ATE514696T1 - Diphenyl-dihydro-imidazopyridinone - Google Patents
Diphenyl-dihydro-imidazopyridinoneInfo
- Publication number
- ATE514696T1 ATE514696T1 AT08735669T AT08735669T ATE514696T1 AT E514696 T1 ATE514696 T1 AT E514696T1 AT 08735669 T AT08735669 T AT 08735669T AT 08735669 T AT08735669 T AT 08735669T AT E514696 T1 ATE514696 T1 AT E514696T1
- Authority
- AT
- Austria
- Prior art keywords
- imidazopyridinone
- dihydro
- diphenyl
- Prior art date
Links
- LQCBVQFFDSIHOY-UHFFFAOYSA-N 1,3-diphenylimidazo[4,5-b]pyridin-2-one Chemical compound C12=CC=CN=C2N(C=2C=CC=CC=2)C(=O)N1C1=CC=CC=C1 LQCBVQFFDSIHOY-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92311007P | 2007-04-12 | 2007-04-12 | |
| PCT/EP2008/053903 WO2008125487A1 (en) | 2007-04-12 | 2008-04-02 | Diphenyl-dihydro-imidazopyridinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE514696T1 true ATE514696T1 (de) | 2011-07-15 |
Family
ID=39478351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08735669T ATE514696T1 (de) | 2007-04-12 | 2008-04-02 | Diphenyl-dihydro-imidazopyridinone |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7625895B2 (de) |
| EP (1) | EP2146986B1 (de) |
| JP (1) | JP2010523616A (de) |
| KR (1) | KR20090118116A (de) |
| CN (1) | CN101657449B (de) |
| AR (1) | AR066014A1 (de) |
| AT (1) | ATE514696T1 (de) |
| AU (1) | AU2008238062A1 (de) |
| BR (1) | BRPI0810495A2 (de) |
| CA (1) | CA2684008A1 (de) |
| CL (1) | CL2008001047A1 (de) |
| ES (1) | ES2367228T3 (de) |
| IL (1) | IL201021A0 (de) |
| MX (1) | MX2009011019A (de) |
| PE (1) | PE20090229A1 (de) |
| RU (1) | RU2009141522A (de) |
| TW (1) | TW200848033A (de) |
| WO (1) | WO2008125487A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2463820T3 (es) | 2009-01-16 | 2014-05-29 | Daiichi Sankyo Company, Limited | Derivado de imidazotiazol que tiene estructura de anillo de prolina |
| CN104876938A (zh) | 2009-11-12 | 2015-09-02 | 密歇根大学董事会 | 螺-吲哚酮mdm2拮抗剂 |
| US10159669B2 (en) * | 2010-03-02 | 2018-12-25 | Ian H. Chan | Individual and combination of mdivi-1 and nutlin-3 for topical or intravitreal ophthalmic use |
| JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
| FR2967072B1 (fr) | 2010-11-05 | 2013-03-29 | Univ Dundee | Procede pour ameliorer la production de virus et semences vaccinales influenza |
| PE20140408A1 (es) | 2010-11-12 | 2014-04-10 | Univ Michigan | Derivados espiro-oxindol como antagonistas de mdm2 |
| MX346375B (es) | 2011-05-11 | 2017-03-16 | Univ Michigan Regents | Antagonistas de espiro-oxindol de mdm2. |
| MX352672B (es) | 2011-09-27 | 2017-12-04 | Amgen Inc | Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer. |
| WO2014100065A1 (en) | 2012-12-20 | 2014-06-26 | Merck Sharp & Dohme Corp. | Substituted imidazopyridines as hdm2 inhibitors |
| US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
| WO2014134201A1 (en) | 2013-02-28 | 2014-09-04 | Amgen Inc. | A benzoic acid derivative mdm2 inhibitor for the treatment of cancer |
| WO2014151863A1 (en) | 2013-03-14 | 2014-09-25 | Amgen Inc. | Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer |
| MA53572A1 (fr) | 2013-06-10 | 2021-10-29 | Amgen Inc | Procédés de production et formes cristallines d'un inhibiteur mdm2 |
| MY192088A (en) | 2013-11-11 | 2022-07-26 | Amgen Inc | Combinantion therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers |
| US10328058B2 (en) | 2014-01-28 | 2019-06-25 | Mayo Foundation For Medical Education And Research | Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques |
| US9993472B2 (en) | 2014-01-28 | 2018-06-12 | Unity Biotechnology, Inc. | Treatment for osteoarthritis in a joint by administering a means for inhibiting MDM2 |
| US20190269675A1 (en) | 2014-01-28 | 2019-09-05 | Buck Institute for Research and Aging | Treatment of parkinson's disease and other conditions caused or mediated by senescent astrocytes using small molecule senolytic agents |
| US20170216286A1 (en) | 2014-01-28 | 2017-08-03 | Mayo Foundation For Medical Education And Research | Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid |
| EP3440082A1 (de) | 2016-04-06 | 2019-02-13 | The Regents of The University of Michigan | Monofunktionelle zwischenprodukte für den ligandenabhängigen zielproteinabbau |
