BRPI0810632A2 - Derivados de piridopirazina, processo de fabricação e usos dos mesmos - Google Patents

Derivados de piridopirazina, processo de fabricação e usos dos mesmos

Info

Publication number
BRPI0810632A2
BRPI0810632A2 BRPI0810632-0A2A BRPI0810632A BRPI0810632A2 BR PI0810632 A2 BRPI0810632 A2 BR PI0810632A2 BR PI0810632 A BRPI0810632 A BR PI0810632A BR PI0810632 A2 BRPI0810632 A2 BR PI0810632A2
Authority
BR
Brazil
Prior art keywords
pyropyrozine
derivatives
manufacturing process
manufacturing
pyropyrozine derivatives
Prior art date
Application number
BRPI0810632-0A2A
Other languages
English (en)
Inventor
Matthias Gerlach
Irene Seipelt
Eckhard Guenther
Emmanuel Polymeropoulos
Tilmann Schuster
Eckhard Claus
Original Assignee
Aeterna Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aeterna Zentaris Gmbh filed Critical Aeterna Zentaris Gmbh
Publication of BRPI0810632A2 publication Critical patent/BRPI0810632A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Otolaryngology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
BRPI0810632-0A2A 2007-05-10 2008-05-09 Derivados de piridopirazina, processo de fabricação e usos dos mesmos BRPI0810632A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91712907P 2007-05-10 2007-05-10
EP07107976A EP1990342A1 (en) 2007-05-10 2007-05-10 Pyridopyrazine Derivatives, Process of Manufacturing and Uses thereof
PCT/EP2008/055728 WO2008138878A2 (en) 2007-05-10 2008-05-09 Novel pyridopyrazine derivatives, process of manufacturing and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0810632A2 true BRPI0810632A2 (pt) 2014-11-04

Family

ID=38617324

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0810632-0A2A BRPI0810632A2 (pt) 2007-05-10 2008-05-09 Derivados de piridopirazina, processo de fabricação e usos dos mesmos

Country Status (18)

Country Link
US (4) US8202883B2 (pt)
EP (2) EP1990342A1 (pt)
JP (3) JP5528326B2 (pt)
KR (1) KR20100016425A (pt)
CN (1) CN101715451B (pt)
AR (1) AR067315A1 (pt)
AU (1) AU2008250282B2 (pt)
BR (1) BRPI0810632A2 (pt)
CA (1) CA2686489C (pt)
IL (1) IL201375A0 (pt)
MX (1) MX2009012144A (pt)
NZ (1) NZ580268A (pt)
RU (1) RU2495038C2 (pt)
SG (1) SG183692A1 (pt)
TW (1) TWI432199B (pt)
UA (1) UA99128C2 (pt)
WO (1) WO2008138878A2 (pt)
ZA (1) ZA200906861B (pt)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1990342A1 (en) 2007-05-10 2008-11-12 AEterna Zentaris GmbH Pyridopyrazine Derivatives, Process of Manufacturing and Uses thereof
WO2010052448A2 (en) * 2008-11-05 2010-05-14 Ucb Pharma S.A. Fused pyrazine derivatives as kinase inhibitors
EP2241557A1 (de) * 2009-04-02 2010-10-20 Æterna Zentaris GmbH Chinoxalin-Derivate und deren Anwendung zur Behandlung gutartiger und bösartiger Tumorerkrankungen
US8575203B2 (en) 2010-04-21 2013-11-05 Boehringer Ingelheim International Gmbh Chemical compounds
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
JP6104824B2 (ja) 2011-03-09 2017-03-29 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ピリド［２，３−ｂ］ピラジン誘導体およびそれらの治療的使用
EP2508184A1 (en) 2011-04-06 2012-10-10 Æterna Zentaris GmbH Pyridopyrazine derivatives and their use
AR086744A1 (es) * 2011-06-28 2014-01-22 Nippon Soda Co Compuesto heterociclico conteniendo nitrogeno y fungicida para el uso en agricultura y jardineria
WO2013018733A1 (ja) * 2011-07-29 2013-02-07 富士フイルム株式会社 １，５－ナフチリジン誘導体又はその塩
GB201118654D0 (en) * 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
CN103159686A (zh) * 2011-12-09 2013-06-19 天津市国际生物医药联合研究院 一种hiv-1蛋白酶的脲类抑制剂
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201209609D0 (en) * 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
US9611267B2 (en) 2012-06-13 2017-04-04 Incyte Holdings Corporation Substituted tricyclic compounds as FGFR inhibitors
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