BRPI0815334A2 - derivados de pirazolo[3,4-d]-piramidina como agentes antiproliferativos - Google Patents

derivados de pirazolo[3,4-d]-piramidina como agentes antiproliferativos

Info

Publication number
BRPI0815334A2
BRPI0815334A2 BRPI0815334A BRPI0815334A BRPI0815334A2 BR PI0815334 A2 BRPI0815334 A2 BR PI0815334A2 BR PI0815334 A BRPI0815334 A BR PI0815334A BR PI0815334 A BRPI0815334 A BR PI0815334A BR PI0815334 A2 BRPI0815334 A2 BR PI0815334A2
Authority
BR
Brazil
Prior art keywords
pharmaceutically
compounds
pyrazolo
tumor
esters
Prior art date
Application number
BRPI0815334A
Other languages
English (en)
Inventor
Joseph Bartkovitz David
Thomas Luk Kin-Chun
Chu Xin-Jie
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0815334A2 publication Critical patent/BRPI0815334A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0815334A 2007-08-14 2008-08-04 derivados de pirazolo[3,4-d]-piramidina como agentes antiproliferativos BRPI0815334A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95565307P 2007-08-14 2007-08-14
PCT/EP2008/060215 WO2009021869A1 (en) 2007-08-14 2008-08-04 Pyrazolo[3,4-d]-pyramidine derivatives as antiproliferative agents

Publications (1)

Publication Number Publication Date
BRPI0815334A2 true BRPI0815334A2 (pt) 2019-09-24

Family

ID=39760502

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0815334A BRPI0815334A2 (pt) 2007-08-14 2008-08-04 derivados de pirazolo[3,4-d]-piramidina como agentes antiproliferativos

Country Status (12)

Country Link
US (1) US7968554B2 (pt)
EP (1) EP2188290B1 (pt)
JP (1) JP5296790B2 (pt)
KR (1) KR20100038431A (pt)
CN (1) CN101965349B (pt)
AT (1) ATE512152T1 (pt)
AU (1) AU2008288538A1 (pt)
BR (1) BRPI0815334A2 (pt)
CA (1) CA2694666C (pt)
ES (1) ES2366268T3 (pt)
MX (1) MX2010001636A (pt)
WO (1) WO2009021869A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9408885B2 (en) 2011-12-01 2016-08-09 Vib Vzw Combinations of therapeutic agents for treating melanoma
WO2018146253A1 (en) 2017-02-10 2018-08-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway
WO2019133810A1 (en) 2017-12-28 2019-07-04 Tract Pharmaceuticals, Inc. Stem cell culture systems for columnar epithelial stem cells, and uses related thereto
SG11202110547YA (en) * 2019-04-10 2021-10-28 Cellestia Biotech Ag Compounds for the treatment of oncovirus induced cancer and methods of use thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2732970B1 (fr) 1995-04-14 1997-05-16 Hoechst Schering Agrevo Sa Nouveaux derives de l'acide beta-methoxy acrylique, leur procede de preparation et leur application comme pesticides
UA60365C2 (uk) 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
US6232320B1 (en) 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
US6383790B1 (en) * 1999-01-11 2002-05-07 Princeton University High affinity protein kinase inhibitors
HN2000000051A (es) 1999-05-19 2001-02-02 Pfizer Prod Inc Derivados heterociclicos utiles como agentes anticancerosos
IL155371A0 (en) 2000-11-28 2003-11-23 Pfizer Prod Inc Salts of a isothiazole-4-carboxamide and their use as anti-hyperproliferation agents
WO2003082272A1 (en) 2002-03-29 2003-10-09 Chiron Corporation Substituted benzazoles and use thereof as raf kinase inhibitors
WO2004041285A1 (en) 2002-10-31 2004-05-21 Amgen Inc. Antiinflammation agents
WO2004100947A2 (en) 2003-05-06 2004-11-25 Smithkline Beecham Corporation Novel chemical compounds
US20050026944A1 (en) 2003-07-24 2005-02-03 Patrick Betschmann Thienopyridine and furopyridine kinase inhibitors
US7202363B2 (en) 2003-07-24 2007-04-10 Abbott Laboratories Thienopyridine and furopyridine kinase inhibitors
US20050020619A1 (en) 2003-07-24 2005-01-27 Patrick Betschmann Thienopyridine kinase inhibitors
JP4557984B2 (ja) 2003-12-05 2010-10-06 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド Ｉｋｋインヒビターとしての置換３−アミノ−チエノ−［２，３−ｂ］ピリジン−２−カルボン酸アミド化合物
JP2007520559A (ja) * 2004-02-03 2007-07-26 アボット・ラボラトリーズ 治療薬としてのアミノベンゾオキサゾール類
US20050256154A1 (en) 2004-05-04 2005-11-17 Kin-Chun Luk 4-Amino-thieno[3,2-c]pyridine-7-carboxylic acid amides
US7405220B2 (en) 2004-06-09 2008-07-29 Hoffmann-La Roche Inc. Pyrazolopyrimidines
EP1831225A2 (en) 2004-11-19 2007-09-12 The Regents of the University of California Anti-inflammatory pyrazolopyrimidines
CA2609299A1 (en) 2005-05-20 2006-11-23 Array Biopharma Inc. Raf inhibitor compounds and methods of use thereof
UA95244C2 (ru) * 2005-06-22 2011-07-25 Плексикон, Инк. Соединения и способ модулирования активности киназ, и показания для их применения
AR057455A1 (es) * 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
WO2007031428A1 (en) * 2005-09-15 2007-03-22 F. Hoffmann-La Roche Ag 4-amino-thieno[3,2-c]pyridine-7-carboxylic acid derivatives
JP5237108B2 (ja) * 2005-12-08 2013-07-17 アボット・ラボラトリーズ タンパク質キナーゼ阻害薬としての９員ヘテロ二環式化合物
JP2009520028A (ja) 2005-12-19 2009-05-21 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド Ｉｇｆｒ抑制剤および抗癌剤の併用

Also Published As

Publication number Publication date
CN101965349A (zh) 2011-02-02
CA2694666C (en) 2015-07-14
EP2188290B1 (en) 2011-06-08
US20090048274A1 (en) 2009-02-19
WO2009021869A1 (en) 2009-02-19
CN101965349B (zh) 2016-05-04
JP2010535835A (ja) 2010-11-25
KR20100038431A (ko) 2010-04-14
ATE512152T1 (de) 2011-06-15
EP2188290A1 (en) 2010-05-26
JP5296790B2 (ja) 2013-09-25
MX2010001636A (es) 2010-03-15
AU2008288538A1 (en) 2009-02-19
US7968554B2 (en) 2011-06-28
CA2694666A1 (en) 2009-02-19
ES2366268T3 (es) 2011-10-18

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.