BRPI0812588A2 - Derivados de 1-benzilpirazol, o respectivo preparo e a respectiva aplicação em terapêutica - Google Patents

Derivados de 1-benzilpirazol, o respectivo preparo e a respectiva aplicação em terapêutica

Info

Publication number
BRPI0812588A2
BRPI0812588A2 BRPI0812588-0A2A BRPI0812588A BRPI0812588A2 BR PI0812588 A2 BRPI0812588 A2 BR PI0812588A2 BR PI0812588 A BRPI0812588 A BR PI0812588A BR PI0812588 A2 BRPI0812588 A2 BR PI0812588A2
Authority
BR
Brazil
Prior art keywords
benzylpirazol
derivatives
preparation
therapeutic application
therapeutic
Prior art date
Application number
BRPI0812588-0A2A
Other languages
English (en)
Inventor
Francis Barth
Laurent Boulu
Joseph Millan
Murielle Rianldi-Carmona
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of BRPI0812588A2 publication Critical patent/BRPI0812588A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BRPI0812588-0A2A 2007-06-04 2008-06-02 Derivados de 1-benzilpirazol, o respectivo preparo e a respectiva aplicação em terapêutica BRPI0812588A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0703972A FR2916758B1 (fr) 2007-06-04 2007-06-04 Derives de 1-benzylpyrazole, leur preparation et leur application en therapeutique
PCT/FR2008/000739 WO2009004171A2 (fr) 2007-06-04 2008-06-02 Dérives de 1 -benzylpyrazole, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
BRPI0812588A2 true BRPI0812588A2 (pt) 2015-02-18

Family

ID=38935820

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0812588-0A2A BRPI0812588A2 (pt) 2007-06-04 2008-06-02 Derivados de 1-benzilpirazol, o respectivo preparo e a respectiva aplicação em terapêutica

Country Status (13)

Country Link
US (1) US20100144818A1 (pt)
EP (1) EP2167472A2 (pt)
JP (1) JP2010529093A (pt)
KR (1) KR20100017964A (pt)
CN (1) CN101687807A (pt)
AU (1) AU2008270124A1 (pt)
BR (1) BRPI0812588A2 (pt)
CA (1) CA2689116A1 (pt)
FR (1) FR2916758B1 (pt)
IL (1) IL202474A0 (pt)
MX (1) MX2009013139A (pt)
RU (1) RU2009148323A (pt)
WO (1) WO2009004171A2 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011277426B2 (en) 2010-07-15 2015-04-23 Sumitomo Pharma Co., Ltd. Pyrazole compound
EP4007752B1 (en) * 2019-08-02 2025-09-24 Amgen Inc. Kif18a inhibitors
CN115210229A (zh) 2020-01-03 2022-10-18 博格有限责任公司 多环酰胺作为治疗癌症的ube2k调节剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2742148B1 (fr) * 1995-12-08 1999-10-22 Sanofi Sa Nouveaux derives du pyrazole-3-carboxamide, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2800372B1 (fr) * 1999-11-03 2001-12-07 Sanofi Synthelabo Derives tricycliques d'acide 1-benzylpyrazole-3- carboxylique, leur preparation, les medicaments en contenant
EP1799673A1 (en) * 2004-10-15 2007-06-27 Memory Pharmaceuticals Corporation Pyrazole derivatives as phosphodiesterase 4 inhibitors
FR2887550A1 (fr) * 2005-06-24 2006-12-29 Sanofi Aventis Sa Derives de 1-benzylpyrazole-3-acetamide, leur preparation et leur application en therapeutique
US7297710B1 (en) * 2006-07-12 2007-11-20 Sanofi-Aventis Derivatives of N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl]sulfonamide, their preparation and their application in therapeutics

Also Published As

Publication number Publication date
FR2916758B1 (fr) 2009-10-09
CN101687807A (zh) 2010-03-31
FR2916758A1 (fr) 2008-12-05
AU2008270124A1 (en) 2009-01-08
RU2009148323A (ru) 2011-07-20
CA2689116A1 (fr) 2009-01-08
JP2010529093A (ja) 2010-08-26
KR20100017964A (ko) 2010-02-16
US20100144818A1 (en) 2010-06-10
WO2009004171A3 (fr) 2009-04-23
WO2009004171A2 (fr) 2009-01-08
IL202474A0 (en) 2010-06-30
MX2009013139A (es) 2010-02-17
EP2167472A2 (fr) 2010-03-31

Similar Documents

Publication Publication Date Title
BRPI0810440A2 (pt) Derivados de triazolopiridina-carboxamidas e triazolopirimidina-carboxamidas, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI0906567A2 (pt) Derivados de ureia de tetra-hidroquinoxalina, o respectivo preparo e a respectiva aplicação em terapêutica j
BRPI0810412A2 (pt) Derivados de triazolo piridina-carboxamidas e triazolo pirimidina - carboxamidas, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI0907381A2 (pt) Derivados de carboxamidas azabicíclicos, o respectivo preparo e a respectiva aplicação em terapêutica.
BRPI1012857A2 (pt) derivados de ciclopenta[c]pirrol-2-carboxilatos, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI0907439A2 (pt) Derivado de carboxamidas azabiciclicos, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI0810430A2 (pt) Derivados de triazolo piridina - carboxamidas, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI0915438A2 (pt) derivados de piridino-piridinonas, o respectivo preparo e a respectiva aplicação em terapêutica.
BRPI0910309A2 (pt) derivados poli-substituídos de 2-aril --fenil-imidazo [1,2-a] piridinas, o respectivo preparo e a respectiva aplicação em terapêtica
IL204663A0 (en) Nicotinamide derivatives, preparastion thereof and therapeutic use thereof
BRPI0715199A2 (pt) derivados de n-(amino-hetero aril)-1h-indol-2-carboxamida, o respectivo preparo e a respectiva aplicaÇço em terapÊutica
BRPI0814807A2 (pt) Derivados de 6-ciclo amino-3-(piridin-4-il) imidazol[1,2-b}-piridazina, o respectivo preparo e a respectiva aplicação
BRPI0908999A2 (pt) Derivados poli-substituídos de 2-aril-6-imidazo[1,2-a]piridinas, o respectivo preparo e respectiva aplicação em terapêutica
BRPI0917464A2 (pt) compostos de azetidinas polissubstituídas, o respectivo preparo e a respectiva aplicação em terapêutica
IL204814A0 (en) Quinazolinedione derivatives, preparation thereof and therapeutic uses thereof
BRPI0907578A2 (pt) derivados de 3-aminoalquil-1,3-di-hidro-2h-indol-2-ona, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI1013553A2 (pt) derivados de nicotinamida, o respectivo preparo e a respectiva aplicação em terapêutica como anticancerígenos
BR112012000104A2 (pt) derivados de pirazóis, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI0923875A2 (pt) Derivados de 2-piridin-2-il-pirazol-3 (2h)-ona, o respectivo preparo e a respectiva aplicação terapêutica.
BRPI0923182A2 (pt) derivados de 6-cicloamino-2,3-di-piridinil-imidazo[1,2-b]piridazina, o respectivo preparo e a respectivo preparo e a respectiva aplicação terapêutica
IL202287A0 (en) Therapeutic pyrazolonaphthyridine derivatives
BRPI0822054A2 (pt) Derivados de azetidinas, o respectivo preparo e a respectiva aplicação em terapêutica
BR112012007883A2 (pt) octa-sacarídeos n-acilas ativadores dos receptores dos fgfs, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI0806969A2 (pt) Derivados de azabicicloalcano, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI0821426A2 (pt) Compostos de n-fenil-imidazol[1,2-a]piridina-2-carboxamidas, o respectivo preparo e a respectiva aplicação em terapêutica.

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.