PL2164510T3 - Stanowiące emulsję kompozycje szczepionek, zawierające antygen i adiuwat w fazie wodnej - Google Patents

Stanowiące emulsję kompozycje szczepionek, zawierające antygen i adiuwat w fazie wodnej

Info

Publication number: PL2164510T3
Authority: PL; Poland
Prior art keywords: adjuvant; antigen; aqueous phase; vaccine compositions; emulsion vaccine
Prior art date: 2007-06-20

Application number

PL08771428T

Other languages

English (en)

Inventor

David Leon Lutz

Jeffrey Harold Rodenberg

Evan James Diehl

Mahesh Kumar

Original Assignee

Zoetis Services Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-06-20

Filing date

2008-06-19

Publication date

2014-03-31

2008-06-19 Application filed by Zoetis Services Llc filed Critical Zoetis Services Llc

2014-03-31 Publication of PL2164510T3 publication Critical patent/PL2164510T3/pl

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16171—Demonstrated in vivo effect

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Immunology (AREA)
Epidemiology (AREA)
Virology (AREA)
Microbiology (AREA)
Mycology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pulmonology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Dispersion Chemistry (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)

PL08771428T 2007-06-20 2008-06-19 Stanowiące emulsję kompozycje szczepionek, zawierające antygen i adiuwat w fazie wodnej PL2164510T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US93657107P	2007-06-20	2007-06-20
PCT/US2008/067433 WO2008157659A1 (en)	2007-06-20	2008-06-19	Emulsion vaccine compositions comprising antigen and adjuvant in the aqueous phase
EP08771428.3A EP2164510B1 (en)	2007-06-20	2008-06-19	Emulsion vaccine compositions comprising antigen and adjuvant in the aqueous phase

Publications (1)

Publication Number	Publication Date
PL2164510T3 true PL2164510T3 (pl)	2014-03-31

Family

ID=39720537

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL08771428T PL2164510T3 (pl)	2007-06-20	2008-06-19	Stanowiące emulsję kompozycje szczepionek, zawierające antygen i adiuwat w fazie wodnej

Country Status (26)

Country	Link
US (2)	US8980288B2 (pl)
EP (1)	EP2164510B1 (pl)
JP (2)	JP5457340B2 (pl)
KR (1)	KR101569218B1 (pl)
CN (2)	CN105148268A (pl)
AR (1)	AR067087A1 (pl)
AU (1)	AU2008265745B2 (pl)
BR (1)	BRPI0812856A2 (pl)
CA (1)	CA2692098C (pl)
CL (1)	CL2008001806A1 (pl)
CO (1)	CO6251273A2 (pl)
CY (1)	CY1114451T1 (pl)
DK (1)	DK2164510T3 (pl)
ES (1)	ES2429296T3 (pl)
HK (1)	HK1218717A1 (pl)
HR (1)	HRP20130939T1 (pl)
ME (1)	ME01527B (pl)
MX (1)	MX2009014070A (pl)
NZ (1)	NZ582132A (pl)
PL (1)	PL2164510T3 (pl)
PT (1)	PT2164510E (pl)
RS (1)	RS52947B (pl)
SI (1)	SI2164510T1 (pl)
TW (1)	TWI507214B (pl)
WO (1)	WO2008157659A1 (pl)
ZA (1)	ZA200909173B (pl)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CL2008001806A1 (es) *	2007-06-20	2008-09-05	Wyeth Corp	Composicion de vacuna en emulsion agua en aceite que comprende un antigeno y un adyuvante en la fase acuosa; y metodo de elaboracion.
ES2569907T3 (es)	2008-06-27	2016-05-13	Zoetis Services Llc	Composiciones adyuvantes novedosas
WO2010114169A1 (en) *	2009-03-31	2010-10-07	Japan As Represented By The Director-General Of National Institute Of Infectious Diseases	Method for prophylaxis of influenza using vaccine for intranasal administration
CN102741537B (zh)	2010-01-29	2016-01-06	唐纳森公司	用于空气滤清器的水分离器组件及发动机空气流入口结构
CN101829323A (zh) *	2010-04-28	2010-09-15	洛阳普莱柯生物工程有限公司	一种禽用油乳剂疫苗及其制备方法
US20140113817A1 (en)	2011-04-12	2014-04-24	Unaio Brasiliense De Educaco E Cultura-Ubec	Peptides with antimicrobial activity, drug compositions for the treatment and prophylaxis of animals, compositions for the treatment and prophylaxis of plants, uses of said peptides, and uses of paenibacillus elgil ourofinensis extract
UA130246C2 (uk)	2013-09-19	2025-12-31	Зоетіс Сервісіз Ллс	Ад'ювант на основі олії
BR112016012838B1 (pt) *	2013-12-06	2023-02-28	Intervet International B.V	Composição para a administração oral de um agente bioativo incluindo partículas que compreendem um agente bioativo e um polímero mucoadesivo em uma solução aquosa, e, método de preparação da composição
CN115317600A (zh)	2015-01-16	2022-11-11	硕腾服务有限责任公司	口蹄疫疫苗
GB201506948D0 (en) *	2015-04-23	2015-06-10	Croda Int Plc	Emulsions for injectable formulations
CN106177939B (zh) *	2015-06-01	2021-01-19	普莱柯生物工程股份有限公司	一种疫苗用佐剂及其应用
CN106344920B (zh) *	2015-07-16	2020-11-27	普莱柯生物工程股份有限公司	一种疫苗用佐剂及其应用
CN107281482B (zh) *	2016-04-05	2021-06-11	普莱柯生物工程股份有限公司	一种免疫佐剂组合物及其制备方法
US11351249B2 (en) *	2018-03-13	2022-06-07	Capsular Technologies Pty Ltd	Vaccine compositions comprising a water-in-oil emulsion, immunogen-loaded hydrogel particles, and cationic polymer
CN110404065B (zh) *	2018-04-27	2023-06-16	洛阳赛威生物科技有限公司	一种猪用佐剂组合物及其制备方法
WO2020012428A1 (en) *	2018-07-13	2020-01-16	Biomune Company	New vaccines against avian reoviruses
WO2020023950A1 (en)	2018-07-27	2020-01-30	Research Development Foundation	Chimeric immunogenic polypeptides
US12246090B2 (en)	2018-10-16	2025-03-11	Intervet Inc.	Stable emulsions of bacterial antigens
CN114306585A (zh) *	2021-12-30	2022-04-12	广西壮族自治区水产科学研究院	一种鱼类高纯度抗原乳剂的制备方法
US12226468B2 (en)	2023-06-26	2025-02-18	Research Development Foundation	Immunoreactive peptides
TW202517283A (zh) *	2023-07-19	2025-05-01	南韓商優特力克斯有限公司	包含源自蜂房哈夫尼菌的脂多糖及卡波姆的免疫增強用組合物
CN119656300A (zh) *	2024-12-17	2025-03-21	长江大学	一种猪繁殖与呼吸综合征灭活苗专用油佐剂及其制备方法和应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3639577A (en) *	1968-02-23	1972-02-01	Haver Lockhart Lab Inc	Injectable adjuvant,method of preparing same and compositions including such adjuvant
NZ221306A (en)	1986-08-15	1990-02-26	Commw Scient Ind Res Org	2-component immunoadjuvant comprising a mycobacterial free immunoadjuvant oil and a polycationic polyelectrolyte immunoadjuvant and vaccines thereof
EP0273512B1 (en)	1986-12-19	1991-02-27	Duphar International Research B.V	Stabilised adjuvant suspension comprising dimethyl dioctadecyl ammonium bromide
US5951988A (en) *	1993-03-30	1999-09-14	University Of Saskatchewan	Adjuvant formulation with enhanced immunogenic activity, and related compositions and methods
BE1008977A5 (fr)	1994-12-27	1996-10-01	Solvay	Adjuvants pour vaccins.
US5744137A (en)	1995-02-06	1998-04-28	The United States Of America As Represented By The Secretary Of The Agriculture	Oil emulsion vaccines prepared with animal, vegetable, and synthetic oils using a mixture of nonionic surfactants
WO1999030737A1 (en) *	1997-12-16	1999-06-24	Chiron Corporation	Use of microparticles combined with submicron oil-in-water emulsions
FR2775601B1 (fr) *	1998-03-03	2001-09-21	Merial Sas	Vaccins vivants recombines et adjuves
FR2776928B1 (fr)	1998-04-03	2000-06-23	Merial Sas	Vaccins adn adjuves
WO2001089559A2 (en) *	2000-05-24	2001-11-29	Merial	Porcine reproductive and respiratory syndrome virus (prrsv) recombinant avipoxvirus vaccine
FR2810888B1 (fr) *	2000-06-29	2004-07-30	Merial Sas	Vaccin contre la fievre aphteuse
US6585978B1 (en) *	2000-09-09	2003-07-01	Akzo Nobel	EIA vaccine and diagnostic
US7018638B2 (en) *	2000-12-19	2006-03-28	Wyeth	Mycoplasma hyopneumoniae bacterin vaccine
US6676958B2 (en)	2001-06-19	2004-01-13	Advanced Bioadjuvants, Llc	Adjuvant composition for mucosal and injection delivered vaccines
US20030129161A1 (en)	2001-09-17	2003-07-10	Hsien-Jue Chu	Interleukin-12 as a veterinary vaccine adjuvant
JP3812814B2 (ja) *	2001-10-19	2006-08-23	株式会社微生物化学研究所	動物用多価オイルアジュバントワクチン
US7862821B2 (en)	2006-06-01	2011-01-04	Merial Limited	Recombinant vaccine against bluetongue virus
CL2008001806A1 (es) *	2007-06-20	2008-09-05	Wyeth Corp	Composicion de vacuna en emulsion agua en aceite que comprende un antigeno y un adyuvante en la fase acuosa; y metodo de elaboracion.

2008
- 2008-06-18 CL CL200801806A patent/CL2008001806A1/es unknown
- 2008-06-19 WO PCT/US2008/067433 patent/WO2008157659A1/en not_active Ceased
- 2008-06-19 US US12/142,160 patent/US8980288B2/en active Active
- 2008-06-19 AU AU2008265745A patent/AU2008265745B2/en not_active Ceased
- 2008-06-19 HR HRP20130939AT patent/HRP20130939T1/hr unknown
- 2008-06-19 CN CN201510450651.5A patent/CN105148268A/zh active Pending
- 2008-06-19 EP EP08771428.3A patent/EP2164510B1/en active Active
- 2008-06-19 BR BRPI0812856-1A2A patent/BRPI0812856A2/pt not_active IP Right Cessation
- 2008-06-19 JP JP2010513396A patent/JP5457340B2/ja not_active Expired - Fee Related
- 2008-06-19 CA CA2692098A patent/CA2692098C/en not_active Expired - Fee Related
- 2008-06-19 ES ES08771428T patent/ES2429296T3/es active Active
- 2008-06-19 KR KR1020107001106A patent/KR101569218B1/ko not_active Expired - Fee Related
- 2008-06-19 DK DK08771428.3T patent/DK2164510T3/da active
- 2008-06-19 CN CN200880024112A patent/CN101790378A/zh active Pending
- 2008-06-19 NZ NZ582132A patent/NZ582132A/en not_active IP Right Cessation
- 2008-06-19 PT PT87714283T patent/PT2164510E/pt unknown
- 2008-06-19 RS RS20130408A patent/RS52947B/sr unknown
- 2008-06-19 MX MX2009014070A patent/MX2009014070A/es active IP Right Grant
- 2008-06-19 ME MEP-2013-101A patent/ME01527B/me unknown
- 2008-06-19 SI SI200831038T patent/SI2164510T1/sl unknown
- 2008-06-19 PL PL08771428T patent/PL2164510T3/pl unknown
- 2008-06-20 AR ARP080102641A patent/AR067087A1/es not_active Application Discontinuation
- 2008-06-20 TW TW097123236A patent/TWI507214B/zh not_active IP Right Cessation
2009
- 2009-12-17 CO CO09144676A patent/CO6251273A2/es not_active Application Discontinuation
- 2009-12-22 ZA ZA200909173A patent/ZA200909173B/xx unknown
2010
- 2010-11-09 HK HK16106725.1A patent/HK1218717A1/zh unknown
2013
- 2013-10-03 CY CY20131100855T patent/CY1114451T1/el unknown
2014
- 2014-01-09 JP JP2014002096A patent/JP5802285B2/ja not_active Expired - Fee Related
2015
- 2015-02-10 US US14/618,628 patent/US9545439B2/en active Active

Also Published As

Publication number	Publication date
CY1114451T1 (el)	2016-10-05
CO6251273A2 (es)	2011-02-21
DK2164510T3 (da)	2013-09-23
KR101569218B1 (ko)	2015-11-13
US20150297710A1 (en)	2015-10-22
RS52947B (sr)	2014-02-28
AR067087A1 (es)	2009-09-30
EP2164510B1 (en)	2013-07-17
US9545439B2 (en)	2017-01-17
JP5457340B2 (ja)	2014-04-02
BRPI0812856A2 (pt)	2014-12-09
JP5802285B2 (ja)	2015-10-28
JP2010530877A (ja)	2010-09-16
ZA200909173B (en)	2010-08-25
US8980288B2 (en)	2015-03-17
CA2692098C (en)	2016-06-14
TW200906448A (en)	2009-02-16
ME01527B (me)	2014-04-20
CA2692098A1 (en)	2008-12-24
AU2008265745B2 (en)	2013-05-30
CN101790378A (zh)	2010-07-28
SI2164510T1 (sl)	2013-11-29
JP2014088423A (ja)	2014-05-15
US20090017067A1 (en)	2009-01-15
CN105148268A (zh)	2015-12-16
WO2008157659A1 (en)	2008-12-24
MX2009014070A (es)	2010-05-19
HRP20130939T1 (hr)	2013-11-22
EP2164510A1 (en)	2010-03-24
NZ582132A (en)	2012-04-27
AU2008265745A1 (en)	2008-12-24
KR20100022115A (ko)	2010-02-26
ES2429296T3 (es)	2013-11-14
CL2008001806A1 (es)	2008-09-05
TWI507214B (zh)	2015-11-11
HK1218717A1 (zh)	2017-03-10
PT2164510E (pt)	2013-10-07

Publication	Publication Date	Title
ZA200909173B (en)	2010-08-25	Emulsion vaccine compositions comprising antigen and adjuvant in the aqueous phase
EP1988918A4 (en)	2010-04-28	ADJUVANZ AND VACCINE COMPOSITIONS
IL213795A (en)	2013-05-30	An immunogenic preparation containing at least two different saccharides and a compound containing the aforementioned immunogenic preparation
PT2086582E (pt)	2013-01-25	Vacina compreendendo uma emulsão adjuvante óleo em água
IL211131A0 (en)	2011-04-28	Inhbb epitope and vaccines containing the same
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