ATE514696T1 - Diphenyl-dihydro-imidazopyridinone - Google Patents
Diphenyl-dihydro-imidazopyridinoneInfo
- Publication number
- ATE514696T1 ATE514696T1 AT08735669T AT08735669T ATE514696T1 AT E514696 T1 ATE514696 T1 AT E514696T1 AT 08735669 T AT08735669 T AT 08735669T AT 08735669 T AT08735669 T AT 08735669T AT E514696 T1 ATE514696 T1 AT E514696T1
- Authority
- AT
- Austria
- Prior art keywords
- imidazopyridinone
- dihydro
- diphenyl
- Prior art date
Links
- LQCBVQFFDSIHOY-UHFFFAOYSA-N 1,3-diphenylimidazo[4,5-b]pyridin-2-one Chemical compound C12=CC=CN=C2N(C=2C=CC=CC=2)C(=O)N1C1=CC=CC=C1 LQCBVQFFDSIHOY-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92311007P | 2007-04-12 | 2007-04-12 | |
| PCT/EP2008/053903 WO2008125487A1 (en) | 2007-04-12 | 2008-04-02 | Diphenyl-dihydro-imidazopyridinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE514696T1 true ATE514696T1 (de) | 2011-07-15 |
Family
ID=39478351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08735669T ATE514696T1 (de) | 2007-04-12 | 2008-04-02 | Diphenyl-dihydro-imidazopyridinone |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7625895B2 (de) |
| EP (1) | EP2146986B1 (de) |
| JP (1) | JP2010523616A (de) |
| KR (1) | KR20090118116A (de) |
| CN (1) | CN101657449B (de) |
| AR (1) | AR066014A1 (de) |
| AT (1) | ATE514696T1 (de) |
| AU (1) | AU2008238062A1 (de) |
| BR (1) | BRPI0810495A2 (de) |
| CA (1) | CA2684008A1 (de) |
| CL (1) | CL2008001047A1 (de) |
| ES (1) | ES2367228T3 (de) |
| IL (1) | IL201021A0 (de) |
| MX (1) | MX2009011019A (de) |
| PE (1) | PE20090229A1 (de) |
| RU (1) | RU2009141522A (de) |
| TW (1) | TW200848033A (de) |
| WO (1) | WO2008125487A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2380892E (pt) | 2009-01-16 | 2014-06-09 | Daiichi Sankyo Co Ltd | Derivado de imidazotiazole compreendendo uma estrutura de anel prolina |
| KR20120099462A (ko) | 2009-11-12 | 2012-09-10 | 더 리젠츠 오브 더 유니버시티 오브 미시건 | 스피로-옥신돌 ｍｄｍ2 길항제 |
| US10159669B2 (en) * | 2010-03-02 | 2018-12-25 | Ian H. Chan | Individual and combination of mdivi-1 and nutlin-3 for topical or intravitreal ophthalmic use |
| JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
| FR2967072B1 (fr) | 2010-11-05 | 2013-03-29 | Univ Dundee | Procede pour ameliorer la production de virus et semences vaccinales influenza |
| AU2011326395B2 (en) | 2010-11-12 | 2016-01-07 | Ascenta Licensing Corporation | Spiro-oxindole MDM2 antagonists |
| US8629141B2 (en) | 2011-05-11 | 2014-01-14 | The Regents Of The University Of Michigan | Spiro-oxindole MDM2 antagonists |
| MX352672B (es) | 2011-09-27 | 2017-12-04 | Amgen Inc | Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer. |
| TW201429969A (zh) | 2012-12-20 | 2014-08-01 | Merck Sharp & Dohme | 作爲ｈｄｍ２抑制劑之經取代咪唑吡啶 |
| US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
| CA2902856C (en) | 2013-02-28 | 2021-02-16 | Amgen Inc. | A benzoic acid derivative mdm2 inhibitor for the treatment of cancer |
| AU2014236812B2 (en) | 2013-03-14 | 2018-03-01 | Amgen Inc. | Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer |
| CN105358530A (zh) | 2013-06-10 | 2016-02-24 | 美国安进公司 | 制备mdm2抑制剂的方法及其结晶形式 |
| HRP20220718T1 (hr) | 2013-11-11 | 2022-09-30 | Amgen Inc. | Kombinacijska terapija uključujući inhibitor mdm2 i jedan ili više dodatnih farmaceutski aktivnih sredstava za liječenje raka |
| US10328058B2 (en) | 2014-01-28 | 2019-06-25 | Mayo Foundation For Medical Education And Research | Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques |
| US20170216286A1 (en) | 2014-01-28 | 2017-08-03 | Mayo Foundation For Medical Education And Research | Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid |
| AU2015211021B2 (en) | 2014-01-28 | 2020-07-02 | Buck Institute For Research On Aging | Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders |
| US20190269675A1 (en) | 2014-01-28 | 2019-09-05 | Buck Institute for Research and Aging | Treatment of parkinson's disease and other conditions caused or mediated by senescent astrocytes using small molecule senolytic agents |
| WO2017176958A1 (en) | 2016-04-06 | 2017-10-12 | The Regents Of The University Of Michigan | Monofunctional intermediates for ligand-dependent target protein degradation |
| AU2017246452C1 (en) | 2016-04-06 | 2021-06-03 | The Regents Of The University Of Michigan | MDM2 protein degraders |
| EP3458101B1 (de) | 2016-05-20 | 2020-12-30 | H. Hoffnabb-La Roche Ag | Protac-antikörper-konjugate und verfahren zur verwendung |
| KR20210072043A (ko) | 2018-10-08 | 2021-06-16 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 소분자 mdm 2 단백질 분해제 |
| US12528785B2 (en) | 2020-03-19 | 2026-01-20 | Kymera Therapeutics, Inc. | MDM2 degraders and uses thereof |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| WO2024240858A1 (en) | 2023-05-23 | 2024-11-28 | Valerio Therapeutics | Protac molecules directed against dna damage repair system and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2358891A1 (fr) * | 1976-07-22 | 1978-02-17 | Yamanouchi Pharma Co Ltd | Composes heterocycliques contenant un azote, utilise comme agents analgesiques et anti-inflammatoires |
| JPH02101065A (ja) | 1988-10-06 | 1990-04-12 | Tanabe Seiyaku Co Ltd | イミダゾリン誘導体及びその製法 |
| GB9704762D0 (en) * | 1997-03-07 | 1997-04-23 | Zeneca Ltd | Chemical process |
| GB2351082A (en) | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Synthesis of Cyclic Substituted Amidines |
| BR0215156A (pt) * | 2001-12-18 | 2004-10-19 | Hoffmann La Roche | Cis-imidazolinas como inibidores de mdm 2 |
| BR0215157A (pt) | 2001-12-18 | 2004-10-19 | Hoffmann La Roche | Cis-2,4,5-trifenil-imidazolinas e seu uso no tratamento de tumores |
| AU2004254187A1 (en) * | 2003-06-17 | 2005-01-13 | F. Hoffmann-La Roche Ag | Cis-2,4,5-triaryl-imidazolines |
| BRPI0511328A (pt) | 2004-05-18 | 2007-12-04 | Hoffmann La Roche | cis-imidazolinas |
| US7893278B2 (en) | 2004-06-17 | 2011-02-22 | Hoffman-La Roche Inc. | CIS-imidazolines |
| BRPI0710477A2 (pt) | 2006-01-18 | 2011-08-16 | Hoffmann La Roche | cis-4, 5- biarila - 2- imidazolinas heterocìclicas como inibidores da mdm2 |
| JP5385125B2 (ja) | 2006-03-22 | 2014-01-08 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ＭＤＭ２とｐ５３の間の相互作用の阻害剤 |
-
2008
- 2008-03-18 US US12/050,235 patent/US7625895B2/en not_active Expired - Fee Related
- 2008-04-02 KR KR1020097021151A patent/KR20090118116A/ko not_active Ceased
- 2008-04-02 BR BRPI0810495A patent/BRPI0810495A2/pt not_active IP Right Cessation
