BRPI0813553A2 - composições farmacêuticas e métodos para tratamento de distúrbios do olho seco - Google Patents
composições farmacêuticas e métodos para tratamento de distúrbios do olho secoInfo
- Publication number
- BRPI0813553A2 BRPI0813553A2 BRPI0813553A BRPI0813553A BRPI0813553A2 BR PI0813553 A2 BRPI0813553 A2 BR PI0813553A2 BR PI0813553 A BRPI0813553 A BR PI0813553A BR PI0813553 A BRPI0813553 A BR PI0813553A BR PI0813553 A2 BRPI0813553 A2 BR PI0813553A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- pharmaceutical compositions
- dry eye
- eye disorders
- treating dry
- Prior art date
Links
- 208000003556 Dry Eye Syndromes Diseases 0.000 title 1
- 206010013774 Dry eye Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94921607P | 2007-07-11 | 2007-07-11 | |
| US6003208P | 2008-06-09 | 2008-06-09 | |
| PCT/IB2008/001819 WO2009007839A1 (en) | 2007-07-11 | 2008-07-04 | Pharmaceutical compositions and methods of treating dry eye disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0813553A2 true BRPI0813553A2 (pt) | 2017-05-09 |
Family
ID=39925011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0813553A BRPI0813553A2 (pt) | 2007-07-11 | 2008-07-04 | composições farmacêuticas e métodos para tratamento de distúrbios do olho seco |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8541426B2 (pt) |
| EP (1) | EP2175858B1 (pt) |
| JP (2) | JP5649270B2 (pt) |
| KR (2) | KR101258316B1 (pt) |
| CN (1) | CN101743009A (pt) |
| AR (1) | AR067495A1 (pt) |
| AU (1) | AU2008273804B2 (pt) |
| BR (1) | BRPI0813553A2 (pt) |
| CA (1) | CA2691914C (pt) |
| ES (1) | ES2523303T3 (pt) |
| NZ (1) | NZ582188A (pt) |
| RU (1) | RU2445098C2 (pt) |
| TW (1) | TWI364281B (pt) |
| WO (1) | WO2009007839A1 (pt) |
| ZA (1) | ZA201000991B (pt) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| WO2006133426A2 (en) | 2005-06-08 | 2006-12-14 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| EP2455382B1 (en) | 2005-12-13 | 2016-10-26 | Incyte Holdings Corporation | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors |
| EP3070090B1 (en) | 2007-06-13 | 2018-12-12 | Incyte Holdings Corporation | Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile |
| US8541426B2 (en) * | 2007-07-11 | 2013-09-24 | Pfizer Inc. | Pharmaceutical compositions and methods of treating dry eye disorders |
| CL2009001884A1 (es) * | 2008-10-02 | 2010-05-14 | Incyte Holdings Corp | Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco. |
| EP2421867B1 (en) * | 2009-04-20 | 2015-09-02 | Auspex Pharmaceuticals, Llc | Piperidine inhibitors of janus kinase 3 |
| SG176111A1 (en) | 2009-05-22 | 2011-12-29 | Incyte Corp | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors |
| JP5775070B2 (ja) | 2009-05-22 | 2015-09-09 | インサイト・コーポレイションIncyte Corporation | ヤヌスキナーゼ阻害剤としてのピラゾール−4−イル−ピロロ[2,3−d]ピリミジンおよびピロール−3−イル−ピロロ[2,3−d]ピリミジンのN−(ヘテロ)アリール−ピロリジン誘導体 |
| CN102470135A (zh) * | 2009-07-28 | 2012-05-23 | 里格尔药品股份有限公司 | 抑制jak途径的组合物和方法 |
| PT3354652T (pt) | 2010-03-10 | 2020-07-20 | Incyte Holdings Corp | Derivados de piperidin-4-ilazetidina como inibidores de jak1 |
| RS54824B1 (sr) | 2010-05-21 | 2016-10-31 | Incyte Holdings Corp | Topikalna formulacija za inhibiciju jak-a |
| CA2818542A1 (en) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors |
| RU2013144975A (ru) * | 2011-04-08 | 2015-05-20 | Пфайзер Инк. | Кристаллические и некристаллические формы тофацитиниба и фармацевтическая композиция, содержащая тофацитиниб, и усилитель проникновения |
| MY165963A (en) | 2011-06-20 | 2018-05-18 | Incyte Holdings Corp | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors |
| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
| US10973680B2 (en) | 2012-01-04 | 2021-04-13 | Sight Sciences, Inc. | Controller for dry eye treatment systems |
| US11285040B2 (en) | 2012-01-04 | 2022-03-29 | Sight Sciences, Inc. | Combination treatment systems |
| US9510972B2 (en) * | 2012-01-04 | 2016-12-06 | Sight Sciences, Inc. | Dry eye treatment systems |
| US9724230B2 (en) | 2012-01-04 | 2017-08-08 | Sight Sciences, Inc. | Dry eye treatment apparatus and methods |
| CN113384546A (zh) | 2012-11-15 | 2021-09-14 | 因赛特公司 | 鲁索利替尼的缓释剂型 |
| CN103073552B (zh) * | 2013-02-05 | 2015-08-12 | 华润赛科药业有限责任公司 | 一种无定型枸橼酸托法替尼的制备方法 |
| WO2014138168A1 (en) | 2013-03-06 | 2014-09-12 | Incyte Corporation | Processes and intermediates for making a jak inhibitor |
| CN104341422A (zh) * | 2013-07-26 | 2015-02-11 | 重庆医药工业研究院有限责任公司 | 托菲替尼的中间体及其制备方法 |
| SG10201801069QA (en) | 2013-08-07 | 2018-03-28 | Incyte Corp | Sustained release dosage forms for a jak1 inhibitor |
| CN104447751A (zh) * | 2013-09-16 | 2015-03-25 | 天津市汉康医药生物技术有限公司 | 一种托法替尼化合物 |
| CN104447752A (zh) * | 2013-09-16 | 2015-03-25 | 天津市汉康医药生物技术有限公司 | 一种托法替尼水合物及其制备方法 |
| US9498467B2 (en) | 2014-05-30 | 2016-11-22 | Incyte Corporation | Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1 |
| WO2016064078A1 (ko) * | 2014-10-22 | 2016-04-28 | 주식회사 지트리비앤티 | 티모신 베타 4를 함유하는 조성물 및 이를 포함하는 약학적 제형 |
| CN104857287B (zh) * | 2015-04-21 | 2021-05-11 | 湖南中医药大学 | 一种治疗干眼症的中药滴眼液及其制备方法 |
| US9867868B2 (en) * | 2015-08-18 | 2018-01-16 | G-Treebnt Co., Ltd. | Pharmaceutical composition for treating or preventing corneal wound comprising thymosin β4 and citric acid |
| EP3712152B1 (en) | 2015-11-03 | 2021-01-13 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors |
| US10556901B2 (en) | 2015-11-03 | 2020-02-11 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as Janus kinase inhibitors |
| CA3031069A1 (en) | 2016-07-18 | 2018-01-25 | Regentree, Llc | Methods of treating dry eye syndrome |
| AR113922A1 (es) | 2017-12-08 | 2020-07-01 | Incyte Corp | Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas |
| EA202091830A1 (ru) | 2018-01-30 | 2020-12-29 | Инсайт Корпорейшн | Способы и промежуточные соединения для получения ингибитора jak |
| US10960006B2 (en) | 2018-01-31 | 2021-03-30 | Twi Pharmaceuticals, Inc. | Topical formulations comprising tofacitinib |
| MD3773593T2 (ro) | 2018-03-30 | 2024-10-31 | Incyte Corp | Tratament hidradenitei supurative utilizând inhibitori ai JAK |
| US12263115B2 (en) | 2018-09-11 | 2025-04-01 | Sight Sciences, Inc. | Forceps treatment systems |
| KR20220044288A (ko) * | 2019-08-07 | 2022-04-07 | 로토 세이야쿠 가부시키가이샤 | 누액 분비 촉진용 안과 조성물 |
| EP4674401A3 (en) * | 2019-12-27 | 2026-02-25 | Rohto Pharmaceutical Co., Ltd | Container accommodating an aqueous ophthalmic composition comprising delgocitinib |
| JP7722931B2 (ja) * | 2019-12-27 | 2025-08-13 | ロート製薬株式会社 | 水性組成物 |
| CN111467349B (zh) * | 2020-05-14 | 2021-06-01 | 华熙生物科技股份有限公司 | 人工泪液及其制备方法 |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
| CN114948991A (zh) * | 2021-02-26 | 2022-08-30 | 复旦大学 | 氢化镁在制备防治干眼病相关眼表炎症药物中的应用 |
| JP2025014078A (ja) * | 2021-11-30 | 2025-01-29 | 興和株式会社 | 新規ニコチンアミド化合物及びその用途 |
| JP2025519987A (ja) * | 2023-04-28 | 2025-07-01 | 維眸生物科技(浙江)有限公司 | 非感染性炎症疾患を治療するための眼科組成物 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4818537A (en) | 1986-10-21 | 1989-04-04 | Liposome Technology, Inc. | Liposome composition for treating dry eye |
| US4966773A (en) | 1986-11-25 | 1990-10-30 | Alcon Laboratories, Inc. | Topical ophthalmic compositions containing microfine retinoid particles |
| US5041434A (en) | 1991-08-17 | 1991-08-20 | Virginia Lubkin | Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application |
| US5290572A (en) | 1992-08-06 | 1994-03-01 | Deo Corporation | Opthalmic composition for treating dry eye |
| US5696166A (en) | 1995-10-31 | 1997-12-09 | Yanni; John M. | Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders |
| WO1997020578A1 (en) | 1995-12-04 | 1997-06-12 | University Of Miami | Non-preserved topical corticosteroid for treatment of dry eye, filamentary keratitis, and delayed tear clearance |
| US5747474A (en) | 1996-07-29 | 1998-05-05 | Immune Modulation, Inc. | Immunosuppression by administration of N6,N6 -disubstituted cAMP's, analogues thereof, and related nucleosides |
| US5800807A (en) | 1997-01-29 | 1998-09-01 | Bausch & Lomb Incorporated | Ophthalmic compositions including glycerin and propylene glycol |
| US6080747A (en) * | 1999-03-05 | 2000-06-27 | Hughes Institute | JAK-3 inhibitors for treating allergic disorders |
| EP1162974A1 (en) * | 1999-03-19 | 2001-12-19 | Parker Hughes Institute | Quinazoline formulations and therapeutic use thereof |
| EP1382339B1 (en) | 1999-12-10 | 2007-12-05 | Pfizer Products Inc. | Compositions containing pyrrolo ¬2,3-d pyrimidine derivatives |
| US20020132767A1 (en) * | 2000-01-31 | 2002-09-19 | Rosen Craig A. | Nucleic acids, proteins, and antibodies |
| US7301023B2 (en) * | 2001-05-31 | 2007-11-27 | Pfizer Inc. | Chiral salt resolution |
| TWI324925B (en) * | 2001-08-23 | 2010-05-21 | Novartis Ag | Ophthalmic composition |
| PY0228255A (es) | 2001-12-06 | 2004-06-01 | Pfizer Prod Inc | Compuestos cristalinos novedosos |
| RU2285511C2 (ru) * | 2004-10-13 | 2006-10-20 | НИИ ГБ им. Гельмгольца | Средство для лечения синдрома сухого глаза |
| RU2290923C2 (ru) * | 2005-03-04 | 2007-01-10 | Московский научно-исследовательский институт глазных болезней им. Гельмгольца | Способ лечения синдрома сухого глаза |
| NZ562468A (en) * | 2005-04-05 | 2009-10-30 | Pharmacopeia Inc | Purine and imidazopyridine derivatives for immunosuppression |
| WO2007007919A2 (en) * | 2005-07-14 | 2007-01-18 | Astellas Pharma Inc. | Heterocyclic janus kinase 3 inhibitors |
| EP2251341A1 (en) * | 2005-07-14 | 2010-11-17 | Astellas Pharma Inc. | Heterocyclic Janus kinase 3 inhibitors |
| BRPI0613876A2 (pt) | 2005-07-29 | 2011-02-15 | Pfizer Prod Inc | derivados de pirrolo [2,3-d] pirimidina; seus intermediários e sìntese |
