BRPI0812856A2 - Composições de vacina de emulsão que compreendem antígeno e adjuvante na fase aquosa. - Google Patents

Composições de vacina de emulsão que compreendem antígeno e adjuvante na fase aquosa.

Info

Publication number
BRPI0812856A2
BRPI0812856A2 BRPI0812856-1A2A BRPI0812856A BRPI0812856A2 BR PI0812856 A2 BRPI0812856 A2 BR PI0812856A2 BR PI0812856 A BRPI0812856 A BR PI0812856A BR PI0812856 A2 BRPI0812856 A2 BR PI0812856A2
Authority
BR
Brazil
Prior art keywords
adjuvant
antigen
vaccine compositions
water stage
emulsion vaccine
Prior art date
Application number
BRPI0812856-1A2A
Other languages
English (en)
Inventor
David Leon Lutz
Jeffrey Harold Rodenberg
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of BRPI0812856A2 publication Critical patent/BRPI0812856A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16171—Demonstrated in vivo effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
BRPI0812856-1A2A 2007-06-20 2008-06-19 Composições de vacina de emulsão que compreendem antígeno e adjuvante na fase aquosa. BRPI0812856A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93657107P 2007-06-20 2007-06-20
PCT/US2008/067433 WO2008157659A1 (en) 2007-06-20 2008-06-19 Emulsion vaccine compositions comprising antigen and adjuvant in the aqueous phase

Publications (1)

Publication Number Publication Date
BRPI0812856A2 true BRPI0812856A2 (pt) 2014-12-09

Family

ID=39720537

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0812856-1A2A BRPI0812856A2 (pt) 2007-06-20 2008-06-19 Composições de vacina de emulsão que compreendem antígeno e adjuvante na fase aquosa.

Country Status (26)

Country Link
US (2) US8980288B2 (pt)
EP (1) EP2164510B1 (pt)
JP (2) JP5457340B2 (pt)
KR (1) KR101569218B1 (pt)
CN (2) CN101790378A (pt)
AR (1) AR067087A1 (pt)
AU (1) AU2008265745B2 (pt)
BR (1) BRPI0812856A2 (pt)
CA (1) CA2692098C (pt)
CL (1) CL2008001806A1 (pt)
CO (1) CO6251273A2 (pt)
CY (1) CY1114451T1 (pt)
DK (1) DK2164510T3 (pt)
ES (1) ES2429296T3 (pt)
HK (1) HK1218717A1 (pt)
HR (1) HRP20130939T1 (pt)
ME (1) ME01527B (pt)
MX (1) MX2009014070A (pt)
NZ (1) NZ582132A (pt)
PL (1) PL2164510T3 (pt)
PT (1) PT2164510E (pt)
RS (1) RS52947B (pt)
SI (1) SI2164510T1 (pt)
TW (1) TWI507214B (pt)
WO (1) WO2008157659A1 (pt)
ZA (1) ZA200909173B (pt)

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CL2008001806A1 (es) * 2007-06-20 2008-09-05 Wyeth Corp Composicion de vacuna en emulsion agua en aceite que comprende un antigeno y un adyuvante en la fase acuosa; y metodo de elaboracion.
CN102076358B (zh) 2008-06-27 2016-08-17 硕腾有限责任公司 新颖的佐剂组合物
US9603919B2 (en) 2009-03-31 2017-03-28 Japan As Represented By The Director-General Of National Institute Of Infectious Diseases Method for prophylaxis of influenza using vaccine for intranasal administration
BR112012018640B1 (pt) 2010-01-29 2020-12-15 Donaldson Company, Inc. Montagens de separador de água de fluxo de ar de entrada e método de separar água de um fluxo de ar de entrada
CN101829323A (zh) * 2010-04-28 2010-09-15 洛阳普莱柯生物工程有限公司 一种禽用油乳剂疫苗及其制备方法
NZ616686A (en) 2011-04-12 2015-05-29 Ouro Fino Participaç Es E Empreendimentos S A Peptides with antimicrobial activity, drug compositions for the treatment and prophylaxis of animals, compositions for the treatment and prophylaxis of plants, uses of said peptides, and uses of paenibacillus elgii ourofinensis extract
RU2730011C2 (ru) * 2013-09-19 2020-08-14 Зоэтис Сервисиз Ллс Адъюванты на масляной основе
US10272036B2 (en) * 2013-12-06 2019-04-30 Intervet Inc. Composition for oral delivery of bioactive agents
FI3244920T3 (fi) 2015-01-16 2023-08-04 Zoetis Services Llc Suu- ja sorkkatautirokote
GB201506948D0 (en) * 2015-04-23 2015-06-10 Croda Int Plc Emulsions for injectable formulations
CN106177939B (zh) * 2015-06-01 2021-01-19 普莱柯生物工程股份有限公司 一种疫苗用佐剂及其应用
CN106344920B (zh) * 2015-07-16 2020-11-27 普莱柯生物工程股份有限公司 一种疫苗用佐剂及其应用
CN107281482B (zh) * 2016-04-05 2021-06-11 普莱柯生物工程股份有限公司 一种免疫佐剂组合物及其制备方法
AU2019235613B2 (en) * 2018-03-13 2025-02-20 Swinburne University Of Technology Vaccine composition
CN110404065B (zh) * 2018-04-27 2023-06-16 洛阳赛威生物科技有限公司 一种猪用佐剂组合物及其制备方法
US11813321B2 (en) 2018-07-13 2023-11-14 Biomune Company Vaccines against avian reoviruses
BR112021001420A2 (pt) 2018-07-27 2021-05-04 Research Development Foundation polipeptídeos imunogênicos quiméricos
EP3866839A1 (en) 2018-10-16 2021-08-25 Intervet International B.V. Stable emulsions of bacterial antigens
CN114306585A (zh) * 2021-12-30 2022-04-12 广西壮族自治区水产科学研究院 一种鱼类高纯度抗原乳剂的制备方法
US12226468B2 (en) 2023-06-26 2025-02-18 Research Development Foundation Immunoreactive peptides
WO2025018848A1 (ko) * 2023-07-19 2025-01-23 주식회사 유틸렉스 하프니아 알베이 유래 지질다당류 및 카보머를 포함하는 면역증강용 조성물
CN119656300A (zh) * 2024-12-17 2025-03-21 长江大学 一种猪繁殖与呼吸综合征灭活苗专用油佐剂及其制备方法和应用

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NZ221306A (en) * 1986-08-15 1990-02-26 Commw Scient Ind Res Org 2-component immunoadjuvant comprising a mycobacterial free immunoadjuvant oil and a polycationic polyelectrolyte immunoadjuvant and vaccines thereof
ATE60999T1 (de) * 1986-12-19 1991-03-15 Duphar Int Res Dimethyldioctadecylammoniumbromid enthaltende stabilisierte adjuvanssuspension.
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US6676958B2 (en) * 2001-06-19 2004-01-13 Advanced Bioadjuvants, Llc Adjuvant composition for mucosal and injection delivered vaccines
US20030129161A1 (en) * 2001-09-17 2003-07-10 Hsien-Jue Chu Interleukin-12 as a veterinary vaccine adjuvant
JP3812814B2 (ja) * 2001-10-19 2006-08-23 株式会社微生物化学研究所 動物用多価オイルアジュバントワクチン
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Also Published As

Publication number Publication date
US20090017067A1 (en) 2009-01-15
HRP20130939T1 (hr) 2013-11-22
EP2164510A1 (en) 2010-03-24
CA2692098C (en) 2016-06-14
ZA200909173B (en) 2010-08-25
KR20100022115A (ko) 2010-02-26
ME01527B (me) 2014-04-20
AU2008265745A1 (en) 2008-12-24
CO6251273A2 (es) 2011-02-21
JP5802285B2 (ja) 2015-10-28
AU2008265745B2 (en) 2013-05-30
KR101569218B1 (ko) 2015-11-13
AR067087A1 (es) 2009-09-30
DK2164510T3 (da) 2013-09-23
CN101790378A (zh) 2010-07-28
ES2429296T3 (es) 2013-11-14
WO2008157659A1 (en) 2008-12-24
JP2010530877A (ja) 2010-09-16
NZ582132A (en) 2012-04-27
CA2692098A1 (en) 2008-12-24
EP2164510B1 (en) 2013-07-17
JP2014088423A (ja) 2014-05-15
US8980288B2 (en) 2015-03-17
RS52947B (sr) 2014-02-28
CN105148268A (zh) 2015-12-16
JP5457340B2 (ja) 2014-04-02
US20150297710A1 (en) 2015-10-22
US9545439B2 (en) 2017-01-17
CY1114451T1 (el) 2016-10-05
PL2164510T3 (pl) 2014-03-31
TW200906448A (en) 2009-02-16
MX2009014070A (es) 2010-05-19
PT2164510E (pt) 2013-10-07
CL2008001806A1 (es) 2008-09-05
TWI507214B (zh) 2015-11-11
HK1218717A1 (zh) 2017-03-10
SI2164510T1 (sl) 2013-11-29

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: PAH W LLC (US)

B25D Requested change of name of applicant approved

Owner name: ZOETIS W LLC (US)

B15K Others concerning applications: alteration of classification

Ipc: A61K 39/39 (2006.01), A61K 39/145 (2006.01)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]