BRPI0813331A2 - Derivados de piperidina/piperazina - Google Patents
Derivados de piperidina/piperazinaInfo
- Publication number
- BRPI0813331A2 BRPI0813331A2 BRPI0813331-0A2A BRPI0813331A BRPI0813331A2 BR PI0813331 A2 BRPI0813331 A2 BR PI0813331A2 BR PI0813331 A BRPI0813331 A BR PI0813331A BR PI0813331 A2 BRPI0813331 A2 BR PI0813331A2
- Authority
- BR
- Brazil
- Prior art keywords
- piperidine
- piperazine derivatives
- piperazine
- derivatives
- Prior art date
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
Classifications
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
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- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Physical Education & Sports Medicine (AREA)
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- Heart & Thoracic Surgery (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07109868 | 2007-06-08 | ||
| EP07115805 | 2007-09-06 | ||
| PCT/EP2008/057060 WO2008148868A1 (en) | 2007-06-08 | 2008-06-06 | Piperidine/piperazine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0813331A2 true BRPI0813331A2 (pt) | 2014-12-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0813331-0A2A BRPI0813331A2 (pt) | 2007-06-08 | 2008-06-06 | Derivados de piperidina/piperazina |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8981094B2 (pt) |
| EP (1) | EP2152270B1 (pt) |
| JP (1) | JP5385263B2 (pt) |
| CN (1) | CN101678019B (pt) |
| AR (1) | AR066911A1 (pt) |
| AU (1) | AU2008258487B2 (pt) |
| BR (1) | BRPI0813331A2 (pt) |
| CA (1) | CA2687754C (pt) |
| CL (1) | CL2008001671A1 (pt) |
| ES (1) | ES2536406T3 (pt) |
| MX (1) | MX2009013335A (pt) |
| PA (1) | PA8783601A1 (pt) |
| PE (1) | PE20090362A1 (pt) |
| RU (1) | RU2470017C2 (pt) |
| TW (1) | TWI426070B (pt) |
| WO (1) | WO2008148868A1 (pt) |
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| USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
| MX2007007101A (es) | 2004-12-14 | 2007-08-21 | Astrazeneca Ab | Derivados de oxadiazol como inhibidores de acil coa:diacilglicerol aciltransferasa. |
| AR058562A1 (es) | 2005-12-22 | 2008-02-13 | Astrazeneca Ab | Derivados de pirimido [4,5 b] (1,4) oxazinas , procedimientos de obtencion y su uso como inhibidores de acetil coa y dgat 1 |
| WO2007126957A2 (en) | 2006-03-31 | 2007-11-08 | Novartis Ag | New compounds |
| BRPI0712802A2 (pt) | 2006-05-30 | 2012-10-23 | Astrazeneca Ab | composto, métodos para produzir uma inibição da atividade de dgat1, e para tratar diabete melito e/ou obesidade em um animal de sangue quente, uso de um composto, composição farmacêutica, e, processo para preparar um composto |
| AU2008258487B2 (en) | 2007-06-08 | 2012-11-15 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
| CA2687918C (en) | 2007-06-08 | 2016-11-08 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
| EP2152271B1 (en) | 2007-06-08 | 2015-10-21 | Janssen Pharmaceutica, N.V. | Piperidine/piperazine derivatives |
| JO2972B1 (en) | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
| AR066169A1 (es) | 2007-09-28 | 2009-07-29 | Novartis Ag | Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat |
| JP5579170B2 (ja) * | 2008-06-05 | 2014-08-27 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Dgat阻害剤とppar作動薬を含有する薬剤組み合わせ物 |
| US9012159B2 (en) | 2009-02-04 | 2015-04-21 | Janssen Research & Development, Llc | Cell based screening assays for the triglyceride synthesis pathway |
| US9452980B2 (en) * | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| CA2946538A1 (en) | 2014-04-04 | 2015-10-08 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
| US9828369B2 (en) * | 2014-09-05 | 2017-11-28 | Merck Sharpe & Dohme Corp. | Isoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 |
| CN108463109B (zh) | 2015-12-22 | 2022-04-29 | 先正达参股股份有限公司 | 杀有害生物活性吡唑衍生物 |
| JP6814814B2 (ja) | 2016-03-17 | 2021-01-20 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Taarのアゴニストとしての活性を有する5−エチル−4−メチル−ピラゾール−3−カルボキサミド誘導体 |
| CN108250185B (zh) * | 2018-01-24 | 2020-08-21 | 浙江工业大学 | 6-(2-(邻甲苯氨基)乙酰氨基)喹唑啉类化合物及制备和应用 |
| CN109438252B (zh) * | 2018-12-27 | 2021-12-14 | 安徽工业大学科技园有限公司 | 一种三(2-氨基乙基)胺的合成工艺 |
| CN109516919B (zh) * | 2018-12-27 | 2021-12-14 | 安徽工业大学科技园有限公司 | 一种三(2-氨基乙基)胺的制备方法 |
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| JO2972B1 (en) | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
| CA2687918C (en) | 2007-06-08 | 2016-11-08 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
| EP2152271B1 (en) | 2007-06-08 | 2015-10-21 | Janssen Pharmaceutica, N.V. | Piperidine/piperazine derivatives |
| JP5579170B2 (ja) | 2008-06-05 | 2014-08-27 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Dgat阻害剤とppar作動薬を含有する薬剤組み合わせ物 |
-
2008
- 2008-06-06 AU AU2008258487A patent/AU2008258487B2/en not_active Ceased
- 2008-06-06 TW TW097121019A patent/TWI426070B/zh not_active IP Right Cessation
- 2008-06-06 CL CL2008001671A patent/CL2008001671A1/es unknown
- 2008-06-06 AR ARP080102427A patent/AR066911A1/es unknown
- 2008-06-06 RU RU2009148320/04A patent/RU2470017C2/ru active
- 2008-06-06 ES ES08760634.9T patent/ES2536406T3/es active Active
- 2008-06-06 CN CN200880019198.0A patent/CN101678019B/zh active Active
- 2008-06-06 CA CA2687754A patent/CA2687754C/en active Active
- 2008-06-06 BR BRPI0813331-0A2A patent/BRPI0813331A2/pt not_active Application Discontinuation
- 2008-06-06 MX MX2009013335A patent/MX2009013335A/es active IP Right Grant
- 2008-06-06 US US12/663,013 patent/US8981094B2/en active Active
- 2008-06-06 JP JP2010510816A patent/JP5385263B2/ja active Active
- 2008-06-06 EP EP08760634.9A patent/EP2152270B1/en active Active
- 2008-06-06 PE PE2008000972A patent/PE20090362A1/es not_active Application Discontinuation
- 2008-06-06 PA PA20088783601A patent/PA8783601A1/es unknown
- 2008-06-06 WO PCT/EP2008/057060 patent/WO2008148868A1/en not_active Ceased
Also Published As
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|---|---|
| PE20090362A1 (es) | 2009-04-04 |
| CA2687754A1 (en) | 2008-12-11 |
| EP2152270A1 (en) | 2010-02-17 |
| TWI426070B (zh) | 2014-02-11 |
| PA8783601A1 (es) | 2009-01-23 |
| CN101678019A (zh) | 2010-03-24 |
| EP2152270B1 (en) | 2015-03-04 |
| MX2009013335A (es) | 2010-01-20 |
| RU2470017C2 (ru) | 2012-12-20 |
| AR066911A1 (es) | 2009-09-23 |
| JP2010529089A (ja) | 2010-08-26 |
| US20100190789A1 (en) | 2010-07-29 |
| TW200911771A (en) | 2009-03-16 |
| WO2008148868A8 (en) | 2009-03-05 |
| JP5385263B2 (ja) | 2014-01-08 |
| CA2687754C (en) | 2015-12-08 |
| US8981094B2 (en) | 2015-03-17 |
| CN101678019B (zh) | 2016-03-30 |
| WO2008148868A1 (en) | 2008-12-11 |
| ES2536406T3 (es) | 2015-05-25 |
| RU2009148320A (ru) | 2011-07-20 |
| AU2008258487B2 (en) | 2012-11-15 |
| AU2008258487A1 (en) | 2008-12-11 |
| CL2008001671A1 (es) | 2009-07-17 |
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