 B8 BRPI0809326 B8 BR PI0809326B8
Authority
BR
Brazil
Prior art keywords
controlled release
microsphere
active ingredient
exendin
composition
Prior art date
Application number
BRPI0809326A
Other languages
English (en)
Inventor
Lim Chae-Jin
Seol Eun-Young
Lee Hee-Yong
Choi Ho-Il
Kim Joon-Sik
Lee Ju-Han
Kim Jung-Soo
Baek Mi-Jin
Baek Mi-Young
Chae Yeon-Jin
Original Assignee
Peptron Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peptron Co Ltd filed Critical Peptron Co Ltd
Publication of BRPI0809326A2 publication Critical patent/BRPI0809326A2/pt
Publication of BRPI0809326B1 publication Critical patent/BRPI0809326B1/pt
Publication of BRPI0809326B8 publication Critical patent/BRPI0809326B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

métodos de preparação de microesfera de liberação controlada contendo exendina com camada de revestimento, composição e microesfera. são proporcionadas uma composição de liberação controlada e microesferas de liberação controlada contendo exendina como ingrediente ativo e um método de preparação da mesma. mais especificamente, são proporcionados uma composição de liberação controlada contendo exendina como ingrediente ativo, um polímero biodegradável como uma viscosidade especifica e materiais de revestimento, tendo elevada biodisponibilidade e exibindo liberação sustentada do ingrediente ativo numa concentração efetiva para um certo período sem uma explosão inicial excessiva do ingrediente ativo: microesferas de liberação controlada contendo um núcleo incluindo exendina como ingrediente ativo e um polímero biodegradável e uma camada de revestimento que recobre o núcleo; e um método de preparação de microesferas de liberação controlada incluindo as etapas de misturar uma exendina, um polímero biodegradável e um solvente, remover o solvente a partir da mistura para preparar a microesferas endurecidas e revestimento sobre a superfície de cada microesfera.
BRPI0809326A 2007-03-27 2008-01-22 métodos de preparação de microesfera de liberação controlada contendo exendina com camada de revestimento, composição e microesfera BRPI0809326B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020070029586A KR100805208B1 (ko) 2007-03-27 2007-03-27 엑센딘 함유 서방성 제제 조성물, 엑센딘 함유 서방성미립구 및 이의 제조 방법
KR10-2007-0029586 2007-03-27
PCT/KR2008/000397 WO2008117927A1 (en) 2007-03-27 2008-01-22 Composition and microsphere for controlled-release of exendin, and method of preparing the same

Publications (3)

Publication Number Publication Date
BRPI0809326A2 BRPI0809326A2 (pt) 2014-09-23
BRPI0809326B1 BRPI0809326B1 (pt) 2020-10-13
BRPI0809326B8 true BRPI0809326B8 (pt) 2021-05-25

Family

ID=39382592

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0809326A BRPI0809326B8 (pt) 2007-03-27 2008-01-22 métodos de preparação de microesfera de liberação controlada contendo exendina com camada de revestimento, composição e microesfera

Country Status (16)

Country Link
US (1) US9155702B2 (pt)
EP (1) EP2134329B1 (pt)
JP (1) JP5135428B2 (pt)
KR (1) KR100805208B1 (pt)
CN (1) CN101646424B (pt)
AU (1) AU2008230297B2 (pt)
BR (1) BRPI0809326B8 (pt)
CA (1) CA2682499C (pt)
ES (1) ES2528282T3 (pt)
IL (1) IL201024A (pt)
MX (1) MX2009010280A (pt)
MY (1) MY150087A (pt)
PL (1) PL2134329T3 (pt)
RU (1) RU2463040C2 (pt)
WO (1) WO2008117927A1 (pt)
ZA (1) ZA200906381B (pt)

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Also Published As

Publication number Publication date
JP2010522743A (ja) 2010-07-08
ZA200906381B (en) 2010-11-24
US9155702B2 (en) 2015-10-13
BRPI0809326B1 (pt) 2020-10-13
KR100805208B1 (ko) 2008-02-21
MY150087A (en) 2013-11-29
US20100136126A1 (en) 2010-06-03
WO2008117927A1 (en) 2008-10-02
EP2134329A1 (en) 2009-12-23
CN101646424B (zh) 2013-03-20
EP2134329A4 (en) 2013-07-10
BRPI0809326A2 (pt) 2014-09-23
ES2528282T3 (es) 2015-02-06
CA2682499C (en) 2013-01-08
CA2682499A1 (en) 2008-10-02
AU2008230297A1 (en) 2008-10-02
RU2009136655A (ru) 2011-05-10
IL201024A0 (en) 2010-05-17
CN101646424A (zh) 2010-02-10
EP2134329B1 (en) 2015-01-07
PL2134329T3 (pl) 2015-07-31
IL201024A (en) 2014-01-30
AU2008230297B2 (en) 2010-07-29
MX2009010280A (es) 2009-10-12
JP5135428B2 (ja) 2013-02-06
RU2463040C2 (ru) 2012-10-10

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