BRPI0810647A2 - " uso de trans carotenóides bipolares como um pré-tratamento e no tratamento de doença vascular periférica ". - Google Patents

" uso de trans carotenóides bipolares como um pré-tratamento e no tratamento de doença vascular periférica ".

Info

Publication number
BRPI0810647A2
BRPI0810647A2 BRPI0810647-9A2A BRPI0810647A BRPI0810647A2 BR PI0810647 A2 BRPI0810647 A2 BR PI0810647A2 BR PI0810647 A BRPI0810647 A BR PI0810647A BR PI0810647 A2 BRPI0810647 A2 BR PI0810647A2
Authority
BR
Brazil
Prior art keywords
pretreatment
treatment
vascular disease
peripheral vascular
bipolar trans
Prior art date
Application number
BRPI0810647-9A2A
Other languages
English (en)
Inventor
John L Gainer
Original Assignee
Diffusion Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diffusion Pharmaceuticals Llc filed Critical Diffusion Pharmaceuticals Llc
Publication of BRPI0810647A2 publication Critical patent/BRPI0810647A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
BRPI0810647-9A2A 2007-04-13 2008-04-11 " uso de trans carotenóides bipolares como um pré-tratamento e no tratamento de doença vascular periférica ". BRPI0810647A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90771807P 2007-04-13 2007-04-13
PCT/US2008/004708 WO2008136900A1 (en) 2007-04-13 2008-04-11 Use of bipolar trans carotenoids as a pretreatment and in the treatment of peripheral vascular disease

Publications (1)

Publication Number Publication Date
BRPI0810647A2 true BRPI0810647A2 (pt) 2014-11-04

Family

ID=39854321

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0810647-9A2A BRPI0810647A2 (pt) 2007-04-13 2008-04-11 " uso de trans carotenóides bipolares como um pré-tratamento e no tratamento de doença vascular periférica ".

Country Status (13)

Country Link
US (2) US8293804B2 (pt)
EP (3) EP2589588A1 (pt)
JP (2) JP2010524855A (pt)
KR (1) KR101570131B1 (pt)
CN (1) CN101687757A (pt)
AU (1) AU2008246305B2 (pt)
BR (1) BRPI0810647A2 (pt)
CA (1) CA2683760C (pt)
EA (1) EA200970944A1 (pt)
IL (1) IL201438A (pt)
MX (1) MX2009010988A (pt)
WO (1) WO2008136900A1 (pt)
ZA (1) ZA200907757B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2477245A1 (en) * 2002-02-25 2003-09-04 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
US7759506B2 (en) * 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
EP2540696B1 (en) 2005-02-24 2020-01-01 Diffusion Pharmaceuticals LLC Trans carotenoids, formulation and uses
CN101687757A (zh) 2007-04-13 2010-03-31 扩散药品有限公司 双极性反式类胡萝卜素作为预治疗及其在周围血管疾病的治疗中的应用
KR20100083820A (ko) * 2007-10-31 2010-07-22 디퓨젼 파마슈티컬즈 엘엘씨 저분자 확산을 촉진시키는 신규한 치료요법
EP2445339B1 (en) * 2009-06-22 2019-08-07 Diffusion Pharmaceuticals LLC Diffusion enhancing compound and its use with a thrombolytic
AU2011262361A1 (en) * 2010-06-02 2013-01-10 Diffusion Pharmaceuticals Llc Oral formulations of bipolar trans carotenoids
GB201120772D0 (en) * 2011-12-02 2012-01-11 Ip Science Ltd Cocoa-based food products
CA3018550A1 (en) 2016-03-24 2017-09-28 Diffusion Pharmaceuticals Llc Use of bipolar trans carotenoids with chemotherapy and radiotherapy for treatment of cancer
CN108403677B (zh) * 2018-05-03 2020-06-05 北京市心肺血管疾病研究所 藏红花素在预防和治疗胸主动脉夹层/主动脉瘤中的应用
CA3107753A1 (en) * 2018-07-30 2020-02-06 Diffusion Pharmaceuticals Llc Diffusion enhancing compounds and their use with thrombectomy and embolectomy and other vascular disease procedures
WO2023081779A1 (en) * 2021-11-03 2023-05-11 Diffusion Pharmaceuticals Llc Crystalline forms of a diffusion enhancing compound

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2948748A (en) * 1960-08-09 Esters thereof
US2175843A (en) * 1936-06-26 1939-10-10 Winthrop Chem Co Inc Polyene carboxylic acids and esters and manufacture thereof
CH468330A (de) * 1966-01-28 1969-02-15 Hoffmann La Roche Verfahren zur Herstellung von isoprenoiden Verbindungen
US3489806A (en) 1967-01-19 1970-01-13 Hoffmann La Roche Isoprenoid compounds and a process for producing the same
US3489809A (en) * 1968-04-17 1970-01-13 Engelhard Min & Chem Selective hydrogenation with a catalyst on a honeycomb support
JPS4514114Y1 (pt) 1969-07-17 1970-06-15
CH522572A (de) 1969-10-31 1972-06-30 Hoffmann La Roche Verfahren zur Herstellung von Polyenverbindungen
US3853993A (en) * 1973-05-01 1974-12-10 Univ Virginia Process for increasing oxygen diffusivity and method for treating atherosclerosis
US3788468A (en) * 1973-05-01 1974-01-29 Univ Virginia Process for increasing oxygen diffusivity
DE2505869C3 (de) * 1975-02-12 1978-05-18 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von symmetrischen Carotinoiden
US3965261A (en) * 1975-04-29 1976-06-22 University Of Virginia Method for treating papillomas
US3975519A (en) * 1975-06-09 1976-08-17 University Of Virginia Method for increasing the oxygen partial pressure in the bloodstream of mammals
US4070460A (en) * 1975-11-10 1978-01-24 University Of Virginia Patents Foundation Method for treating cerebral edema
US4009270A (en) * 1975-11-21 1977-02-22 The University Of Virginia Method for treating spinal cord injury
US4038144A (en) * 1976-04-19 1977-07-26 The University Of Virginia Method of increasing fermentation yields
US4046880A (en) * 1976-04-20 1977-09-06 The University Of Virginia Method of treating hypertension
US4099270A (en) * 1977-02-16 1978-07-11 Jabour Richard J Slip-on rubber gloves
US4216211A (en) * 1977-10-31 1980-08-05 The Procter & Gamble Company Therapeutic composition
US4176179A (en) * 1978-04-17 1979-11-27 The University Of Virginia Alumni Patents Foundation Method for treating arthritis
US4727064A (en) 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
US4699664A (en) 1985-05-01 1987-10-13 Nestec S.A. Stabilized natural pigment complexes
US5032613A (en) 1986-02-12 1991-07-16 W. Keith R. Watson Method and composition for treating arthritis
JPH0661211B2 (ja) 1986-08-29 1994-08-17 花王株式会社 パン用改質剤、パン生地及びパンの製造方法
US4781676A (en) 1987-02-20 1988-11-01 Air Products And Chemicals, Inc. Interstitial administration of perfluorochemical emulsions for reoxygenation of hypoxic tumor cells
US5811119A (en) * 1987-05-19 1998-09-22 Board Of Regents, The University Of Texas Formulation and use of carotenoids in treatment of cancer
US5084274A (en) 1987-11-17 1992-01-28 Scripps Clinic And Research Foundation Inhibition of arterial thrombotic occlusion or thromboembolism
US5472946A (en) * 1988-04-08 1995-12-05 Peck; James V. Transdermal penetration enhancers
GB8822147D0 (en) 1988-09-21 1988-10-26 Ciba Geigy Ag Pharmaceutically active combination
FR2647343B1 (fr) 1989-05-24 1994-05-06 Rhone Poulenc Sante Nouvelle forme pharmaceutique poreuse et sa preparation
IT1233303B (it) 1989-06-07 1992-03-26 Azionaria Costruzioni Acma Spa Apparecchiatura per il convogliamento di prodotti
US5053240A (en) * 1989-10-24 1991-10-01 Kalamazoo Holdings, Inc. Norbixin adducts with water-soluble or water-dispersible proteins or branched-chain or cyclic polysaccharides
JPH04264020A (ja) 1991-02-18 1992-09-18 Yamanouchi Pharmaceut Co Ltd 安定な凍結乾燥製剤
US5107030A (en) * 1991-03-04 1992-04-21 Loyola University Of Chicago Method of making 2,7-dimethyl-2,4,6-octatrienedial and derivatives thereof
JP3176716B2 (ja) 1991-06-21 2001-06-18 武田薬品工業株式会社 溶解性が向上した難水溶性薬物組成物
JP2977961B2 (ja) 1991-07-26 1999-11-15 株式会社資生堂 化粧料
JPH06248193A (ja) * 1993-02-25 1994-09-06 Ensuiko Sugar Refining Co Ltd クロセチン含有着色料
IL110139A0 (en) 1993-06-28 1994-10-07 Howard Foundation Pharmaceutically-active antioxidants
JPH0723736A (ja) 1993-06-30 1995-01-27 Taishiyoo Technos:Kk カロチノイド色素の可溶化方法
JP2704356B2 (ja) 1994-02-08 1998-01-26 正和薬品株式会社 脳機能改善剤
JPH07291854A (ja) 1994-04-26 1995-11-07 Tanabe Seiyaku Co Ltd 溶解性の改善された医薬品製剤
US5576287A (en) 1994-04-29 1996-11-19 Wake Forest University Method for treating acute renal disease and failure
GB2290964A (en) 1994-07-08 1996-01-17 Arto Olavi Urtti Transdermal drug delivery system
US6060511A (en) * 1995-10-05 2000-05-09 Gainer; John L. Trans-sodium crocetinate, methods of making and methods of use thereof
US5800807A (en) 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol
RU2107496C1 (ru) 1997-02-10 1998-03-27 Российская медицинская академия последипломного образования Министерства здравоохранения РФ Способ лечения диабетической ангиопатии
JPH1129466A (ja) 1997-07-09 1999-02-02 Lion Corp 水性皮膚外用剤
US6391336B1 (en) 1997-09-22 2002-05-21 Royer Biomedical, Inc. Inorganic-polymer complexes for the controlled release of compounds including medicinals
US6150561A (en) 1997-10-03 2000-11-21 Roche Vitamins Inc. Method of making carotenoids
JPH11209642A (ja) 1998-01-27 1999-08-03 Taito Kk アナトー色素製剤及びその製造方法
JP2000007570A (ja) 1998-06-24 2000-01-11 Hayashibara Biochem Lab Inc 抗内分泌障害剤
MA25590A1 (fr) 1998-09-14 2002-12-31 Inhale Therapeutic Syst Agent actif de delivraison de poudre seche
BE1012495A3 (fr) 1999-03-02 2000-11-07 Messadek Jallal La glycine-betaine pour son usage antithrombotique.
GB2353934A (en) 1999-09-09 2001-03-14 British Sugar Plc Nutritional compositions comprising trehalose for persons suffering from diabetes
CA2355814C (en) * 2000-09-14 2010-06-29 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Pharmaceutical composition for ophthalmic use
EP1269994A3 (en) 2001-06-22 2003-02-12 Pfizer Products Inc. Pharmaceutical compositions comprising drug and concentration-enhancing polymers
JP2003201238A (ja) 2001-12-03 2003-07-18 Yamanouchi Pharmaceut Co Ltd 脳梗塞治療用医薬組成物
CA2477245A1 (en) 2002-02-25 2003-09-04 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
US7759506B2 (en) 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
US20030180282A1 (en) * 2002-03-25 2003-09-25 Victor Serebruany Method of treatment of thrombotic events
RU2226096C1 (ru) 2002-07-01 2004-03-27 Санкт-Петербургский государственный научно-исследовательский институт скорой помощи им. И.И.Джанелидзе Способ лечения последствий тканевой гипоксии у пациентов в критическом состоянии
CN101845009B (zh) 2002-07-29 2012-10-03 卡达克斯药物公司 用于抑制和改善疾病的类胡萝卜素结构类似物
US7521584B2 (en) 2002-07-29 2009-04-21 Cardax Pharmaceuticals, Inc. Carotenoid analogs or derivatives for the inhibition and amelioration of disease
US7084423B2 (en) 2002-08-12 2006-08-01 Acorn Technologies, Inc. Method for depinning the Fermi level of a semiconductor at an electrical junction and devices incorporating such junctions
EP1569692B1 (en) 2002-11-25 2010-11-10 Jallal Messadek Betaine and salicylic acid compositions
US20040109920A1 (en) * 2002-12-04 2004-06-10 Bioactives Llc Coated carotenoid cyclodextrin complexes
US20070166339A1 (en) 2003-04-18 2007-07-19 Bioderm Research Skin Whitening Methods and Compositions Based on Zeolite - Active Oxygen Donor Complexes
EP1622639B1 (de) 2003-05-02 2013-01-16 Lundbeck, H., A/S Intravenöse injektion nicht-neurotoxischer plasminogen-aktivatoren zur behandlung von schlaganfall
JP2005053841A (ja) 2003-08-05 2005-03-03 Kyouto Biomedical Science:Kk 皮膚外用剤
CA2537210C (en) 2003-08-25 2013-06-04 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
RU2265434C2 (ru) 2003-09-30 2005-12-10 Государственное учреждение Научно-исследовательский Институт Общей реаниматологии Российской Академии Медицинских Наук (ГУ НИИ ОР РАМН) Способ лечения острого респираторного дистресс-синдрома
RU2256446C1 (ru) 2003-10-22 2005-07-20 Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" им. акад. С.Н. Федорова Способ профилактики метастазов после хирургического удаления внутриглазных новообразований
US7446101B1 (en) * 2003-12-12 2008-11-04 Bioactives, Llc Bioavailable carotenoid-cyclodextrin formulations for soft-gels and other encapsulation systems
WO2005120495A1 (en) 2004-06-14 2005-12-22 Salama Zoser B Anti-cancer composition comprising proline or its derivatives and an anti-tumour antibody
JP4514114B2 (ja) 2004-06-18 2010-07-28 ヤマハ発動機株式会社 コイル可動形リニアモータおよび単軸ロボット
EP1802287A2 (en) 2004-09-27 2007-07-04 Sigmoid Biotechnologies Limited Minicapsule formulations
EP2540696B1 (en) * 2005-02-24 2020-01-01 Diffusion Pharmaceuticals LLC Trans carotenoids, formulation and uses
US20090176287A1 (en) 2005-02-24 2009-07-09 Regents Of The University Of Minnesota Producing carotenoids
DE602006018583D1 (de) * 2005-03-04 2011-01-13 Sucampo Ag Verfahren und zusammensetzung zur behandlung von peripheren gefässkrankheiten
WO2006099015A2 (en) 2005-03-09 2006-09-21 Cardax Pharmaceuticals, Inc. Carotenoids, carotenoid analogs, or carotenoid derivatives for the treatment of proliferative disorders
US20060281724A1 (en) 2005-06-08 2006-12-14 Loria Roger M Methods for Treating Shock
JP2006342108A (ja) 2005-06-09 2006-12-21 Mitsubishi Chemicals Corp アミロスフェロイドにより発生する疾患の予防治療剤
EP2258441A3 (en) * 2005-09-02 2011-09-21 Intercell USA, Inc. Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs
US20070135521A1 (en) 2005-12-14 2007-06-14 Yamaha Hatsudoki Kabushiki Kaisha Agent for Preventing Metabolic Syndrome
CA2644423A1 (en) 2006-03-24 2007-10-04 Ian Simon Tracton Stable packaged dosage form and process therefor
CN100571707C (zh) 2006-07-24 2009-12-23 凌沛学 含有海藻糖的关节腔内注射给药制剂
BRPI0716143A2 (pt) 2006-08-29 2013-11-26 Genentech Inc Uso de tenecteplase para tratar derrame isquêmico agudo
JP5781727B2 (ja) 2007-02-23 2015-09-24 株式会社ネクスト２１ 血管攣縮の治療剤又は予防剤
CN101687757A (zh) 2007-04-13 2010-03-31 扩散药品有限公司 双极性反式类胡萝卜素作为预治疗及其在周围血管疾病的治疗中的应用
DK2152250T3 (da) 2007-05-07 2019-12-09 Evonik Degussa Gmbh Faste doseringsformer, der omfatter et enterisk overtræk, med accelereret lægemiddelfrigivelse
KR20100083820A (ko) 2007-10-31 2010-07-22 디퓨젼 파마슈티컬즈 엘엘씨 저분자 확산을 촉진시키는 신규한 치료요법
US20090118227A1 (en) 2007-11-07 2009-05-07 Bristol-Myers Squibb Company Carotenoid-containing compositions and methods
WO2009111688A2 (en) 2008-03-06 2009-09-11 Wisconsin Alumni Research Foundation All-trans retinoid esters as active pharmaceutical ingredients, oral and topical dosage form compositions thereof, and methods of treating skin conditions thereof
JP2009274988A (ja) 2008-05-14 2009-11-26 Mitsubishi Rayon Co Ltd ヒドロキシアルキル（メタ）アクリレート類の製造方法
JP2010110185A (ja) 2008-10-31 2010-05-13 Toshiba Corp 電子装置およびファンの制御方法
AU2011262361A1 (en) 2010-06-02 2013-01-10 Diffusion Pharmaceuticals Llc Oral formulations of bipolar trans carotenoids
US10340357B2 (en) 2017-09-25 2019-07-02 Taiwan Semiconductor Manufacturing Co., Ltd. Dishing prevention dummy structures for semiconductor devices

Also Published As

Publication number Publication date
US8293804B2 (en) 2012-10-23
ZA200907757B (en) 2012-04-25
KR101570131B1 (ko) 2015-11-18
MX2009010988A (es) 2010-03-15
IL201438A (en) 2015-03-31
US20120035256A1 (en) 2012-02-09
WO2008136900A1 (en) 2008-11-13
KR20100016396A (ko) 2010-02-12
IL201438A0 (en) 2010-05-31
EP3483140A1 (en) 2019-05-15
EP2146948A4 (en) 2010-08-04
CA2683760C (en) 2015-05-19
EP2589588A1 (en) 2013-05-08
AU2008246305A1 (en) 2008-11-13
JP2010524855A (ja) 2010-07-22
US8901174B2 (en) 2014-12-02
CA2683760A1 (en) 2008-11-13
EP2146948A1 (en) 2010-01-27
US20080255246A1 (en) 2008-10-16
CN101687757A (zh) 2010-03-31
AU2008246305B2 (en) 2013-03-21
JP2014139221A (ja) 2014-07-31
EA200970944A1 (ru) 2010-06-30

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