- 2008-04-02 AT AT08735669T patent/ATE514696T1/de not_active IP Right Cessation
- 2008-04-02 CN CN2008800116778A patent/CN101657449B/zh not_active Expired - Fee Related
- 2008-04-02 EP EP08735669A patent/EP2146986B1/de not_active Not-in-force
- 2008-04-02 WO PCT/EP2008/053903 patent/WO2008125487A1/en not_active Ceased
- 2008-04-02 RU RU2009141522/04A patent/RU2009141522A/ru not_active Application Discontinuation
- 2008-04-02 AU AU2008238062A patent/AU2008238062A1/en not_active Abandoned
- 2008-04-02 CA CA002684008A patent/CA2684008A1/en not_active Abandoned
- 2008-04-02 MX MX2009011019A patent/MX2009011019A/es active IP Right Grant
- 2008-04-02 JP JP2010502490A patent/JP2010523616A/ja active Pending
- 2008-04-02 ES ES08735669T patent/ES2367228T3/es active Active
- 2008-04-10 PE PE2008000636A patent/PE20090229A1/es not_active Application Discontinuation
- 2008-04-10 AR ARP080101487A patent/AR066014A1/es not_active Application Discontinuation
- 2008-04-11 CL CL2008001047A patent/CL2008001047A1/es unknown
- 2008-04-11 TW TW097113385A patent/TW200848033A/zh unknown
-
2009
- 2009-09-17 IL IL201021A patent/IL201021A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL201021A0 (en) | 2010-05-17 |
| EP2146986A1 (de) | 2010-01-27 |
| TW200848033A (en) | 2008-12-16 |
| ES2367228T3 (es) | 2011-10-31 |
| AR066014A1 (es) | 2009-07-15 |
| RU2009141522A (ru) | 2011-05-20 |
| US7625895B2 (en) | 2009-12-01 |
| MX2009011019A (es) | 2009-10-29 |
| US20080255119A1 (en) | 2008-10-16 |
| AU2008238062A1 (en) | 2008-10-23 |
| KR20090118116A (ko) | 2009-11-17 |
| PE20090229A1 (es) | 2009-03-27 |
| BRPI0810495A2 (pt) | 2018-10-30 |
| EP2146986B1 (de) | 2011-06-29 |
| CN101657449A (zh) | 2010-02-24 |
| JP2010523616A (ja) | 2010-07-15 |
| CL2008001047A1 (es) | 2009-01-16 |
| CN101657449B (zh) | 2012-06-06 |
| CA2684008A1 (en) | 2008-10-23 |
| WO2008125487A1 (en) | 2008-10-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2170321T3 (da) | Ormekur-kombination | |
| DE602008006301D1 (de) | Koaxialnadelanordnung | |
| BRPI0821573A2 (pt) | benzofuropirimidonas | |
| ATE501136T1 (de) | Imidazopyridinone | |
| DE502007001207D1 (de) | Elektrosaugkopf | |
| DK2159224T3 (da) | Bromphenylsubstituerede thiazolyldihydropyrimidiner | |
| ATE514696T1 (de) | Diphenyl-dihydro-imidazopyridinone | |
| DE112008003636A5 (de) | Mehrzuggruppierer | |
| DE602008002772D1 (de) | Polyvinylpyrrolidonpulverzusammensetzungen | |
| DE602008000923D1 (de) | Einzelwaferätzgerät | |
| BRPI0811451A2 (pt) | Exopolissacarídeo | |
| DE602008000749D1 (de) | Buschschneider | |
| BRPI0814519A2 (pt) | Organopolissiloxano | |
| BRPI0815547A2 (pt) | Depsipeptídeos cícliocos | |
| BRPI0812840A2 (pt) | 2-imidazolinas | |
| DE602008004695D1 (de) | Katalysatorträgerwabe | |
| DE602008001234D1 (de) | Bandmaterialzuführvorrichtung | |
| AT505058A3 (de) | Türschliesssystem | |
| BRPI0812994A2 (pt) | Microbiocidas | |
| DE602008005950D1 (de) | Münzvereinzeler | |
| DE602008005589D1 (de) | Rliganden | |
| DE602008001674D1 (de) | Wimpernwickler | |
| DE112008001216A5 (de) | Magnetronplasmaanlage | |
| DE502008001694D1 (de) | Mitfahrhubwagen | |
| DE112008003094A5 (de) | Geomatte |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |