BRPI0809754A2 - método para produção de 1-butanol - Google Patents

método para produção de 1-butanol

Info

Publication number
BRPI0809754A2
BRPI0809754A2 BRPI0809754A BRPI0809754A BRPI0809754A2 BR PI0809754 A2 BRPI0809754 A2 BR PI0809754A2 BR PI0809754 A BRPI0809754 A BR PI0809754A BR PI0809754 A BRPI0809754 A BR PI0809754A BR PI0809754 A2 BRPI0809754 A2 BR PI0809754A2
Authority
BR
Brazil
Prior art keywords
butanol
butanol production
producing
production host
fermentation
Prior art date
Application number
BRPI0809754A
Other languages
English (en)
Inventor
Flint Dennis
S Miller Edward Jr
Singh Manjari
G Bramucci Michael
Sedkova Natalia
K Van Dyk Tina
Nagarajan Vasantha
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of BRPI0809754A2 publication Critical patent/BRPI0809754A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/16—Butanols
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
    • C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
    • C12Y103/01038—Trans-2-enoyl-CoA reductase (NADPH) (1.3.1.38)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
    • C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
    • C12Y103/01044—Trans-2-enoyl-CoA reductase (NAD+) (1.3.1.44)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01017—Enoyl-CoA hydratase (4.2.1.17), i.e. crotonase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01055—3-Hydroxybutyryl-CoA dehydratase (4.2.1.55)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"método para produzir 1-butanol" a presente invenção trata de um método para produção de 1-butanol por fermentação, utilizando-se um hospedeiro microbiano de produção. o método emprega uma redução na temperatura durante o processo de fermentação, que resulta em maior tolerância do hospedeiro de produção ao produto 1-butanol.
BRPI0809754A 2007-05-02 2008-04-29 método para produção de 1-butanol BRPI0809754A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91545507P 2007-05-02 2007-05-02
PCT/US2008/061855 WO2008137402A1 (en) 2007-05-02 2008-04-29 Method for the production of 1-butanol

Publications (1)

Publication Number Publication Date
BRPI0809754A2 true BRPI0809754A2 (pt) 2019-03-06

Family

ID=39643017

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0809754A BRPI0809754A2 (pt) 2007-05-02 2008-04-29 método para produção de 1-butanol

Country Status (5)

Country Link
US (2) US8426173B2 (pt)
EP (1) EP2142656B1 (pt)
BR (1) BRPI0809754A2 (pt)
CA (1) CA2685151A1 (pt)
WO (1) WO2008137402A1 (pt)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9297028B2 (en) * 2005-09-29 2016-03-29 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
US8273558B2 (en) 2005-10-26 2012-09-25 Butamax(Tm) Advanced Biofuels Llc Fermentive production of four carbon alcohols
WO2008006038A2 (en) * 2006-07-06 2008-01-10 Integrated Genomics, Inc. Methods and compositions for butanol production
EP2102327A4 (en) * 2006-12-01 2010-01-06 Gevo Inc MANIPULATED MICROORGANISMS FOR THE MANUFACTURE OF N-BUTANOL AND CORRESPONDING METHODS
TWI568847B (zh) 2007-03-16 2017-02-01 奇諾麥提卡公司 用於１，４-丁二醇及其前驅物之生物合成的組合物及方法
US8426173B2 (en) * 2007-05-02 2013-04-23 Butamax (Tm) Advanced Biofuels Llc Method for the production of 1-butanol
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
US9249431B2 (en) 2008-02-28 2016-02-02 Green Biologics Limited Production process
US20090238920A1 (en) * 2008-03-21 2009-09-24 Lewis Ted C Process for making high grade protein product
US8188250B2 (en) 2008-04-28 2012-05-29 Butamax(Tm) Advanced Biofuels Llc Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans
CA2735883C (en) 2008-09-10 2020-05-05 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol
WO2010030332A1 (en) * 2008-09-11 2010-03-18 Superbulbs, Inc. End-of-life bulb circuitry
US7833778B2 (en) * 2009-02-23 2010-11-16 Butler Iii Eugene T Continuous single vessel butanol synthesis by fermentation
WO2010096065A1 (en) * 2009-02-23 2010-08-26 Butler Eugene T Iii Continuous single vessel butanol synthesis by fermentation
US20110281336A1 (en) 2009-02-26 2011-11-17 Lanzatech New Zealand Limited Methods of sustaining culture viability
US8178329B2 (en) * 2009-04-01 2012-05-15 Richard Allen Kohn Process to produce organic compounds from synthesis gases
JP4760951B2 (ja) 2009-05-08 2011-08-31 トヨタ自動車株式会社 ブタノール生産能を有する組換え微生物及びブタノールの製造方法
PL2438036T3 (pl) 2009-06-04 2017-09-29 Genomatica, Inc. Sposób oddzielania składników brzeczki fermentacyjnej
BRPI1010581A2 (pt) 2009-06-04 2016-11-08 Genomatica Inc micro-organismos para a produção de 1,4-butanodiol e métodos relacionados
US8232089B2 (en) * 2009-08-12 2012-07-31 Gevo, Inc. Cytosolic isobutanol pathway localization for the production of isobutanol
AU2010306785B2 (en) 2009-10-13 2016-01-14 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA, putrescine and related compounds, and methods related thereto
US8530210B2 (en) 2009-11-25 2013-09-10 Genomatica, Inc. Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
US20110137088A1 (en) * 2009-12-03 2011-06-09 Bp Corporation North America Inc. Methods and Apparatuses for Producing Renewable Materials From Inhibiting Compounds
WO2011078709A1 (en) * 2009-12-23 2011-06-30 Lanzatech New Zealand Limited, Alcohol production process
US8637286B2 (en) 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
DE102010029973A1 (de) * 2010-06-11 2011-12-15 Evonik Degussa Gmbh Mikrobiologische Herstellung von C4-Körpern aus Saccharose und Kohlendioxid
JP2013528399A (ja) 2010-06-18 2013-07-11 ブタマックス（ティーエム） アドバンスド バイオフューエルズ エルエルシー 抽出発酵におけるアルコール除去のための、油に由来する抽出溶媒
DK3235907T5 (da) 2010-07-12 2024-10-14 Inbiose Nv Metabolisk modificerede organismer til produktion af bioprodukter med merværdi
US8895279B2 (en) 2010-12-02 2014-11-25 Dennis A. Burke Applications of the rotating photobioreactor
WO2012135731A2 (en) * 2011-04-01 2012-10-04 The Regents Of The University Of California Alcohol production from recombinant microorganisms
JP2015501643A (ja) 2011-12-09 2015-01-19 ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー 発酵ブロスから生成物アルコールを取り出す方法
AU2013235391A1 (en) 2012-03-23 2014-09-04 Butamax Advanced Biofuels Llc Acetate supplemention of medium for butanologens
KR20150007329A (ko) 2012-05-04 2015-01-20 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 알코올 생산 및 회수를 위한 공정 및 시스템
CN111705028A (zh) 2012-06-04 2020-09-25 基因组股份公司 制造4-羟基丁酸酯、1，4-丁二醇和相关化合物的微生物和方法
US9605281B2 (en) 2012-09-12 2017-03-28 Butamax Advanced Biofuels Llc Processes and systems for the fermentative production of alcohols
EP2877440A1 (en) 2012-07-26 2015-06-03 Butamax Advanced Biofuels LLC Butanol purification
US9109196B2 (en) 2012-09-12 2015-08-18 Butamax Advanced Biofuels Llc Processes and systems for the production of fermentation products
AU2013317963A1 (en) 2012-09-21 2015-03-12 Butamax(Tm) Advanced Biofuels Llc A method for producing butanol using two-phase extractive fermentation and recyclable extractant compositions
WO2014159309A1 (en) 2013-03-12 2014-10-02 Butamax Advanced Biofuels Llc Processes and systems for the production of alcohols
WO2014144728A1 (en) 2013-03-15 2014-09-18 Butamax Advanced Biofuels Llc Method for production of butanol using extractive fermentation
WO2014151645A1 (en) * 2013-03-15 2014-09-25 Butamax Advanced Biofuels Llc Process for maximizing biomass growth and butanol yield by feedback control
US9771602B2 (en) 2013-03-15 2017-09-26 Butamax Advanced Biofuels Llc Competitive growth and/or production advantage for butanologen microorganism
US9517985B2 (en) 2013-03-15 2016-12-13 Butamax Advanced Biofuels Llc Method for producing butanol using extractive fermentation
US9663759B2 (en) 2013-07-03 2017-05-30 Butamax Advanced Biofuels Llc Partial adaptation for butanol production
JP2017513697A (ja) 2014-04-11 2017-06-01 ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー 汚染軽減
CN107404882A (zh) 2015-02-27 2017-11-28 白狗实验室有限公司 用于生产丙酮、异丙醇、丁酸、其他生物产品及其混合物的混合营养发酵方法
WO2018019867A1 (en) 2016-07-27 2018-02-01 Evonik Degussa Gmbh N-acetyl homoserine

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2198104A (en) * 1938-12-15 1940-04-23 Commercial Solvents Corp Butyl alcohol fermentation process
US4424275A (en) 1979-09-17 1984-01-03 Sidney Levy Continuous process for producing N-butanol employing anaerobic fermentation
US4568643A (en) 1981-08-03 1986-02-04 Sidney Levy Continuous process for producing n-butanol employing anaerobic fermentation
US4520104A (en) 1982-11-18 1985-05-28 Cpc International Inc. Production of butanol by a continuous fermentation process
JPS61209594A (ja) 1985-03-14 1986-09-17 Res Assoc Petroleum Alternat Dev<Rapad> アルコ−ルの製造方法
JPS6317695A (ja) 1986-07-09 1988-01-25 Idemitsu Kosan Co Ltd アルコ−ル類の製造法
JPS63102687A (ja) 1986-10-20 1988-05-07 Res Assoc Petroleum Alternat Dev<Rapad> ブタノ−ルの製造方法
AT388174B (de) 1987-03-10 1989-05-10 Vogelbusch Gmbh Verfahren zur vergaerung von kohlenhydrathaeltigen medien mit hilfe von bakterien
JPS63254986A (ja) 1987-04-10 1988-10-21 Res Assoc Petroleum Alternat Dev<Rapad> アルコ−ルの製造法
JPH084515B2 (ja) 1987-11-09 1996-01-24 出光興産株式会社 有機化合物の製造方法
US5424202A (en) 1988-08-31 1995-06-13 The University Of Florida Ethanol production by recombinant hosts
US5000000A (en) 1988-08-31 1991-03-19 University Of Florida Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes
US5063156A (en) 1990-04-30 1991-11-05 Glassner David A Process for the fermentative production of acetone, butanol and ethanol
US5192673A (en) 1990-04-30 1993-03-09 Michigan Biotechnology Institute Mutant strain of C. acetobutylicum and process for making butanol
US5210032A (en) 1992-01-21 1993-05-11 Trustees Of The Boston University Degeneration-resistant solventogenic clostridia
WO1998051813A1 (en) 1997-05-14 1998-11-19 The Board Of Trustees Of The University Of Illinois A METHOD OF PRODUCING BUTANOL USING A MUTANT STRAIN OF $i(CLOSTRIDIUM BEIJERINCKII)
US6835820B2 (en) 1999-01-07 2004-12-28 The University Of Massachusetts Polyhydroxyalkanoate biosynthesis associated proteins and coding region in bacillus megaterium
EP1149918A1 (de) 2000-04-27 2001-10-31 Creavis Gesellschaft für Technologie und Innovation mbH Verfahren zur Oxidation von Kohlenwasserstoffen unter Verwendung von Mikroorganismen
US6960465B1 (en) 2001-06-27 2005-11-01 Northwestern University Increased cell resistance to toxic organic substances
MXPA05009553A (es) 2003-03-10 2006-03-17 Broin And Associates Inc Metodo para producir etanol utilizando almidon como materia prima.
US9297028B2 (en) * 2005-09-29 2016-03-29 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
US7659104B2 (en) 2006-05-05 2010-02-09 E.I. Du Pont De Nemours And Company Solvent tolerant microorganisms and methods of isolation
US7541173B2 (en) 2006-06-15 2009-06-02 E.I. Du Pont De Nemours And Company Solvent tolerant microorganisms and methods of isolation
WO2008006038A2 (en) 2006-07-06 2008-01-10 Integrated Genomics, Inc. Methods and compositions for butanol production
WO2008013996A2 (en) * 2006-07-27 2008-01-31 Gevo Inc. Engineered microorganisms for increasing product yield in biotransformations, related methods and systems
WO2008052991A2 (en) 2006-10-31 2008-05-08 Dsm Ip Assets B.V. Butanol production in a eukaryotic cell
US8017364B2 (en) 2006-12-12 2011-09-13 Butamax(Tm) Advanced Biofuels Llc Solvent tolerant microorganisms
EP2094844A4 (en) 2006-12-15 2010-01-06 Biofuelchem Co Ltd IMPROVED BUTANOL PRODUCING MICROORGANISMS AND METHOD FOR THE PRODUCTION OF BUTANOL THEREWITH
US8426173B2 (en) * 2007-05-02 2013-04-23 Butamax (Tm) Advanced Biofuels Llc Method for the production of 1-butanol

Also Published As

Publication number Publication date
CA2685151A1 (en) 2008-11-13
WO2008137402A1 (en) 2008-11-13
US8426173B2 (en) 2013-04-23
EP2142656A1 (en) 2010-01-13
EP2142656B1 (en) 2015-04-08
US20130217060A1 (en) 2013-08-22
US20080274524A1 (en) 2008-11-06

Similar Documents

Publication Publication Date Title
BR112013002003A2 (pt) processo para recuperação de compostos oleaginosos de biomassa
BRPI0818528A8 (pt) Aumento do rendimento da metionina
BRPI0715408B8 (pt) Processo para a preparação de 5-(1-alquiltio)alquilpiridinas 2-substituída
BR112014014652A2 (pt) microrganismos modificados e métodos de fazer butadieno usando os mesmos
BR112012015501A2 (pt) &#34;processo de biodegradação e composição&#34;
BRPI0914321A2 (pt) processo de avaliação da quantidade de metano produzida por um ruminante leiteiro e processo para diminuir e controlar essa quantidade
BRPI0712219A2 (pt) processo para a preparação de l-metionina
BR112014014062A2 (pt) produção de 1,3-dienos por conversão enzimática de 3- hidroxialc-4-enoatos e/ou 3-fosfonoxialc-4-enoatos
BRPI0813284A8 (pt) Processo para a preparação de um composto da fórmula (i) e composto
BR112014031425A2 (pt) microrganismo recombinante para produção fermentativa de metionina
BRPI0719367B8 (pt) processo para a preparação de nebivolol, seus intermediários e usos
BR112012010808A2 (pt) Processo para a hidrólise enzimática de materiais lignocelulósicos e fermentação de açúcares
BR112014013964A2 (pt) método para fazer uma componente de lignina, um componente de lignina e seus usos e um produto
BR112014014762A8 (pt) método para preparação de cisteína ou de um derivado desta usando uma nova o-fosferina sulfidrilase
BR112015010621A2 (pt) método para produzir pelo menos um produto a partir de um substrato gasoso
BRPI0519624A2 (pt) processos para produÇço de ansamitocinas
BR112013026660A2 (pt) métodos ou processos para produção de depsipeptídeos macrocíclicos e intermediários
BR112014003602A2 (pt) método para a produção de um sal de metionina
BR112012019006A2 (pt) processo para a produção de ácidos carboxilícos com 1 a 3 átomos de carbono a partir de fontes renováveis
BR112014001371A2 (pt) fermentação de glicerol para ácidos orgânicos
BRPI0915365B8 (pt) Processo para a preparação de 2-triflúor-metil-5-alquil-piridinas substituídas na posição 1
BR112012019838A2 (pt) metodo para a producao de um produto de fermentacao a partir de uma materia-prima lignocelulosica
BRPI0810846A8 (pt) processo para a carbonilação de éter dimetílico
BR112013023880A2 (pt) vidro plano e processo para produzir o mesmo
BR112014026199A2 (pt) processo de fermentação

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: BUTAMAX ADVANCED BIOFUELS LLC (US)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 12A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2564 DE 2020-02-27

B350 Update of information on the portal [chapter 15.35 patent gazette]