BRPI0814651A2 - Métodos e composições para expansão e implante de células-tronco mesenquimais otimizados. - Google Patents

Métodos e composições para expansão e implante de células-tronco mesenquimais otimizados.

Info

Publication number
BRPI0814651A2
BRPI0814651A2 BRPI0814651-9A2A BRPI0814651A BRPI0814651A2 BR PI0814651 A2 BRPI0814651 A2 BR PI0814651A2 BR PI0814651 A BRPI0814651 A BR PI0814651A BR PI0814651 A2 BRPI0814651 A2 BR PI0814651A2
Authority
BR
Brazil
Prior art keywords
mesquemal
implantation
optimized
compositions
expansion
Prior art date
Application number
BRPI0814651-9A2A
Other languages
English (en)
Inventor
Christopher J Centeno
Cristin Keohan
Original Assignee
Regenerative Sciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regenerative Sciences Llc filed Critical Regenerative Sciences Llc
Publication of BRPI0814651A2 publication Critical patent/BRPI0814651A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/19—Platelets; Megacaryocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/70—Undefined extracts
    • C12N2500/80—Undefined extracts from animals
    • C12N2500/84—Undefined extracts from animals from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/115—Platelets, megakaryocytes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
BRPI0814651-9A2A 2007-07-05 2008-06-25 Métodos e composições para expansão e implante de células-tronco mesenquimais otimizados. BRPI0814651A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/773,774 US9095562B2 (en) 2007-07-05 2007-07-05 Methods and compositions for optimized expansion and implantation of mesenchymal stem cells
PCT/US2008/068202 WO2009006161A1 (en) 2007-07-05 2008-06-25 Methods and compositions for optimized expansion and implantation of mesenchymal stem cells

Publications (1)

Publication Number Publication Date
BRPI0814651A2 true BRPI0814651A2 (pt) 2015-01-27

Family

ID=40221599

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0814651-9A2A BRPI0814651A2 (pt) 2007-07-05 2008-06-25 Métodos e composições para expansão e implante de células-tronco mesenquimais otimizados.

Country Status (9)

