BRPI0813462A2 - Dispositivos, sistemas e métodos para limpar, desinfetar, enxaguar e preparar dispositivos de separação sanguínea e linhas de fluido associadas. - Google Patents
Dispositivos, sistemas e métodos para limpar, desinfetar, enxaguar e preparar dispositivos de separação sanguínea e linhas de fluido associadas.Info
- Publication number
- BRPI0813462A2 BRPI0813462A2 BRPI0813462-6A2A BRPI0813462A BRPI0813462A2 BR PI0813462 A2 BRPI0813462 A2 BR PI0813462A2 BR PI0813462 A BRPI0813462 A BR PI0813462A BR PI0813462 A2 BRPI0813462 A2 BR PI0813462A2
- Authority
- BR
- Brazil
- Prior art keywords
- devices
- disinfect
- rinse
- clean
- systems
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/104—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body
- A61M60/109—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems
- A61M60/113—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
- A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
- A61L2/18—Liquid substances
- A61L2/186—Peroxide solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
- A61L2/24—Apparatus using programmed or automatic operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/168—Sterilisation or cleaning before or after use
- A61M1/169—Sterilisation or cleaning before or after use using chemical substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3643—Priming, rinsing before or after use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3643—Priming, rinsing before or after use
- A61M1/3644—Mode of operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
- A61M60/36—Medical purposes thereof other than the enhancement of the cardiac output for specific blood treatment; for specific therapy
- A61M60/37—Haemodialysis, haemofiltration or diafiltration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/50—Details relating to control
- A61M60/508—Electronic control means, e.g. for feedback regulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2103/00—Materials or objects being the target of disinfection or sterilisation
- A61L2103/15—Laboratory, medical or dentistry appliances, e.g. catheters or sharps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/10—Apparatus features
- A61L2202/17—Combination with washing or cleaning means
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/824,322 US8562908B2 (en) | 2007-06-29 | 2007-06-29 | Devices, systems, and methods for cleaning, disinfecting, rinsing, and priming blood separation devices and associated fluid lines |
| PCT/US2008/068491 WO2009006261A2 (en) | 2007-06-29 | 2008-06-27 | Devices, systems and methods for cleaning, disinfecting, rinsing, and priming blood separation devices and associated fluid lines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0813462A2 true BRPI0813462A2 (pt) | 2014-10-07 |
Family
ID=40021578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0813462-6A2A BRPI0813462A2 (pt) | 2007-06-29 | 2008-06-27 | Dispositivos, sistemas e métodos para limpar, desinfetar, enxaguar e preparar dispositivos de separação sanguínea e linhas de fluido associadas. |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US8562908B2 (pt) |
| EP (2) | EP2175893A2 (pt) |
| JP (1) | JP5767474B2 (pt) |
| BR (1) | BRPI0813462A2 (pt) |
| CA (1) | CA2691655A1 (pt) |
| WO (1) | WO2009006261A2 (pt) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8834399B2 (en) | 2010-12-07 | 2014-09-16 | Zoll Lifebridge Gmbh | Cardiopulmonary apparatus and methods for preserving organ viability |
| US8597505B2 (en) | 2007-09-13 | 2013-12-03 | Fresenius Medical Care Holdings, Inc. | Portable dialysis machine |
| US8105487B2 (en) | 2007-09-25 | 2012-01-31 | Fresenius Medical Care Holdings, Inc. | Manifolds for use in conducting dialysis |
| US9358331B2 (en) | 2007-09-13 | 2016-06-07 | Fresenius Medical Care Holdings, Inc. | Portable dialysis machine with improved reservoir heating system |
| US8240636B2 (en) | 2009-01-12 | 2012-08-14 | Fresenius Medical Care Holdings, Inc. | Valve system |
| US9308307B2 (en) | 2007-09-13 | 2016-04-12 | Fresenius Medical Care Holdings, Inc. | Manifold diaphragms |
| CA3057807C (en) | 2007-11-29 | 2021-04-20 | Thomas P. Robinson | System and method for conducting hemodialysis and hemofiltration |
| AU2009302327C1 (en) | 2008-10-07 | 2015-09-10 | Fresenius Medical Care Holdings, Inc. | Priming system and method for dialysis systems |
| CA2739807C (en) * | 2008-10-30 | 2017-02-28 | Fresenius Medical Care Holdings, Inc. | Modular, portable dialysis system |
| DE102008061122A1 (de) * | 2008-12-09 | 2010-06-17 | Fresenius Medical Care Deutschland Gmbh | Verfahren und Vorrichtung zum Ermitteln und/oder Überwachen eines körperlichen Zustandes, insbesondere einer kardiovaskulären Größe, eines Patienten basierend auf einer Amplitude eines Drucksignals |
| WO2010114932A1 (en) | 2009-03-31 | 2010-10-07 | Xcorporeal, Inc. | Modular reservoir assembly for a hemodialysis and hemofiltration system |
| ITRM20090523A1 (it) * | 2009-10-09 | 2011-04-10 | Over S R L | Apparecchiatura per emodialisi extracorporea predisposta per la decontaminazione delle linee e dei filtri. |
| CN107335104A (zh) | 2010-12-07 | 2017-11-10 | 措尔生命桥梁有限责任公司 | 使过滤器逐步注满的用于体外血液治疗的装置的填充和排气的方法及系统 |
| EP2462967B1 (de) * | 2010-12-07 | 2014-09-03 | ZOLL LifeBridge GmbH | Vorrichtung zur extrakorporalen Blutbehandlung, und Computerprogramm zur Steuerung der Befüllung und Entlüftung der Vorrichtung |
| ES2700521T3 (es) | 2011-05-27 | 2019-02-18 | Gambro Lundia Ab | Aparato para el tratamiento de la sangre, adaptado para conservar partes de este |
| US9201036B2 (en) | 2012-12-21 | 2015-12-01 | Fresenius Medical Care Holdings, Inc. | Method and system of monitoring electrolyte levels and composition using capacitance or induction |
| US9157786B2 (en) | 2012-12-24 | 2015-10-13 | Fresenius Medical Care Holdings, Inc. | Load suspension and weighing system for a dialysis machine reservoir |
| US10022484B2 (en) * | 2013-02-06 | 2018-07-17 | Nxstage Medical, Inc. | Fluid circuit priming methods, devices, and systems |
| US9354640B2 (en) | 2013-11-11 | 2016-05-31 | Fresenius Medical Care Holdings, Inc. | Smart actuator for valve |
| WO2015153370A2 (en) | 2014-03-29 | 2015-10-08 | Labib Mohamed E | Blood processing cartridges and systems, and methods for extracorporeal blood therapies |
| DE102014011671B4 (de) * | 2014-08-05 | 2023-12-28 | Fresenius Medical Care Deutschland Gmbh | Extrakoporale Blutbehandlungseinheit |
| DE102015102719A1 (de) | 2015-02-25 | 2016-08-25 | B. Braun Avitum Ag | Konnektor für einen Dialysator |
| US10426884B2 (en) | 2015-06-26 | 2019-10-01 | Novaflux Inc. | Cartridges and systems for outside-in flow in membrane-based therapies |
| US10399040B2 (en) | 2015-09-24 | 2019-09-03 | Novaflux Inc. | Cartridges and systems for membrane-based therapies |
| DE102015120003A1 (de) * | 2015-11-18 | 2017-06-01 | B. Braun Avitum Ag | Verfahren zur Sterilisation und Integritätsprüfung von Dialysatoren |
| US11504517B2 (en) | 2015-12-11 | 2022-11-22 | Nxstage Medical, Inc. | Fluid line connector devices methods and systems |
| EP3248627B1 (en) * | 2016-05-27 | 2020-02-26 | Fenwal, Inc. | Systems and methods for priming a fluid circuit |
| EP3476414A1 (en) * | 2017-10-27 | 2019-05-01 | Gambro Lundia AB | Dialysis machine and method |
| AU2019282329B2 (en) | 2018-06-07 | 2022-06-30 | Becton, Dickinson And Company | Biological fluid separation device |
| JP2022511937A (ja) * | 2018-12-11 | 2022-02-01 | ロンザ ウォーカーズヴィル,インコーポレーテッド | ベッドサイド自動細胞工学システムおよび方法 |
| US11963669B2 (en) | 2018-12-18 | 2024-04-23 | Asp Global Manufacturing Gmbh | Reprocessing case |
