PL2134329T3 - Kompozycja i mikrosfera do kontrolowanego uwalniania eksendyny i sposób ich otrzymywania - Google Patents

Kompozycja i mikrosfera do kontrolowanego uwalniania eksendyny i sposób ich otrzymywania

Info

Publication number
PL2134329T3
PL2134329T3 PL08712168T PL08712168T PL2134329T3 PL 2134329 T3 PL2134329 T3 PL 2134329T3 PL 08712168 T PL08712168 T PL 08712168T PL 08712168 T PL08712168 T PL 08712168T PL 2134329 T3 PL2134329 T3 PL 2134329T3
Authority
PL
Poland
Prior art keywords
exendin
microsphere
preparing
release
composition
Prior art date
Application number
PL08712168T
Other languages
English (en)
Inventor
Hee-Yong Lee
Eun-Young Seol
Joon-Sik Kim
Mi-Jin Baek
Jung-Soo Kim
Ju-Han Lee
Yeon-Jin Chae
Chae-Jin Lim
Mi-Young Baek
Ho-Il Choi
Original Assignee
Peptron Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peptron Co Ltd filed Critical Peptron Co Ltd
Publication of PL2134329T3 publication Critical patent/PL2134329T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL08712168T 2007-03-27 2008-01-22 Kompozycja i mikrosfera do kontrolowanego uwalniania eksendyny i sposób ich otrzymywania PL2134329T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020070029586A KR100805208B1 (ko) 2007-03-27 2007-03-27 엑센딘 함유 서방성 제제 조성물, 엑센딘 함유 서방성미립구 및 이의 제조 방법
PCT/KR2008/000397 WO2008117927A1 (en) 2007-03-27 2008-01-22 Composition and microsphere for controlled-release of exendin, and method of preparing the same
EP08712168.7A EP2134329B1 (en) 2007-03-27 2008-01-22 Composition and microsphere for controlled-release of exendin, and method of preparing the same

Publications (1)

Publication Number Publication Date
PL2134329T3 true PL2134329T3 (pl) 2015-07-31

Family

ID=39382592

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08712168T PL2134329T3 (pl) 2007-03-27 2008-01-22 Kompozycja i mikrosfera do kontrolowanego uwalniania eksendyny i sposób ich otrzymywania

Country Status (16)

Country Link
US (1) US9155702B2 (pl)
EP (1) EP2134329B1 (pl)
JP (1) JP5135428B2 (pl)
KR (1) KR100805208B1 (pl)
CN (1) CN101646424B (pl)
AU (1) AU2008230297B2 (pl)
BR (1) BRPI0809326B8 (pl)
CA (1) CA2682499C (pl)
ES (1) ES2528282T3 (pl)
IL (1) IL201024A (pl)
MX (1) MX2009010280A (pl)
MY (1) MY150087A (pl)
PL (1) PL2134329T3 (pl)
RU (1) RU2463040C2 (pl)
WO (1) WO2008117927A1 (pl)
ZA (1) ZA200906381B (pl)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2139458A4 (en) 2007-04-19 2013-01-23 Dong A Pharm Co Ltd BIODEGRADABLE MICRO BEADS COMPOSITION FOR CONTROLLED RELEASE OF GLUCOSE-CONTROLLED PEPTIDE AND FORMULATION THEREOF
US9292307B2 (en) 2008-07-30 2016-03-22 Kyocera Corporation User interface generation apparatus
US20100183876A1 (en) * 2008-12-23 2010-07-22 Hell Andre Process for the Preparation of a Peptide Powder Form
CA2791278C (en) 2010-02-25 2015-11-24 The Johns Hopkins University Sustained delivery of therapeutic agents to an eye compartment
CN102370611B (zh) * 2010-08-17 2013-09-18 东莞太力生物工程有限公司 一种包含exendin-4的温度敏感型水凝胶及其注射剂
JP2014502985A (ja) * 2011-01-19 2014-02-06 ノヴォ ノルディスク アー／エス Ｇｌｐ−１粒子および組成物
WO2012109363A2 (en) 2011-02-08 2012-08-16 The Johns Hopkins University Mucus penetrating gene carriers
RU2768492C2 (ru) 2011-11-18 2022-03-24 Ридженерон Фармасьютикалз, Инк. Полимерные белковые микрочастицы
CN102688198B (zh) * 2012-06-19 2015-04-15 广州帝奇医药技术有限公司 多肽药物缓释微球制剂及其制备方法
WO2014124006A1 (en) * 2013-02-05 2014-08-14 The Johns Hopkins University Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof
CN104107165B (zh) * 2013-04-17 2018-11-30 长春百益制药有限责任公司 一种艾塞那肽微球制剂、其制备方法及其应用
CN104840415B (zh) 2014-02-19 2019-03-15 香港浸会大学 含有降血糖活性成分的长效控释脂质体凝胶组合物及其制备方法
JP2017511371A (ja) * 2014-04-16 2017-04-20 シャンドン ルイ ファーマシューティカル カンパニー リミテッド エクセナチド含有組成物及びその製造方法
WO2015175545A1 (en) 2014-05-12 2015-11-19 The Johns Hopkins University Highly stable biodegradable gene vector platforms for overcoming biological barriers
US9480640B2 (en) * 2014-09-24 2016-11-01 Hongkai Zhang Nano freeze dry process of preparation of highly bioactive agent and its method of use
CA2974715C (en) 2015-01-27 2020-05-05 The Johns Hopkins University Hypotonic hydrogel formulations for enhanced transport of active agents at mucosal surfaces
CN116942677A (zh) 2015-09-21 2023-10-27 梯瓦制药国际有限责任公司 缓释奥氮平制剂
CA3001065A1 (en) 2015-10-14 2017-04-20 Xiaoxi WEI Compositions and methods for reducing ice crystal formation
WO2017107906A1 (zh) * 2015-12-22 2017-06-29 四川科伦药物研究院有限公司 一种艾塞那肽微球制剂及其制备方法
KR20190086460A (ko) * 2016-10-20 2019-07-22 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 신경보호 폴리펩티드를 중추 신경계에 전달하는 방법
CA3057438A1 (en) 2017-03-20 2018-09-27 Teva Pharmaceuticals International Gmbh Sustained release olanzapine formulaitons
KR102034872B1 (ko) * 2018-01-10 2019-10-21 주식회사 지투지바이오 콜라겐 펩타이드가 함유된 폴리카프로락톤 미립구 필러 및 그 제조방법
US12274787B2 (en) 2018-12-17 2025-04-15 G2Gbio, Inc. Sustained-release injection comprising deslorelin, and preparation method therefor
US12496279B2 (en) 2019-04-11 2025-12-16 The Johns Hopkins University Nanoparticles for drug delivery to brain
CN114206374A (zh) * 2019-07-29 2022-03-18 佩特通公司 用于治疗左旋多巴诱导的运动障碍或用于抑制其进展的药物组合物
BR112022001595A2 (pt) 2019-07-29 2022-03-22 Peptron Inc Composição farmacêutica para tratamento ou inibição da progressão da discinesia induzida por levodopa
WO2022153262A1 (en) 2021-01-18 2022-07-21 Anton Frenkel Pharmaceutical dosage form
CN117098529A (zh) * 2021-01-29 2023-11-21 天温轮特拉皮踢诗 初期突发释放受控的贮库组合物及其方法
US20240277654A1 (en) 2021-07-06 2024-08-22 Mark Hasleton Treatment of serotonin reuptake inhibitor withdrawal syndrome

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US5271961A (en) * 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
GB9210574D0 (en) 1992-05-18 1992-07-01 Ca Nat Research Council Biotherapeutic cell-coated microspheres for wound/burn and prothesis implant applications
JPH09315975A (ja) 1995-09-28 1997-12-09 Takeda Chem Ind Ltd ２−ピペラジノン−１−酢酸誘導体の徐放剤
JP4900984B2 (ja) 1997-07-15 2012-03-21 武田薬品工業株式会社 徐放性製剤の製造法
EP1658856B1 (en) * 1999-01-14 2010-03-17 Amylin Pharmaceuticals, Inc. Exendins for glucagon suppression
CN101181236A (zh) * 1999-01-14 2008-05-21 安米林药品公司 新型exendin激动剂制剂及其给药方法
EP1246638B2 (en) * 2000-01-10 2014-07-30 Amylin Pharmaceuticals, Inc. Use of exendins and agonists thereof for the treatment of hypertriglyceridemia
JP5160005B2 (ja) 2000-12-28 2013-03-13 武田薬品工業株式会社 徐放性製剤
KR100566573B1 (ko) 2002-04-13 2006-03-31 주식회사 펩트론 Ｌｈｒｈ 동족체를 함유하는 서방성 미립구의 제조방법
WO2004036186A2 (en) * 2002-10-17 2004-04-29 Alkermes Controlled Therapeutics, Inc. Ii Microencapsulation and sustained release of biologically active polypeptides
SI21402A (sl) * 2003-02-12 2004-08-31 LEK farmacevtska dru�ba d.d. Obloženi delci in farmacevtske oblike
US7456254B2 (en) * 2004-04-15 2008-11-25 Alkermes, Inc. Polymer-based sustained release device
PL2409707T3 (pl) * 2004-04-15 2015-08-31 Amylin Pharmaceuticals Llc Urządzenie o przedłużonym uwalnianiu na bazie polimeru
ATE424848T1 (de) * 2004-08-12 2009-03-15 Quest Pharmaceutical Services Pharmazeutische zusammensetzungen für die kontrollierte freigabe von biologischen wirkstoffen
EP1824460B1 (en) * 2004-11-10 2014-12-24 Tolmar Therapeutics, Inc. A stabilized polymeric delivery system

Also Published As

Publication number Publication date
CA2682499C (en) 2013-01-08
CN101646424A (zh) 2010-02-10
ZA200906381B (en) 2010-11-24
BRPI0809326A2 (pt) 2014-09-23
EP2134329A4 (en) 2013-07-10
JP2010522743A (ja) 2010-07-08
EP2134329B1 (en) 2015-01-07
CA2682499A1 (en) 2008-10-02
JP5135428B2 (ja) 2013-02-06
IL201024A0 (en) 2010-05-17
MY150087A (en) 2013-11-29
ES2528282T3 (es) 2015-02-06
BRPI0809326B8 (pt) 2021-05-25
AU2008230297B2 (en) 2010-07-29
MX2009010280A (es) 2009-10-12
AU2008230297A1 (en) 2008-10-02
IL201024A (en) 2014-01-30
BRPI0809326B1 (pt) 2020-10-13
RU2009136655A (ru) 2011-05-10
WO2008117927A1 (en) 2008-10-02
KR100805208B1 (ko) 2008-02-21
US20100136126A1 (en) 2010-06-03
US9155702B2 (en) 2015-10-13
EP2134329A1 (en) 2009-12-23
CN101646424B (zh) 2013-03-20
RU2463040C2 (ru) 2012-10-10

Similar Documents

Publication Publication Date Title
ZA200906381B (en) Composition and microsphere for controlled-release of exendin,and method of preparing the same
HRP20190408T1 (hr) Ariloazol-2-il-cijanoetilamino-spojevi, postupak njihove proizvodnje i postupak njihove uporabe
IL214183A (en) Pharma-informatics system and method, preparation for use with it and method for preparation of the preparation
IL225637A0 (en) The compositions, tablets containing such compositions, their use and a process for their preparation
GB2456752B (en) Agrochemical composition and method for preparing the same
ZA200805939B (en) Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
IL195528A (en) Pyridazine compound, methods of preparation, a pharmaceutical composition containing it, its use and intermediate material
IL200994A (en) Compounds of Imidazole, Pyrazole, Triazole, Pyridinone, Benzyl and Bipinyl, Their Processes and Uses
PL2164322T3 (pl) Kompozycja agrochemiczna oraz sposób jej wytwarzania i stosowania
IL205073A (en) 2 bst antibodies, methods of making them, medicinal preparations containing them and their use
IL193339A0 (en) Novel aminoalcohol-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
IL193341A0 (en) Novel azacyclyl-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments
IL213452A0 (en) Phenylpyrimidone compounds, pharmaceutical compositions, preparation methods and uses thereof
ZA200801896B (en) Slow-release composition, method for the preparation thereof, and use of the same
EP2340297A4 (en) COMPOSITION, ITS MANUFACTURING METHOD AND USE
IL207420A (en) A pharmaceutical preparation containing Rifbutin, clarithromycin and clopazimine and a method of preparation of the preparation
EP2201011A4 (en) NEW COMPOUNDS WITH INDAZOUS OUTS, METHOD OF MANUFACTURING THEREOF AND PHARMACEUTICAL COMPOSITION THEREWITH
EP2123662A4 (en) TREHALOSE COMPOUND, METHOD FOR PRODUCING THE COMPOUND, AND IMMUNOSTIMULATING AGENT COMPRISING THE COMPOUND
ZA200904530B (en) Solid of macrolide compound, method for production thereof, and pharmaceutical composition comprising the same
ZA201000520B (en) Substituted tetrahydronaphthalenes, process for the preparation thereof and the use thereof as medicaments
EP2039697A4 (en) FLUORBOR COMPOUND, AMINOMETHYLATING AGENT FOR AROMATIC RINGS CONTAINING THE COMPOUND, AND METHOD FOR PRODUCING A COMPOUND WITH AMINOMETHYLAROMATIC RING USING THE AMINOMETHYLIER
ZA201003264B (en) Method for the preparation of 2 chloro1,1,1,2,3,3,3 heptafluopropane
GB0601684D0 (en) Composition, process for preparation and method of use
PL383867A1 (pl) Sposób otrzymywania 4-N-furfurylocytozyny, kompozycja antystarzeniowa oraz zastosowanie 4-N-furfurylocytozyny do wytwarzania kompozycji antystarzeniowej
IL200952A0 (en) Substituted sulphonamides, process for their preparation, pharmaceutical composition comprising thereof and their use