Country Link
US (2) US9095562B2 (pt)
EP (1) EP2167648B1 (pt)
JP (1) JP2010532370A (pt)
KR (1) KR20100063696A (pt)
CN (1) CN101878297A (pt)
BR (1) BRPI0814651A2 (pt)
CA (1) CA2691427A1 (pt)
MX (1) MX2009014273A (pt)
WO (1) WO2009006161A1 (pt)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007087519A2 (en) * 2006-01-24 2007-08-02 Centeno Christopher J Mesenchymal stem cell isolation and transplantation method and system to be used in a clinical setting
US9095562B2 (en) 2007-07-05 2015-08-04 Regenerative Sciences, Inc. Methods and compositions for optimized expansion and implantation of mesenchymal stem cells
WO2009085969A2 (en) * 2007-12-19 2009-07-09 Regenerative Sciences, Llc Compositions and methods to promote implantation and engrafment of stem cells
WO2009114785A2 (en) 2008-03-14 2009-09-17 Regenerative Sciences, Inc. Compositions and methods for cartilage repair
KR20120006481A (ko) 2008-12-05 2012-01-18 리제너러티브 사이언시즈, 엘엘씨 무혈관 조직의 복구를 촉진하기 위한 방법 및 조성물
US20100168022A1 (en) * 2008-12-11 2010-07-01 Centeno Christopher J Use of In-Vitro Culture to Design or Test Personalized Treatment Regimens
US20110054929A1 (en) * 2009-09-01 2011-03-03 Cell Solutions Colorado Llc Stem Cell Marketplace
US9113950B2 (en) 2009-11-04 2015-08-25 Regenerative Sciences, Llc Therapeutic delivery device
EP4663241A3 (en) 2010-10-08 2026-03-25 Mesoblast International Sàrl Enhanced msc preparations
US20120231542A1 (en) * 2011-03-11 2012-09-13 General Biotechnology, Llc Biologically Active Human Umbilical Cord Blood Cell Extract Compounds and Methods
WO2013003595A1 (en) 2011-06-29 2013-01-03 Biorestorative Therapies, Inc. Brown fat cell compositions and methods
CA2840307C (en) * 2011-07-06 2021-10-19 Cell Therapy Limited Progenitor cells of mesodermal lineage
US8961956B2 (en) 2011-11-30 2015-02-24 Ocata Therapeutics, Inc. Mesenchymal stromal cells and uses related thereto
RS57886B1 (sr) * 2011-11-30 2019-01-31 Astellas Inst For Regenerative Medicine Mezenhimalne stromalne ćelije i primene vezane za njih
EP2626410A1 (de) * 2012-02-08 2013-08-14 Technische Hochshule Mittelhessen Vorrichtung und Verfahren zur Expansion und Ernte von adhärenten Zellinien
WO2013123607A1 (zh) * 2012-02-20 2013-08-29 光丽生医股份有限公司 用于成体干细胞的体外无血清培养的方法和培养基
CN102533641B (zh) * 2012-02-20 2016-08-17 光丽生医股份有限公司 体外无血清成体干细胞放大培养的方法及其培养液
CA2876499C (en) 2012-07-12 2021-10-26 Imstem Biotechnology, Inc. Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
US8835175B2 (en) * 2012-11-13 2014-09-16 Grifols, S.A. Culture medium for human mesenchymal stem cells
CN105050658B (zh) * 2013-04-02 2017-09-12 帝人制药株式会社 磁刺激装置
ES2957410T3 (es) 2013-04-19 2024-01-18 Biorestorative Therapies Inc Células madre derivadas de tejido adiposo marrón humano y sus utilizaciones
WO2015022670A1 (en) * 2013-08-14 2015-02-19 Stempeutics Research Pvt. Ltd. Management of osteoarthritis using pooled allogeneic mesenchymal stem cells
TWI566774B (zh) * 2014-10-06 2017-01-21 佛教慈濟醫療財團法人花蓮慈濟醫院 治療關節疾病的組成物及其方法
SG11201706117UA (en) * 2015-01-26 2017-08-30 Ube Industries Cell culture method using bone marrow-like structure, and polyimide porous membrane for treating bone damage site
CN106282103A (zh) * 2015-06-03 2017-01-04 周宇璠 动物间充质干细胞免疫抑制能增强无血清培养液
CN105708860A (zh) * 2016-01-26 2016-06-29 深圳爱生再生医学科技有限公司 用于修复皮肤溃疡的干细胞制剂
US11984312B2 (en) * 2016-03-30 2024-05-14 University of Pittsburgh—of the Commonwealth System of Higher Education System for portable gas storage and delivery
EP3452500A4 (en) * 2016-05-06 2019-12-11 Lacerta Technologies Inc. PROLIFERATION OF MESENCHYMAL STEM CELLS
US20190183937A1 (en) * 2016-08-18 2019-06-20 Sapporo Medical University Life extension agent
SG11202001585PA (en) * 2017-09-20 2020-03-30 Novadip Biosciences Biomaterial comprising adipose-derived stem cells and method for producing the same
AU2018372631B2 (en) 2017-11-22 2025-06-05 Mesoblast International Sarl Cellular compositions and methods of treatment I
WO2020161746A1 (en) 2019-02-08 2020-08-13 Regrow Biosciences Private Limited Platelet lysate, and method of preparation thereof
WO2021072595A1 (zh) * 2019-10-14 2021-04-22 玛旺干细胞医学生物科技股份有限公司 间充质干细胞在治疗听力障碍上的医药用途
CN111514374A (zh) * 2020-04-24 2020-08-11 南京鼓楼医院 一种基于共培养系统构建的组织工程软骨促进软骨修复的方法
CN112053751A (zh) * 2020-09-02 2020-12-08 成都域时信息科技有限公司 机器学习定量预测间充质干细胞疗法后软骨修复率的方法
US20230365937A1 (en) * 2020-10-26 2023-11-16 Hadasit Medical Research Services And Development Ltd. Mesenchymal stem cells and their culture
JP7670269B2 (ja) * 2021-01-14 2025-04-30 学校法人日本医科大学 不死化間葉系細胞を含む細胞集団を製造する方法及び不死化間葉系細胞を含む細胞集団
KR102647353B1 (ko) 2021-02-19 2024-03-13 한국화학연구원 중간엽 줄기세포 증식 및/또는 이동 촉진용 조성물
KR102842962B1 (ko) 2021-07-19 2025-08-05 한국화학연구원 중간엽 줄기세포 이동 촉진용 조성물
CN115025120B (zh) * 2022-06-23 2024-03-08 深圳凯兰赛尔健康管理有限公司 一种间充质干细胞注射液及其应用
CN117180312A (zh) * 2023-10-09 2023-12-08 上海市第六人民医院 iMSCs线粒体在制备治疗骨缺损的药物中的应用

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145676A (en) * 1981-09-08 1992-09-08 The Rockefeller University Method and agents for promoting wound healing
US5165938A (en) * 1984-11-29 1992-11-24 Regents Of The University Of Minnesota Wound healing agents derived from platelets
US4832044A (en) * 1987-09-16 1989-05-23 Garg Rakesh K Cannula including a valve structure and associated instrument elements
SE8801537D0 (sv) * 1988-04-26 1988-04-26 Ellco Food Ab Cellodlingsmedium samt forfarande for dess framstellning
US5226914A (en) * 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US7229959B1 (en) * 1990-11-27 2007-06-12 The American National Red Cross Supplemented fibrin matrix delivery systems
US5769899A (en) * 1994-08-12 1998-06-23 Matrix Biotechnologies, Inc. Cartilage repair unit
US5736396A (en) * 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US5749874A (en) * 1995-02-07 1998-05-12 Matrix Biotechnologies, Inc. Cartilage repair unit and method of assembling same
US5693341A (en) * 1995-03-16 1997-12-02 Collagen Corporation Affinity bound collagen matrices for the delivery of biologically active agents
US6200606B1 (en) * 1996-01-16 2001-03-13 Depuy Orthopaedics, Inc. Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration
US5842477A (en) * 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
US5834418A (en) 1996-03-20 1998-11-10 Theratechnologies, Inc. Process for the preparation of platelet growth factors extract
US5770215A (en) * 1997-01-06 1998-06-23 Moshyedi; Emil Payman Multivitamin/vascular occlusion inhibiting composition
EP2110431A1 (en) 1997-05-13 2009-10-21 Osiris Therapeutics, Inc. Cartilage regeneration using human mesenchymal stem cells
EP1032367B1 (en) * 1997-11-17 2009-08-12 Haemacure Corporation Fibrin sealants or adhesives comprising a hyaluronic acid derivative material
US6835377B2 (en) * 1998-05-13 2004-12-28 Osiris Therapeutics, Inc. Osteoarthritis cartilage regeneration
US6530956B1 (en) * 1998-09-10 2003-03-11 Kevin A. Mansmann Resorbable scaffolds to promote cartilage regeneration
IT1302534B1 (it) * 1998-12-21 2000-09-05 Fidia Advanced Biopolymers Srl Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per
ATE292282T1 (de) * 1999-05-28 2005-04-15 Stemcell Technologies Inc Verfahren zur zellseparation unter verwendung von immunorosetten
ES2353061T5 (es) * 2000-04-25 2014-04-07 Osiris Therapeutics, Inc. Reparación de articulaciones utilizando células madre mesenquimatosas
US20070122904A1 (en) * 2000-09-29 2007-05-31 Unisearch Limited Method and apparatus for culturing cells
US20030050709A1 (en) * 2001-02-23 2003-03-13 Ulrich Noth Trabecular bone-derived human mesenchymal stem cells
US6623733B1 (en) * 2001-06-27 2003-09-23 Advanced Cardiovascular Systems, Inc. Methods for treatment of vascular disease and device for preparation of an autologous composition for treating vascular disease
KR20030024028A (ko) * 2001-09-15 2003-03-26 하철원 혈관신생조절 유전자가 삽입된 줄기세포를 이용한무혈성골괴사의 치료
US6811777B2 (en) * 2002-04-13 2004-11-02 Allan Mishra Compositions and minimally invasive methods for treating incomplete connective tissue repair
JPWO2004018615A1 (ja) * 2002-08-23 2005-12-08 旭化成メディカル株式会社 フィブリン含有組成物
US20040136968A1 (en) * 2002-09-27 2004-07-15 Verigen Ag Autologous cells on a support matrix for tissue repair
US7824701B2 (en) * 2002-10-18 2010-11-02 Ethicon, Inc. Biocompatible scaffold for ligament or tendon repair
EP1592373B1 (en) 2003-01-30 2013-04-24 ProChon Biotech Ltd. Freeze-dried fibrin matrices and methods for preparation thereof
US20030224411A1 (en) * 2003-03-13 2003-12-04 Stanton Lawrence W. Genes that are up- or down-regulated during differentiation of human embryonic stem cells
US7291450B2 (en) * 2003-03-28 2007-11-06 Smith & Nephew, Inc. Preparation of a cell concentrate from a physiological solution
US8273347B2 (en) * 2003-05-13 2012-09-25 Depuy Spine, Inc. Autologous treatment of degenerated disc with cells
US20040229878A1 (en) * 2003-05-13 2004-11-18 Depuy Spine, Inc. Transdiscal administration of specific inhibitors of P38 kinase
US7485460B2 (en) 2003-05-21 2009-02-03 Tulane University Health Sciences Center Enhanced growth of adult stem cells with Dkk-1
ES2564044T3 (es) * 2003-06-27 2016-03-17 DePuy Synthes Products, Inc. Células posparto derivadas de tejido del cordón umbilical y métodos de preparación y uso de las mismas
US10583220B2 (en) * 2003-08-11 2020-03-10 DePuy Synthes Products, Inc. Method and apparatus for resurfacing an articular surface
NZ547140A (en) * 2003-10-22 2009-09-25 Encelle Inc Bioactive hydrogel compositions in dehydrated form for regenerating connective tissue
GB0325120D0 (en) 2003-10-28 2003-12-03 Smith & Nephew Apparatus with actives
KR100531922B1 (ko) * 2003-12-23 2005-11-29 주식회사 셀론텍 연골치료제 조성물 및 그 사용방법
US20060275273A1 (en) * 2004-02-20 2006-12-07 Seyedin Mitchell S Intervertebral Disc Repair, Methods and Devices Therefor
GB0404656D0 (en) 2004-03-02 2004-04-07 Univ Manchester Treatment of spinal conditions
KR20070002067A (ko) * 2004-03-26 2007-01-04 셀진 코포레이션 줄기 세포 은행의 제공 시스템 및 제공 방법
CN101897618A (zh) * 2004-04-23 2010-12-01 伦纳德·爱德华·福里斯特 用于治疗或排出椎间盘的装置
US20070280959A1 (en) 2004-05-05 2007-12-06 Thomas Meury Use Of Platelets Or Platelet Rich Plasma(Prp)
ES2313805B1 (es) * 2004-10-04 2009-12-23 Cellerix, S.L. Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral.
US20070128722A1 (en) * 2005-12-05 2007-06-07 Industrial Technology Research Institute Human mesenchymal stem cells and culturing methods thereof
WO2007087519A2 (en) 2006-01-24 2007-08-02 Centeno Christopher J Mesenchymal stem cell isolation and transplantation method and system to be used in a clinical setting
US20090274665A1 (en) * 2006-04-27 2009-11-05 Cell Therapy Technologies, Inc. Stem Cells For Treating Lung Diseases
EP2069479A1 (en) 2006-09-18 2009-06-17 Medizinische Universität Graz Plasma-free platelet lysate for use as a supplement in cell cultures and for the preparation of cell therapeutics
US20080188826A1 (en) 2007-02-01 2008-08-07 Laurimed, Llc Methods and devices for treating tissue
US9095562B2 (en) 2007-07-05 2015-08-04 Regenerative Sciences, Inc. Methods and compositions for optimized expansion and implantation of mesenchymal stem cells
WO2009085969A2 (en) 2007-12-19 2009-07-09 Regenerative Sciences, Llc Compositions and methods to promote implantation and engrafment of stem cells
WO2009114785A2 (en) 2008-03-14 2009-09-17 Regenerative Sciences, Inc. Compositions and methods for cartilage repair
WO2009124192A1 (en) 2008-04-02 2009-10-08 Laurimed, Llc Methods and devices for delivering injections
KR20120006481A (ko) 2008-12-05 2012-01-18 리제너러티브 사이언시즈, 엘엘씨 무혈관 조직의 복구를 촉진하기 위한 방법 및 조성물
US20100168022A1 (en) * 2008-12-11 2010-07-01 Centeno Christopher J Use of In-Vitro Culture to Design or Test Personalized Treatment Regimens
US20110054929A1 (en) * 2009-09-01 2011-03-03 Cell Solutions Colorado Llc Stem Cell Marketplace
US9113950B2 (en) * 2009-11-04 2015-08-25 Regenerative Sciences, Llc Therapeutic delivery device
WO2013074507A2 (en) 2011-11-14 2013-05-23 Regenerative Sciences, Llc Suspended particle delivery systems and methods

Also Published As

Publication number Publication date
EP2167648B1 (en) 2016-05-04
US9700583B2 (en) 2017-07-11
CA2691427A1 (en) 2009-01-08
US20160106780A1 (en) 2016-04-21
MX2009014273A (es) 2010-04-01
KR20100063696A (ko) 2010-06-11
EP2167648A4 (en) 2011-07-06
JP2010532370A (ja) 2010-10-07
US9095562B2 (en) 2015-08-04
EP2167648A1 (en) 2010-03-31
WO2009006161A1 (en) 2009-01-08
US20090010896A1 (en) 2009-01-08
CN101878297A (zh) 2010-11-03

Similar Documents

Publication Publication Date Title
EP2076587A4 (en) ISOLATION, EXPANSION AND USE OF TUMOR STAMMING CELLS
EP2094839A4 (en) EXPANSION OF HEMATOPOETIC STEM CELLS
PL3255061T3 (pl) Selektywna deplecja immunologiczna niszy endogennych komórek macierzystych do wszczepienia
DE602006011762D1 (de) Expandierbares Zwischenwirbelimplantat
BRPI0817306A2 (pt) Implante para se ajustar dentro de um espaço intervertebral
BRPI0813318A2 (pt) implante pélvico, e, kit
FI20096288A0 (fi) Formulations and methods for culturing stem cells
SE0950586L (sv) Förbättrad odling av stamceller
DK2634243T4 (da) Forbedret fremgangsmåde til dyrkning af celler
BRPI0818732A2 (pt) Composições de análogo de prostaglandina e métodos para tratar condições relacionadas epiteliais.
BRPI0819665A2 (pt) implante intervertebral
LT3677302T (lt) Protezinis tarpiklis implantavimui natūralaus mitralinio vožtuvo srityje
EP2148569A4 (en) METHOD AND COMPOSITIONS FOR THE SELF-RENEWAL OF STEM CELLS
DE602007000497D1 (de) Expansionsventil
DK2650359T3 (da) Endokrine prekursorceller, pancreatiske hormon-udtrykkende celler og fremstillingsfremgangsmåder
BRPI1014635A2 (pt) compostos heterocíclicos e de expansão para células-tronco hematopoiéticas
BRPI1011127A2 (pt) métodos para o cultivo de células tronco e células progenitoras
BRPI0717389A2 (pt) Dispositivos e métodos para avanço de stent
ZA201003515B (en) Method of inhibitor of leukemic stem cells
PL2209888T3 (pl) Ulepszony sposób wytwarzania komórek rpe i kompozycji komórek rpe
BRPI0814102A2 (pt) Implante pélvico, e, kit.
BRPI0919911A2 (pt) métodos e sistemas para fabricação e montagem de válvula de stent
EA201200118A1 (ru) Дифференцировка мезенхемальных стволовых клеток
BRPI0807220B1 (pt) composição, e, métodos para aumentar a força de compressão de uma composição e para aumentar a retenção de fragrância de uma composição
BR112012002084A2 (pt) composições e métodos para inibir crescimento de pelo

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according art. 34 industrial property law
B08F Application fees: dismissal - article 86 of industrial property law
B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)