| JP6880097B2 (ja) * | 2019-03-29 | 2021-06-02 | 三菱電機株式会社 | チューブ洗浄装置 |
| CN113020109A (zh) * | 2021-05-17 | 2021-06-25 | 马鑫 | 一种透析器预充超声清洗装置及预充超声清洗工艺 |
| CN119365224A (zh) * | 2022-07-20 | 2025-01-24 | 上海心光生物医药有限责任公司 | 净化回路、冲洗净化回路的方法、以及透析设备 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3753493A (en) * | 1971-04-23 | 1973-08-21 | E Mellor | Artificial kidney cleaning apparatus |
| GB1368518A (en) | 1972-03-14 | 1974-09-25 | Dialysis Systems Ltd | Artificial kidney machines |
| US3920030A (en) | 1974-10-18 | 1975-11-18 | Made Inc | Device for cleaning and sterilizing artificial kidneys |
| US4552721A (en) * | 1983-08-19 | 1985-11-12 | Baxter Travenol Laboratories, Inc. | Method for disinfecting, for reuse, separation devices for blood and associated fluid lines |
| US4707335A (en) * | 1983-08-19 | 1987-11-17 | Baxter Travenol Laboratories, Inc. | System and apparatus for disinfecting, for reuse, separation devices for blood and associated fluid lines |
| US4695385A (en) * | 1985-04-29 | 1987-09-22 | Colorado Medical, Inc. | Dialyzer reuse system |
| SE453361B (sv) | 1985-06-04 | 1988-02-01 | Gambro Ab | System for styrning av en medicinsk behandling, t ex dialys |
| US5100394A (en) | 1988-01-25 | 1992-03-31 | Baxter International Inc. | Pre-slit injection site |
| US5268144A (en) | 1989-11-04 | 1993-12-07 | Fresenius Ag | Method for sterilizing a medical unit |
| US5256371A (en) | 1989-12-13 | 1993-10-26 | Medical Support Gmbh | Method and arrangement for disinfecting a dialysis fluid circuit |
| US5032265A (en) | 1990-06-20 | 1991-07-16 | Millipore Corporation | Method and system for producing sterile aqueous solutions |
| US5336165A (en) | 1991-08-21 | 1994-08-09 | Twardowski Zbylut J | Artificial kidney for frequent (daily) Hemodialysis |
| US5591344A (en) | 1995-02-13 | 1997-01-07 | Aksys, Ltd. | Hot water disinfection of dialysis machines, including the extracorporeal circuit thereof |
| US6153102A (en) | 1995-02-13 | 2000-11-28 | Aksys, Ltd. | Disinfection of dead-ended lines in medical instruments |
| US5772624A (en) | 1995-07-20 | 1998-06-30 | Medisystems Technology Corporation | Reusable blood lines |
| US6044691A (en) | 1998-08-26 | 2000-04-04 | Aksys, Ltd. | Blood tubing set integrity tests for extracorporeal circuits |
| ITTO990148U1 (it) * | 1999-07-30 | 2001-01-30 | Hospal Dasco Spa | Unita' di filtrazione per una macchina di dialisi. |
| US8029454B2 (en) * | 2003-11-05 | 2011-10-04 | Baxter International Inc. | High convection home hemodialysis/hemofiltration and sorbent system |
-
2007
- 2007-06-29 US US11/824,322 patent/US8562908B2/en active Active
-
2008
- 2008-06-27 WO PCT/US2008/068491 patent/WO2009006261A2/en not_active Ceased
- 2008-06-27 JP JP2010515165A patent/JP5767474B2/ja active Active
- 2008-06-27 BR BRPI0813462-6A2A patent/BRPI0813462A2/pt not_active IP Right Cessation
- 2008-06-27 CA CA002691655A patent/CA2691655A1/en not_active Abandoned
- 2008-06-27 EP EP08781058A patent/EP2175893A2/en not_active Ceased
- 2008-06-27 EP EP13192914.3A patent/EP2698172A1/en not_active Withdrawn
-
2013
- 2013-09-20 US US14/032,940 patent/US9616162B2/en active Active
-
2017
- 2017-04-03 US US15/477,630 patent/US10471186B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20140054220A1 (en) | 2014-02-27 |
| JP5767474B2 (ja) | 2015-08-19 |
| US10471186B2 (en) | 2019-11-12 |
| US9616162B2 (en) | 2017-04-11 |
| EP2698172A1 (en) | 2014-02-19 |
| US8562908B2 (en) | 2013-10-22 |
| US20090004053A1 (en) | 2009-01-01 |
| US20170203014A1 (en) | 2017-07-20 |
| WO2009006261A3 (en) | 2009-02-26 |
| EP2175893A2 (en) | 2010-04-21 |
| CA2691655A1 (en) | 2009-01-08 |
| JP2010532228A (ja) | 2010-10-07 |
| WO2009006261A2 (en) | 2009-01-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2329 DE 25-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |