BRPI0810495A2 - difenil-di-hidro-imidazopiridinonas - Google Patents
difenil-di-hidro-imidazopiridinonasInfo
- Publication number
- BRPI0810495A2 BRPI0810495A2 BRPI0810495A BRPI0810495A BRPI0810495A2 BR PI0810495 A2 BRPI0810495 A2 BR PI0810495A2 BR PI0810495 A BRPI0810495 A BR PI0810495A BR PI0810495 A BRPI0810495 A BR PI0810495A BR PI0810495 A2 BRPI0810495 A2 BR PI0810495A2
- Authority
- BR
- Brazil
- Prior art keywords
- dihydroimidazopyridinones
- diphenyl
- diphenyl dihydroimidazopyridinones
- Prior art date
Links
- LQCBVQFFDSIHOY-UHFFFAOYSA-N 1,3-diphenylimidazo[4,5-b]pyridin-2-one Chemical class C12=CC=CN=C2N(C=2C=CC=CC=2)C(=O)N1C1=CC=CC=C1 LQCBVQFFDSIHOY-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92311007P | 2007-04-12 | 2007-04-12 | |
| PCT/EP2008/053903 WO2008125487A1 (en) | 2007-04-12 | 2008-04-02 | Diphenyl-dihydro-imidazopyridinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0810495A2 true BRPI0810495A2 (pt) | 2018-10-30 |
Family
ID=39478351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0810495A BRPI0810495A2 (pt) | 2007-04-12 | 2008-04-02 | difenil-di-hidro-imidazopiridinonas |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7625895B2 (pt) |
| EP (1) | EP2146986B1 (pt) |
| JP (1) | JP2010523616A (pt) |
| KR (1) | KR20090118116A (pt) |
| CN (1) | CN101657449B (pt) |
| AR (1) | AR066014A1 (pt) |
| AT (1) | ATE514696T1 (pt) |
| AU (1) | AU2008238062A1 (pt) |
| BR (1) | BRPI0810495A2 (pt) |
| CA (1) | CA2684008A1 (pt) |
| CL (1) | CL2008001047A1 (pt) |
| ES (1) | ES2367228T3 (pt) |
| IL (1) | IL201021A0 (pt) |
| MX (1) | MX2009011019A (pt) |
| PE (1) | PE20090229A1 (pt) |
| RU (1) | RU2009141522A (pt) |
| TW (1) | TW200848033A (pt) |
| WO (1) | WO2008125487A1 (pt) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2380892T3 (pl) | 2009-01-16 | 2014-08-29 | Daiichi Sankyo Co Ltd | Pochodna imidazotiazolowa mająca strukturę pierścienia proliny |
| UA107814C2 (uk) | 2009-11-12 | 2015-02-25 | Дзе Ріджентс Оф Дзе Юніверсіті Оф Мічіган | Спірооксіндольні антагоністи мdм2 |
| US10159669B2 (en) * | 2010-03-02 | 2018-12-25 | Ian H. Chan | Individual and combination of mdivi-1 and nutlin-3 for topical or intravitreal ophthalmic use |
| JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
| FR2967072B1 (fr) | 2010-11-05 | 2013-03-29 | Univ Dundee | Procede pour ameliorer la production de virus et semences vaccinales influenza |
| JP2014500870A (ja) | 2010-11-12 | 2014-01-16 | ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、ミシガン | スピロ−オキシインドールｍｄｍ２アンタゴニスト |
| WO2012155066A2 (en) | 2011-05-11 | 2012-11-15 | Shaomeng Wang | Spiro-oxindole mdm2 antagonists |
| US9376425B2 (en) | 2011-09-27 | 2016-06-28 | Amgen, Inc. | Heterocyclic compounds as MDM2 inhibitors for the treatment of cancer |
| KR102196882B1 (ko) | 2012-12-20 | 2020-12-30 | 머크 샤프 앤드 돔 코포레이션 | Hdm2 억제제로서의 치환된 이미다조피리딘 |
| US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
| WO2014134201A1 (en) | 2013-02-28 | 2014-09-04 | Amgen Inc. | A benzoic acid derivative mdm2 inhibitor for the treatment of cancer |
| MX374513B (es) | 2013-03-14 | 2025-03-06 | Amgen Inc | Compuestos de morfolinona de ácido heteroarilo como inhibidores mdm2 para el tratamiento de cáncer. |
| CN105358530A (zh) | 2013-06-10 | 2016-02-24 | 美国安进公司 | 制备mdm2抑制剂的方法及其结晶形式 |
| BR112016010564A2 (pt) | 2013-11-11 | 2017-10-10 | Amgen Inc | terapia de combinação incluindo um inibidor de mdm2 e um ou mais agentes farmaceuticamente ativos para tratamento de cânceres |
| US20170216286A1 (en) | 2014-01-28 | 2017-08-03 | Mayo Foundation For Medical Education And Research | Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid |
| IL286427B2 (en) | 2014-01-28 | 2024-08-01 | Mayo Found Medical Education & Res | Inhibitors bcl-2 anti-apoptotic protein family members for treatment of non cancer pulmonary disease or an opthalmic disease |
| US20190269675A1 (en) | 2014-01-28 | 2019-09-05 | Buck Institute for Research and Aging | Treatment of parkinson's disease and other conditions caused or mediated by senescent astrocytes using small molecule senolytic agents |
| US10328058B2 (en) | 2014-01-28 | 2019-06-25 | Mayo Foundation For Medical Education And Research | Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques |
| US10759808B2 (en) | 2016-04-06 | 2020-09-01 | The Regents Of The University Of Michigan | Monofunctional intermediates for ligand-dependent target protein degradation |
| SG11201808728QA (en) | 2016-04-06 | 2018-11-29 | Univ Michigan Regents | Mdm2 protein degraders |
| CN118436801A (zh) | 2016-05-20 | 2024-08-06 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| CN112912143A (zh) | 2018-10-08 | 2021-06-04 | 美国密歇根州立大学试剂中心 | 小分子mdm2蛋白降解剂 |
| KR20230005160A (ko) | 2020-03-19 | 2023-01-09 | 카이메라 쎄라퓨틱스 인코포레이티드 | Mdm2 분해제 및 이의 용도 |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| WO2024240858A1 (en) | 2023-05-23 | 2024-11-28 | Valerio Therapeutics | Protac molecules directed against dna damage repair system and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2358891A1 (fr) * | 1976-07-22 | 1978-02-17 | Yamanouchi Pharma Co Ltd | Composes heterocycliques contenant un azote, utilise comme agents analgesiques et anti-inflammatoires |
| JPH02101065A (ja) | 1988-10-06 | 1990-04-12 | Tanabe Seiyaku Co Ltd | イミダゾリン誘導体及びその製法 |
| GB9704762D0 (en) * | 1997-03-07 | 1997-04-23 | Zeneca Ltd | Chemical process |
| GB2351082A (en) | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Synthesis of Cyclic Substituted Amidines |
| PL370823A1 (en) * | 2001-12-18 | 2005-05-30 | F.Hoffmann-La Roche Ag | Cis-2,4,5- triphenyl-imidazolines and their use in the treatment of tumors |
| ATE397925T1 (de) * | 2001-12-18 | 2008-07-15 | Hoffmann La Roche | Cis-imidazoline als mdm2-hemmer |
| CN100465163C (zh) * | 2003-06-17 | 2009-03-04 | 霍夫曼-拉罗奇有限公司 | 顺式-2,4,5-三芳基-咪唑啉类化合物 |
| JP4814228B2 (ja) | 2004-05-18 | 2011-11-16 | エフ．ホフマン−ラ ロシュ アーゲー | 新規ｃｉｓ−イミダゾリン |
| US7893278B2 (en) | 2004-06-17 | 2011-02-22 | Hoffman-La Roche Inc. | CIS-imidazolines |
| KR101015073B1 (ko) | 2006-01-18 | 2011-02-16 | 에프. 호프만-라 로슈 아게 | Ｍｄｍ2 억제제로서의시스-4,5-비아릴-2-헤테로시클릭-이미다졸린 |
| US8232298B2 (en) | 2006-03-22 | 2012-07-31 | Janssen Pharmaceutica N.V. | Inhibitors of the interaction between MDM2 and P53 |
-
2008
- 2008-03-18 US US12/050,235 patent/US7625895B2/en not_active Expired - Fee Related
- 2008-04-02 CN CN2008800116778A patent/CN101657449B/zh not_active Expired - Fee Related
- 2008-04-02 JP JP2010502490A patent/JP2010523616A/ja active Pending
- 2008-04-02 WO PCT/EP2008/053903 patent/WO2008125487A1/en not_active Ceased
- 2008-04-02 RU RU2009141522/04A patent/RU2009141522A/ru not_active Application Discontinuation
- 2008-04-02 AU AU2008238062A patent/AU2008238062A1/en not_active Abandoned
- 2008-04-02 MX MX2009011019A patent/MX2009011019A/es active IP Right Grant
- 2008-04-02 AT AT08735669T patent/ATE514696T1/de not_active IP Right Cessation
- 2008-04-02 ES ES08735669T patent/ES2367228T3/es active Active
- 2008-04-02 KR KR1020097021151A patent/KR20090118116A/ko not_active Ceased
- 2008-04-02 BR BRPI0810495A patent/BRPI0810495A2/pt not_active IP Right Cessation
- 2008-04-02 CA CA002684008A patent/CA2684008A1/en not_active Abandoned
- 2008-04-02 EP EP08735669A patent/EP2146986B1/en not_active Not-in-force
- 2008-04-10 PE PE2008000636A patent/PE20090229A1/es not_active Application Discontinuation
- 2008-04-10 AR ARP080101487A patent/AR066014A1/es not_active Application Discontinuation
- 2008-04-11 CL CL2008001047A patent/CL2008001047A1/es unknown
- 2008-04-11 TW TW097113385A patent/TW200848033A/zh unknown
-
2009
- 2009-09-17 IL IL201021A patent/IL201021A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2009011019A (es) | 2009-10-29 |
| US7625895B2 (en) | 2009-12-01 |
| EP2146986B1 (en) | 2011-06-29 |
| US20080255119A1 (en) | 2008-10-16 |
| WO2008125487A1 (en) | 2008-10-23 |
| ATE514696T1 (de) | 2011-07-15 |
| EP2146986A1 (en) | 2010-01-27 |
| CN101657449B (zh) | 2012-06-06 |
| PE20090229A1 (es) | 2009-03-27 |
| IL201021A0 (en) | 2010-05-17 |
| KR20090118116A (ko) | 2009-11-17 |
| CL2008001047A1 (es) | 2009-01-16 |
| ES2367228T3 (es) | 2011-10-31 |
| AU2008238062A1 (en) | 2008-10-23 |
| JP2010523616A (ja) | 2010-07-15 |
| CA2684008A1 (en) | 2008-10-23 |
| AR066014A1 (es) | 2009-07-15 |
| CN101657449A (zh) | 2010-02-24 |
| RU2009141522A (ru) | 2011-05-20 |
| TW200848033A (en) | 2008-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A, 7A, 8A, 9A E 10A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2497 DE 13-11-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |