BRPI0811499A2 - Métodos para purificar um vírus ou antígeno viral, e para preparar uma vacina contra um vírus ou antígeno viral. - Google Patents

Métodos para purificar um vírus ou antígeno viral, e para preparar uma vacina contra um vírus ou antígeno viral.

Info

Publication number: BRPI0811499A2
Authority: BR; Brazil
Prior art keywords: antigen; viral virus; purifying; preparing; methods
Prior art date: 2007-05-04

Application number

BRPI0811499-4A2A

Other languages

English (en)

Inventor

Manfred Reiter

Leopold Grillberger

Wolfgang Mundt

Artur Mitterer

Horst Schafhauser

Original Assignee

Baxter Int

Baxter Healthcare Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-05-04

Filing date

2008-04-30

Publication date

2014-10-14

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39596388&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0811499(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-04-30 Application filed by Baxter Int, Baxter Healthcare Sa filed Critical Baxter Int

2014-10-14 Publication of BRPI0811499A2 publication Critical patent/BRPI0811499A2/pt

2019-06-04 Publication of BRPI0811499B1 publication Critical patent/BRPI0811499B1/pt

2021-05-25 Publication of BRPI0811499B8 publication Critical patent/BRPI0811499B8/pt

Links

241000700605 Viruses Species 0.000 title 2
239000000427 antigen Substances 0.000 title 2
102000036639 antigens Human genes 0.000 title 2
108091007433 antigens Proteins 0.000 title 2
230000003612 virological effect Effects 0.000 title 2
229960005486 vaccine Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14311—Parvovirus, e.g. minute virus of mice
- C12N2750/14351—Methods of production or purification of viral material
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
- C12N2760/16152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16251—Methods of production or purification of viral material
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16251—Methods of production or purification of viral material
- C12N2760/16252—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Virology (AREA)
Immunology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Microbiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Mycology (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pulmonology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Analytical Chemistry (AREA)
Biophysics (AREA)
Peptides Or Proteins (AREA)
Physics & Mathematics (AREA)

BRPI0811499A 2007-05-04 2008-04-30 métodos para purificar um vírus ou antígeno viral, e para preparar uma vacina contra um vírus ou antígeno viral. BRPI0811499B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US92769207P	2007-05-04	2007-05-04
US60/927692		2007-05-04
PCT/EP2008/003531 WO2008135229A2 (en)	2007-05-04	2008-04-30	Formulation of sugar solutions for continuous ultracentrifugation for virus purification

Publications (3)

Publication Number	Publication Date
BRPI0811499A2 true BRPI0811499A2 (pt)	2014-10-14
BRPI0811499B1 BRPI0811499B1 (pt)	2019-06-04
BRPI0811499B8 BRPI0811499B8 (pt)	2021-05-25

Family

ID=39596388

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0811499A BRPI0811499B8 (pt)	2007-05-04	2008-04-30	métodos para purificar um vírus ou antígeno viral, e para preparar uma vacina contra um vírus ou antígeno viral.

Country Status (18)

Country	Link
US (4)	US20100239609A1 (pt)
EP (1)	EP2155864B1 (pt)
JP (2)	JP5745717B2 (pt)
KR (4)	KR101998537B1 (pt)
CN (2)	CN104694489A (pt)
AR (1)	AR066449A1 (pt)
AU (1)	AU2008248904B2 (pt)
BR (1)	BRPI0811499B8 (pt)
CA (1)	CA2687119C (pt)
CL (1)	CL2008001294A1 (pt)
HK (1)	HK1211320A1 (pt)
IL (1)	IL201898A (pt)
MX (1)	MX2009011897A (pt)
PE (1)	PE20090284A1 (pt)
RU (1)	RU2503719C2 (pt)
TW (1)	TWI472620B (pt)
WO (1)	WO2008135229A2 (pt)
ZA (1)	ZA200907743B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2687119C (en) *	2007-05-04	2021-06-08	Baxter International Inc.	Formulation of sugar solutions for continuous ultracentrifugation for virus purification
CA2750055A1 (en)	2009-02-06	2010-08-12	Glaxosmithkline Biologicals S.A.	Method for purifying viruses using a density gradient
US9644187B2 (en)	2010-04-14	2017-05-09	Emd Millipore Corporation	Methods of producing high titer, high purity virus stocks and methods of use thereof
CN101948813B (zh) *	2010-09-04	2012-07-25	国家海洋局第一海洋研究所	一种刺参球形病毒的分离方法
JP6719468B2 (ja)	2014-12-16	2020-07-08	グラクソスミスクラインバイオロジカルズソシエテアノニム	大規模なウイルス精製方法
EP3255054A1 (en)	2016-06-06	2017-12-13	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Method for the purification of biological macromolecular complexes
KR102482744B1 (ko)	2016-11-04	2022-12-30	다케다 야쿠힌 고교 가부시키가이샤	아데노-연관 바이러스 정제 방법
BR112019018216A2 (pt)	2017-03-03	2020-06-23	Baxalta GmbH	Métodos para determinar a potência de preparações de vírus adeno-associados
CN113125756B (zh) *	2020-07-15	2022-10-25	南京岚煜生物科技有限公司	抗体标准品赋值和抗原中和当量确定的方法
EP4330270A2 (en)	2021-04-30	2024-03-06	Takeda Pharmaceutical Company Limited	Aav8 capsid variants with enhanced liver targeting
WO2022229703A2 (en)	2021-04-30	2022-11-03	Takeda Pharmaceutical Company, Ltd.	New aav8 based immune escaping variants
CA3234817A1 (en) *	2021-10-12	2023-04-20	Remo MOOMIAIE	Systems and methods for manufacturing of therapeutic cells

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4158054A (en) *	1973-10-18	1979-06-12	Duncan Flockhart & Co. Ltd.	Preparation of virus sub-unit vaccines
DE2964132D1 (en) *	1978-05-08	1983-01-05	Merck & Co Inc	A process for the direct extraction of small size particles of up to 50 nm from a protein aceous liquid
US4217418A (en) *	1978-05-08	1980-08-12	Merck & Co., Inc.	Recovery of small particles by flow centrifugation
JPH06247995A (ja) *	1991-06-24	1994-09-06	Asahi Chem Ind Co Ltd	新規なシアリル（α２−６）ラクトテトラオシルセラミド
RU2080124C1 (ru) *	1995-10-19	1997-05-27	Санкт-Петербургский научно-исследовательский институт вакцин и сывороток	Способ получения живой гриппозной вакцины
EP1608683B1 (en) *	2003-04-01	2011-11-23	Institut National De La Sante Et De La Recherche Medicale (Inserm)	Antibodies directed against hepatitis c virus e1e2 complex and pharmaceutical compositions
JP2007068401A (ja) *	2003-08-07	2007-03-22	Chemo Sero Therapeut Res Inst	西ナイルウイルスワクチン
CN1739801A (zh) *	2004-08-27	2006-03-01	上海生物制品研究所	一种流行性感冒病毒裂解疫苗及其制备方法
CA2687119C (en) *	2007-05-04	2021-06-08	Baxter International Inc.	Formulation of sugar solutions for continuous ultracentrifugation for virus purification

2008
- 2008-04-30 CA CA2687119A patent/CA2687119C/en active Active
- 2008-04-30 KR KR1020187018257A patent/KR101998537B1/ko active Active
- 2008-04-30 KR KR1020097025228A patent/KR20100017594A/ko not_active Ceased
- 2008-04-30 BR BRPI0811499A patent/BRPI0811499B8/pt active IP Right Grant
- 2008-04-30 EP EP08749278.1A patent/EP2155864B1/en not_active Not-in-force
- 2008-04-30 WO PCT/EP2008/003531 patent/WO2008135229A2/en not_active Ceased
- 2008-04-30 RU RU2009144980/10A patent/RU2503719C2/ru active
- 2008-04-30 US US12/598,749 patent/US20100239609A1/en not_active Abandoned
- 2008-04-30 US US12/112,191 patent/US8969533B2/en active Active
- 2008-04-30 JP JP2010504577A patent/JP5745717B2/ja active Active
- 2008-04-30 MX MX2009011897A patent/MX2009011897A/es active IP Right Grant
- 2008-04-30 AU AU2008248904A patent/AU2008248904B2/en not_active Ceased
- 2008-04-30 KR KR1020157017179A patent/KR101744430B1/ko not_active Expired - Fee Related
- 2008-04-30 KR KR1020177014708A patent/KR101873891B1/ko active Active
- 2008-04-30 CN CN201510079372.2A patent/CN104694489A/zh active Pending
- 2008-04-30 CN CN200880021203A patent/CN101688187A/zh active Pending
- 2008-05-02 TW TW97116163A patent/TWI472620B/zh not_active IP Right Cessation
- 2008-05-05 AR ARP080101902A patent/AR066449A1/es not_active Application Discontinuation
- 2008-05-05 CL CL2008001294A patent/CL2008001294A1/es unknown
- 2008-05-05 PE PE2008000785A patent/PE20090284A1/es not_active Application Discontinuation
2009
- 2009-11-03 IL IL201898A patent/IL201898A/en active IP Right Grant
- 2009-11-04 ZA ZA200907743A patent/ZA200907743B/xx unknown
2014
- 2014-12-22 JP JP2014258342A patent/JP6031082B2/ja active Active
2015
- 2015-01-23 US US14/604,018 patent/US9732327B2/en not_active Expired - Fee Related
- 2015-12-09 HK HK15112162.0A patent/HK1211320A1/xx unknown
2017
- 2017-07-11 US US15/646,450 patent/US20170369853A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US9732327B2 (en)	2017-08-15
US20160060603A1 (en)	2016-03-03
CA2687119C (en)	2021-06-08
CN104694489A (zh)	2015-06-10
US20080274138A1 (en)	2008-11-06
PE20090284A1 (es)	2009-03-17
US20100239609A1 (en)	2010-09-23
KR101998537B1 (ko)	2019-07-09
ZA200907743B (en)	2010-09-29
EP2155864B1 (en)	2013-07-17
RU2009144980A (ru)	2011-06-10
JP2010525798A (ja)	2010-07-29
RU2503719C2 (ru)	2014-01-10
TW200914615A (en)	2009-04-01
CL2008001294A1 (es)	2009-03-06
KR20170065671A (ko)	2017-06-13
BRPI0811499B8 (pt)	2021-05-25
TWI472620B (zh)	2015-02-11
EP2155864A2 (en)	2010-02-24
JP6031082B2 (ja)	2016-11-24
HK1138318A1 (en)	2010-08-20
HK1211320A1 (en)	2016-05-20
KR20180077305A (ko)	2018-07-06
MX2009011897A (es)	2010-02-04
IL201898A0 (en)	2011-08-01
JP2015061538A (ja)	2015-04-02
KR101744430B1 (ko)	2017-06-20
US20170369853A1 (en)	2017-12-28
WO2008135229A2 (en)	2008-11-13
JP5745717B2 (ja)	2015-07-08
CA2687119A1 (en)	2008-11-13
KR20150082676A (ko)	2015-07-15
US8969533B2 (en)	2015-03-03
WO2008135229A3 (en)	2008-12-31
KR101873891B1 (ko)	2018-07-04
KR20100017594A (ko)	2010-02-16
BRPI0811499B1 (pt)	2019-06-04
IL201898A (en)	2013-11-28
AR066449A1 (es)	2009-08-19
CN101688187A (zh)	2010-03-31
AU2008248904B2 (en)	2014-10-09
AU2008248904A1 (en)	2008-11-13

Legal Events

Date	Code	Title	Description
2015-10-13	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2017-01-10	B25A	Requested transfer of rights approved	Owner name: BAXALTA GMBH (CH) , BAXALTA INCORPORATED (US)
2018-03-20	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]	Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI
2018-10-16	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2019-04-09	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2019-06-04	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 04/06/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 04/06/2019, OBSERVADAS AS CONDICOES LEGAIS
2021-05-25	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 30/04/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF
2022-08-02	B25A	Requested transfer of rights approved	Owner name: TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP)

Publication	Publication Date	Title
BRPI0811499A2 (pt)	2014-10-14	Métodos para purificar um vírus ou antígeno viral, e para preparar uma vacina contra um vírus ou antígeno viral.
BRPI0809600A2 (pt)	2016-07-12	vírus atenuado útil para vacinas
IL248607A (en)	2016-12-29	Methods and compositions for immunization against virus
PL1858917T3 (pl)	2015-05-29	Szczepionka przeciw wirusowi ospy wietrznej i półpaśca
BRPI0716536A2 (pt)	2013-09-24	produÇço de vacinas de vÍrus influenza, sem a utilizaÇço de ovos
BRPI1014322A2 (pt)	2015-08-25	Método para tratar infecção, e para interromper ou evitar a produção de partículas virais infecciosas, combinação, e, composição farmacêutica.
IL203869A (en)	2016-05-31	Method for the manufcture of a preparation comprising virus or viral antigens and various aspects related thereto, uses thereof and a split virus vaccine preparation obtained by the method
ZA200800505B (en)	2008-12-31	Modified influenza virus for monitoring and improving vaccine efficiency
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