| AU2017246452C1 (en) | 2016-04-06 | 2021-06-03 | The Regents Of The University Of Michigan | MDM2 protein degraders |
| CN109152843A (zh) | 2016-05-20 | 2019-01-04 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| BR112021006647A2 (pt) | 2018-10-08 | 2021-07-13 | The Regents Of The University Of Michigan | degradores de proteína mdm2 de pequenas moléculas |
| WO2021188948A1 (en) | 2020-03-19 | 2021-09-23 | Kymera Therapeutics, Inc. | Mdm2 degraders and uses thereof |
| WO2022183006A1 (en) | 2021-02-25 | 2022-09-01 | Mayo Foundation For Medical Education And Research | Compounds for programmable protein degradation and methods of use for the disease treatment |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| WO2024240858A1 (en) | 2023-05-23 | 2024-11-28 | Valerio Therapeutics | Protac molecules directed against dna damage repair system and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1067079A (en) * | 1976-07-22 | 1979-11-27 | Yamanouchi Pharmaceutical Co. | Nitrogen-containing heterobicyclic compounds |
| JPH02101065A (ja) | 1988-10-06 | 1990-04-12 | Tanabe Seiyaku Co Ltd | イミダゾリン誘導体及びその製法 |
| GB9704762D0 (en) | 1997-03-07 | 1997-04-23 | Zeneca Ltd | Chemical process |
| GB2351082A (en) | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Synthesis of Cyclic Substituted Amidines |
| KR100650966B1 (ko) | 2001-12-18 | 2006-11-30 | 에프. 호프만-라 로슈 아게 | 시스-2,4,5-트리페닐-이미다졸린 및 종양 치료에서의 그의용도 |
| JP4361798B2 (ja) | 2001-12-18 | 2009-11-11 | エフ．ホフマン−ラ ロシュ アーゲー | Ｍｄｍ２インヒビターとしてのシス−イミダゾリン |
| WO2005003097A1 (en) * | 2003-06-17 | 2005-01-13 | F. Hoffmann-La Roche Ag | Cis-2,4,5-triaryl-imidazolines |
| KR20080027969A (ko) | 2004-05-18 | 2008-03-28 | 에프. 호프만-라 로슈 아게 | 신규 ｃｉｓ-이미다졸린 |
| US7893278B2 (en) | 2004-06-17 | 2011-02-22 | Hoffman-La Roche Inc. | CIS-imidazolines |
| BRPI0710477A2 (pt) | 2006-01-18 | 2011-08-16 | Hoffmann La Roche | cis-4, 5- biarila - 2- imidazolinas heterocìclicas como inibidores da mdm2 |
| WO2007107543A1 (en) | 2006-03-22 | 2007-09-27 | Janssen Pharmaceutica N.V. | Inhibitors of the interaction between mdm2 and p53 |
-
2008
- 2008-03-18 US US12/050,235 patent/US7625895B2/en not_active Expired - Fee Related
- 2008-04-02 ES ES08735669T patent/ES2367228T3/es active Active
- 2008-04-02 RU RU2009141522/04A patent/RU2009141522A/ru not_active Application Discontinuation
- 2008-04-02 BR BRPI0810495A patent/BRPI0810495A2/pt not_active IP Right Cessation
- 2008-04-02 MX MX2009011019A patent/MX2009011019A/es active IP Right Grant
- 2008-04-02 CA CA002684008A patent/CA2684008A1/en not_active Abandoned
- 2008-04-02 WO PCT/EP2008/053903 patent/WO2008125487A1/en not_active Ceased
- 2008-04-02 JP JP2010502490A patent/JP2010523616A/ja active Pending
- 2008-04-02 KR KR1020097021151A patent/KR20090118116A/ko not_active Ceased
- 2008-04-02 EP EP08735669A patent/EP2146986B1/de not_active Not-in-force
- 2008-04-02 CN CN2008800116778A patent/CN101657449B/zh not_active Expired - Fee Related
- 2008-04-02 AU AU2008238062A patent/AU2008238062A1/en not_active Abandoned
- 2008-04-02 AT AT08735669T patent/ATE514696T1/de not_active IP Right Cessation
- 2008-04-10 AR ARP080101487A patent/AR066014A1/es not_active Application Discontinuation
- 2008-04-10 PE PE2008000636A patent/PE20090229A1/es not_active Application Discontinuation
- 2008-04-11 TW TW097113385A patent/TW200848033A/zh unknown
- 2008-04-11 CL CL2008001047A patent/CL2008001047A1/es unknown
-
2009
- 2009-09-17 IL IL201021A patent/IL201021A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200848033A (en) | 2008-12-16 |
| KR20090118116A (ko) | 2009-11-17 |
| EP2146986B1 (de) | 2011-06-29 |
| AR066014A1 (es) | 2009-07-15 |
| AU2008238062A1 (en) | 2008-10-23 |
| US7625895B2 (en) | 2009-12-01 |
| CA2684008A1 (en) | 2008-10-23 |
| JP2010523616A (ja) | 2010-07-15 |
| CL2008001047A1 (es) | 2009-01-16 |
| RU2009141522A (ru) | 2011-05-20 |
| US20080255119A1 (en) | 2008-10-16 |
| IL201021A0 (en) | 2010-05-17 |
| MX2009011019A (es) | 2009-10-29 |
| EP2146986A1 (de) | 2010-01-27 |
| WO2008125487A1 (en) | 2008-10-23 |
| ES2367228T3 (es) | 2011-10-31 |
| PE20090229A1 (es) | 2009-03-27 |
| CN101657449B (zh) | 2012-06-06 |
| BRPI0810495A2 (pt) | 2018-10-30 |
| CN101657449A (zh) | 2010-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |