BRPI0814056A2 - Método para determinar a atividade do fator von willebrand na ausência de ristocetina e para determinar a adamts-13 protease - Google Patents

Método para determinar a atividade do fator von willebrand na ausência de ristocetina e para determinar a adamts-13 protease

Info

Publication number
BRPI0814056A2
BRPI0814056A2 BRPI0814056-1A2A BRPI0814056A BRPI0814056A2 BR PI0814056 A2 BRPI0814056 A2 BR PI0814056A2 BR PI0814056 A BRPI0814056 A BR PI0814056A BR PI0814056 A2 BRPI0814056 A2 BR PI0814056A2
Authority
BR
Brazil
Prior art keywords
determining
ristoketin
adamts
protease
absence
Prior art date
Application number
BRPI0814056-1A2A
Other languages
English (en)
Inventor
Harald Althaus
Tobias Obser
Juergen Patzke
Reinhard Schneppenheim
Original Assignee
Siemens Healthcare Diagnostics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Healthcare Diagnostics filed Critical Siemens Healthcare Diagnostics
Publication of BRPI0814056A2 publication Critical patent/BRPI0814056A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/755—Factors VIII, e.g. factor VIII C [AHF], factor VIII Ag [VWF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/222—Platelet disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/226—Thrombotic disorders, i.e. thrombo-embolism irrespective of location/organ involved, e.g. renal vein thrombosis, venous thrombosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Inorganic Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BRPI0814056-1A2A 2007-07-06 2008-07-03 Método para determinar a atividade do fator von willebrand na ausência de ristocetina e para determinar a adamts-13 protease BRPI0814056A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007031708A DE102007031708A1 (de) 2007-07-06 2007-07-06 Bestimmung der von Willebrand Faktor-Aktivität in Abwesenheit von Ristocetin
PCT/EP2008/005416 WO2009007051A2 (de) 2007-07-06 2008-07-03 Verfahren zur bestimmung der von willebrand faktor-aktivität in abwesenheit von ristocetin und zur bestimmung der adamts-13-protease

Publications (1)

Publication Number Publication Date
BRPI0814056A2 true BRPI0814056A2 (pt) 2015-01-06

Family

ID=40092552

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0814056-1A2A BRPI0814056A2 (pt) 2007-07-06 2008-07-03 Método para determinar a atividade do fator von willebrand na ausência de ristocetina e para determinar a adamts-13 protease

Country Status (9)

Country Link
US (4) US9222942B2 (pt)
EP (2) EP2167978B1 (pt)
JP (2) JP5745270B2 (pt)
CN (3) CN101755211A (pt)
BR (1) BRPI0814056A2 (pt)
CA (2) CA2692576C (pt)
DE (1) DE102007031708A1 (pt)
ES (2) ES2425797T3 (pt)
WO (1) WO2009007051A2 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007031708A1 (de) 2007-07-06 2009-01-08 Dade Behring Marburg Gmbh Bestimmung der von Willebrand Faktor-Aktivität in Abwesenheit von Ristocetin
ES2672320T3 (es) 2007-08-23 2018-06-13 Bloodcenter Of Wisconsin, Inc. Métodos y kits para la medida del factor de von Willebrand
US8637268B2 (en) * 2010-11-17 2014-01-28 Puget Sound Blood Center Determination of von Willebrand Factor cleavage by ADAMTS13
CN102279273A (zh) * 2011-07-19 2011-12-14 苏州大学 一种血管性血友病因子瑞斯托霉素辅因子酶联免疫试剂盒
EP2634577A1 (de) 2012-02-29 2013-09-04 Siemens Healthcare Diagnostics Products GmbH Verfahren zur Erkennung von Interferenzen in in vitro-diagnostischen Testen
EP2637024A1 (de) 2012-03-05 2013-09-11 Siemens Healthcare Diagnostics Products GmbH Screeningverfahren zum Auffinden von Proben mit einer Störung der Funktionalität der GPIb-Von Willebrand Faktor-Interaktion
EP2708892B1 (de) 2012-09-18 2015-04-15 Siemens Healthcare Diagnostics Products GmbH Verfahren zur Bestimmung Plättchen-assoziierter Analyten
EP2829878A1 (de) 2013-07-23 2015-01-28 Siemens Healthcare Diagnostics Products GmbH Verfahren zur Bestimmung der GPIb-Rezeptor-abhängigen Plättchenfunktion
EP2919013B1 (de) * 2014-03-11 2016-11-02 Siemens Healthcare Diagnostics Products GmbH Verfahren zur Detektion von Modulatoren der GPIb-Thrombin-Interaktion
CN110139935A (zh) 2016-10-11 2019-08-16 美国控股实验室公司 用于测定adamts13酶活性的方法和系统
BR112020013419A8 (pt) 2018-02-20 2022-07-05 Grifols Diagnostic Solutions Inc Composição compreendendo proteína receptora de gplb¿lfa recombinante
CN110785499B (zh) 2018-05-25 2024-12-03 伊鲁米那股份有限公司 对先兆子痫具有特异性的循环rna标识
WO2021102236A1 (en) 2019-11-22 2021-05-27 Illumina, Inc. Circulating rna signatures specific to preeclampsia
EP4585926A1 (de) 2024-01-09 2025-07-16 Siemens Healthcare Diagnostics Products GmbH Verfahren und kit zur reduzierung von interferenzen in immunoassays

Family Cites Families (21)

* Cited by examiner, † Cited by third party
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US5011912A (en) 1986-12-19 1991-04-30 Immunex Corporation Hybridoma and monoclonal antibody for use in an immunoaffinity purification system
IL88308A0 (en) 1987-11-17 1989-06-30 Scripps Clinic Res Peptides that block the binding of von willebrand factor
NZ237244A (en) 1990-03-02 1992-10-28 Bio Technology General Corp Cloning and production of human von willebrand factor analogues and compositions thereof
US5317097A (en) 1991-10-07 1994-05-31 The Research Foundation Of State University Of New York Mutations in the gene encoding the α chain on platelet glycoprotein IB
WO1993016712A1 (en) 1992-02-26 1993-09-02 The Scripps Research Institute MUTANT GPIbα FRAGMENTS AND RECOMBINANT EXPRESSION THEREOF
CA2362483A1 (en) 1999-02-25 2000-08-31 Bernhard Lammle Test kit for analysing factor viii-splitting protease
EP1190260B1 (en) 1999-07-05 2011-01-26 K.U. Leuven Research & Development Detection of von-willebrand factor (vwf) activity
AR035779A1 (es) * 2001-02-06 2004-07-14 Genetics Inst Llc Polipeptidos de fusion derivados de glicoproteina ib alfa de plaqueta y metodos de uso de los mismos
CN1211400C (zh) 2001-09-18 2005-07-20 中国人民解放军军事医学科学院野战输血研究所 人血小板糖蛋白GPIbα的制备方法及其专用引物
DE20213920U1 (de) * 2002-07-03 2003-01-16 Böhm, Martina, 60439 Frankfurt Diagnostikum zum Nachweis der den von Willebrand-Faktorspaltenden Aktivität von ADAMTS13
US7718763B2 (en) 2002-10-18 2010-05-18 Japan As Represented By The President Of National Cardiovascular Center Substrate polyeptides for von Willebrand factor cleaving protease ADAMTS-13
US7763430B2 (en) * 2003-04-22 2010-07-27 Baxter International Inc. Diagnostic assay for anti-von Willebrand Factor cleaving protease (ADAMTS13) antibodies
AU2004247737B2 (en) * 2003-06-11 2009-04-23 Wyeth Platelet glycoprotein IB alpha variant fusion polypeptides and methods of use thereof
US7780831B2 (en) * 2003-07-07 2010-08-24 The University Of North Carolina At Chapel Hill Assays for detection of von willebrand factor (vWF) multimers and for degradation of vWF by agents such as ADAMTS13 and related methods
US20050186646A1 (en) 2004-01-26 2005-08-25 Cruz Miguel A. Rapid assay to detect ADAMTS-13 activity
ATE488766T1 (de) * 2004-06-21 2010-12-15 Progenra Inc Diagnostik und screening-methode und kit in verbindung mit proteolytischer aktivität
EP1859051A4 (en) * 2005-03-18 2009-08-05 Univ Hong Kong Chinese MARKERS FOR PRENATAL DIAGNOSIS AND SURVEILLANCE
EP1736481A1 (en) * 2005-05-13 2006-12-27 Charite Universitätsmedizin-Berlin Erythropoietin variants
DE102007031708A1 (de) * 2007-07-06 2009-01-08 Dade Behring Marburg Gmbh Bestimmung der von Willebrand Faktor-Aktivität in Abwesenheit von Ristocetin
ES2672320T3 (es) * 2007-08-23 2018-06-13 Bloodcenter Of Wisconsin, Inc. Métodos y kits para la medida del factor de von Willebrand
EP2637024A1 (de) * 2012-03-05 2013-09-11 Siemens Healthcare Diagnostics Products GmbH Screeningverfahren zum Auffinden von Proben mit einer Störung der Funktionalität der GPIb-Von Willebrand Faktor-Interaktion

Also Published As

Publication number Publication date
EP2167978A2 (de) 2010-03-31
CN104897910B (zh) 2017-09-29
WO2009007051A2 (de) 2009-01-15
US20160231331A1 (en) 2016-08-11
CN103076459A (zh) 2013-05-01
CN104897910A (zh) 2015-09-09
US8932820B2 (en) 2015-01-13
US9869683B2 (en) 2018-01-16
US20100136589A1 (en) 2010-06-03
JP5802968B2 (ja) 2015-11-04
EP2167978B1 (de) 2015-10-28
DE102007031708A1 (de) 2009-01-08
CA2692576C (en) 2016-11-01
CA2938781C (en) 2018-04-24
JP2014036663A (ja) 2014-02-27
US10591490B2 (en) 2020-03-17
CA2938781A1 (en) 2009-01-15
CN101755211A (zh) 2010-06-23
CA2692576A1 (en) 2009-01-15
EP2388596B1 (de) 2013-05-22
US20130078652A1 (en) 2013-03-28
CN103076459B (zh) 2015-04-29
ES2554162T3 (es) 2015-12-16
ES2425797T3 (es) 2013-10-17
JP5745270B2 (ja) 2015-07-08
US9222942B2 (en) 2015-12-29
WO2009007051A3 (de) 2009-05-28
US20180088133A1 (en) 2018-03-29
JP2010532467A (ja) 2010-10-07
EP2388596A1 (de) 2011-11-23

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B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]