| WO2007062459A1 (en) | 2005-11-29 | 2007-06-07 | Cytopia Research Pty Ltd | Selective kinase inhibitors based on pyridine scaffold |
| JP2007314326A (ja) * | 2006-05-26 | 2007-12-06 | Mitsubishi Heavy Ind Ltd | チョッパ折り方法及び装置 |
| TW200837064A (en) | 2006-10-04 | 2008-09-16 | Pharmacopeia Inc | 8-substituted 2-(benzimidazolyl)purine derivatives for immunosuppression |
| TW200902025A (en) * | 2007-04-11 | 2009-01-16 | Alcon Res Ltd | Use of an inhibitor of TNF α plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis |
| US8541426B2 (en) * | 2007-07-11 | 2013-09-24 | Pfizer Inc. | Pharmaceutical compositions and methods of treating dry eye disorders |
-
2008
- 2008-07-04 US US12/668,604 patent/US8541426B2/en not_active Expired - Fee Related
- 2008-07-04 WO PCT/IB2008/001819 patent/WO2009007839A1/en not_active Ceased
- 2008-07-04 CN CN200880024111A patent/CN101743009A/zh active Pending
- 2008-07-04 EP EP08776352.0A patent/EP2175858B1/en not_active Not-in-force
- 2008-07-04 ES ES08776352.0T patent/ES2523303T3/es active Active
- 2008-07-04 AU AU2008273804A patent/AU2008273804B2/en not_active Expired - Fee Related
- 2008-07-04 KR KR1020107000362A patent/KR101258316B1/ko not_active Expired - Fee Related
- 2008-07-04 NZ NZ582188A patent/NZ582188A/en not_active IP Right Cessation
- 2008-07-04 BR BRPI0813553A patent/BRPI0813553A2/pt not_active IP Right Cessation
- 2008-07-04 RU RU2009149687/15A patent/RU2445098C2/ru not_active IP Right Cessation
- 2008-07-04 KR KR1020127022597A patent/KR20120115413A/ko not_active Abandoned
- 2008-07-04 CA CA2691914A patent/CA2691914C/en not_active Expired - Fee Related
- 2008-07-09 JP JP2008178868A patent/JP5649270B2/ja not_active Expired - Fee Related
- 2008-07-10 TW TW097126126A patent/TWI364281B/zh not_active IP Right Cessation
- 2008-07-10 AR ARP080102963A patent/AR067495A1/es unknown
-
2010
- 2010-02-10 ZA ZA2010/00991A patent/ZA201000991B/en unknown
-
2013
- 2013-05-10 JP JP2013100072A patent/JP2013147517A/ja not_active Withdrawn
- 2013-07-17 US US13/944,816 patent/US20130303557A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20100267751A1 (en) | 2010-10-21 |
| TWI364281B (en) | 2012-05-21 |
| AR067495A1 (es) | 2009-10-14 |
| EP2175858B1 (en) | 2014-09-10 |
| KR20100029823A (ko) | 2010-03-17 |
| US8541426B2 (en) | 2013-09-24 |
| ES2523303T3 (es) | 2014-11-24 |
| KR20120115413A (ko) | 2012-10-17 |
| RU2009149687A (ru) | 2011-07-10 |
| US20130303557A1 (en) | 2013-11-14 |
| NZ582188A (en) | 2012-03-30 |
| EP2175858A1 (en) | 2010-04-21 |
| AU2008273804B2 (en) | 2014-07-10 |
| JP5649270B2 (ja) | 2015-01-07 |
| JP2009046470A (ja) | 2009-03-05 |
| CA2691914A1 (en) | 2009-01-15 |
| ZA201000991B (en) | 2010-12-29 |
| CN101743009A (zh) | 2010-06-16 |
| RU2445098C2 (ru) | 2012-03-20 |
| WO2009007839A1 (en) | 2009-01-15 |
| JP2013147517A (ja) | 2013-08-01 |
| KR101258316B1 (ko) | 2013-04-30 |
| TW200911265A (en) | 2009-03-16 |
| AU2008273804A1 (en) | 2009-01-15 |
| CA2691914C (en) | 2012-06-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] | ||
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| B350 | Update of information on the portal [chapter 15.35 patent gazette] |