BRPI0819991A2 - Derivados de indolinona e processo para fabricação dos mesmos - Google Patents

Derivados de indolinona e processo para fabricação dos mesmos

Info

Publication number: BRPI0819991A2
Authority: BR; Brazil
Prior art keywords: manufacturing process; indolinone derivatives; indolinone; derivatives; manufacturing
Prior art date: 2007-12-03

Application number

Other languages

English (en)

Inventor

Joern Merten

Svenja Renner

Carsten Reichel

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-03

Filing date

2008-12-02

Publication date

2015-05-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40718253&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0819991(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-12-02 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2015-05-12 Publication of BRPI0819991A2 publication Critical patent/BRPI0819991A2/pt

2022-02-15 Publication of BRPI0819991B1 publication Critical patent/BRPI0819991B1/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Epidemiology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Heat Sensitive Colour Forming Recording (AREA)

BRPI0819991-4A 2007-12-03 2008-12-02 Derivados de indolinona e processo para fabricação dos mesmos BRPI0819991B1 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP07122123		2007-12-03
EP07122123.8		2007-12-03
PCT/EP2008/066581 WO2009071524A2 (en)	2007-12-03	2008-12-02	Indolinone derivatives and process for their manufacture

Publications (2)

Publication Number	Publication Date
BRPI0819991A2 true BRPI0819991A2 (pt)	2015-05-12
BRPI0819991B1 BRPI0819991B1 (pt)	2022-02-15

Family

ID=40718253

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0819991-4A BRPI0819991B1 (pt)	2007-12-03	2008-12-02	Derivados de indolinona e processo para fabricação dos mesmos

Country Status (35)

Country	Link
US (1)	US8067617B2 (pt)
EP (1)	EP2229360B1 (pt)
JP (2)	JP5933924B2 (pt)
KR (2)	KR101712810B1 (pt)
CN (1)	CN101883755B (pt)
AR (1)	AR069531A1 (pt)
AU (1)	AU2008333287B2 (pt)
BR (1)	BRPI0819991B1 (pt)
CA (1)	CA2705490C (pt)
CL (1)	CL2008003599A1 (pt)
CO (1)	CO6210751A2 (pt)
CY (1)	CY1123333T1 (pt)
DK (1)	DK2229360T3 (pt)
EA (1)	EA016196B1 (pt)
EC (1)	ECSP10010195A (pt)
ES (1)	ES2818993T3 (pt)
HR (1)	HRP20201480T1 (pt)
HU (1)	HUE051550T2 (pt)
IL (1)	IL205348A (pt)
LT (1)	LT2229360T (pt)
MA (1)	MA31989B1 (pt)
MX (1)	MX2010005557A (pt)
MY (1)	MY148574A (pt)
NZ (1)	NZ585798A (pt)
PE (1)	PE20091445A1 (pt)
PL (1)	PL2229360T3 (pt)
PT (1)	PT2229360T (pt)
RS (1)	RS60818B1 (pt)
SI (1)	SI2229360T1 (pt)
TN (1)	TN2010000248A1 (pt)
TW (1)	TWI432415B (pt)
UA (1)	UA97872C2 (pt)
UY (1)	UY31506A1 (pt)
WO (1)	WO2009071524A2 (pt)
ZA (1)	ZA201002723B (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PE20091445A1 (es) *	2007-12-03	2009-10-19	Boehringer Ingelheim Int	Derivados de indolinona y procedimiento para su fabricacion
US20170065529A1 (en)	2015-09-09	2017-03-09	Boehringer Ingelheim International Gmbh	Pharmaceutical dosage form for immediate release of an indolinone derivative
WO2012068441A2 (en)	2010-11-19	2012-05-24	Ratiopharm Gmbh	Intedanib salts and solid state forms thereof
CN103787949A (zh) *	2012-10-31	2014-05-14	韩冰	一类保护移植器官的化合物及其用途
US20140350022A1 (en)	2013-05-10	2014-11-27	Boehringer Ingelheim International Gmbh	Efficacious treatment of NSCLC and predictive clinical marker of the responsiveness of a tumour to a treatment
CA3280124A1 (en)	2013-07-31	2025-10-31	Avalyn Pharma Inc.	Aerosol imatinib compounds and uses thereof
US20140342772A1 (en) *	2013-09-12	2014-11-20	Bandwidth.Com, Inc.	Predictive Caching of IP Data
CN104262232B (zh) *	2014-09-09	2016-05-04	苏州明锐医药科技有限公司	尼泰达尼的制备方法
CN105712923A (zh) *	2014-12-03	2016-06-29	江苏先声药业有限公司	一种尼达尼布杂质及其制备方法与应用
WO2016178064A1 (en)	2015-05-06	2016-11-10	Suven Life Sciences Limited	Polymorph of nintedanib ethanesulphonate, processes and intermediates thereof
CN105001143A (zh) *	2015-07-24	2015-10-28	南京正大天晴制药有限公司	一种制备高纯度乙磺酸尼达尼布的方法
WO2017077551A2 (en)	2015-11-03	2017-05-11	Mylan Laboratories Limited	An amorphous nintedanib esylate and solid dispersion thereof
WO2017198202A1 (zh) *	2016-05-19	2017-11-23	上海诚妙医药科技有限公司	尼达尼布的新晶型及其制备方法及其用途
CN106543069A (zh) *	2016-09-20	2017-03-29	北京万全德众医药生物技术有限公司	6‑甲氧基羰基‑2‑氧代二氢吲哚的制备
CN108610308A (zh) *	2016-12-09	2018-10-02	上海奥博生物医药技术有限公司	一锅法制备尼达尼布中间体的方法
CN106841495B (zh) *	2017-04-21	2018-05-11	常州佳德医药科技有限公司	乙磺酸尼达尼布中基因毒性杂质的高灵敏度分析方法
WO2019048974A1 (en) *	2017-09-06	2019-03-14	Glenmark Pharmaceuticals Limited	Process for the preparation of nintedanib
JP7382317B2 (ja)	2017-11-17	2023-11-16	フェルミオンオサケユキチュア	ニンテダニブを製造するための中間体として公知の２－インドリノン誘導体の合成
CN110746378B (zh) *	2018-12-03	2021-11-05	江苏豪森药业集团有限公司	一种胺基中间体的制备方法
CN111377845A (zh) *	2018-12-27	2020-07-07	江苏先声药业有限公司	3-(二甲氨基(苯基)亚甲基)-2-氧化吲哚-6-羧酸甲酯及其制备方法与应用
CN111662223B (zh) *	2019-03-08	2023-07-14	四川科伦药物研究院有限公司	二氢吲哚酮衍生物及其中间体的制备方法
CA3191013A1 (en) *	2020-08-07	2022-02-10	Bdr Lifesciences Private Limited	An improved highly efficient process for the prepration of nintedanib and pharmaceutically acceptable salt thereof
CN116947732A (zh) *	2023-07-28	2023-10-27	江苏阿尔法药业股份有限公司	一种尼达尼布中间体的合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS4876863A (pt) *	1972-01-22	1973-10-16
US6469181B1 (en) *	1995-01-30	2002-10-22	Catalytica, Inc.	Process for preparing 2-oxindoles and N-hydroxy-2-oxindoles
GB9516943D0 (en) *	1995-08-18	1995-10-18	Cancer Soc Auckland Div Nz Inc	Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs
CN1319090A (zh)	1998-09-25	2001-10-24	贝林格尔英格海姆法玛公司	新的取代的二氢吲哚酮、它们的制备方法和它们作为药物的用途
US7291641B2 (en) *	1999-10-11	2007-11-06	Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.)	Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
UA75054C2 (uk) *	1999-10-13	2006-03-15	Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг	Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу
DE10117204A1 (de) *	2001-04-06	2002-10-10	Boehringer Ingelheim Pharma	In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
DE10233500A1 (de) *	2002-07-24	2004-02-19	Boehringer Ingelheim Pharma Gmbh & Co. Kg	3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel
US7148249B2 (en)	2002-09-12	2006-12-12	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments
CN101535302A (zh) *	2006-11-06	2009-09-16	株式会社泰丽巴镠斯	新型羟基吲哚衍生物
TR201802086T4 (tr) *	2007-12-03	2018-03-21	Boehringer Ingelheim Int	Bir indolinon türevinin imalatı için proses.
PE20091445A1 (es) *	2007-12-03	2009-10-19	Boehringer Ingelheim Int	Derivados de indolinona y procedimiento para su fabricacion

2008
- 2008-12-01 PE PE2008002005A patent/PE20091445A1/es not_active Application Discontinuation
- 2008-12-01 UY UY31506A patent/UY31506A1/es not_active Application Discontinuation
- 2008-12-02 WO PCT/EP2008/066581 patent/WO2009071524A2/en not_active Ceased
- 2008-12-02 CA CA2705490A patent/CA2705490C/en active Active
- 2008-12-02 LT LTEP08857503.0T patent/LT2229360T/lt unknown
- 2008-12-02 ES ES08857503T patent/ES2818993T3/es active Active
- 2008-12-02 SI SI200832138T patent/SI2229360T1/sl unknown
- 2008-12-02 CN CN2008801190684A patent/CN101883755B/zh active Active
- 2008-12-02 KR KR1020157026969A patent/KR101712810B1/ko active Active
- 2008-12-02 BR BRPI0819991-4A patent/BRPI0819991B1/pt active IP Right Grant
- 2008-12-02 PT PT88575030T patent/PT2229360T/pt unknown
- 2008-12-02 HR HRP20201480TT patent/HRP20201480T1/hr unknown
- 2008-12-02 EP EP08857503.0A patent/EP2229360B1/en active Active
- 2008-12-02 DK DK08857503.0T patent/DK2229360T3/da active
- 2008-12-02 HU HUE08857503A patent/HUE051550T2/hu unknown
- 2008-12-02 KR KR1020107012251A patent/KR101676261B1/ko active Active
- 2008-12-02 MX MX2010005557A patent/MX2010005557A/es active IP Right Grant
- 2008-12-02 MY MYPI2010002337A patent/MY148574A/en unknown
- 2008-12-02 AR ARP080105254A patent/AR069531A1/es unknown
- 2008-12-02 UA UAA201007864A patent/UA97872C2/ru unknown
- 2008-12-02 RS RS20201116A patent/RS60818B1/sr unknown
- 2008-12-02 PL PL08857503T patent/PL2229360T3/pl unknown
- 2008-12-02 NZ NZ585798A patent/NZ585798A/en unknown
- 2008-12-02 JP JP2010535407A patent/JP5933924B2/ja active Active
- 2008-12-02 EA EA201000883A patent/EA016196B1/ru not_active IP Right Cessation
- 2008-12-02 US US12/745,788 patent/US8067617B2/en active Active
- 2008-12-02 TW TW097146808A patent/TWI432415B/zh not_active IP Right Cessation
- 2008-12-02 CL CL2008003599A patent/CL2008003599A1/es unknown
- 2008-12-02 AU AU2008333287A patent/AU2008333287B2/en active Active
2010
- 2010-04-19 ZA ZA2010/02723A patent/ZA201002723B/en unknown
- 2010-04-26 IL IL205348A patent/IL205348A/en active IP Right Grant
- 2010-05-21 EC EC2010010195A patent/ECSP10010195A/es unknown
- 2010-06-01 TN TN2010000248A patent/TN2010000248A1/fr unknown
- 2010-06-03 CO CO10067260A patent/CO6210751A2/es active IP Right Grant
- 2010-07-01 MA MA32974A patent/MA31989B1/fr unknown
2014
- 2014-10-27 JP JP2014218112A patent/JP6044025B2/ja active Active
2020
- 2020-09-08 CY CY20201100845T patent/CY1123333T1/el unknown

Also Published As

Publication number	Publication date
PE20091445A1 (es)	2009-10-19
CY1123333T1 (el)	2021-12-31
CA2705490C (en)	2016-02-02
BRPI0819991B1 (pt)	2022-02-15
KR20150116909A (ko)	2015-10-16
UA97872C2 (ru)	2012-03-26
DK2229360T3 (da)	2020-09-28
EA201000883A1 (ru)	2010-12-30
TW200930702A (en)	2009-07-16
EP2229360A2 (en)	2010-09-22
EA016196B1 (ru)	2012-03-30
HRP20201480T1 (hr)	2020-12-11
UY31506A1 (es)	2009-08-03
CN101883755B (zh)	2013-06-26
US20100311985A1 (en)	2010-12-09
SI2229360T1 (sl)	2020-11-30
JP6044025B2 (ja)	2016-12-14
IL205348A (en)	2014-06-30
HK1145682A1 (en)	2011-04-29
AR069531A1 (es)	2010-01-27
HUE051550T2 (hu)	2021-03-01
KR101676261B1 (ko)	2016-11-15
CL2008003599A1 (es)	2010-08-20
MY148574A (en)	2013-04-30
JP2015071602A (ja)	2015-04-16
ZA201002723B (en)	2010-12-29
ECSP10010195A (es)	2010-07-30
JP5933924B2 (ja)	2016-06-15
IL205348A0 (en)	2010-12-30
PT2229360T (pt)	2020-09-15
JP2011505346A (ja)	2011-02-24
NZ585798A (en)	2011-06-30
TWI432415B (zh)	2014-04-01
CN101883755A (zh)	2010-11-10
AU2008333287B2 (en)	2013-12-19
US8067617B2 (en)	2011-11-29
ES2818993T3 (es)	2021-04-14
KR101712810B1 (ko)	2017-03-07
KR20100097129A (ko)	2010-09-02
MA31989B1 (fr)	2011-01-03
WO2009071524A3 (en)	2009-10-01
TN2010000248A1 (fr)	2011-11-11
RS60818B1 (sr)	2020-10-30
PL2229360T3 (pl)	2020-12-14
CO6210751A2 (es)	2010-10-20
EP2229360B1 (en)	2020-07-01
AU2008333287A1 (en)	2009-06-11
WO2009071524A2 (en)	2009-06-11
LT2229360T (lt)	2020-10-12
MX2010005557A (es)	2010-06-01
CA2705490A1 (en)	2009-06-11

Publication	Publication Date	Title
BRPI0810632A2 (pt)	2014-11-04	Derivados de piridopirazina, processo de fabricação e usos dos mesmos
BRPI0910899A2 (pt)	2015-09-29	processo e dispositivo para produção de sacos
BRPI0819182A2 (pt)	2015-05-05	Polímero, proceso para preparar o mesmo, derivados, e, processo para preparar os mesmos
BRPI0809681A2 (pt)	2016-03-15	processo para fabricação de polímeros
BRPI0808800A2 (pt)	2017-05-02	elementos de cerâmicas de alta resistência e processo para fabricação e utilização dos mesmos
BRPI0822705A2 (pt)	2015-07-07	Painel de ligações impresso e método para fabricar o mesmo
BRPI0921106A2 (pt)	2017-03-28	biocombustível e processo para preparação de biocombustível
BRPI0821944A2 (pt)	2015-06-23	Processo
BRPI0919868A2 (pt)	2015-12-15	processo
BRPI0920414A2 (pt)	2015-08-04	Processo para a produção de alfa-tocotrienal e seus derivados
BRPI0916588A2 (pt)	2016-09-13	cobertor, produtos correlacionados e métodos de produção dos mesmos
BRPI0810850A2 (pt)	2014-10-29	Processo para carbonilação de dimetil éter
PT2144998T (pt)	2017-04-07	Métodos e composições para vírus vivos atenuados
BRPI0921374A2 (pt)	2015-12-29	processo
BRPI0810846A2 (pt)	2014-10-29	Processo para carbonilção de dimetil éter
BRPI0716479A2 (pt)	2015-05-26	Processo sol-gel
FI20065348L (fi)	2007-11-25	Spektrometri ja inferferometrinen menetelmä
BRPI0818820A2 (pt)	2015-04-22	Processo para continuamente produzir derivados de 3-isotiazoinona e produtos intermediários dos mesmos
BRPI0816911A2 (pt)	2015-03-17	Processo para preparação de 4-aminobut-2-enolidas
BRPI0813660A2 (pt)	2014-10-07	Processo para o cultivo de microalgas
PT2201156E (pt)	2014-01-07	Composição biocombustível e processo de fabrico
BRPI0914221A2 (pt)	2019-09-24	processo, e, composto
BRPI0910906A2 (pt)	2015-09-29	dispositivo e processo para produção de sacos
BRPI0813960A2 (pt)	2015-01-06	Processo para produção de biarilas
BRPI0910939A2 (pt)	2018-01-09	dispositivo estabilizador e processo de produção do mesmo

Legal Events

Date	Code	Title	Description
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2020-06-23	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]	Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.
2021-05-11	B15K	Others concerning applications: alteration of classification	Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 209/34 Ipc: C07D 209/34 (2006.01), A61P 35/00 (2006.01)
2021-09-21	B06U	Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
2021-09-21	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2021-12-07	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2022-02-15	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/12/2008, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.