BRPI0815773A2 - composto, e, medicamento. - Google Patents
composto, e, medicamento.Info
- Publication number
- BRPI0815773A2 BRPI0815773A2 BRPI0815773A BRPI0815773A BRPI0815773A2 BR PI0815773 A2 BRPI0815773 A2 BR PI0815773A2 BR PI0815773 A BRPI0815773 A BR PI0815773A BR PI0815773 A BRPI0815773 A BR PI0815773A BR PI0815773 A2 BRPI0815773 A2 BR PI0815773A2
- Authority
- BR
- Brazil
- Prior art keywords
- medicine
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007225045 | 2007-08-31 | ||
| JP2008020009 | 2008-01-31 | ||
| JP2008123057 | 2008-05-09 | ||
| PCT/JP2008/065365 WO2009028588A1 (ja) | 2007-08-31 | 2008-08-28 | 多環式化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0815773A2 true BRPI0815773A2 (pt) | 2019-09-24 |
Family
ID=40387302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0815773A BRPI0815773A2 (pt) | 2007-08-31 | 2008-08-28 | composto, e, medicamento. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9453000B2 (pt) |
| EP (2) | EP2181992B8 (pt) |
| JP (1) | JP5433418B2 (pt) |
| KR (1) | KR20100055456A (pt) |
| CN (1) | CN101815713B (pt) |
| AR (1) | AR068121A1 (pt) |
| AU (1) | AU2008292390B2 (pt) |
| BR (1) | BRPI0815773A2 (pt) |
| CA (1) | CA2694401C (pt) |
| CL (1) | CL2008002542A1 (pt) |
| ES (1) | ES2529648T3 (pt) |
| IL (1) | IL203778A (pt) |
| MX (1) | MX2010002098A (pt) |
| MY (1) | MY150507A (pt) |
| NZ (1) | NZ583515A (pt) |
| PE (1) | PE20090674A1 (pt) |
| TW (1) | TW200916469A (pt) |
| WO (1) | WO2009028588A1 (pt) |
| ZA (1) | ZA201000474B (pt) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| US7935815B2 (en) * | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
| AR068121A1 (es) | 2007-08-31 | 2009-11-04 | Eisai R&D Man Co Ltd | Compuestos multiciclicos para tratar enfermedades neurodegenerativas |
| US20090124651A1 (en) * | 2007-08-31 | 2009-05-14 | H. Lundbeck A/S | Catecholamine derivatives and prodrugs thereof |
| CN102137855A (zh) * | 2008-08-27 | 2011-07-27 | 卫材R&D管理有限公司 | 制备某些肉桂酰胺化合物的方法 |
| HUE026815T2 (en) | 2008-11-19 | 2016-07-28 | Forum Pharmaceuticals Inc | Treatment of Cognitive Disorders with (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof |
| TW201030002A (en) | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
| BRPI1007883A2 (pt) * | 2009-02-26 | 2016-02-23 | Eisai R&D Man Co Ltd | sal, e, cristal. |
| RU2515976C2 (ru) | 2009-02-26 | 2014-05-20 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Азотсодержащие конденсированные гетероциклические соединения и их применение в качестве ингибиторов продукции бета-амилоида |
| JP2012121809A (ja) * | 2009-02-26 | 2012-06-28 | Eisai R & D Management Co Ltd | 多環式化合物の製造法およびその中間体 |
| JP2012051805A (ja) * | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | テトラヒドロトリアゾロピリジン誘導体の製造方法 |
| CN102573839A (zh) * | 2009-05-11 | 2012-07-11 | 加利福尼亚大学董事会 | 降低泛素化蛋白水平的方法 |
| AU2010247835A1 (en) * | 2009-05-11 | 2011-12-08 | Envivo Pharmaceuticals, Inc. | Treatment of cognitive disorders with certain alpha-7 nicotinic acid receptors in combination with acetylcholinesterase inhibitors |
| US20120165541A1 (en) * | 2009-07-31 | 2012-06-28 | Sandoz Ag | Method for the preparation of w-amino- alkaneamides and w-amino-alkanethioamides as well as intermediates of this method |
| PH12012501381A1 (en) | 2010-01-15 | 2012-10-22 | Janssen Pharmaceuticals Inc | Novel substituted bicyclic triazole derivatives as gamma secretase modulators |
| TWI519532B (zh) | 2010-05-17 | 2016-02-01 | 艾維沃製藥公司 | (R)-7-氯-N-(啶-3-基)苯並[b]噻吩-2-羧醯胺鹽酸鹽單水合物之結晶形體 |
| WO2012131539A1 (en) | 2011-03-31 | 2012-10-04 | Pfizer Inc. | Novel bicyclic pyridinones |
| RU2017136693A (ru) | 2012-05-08 | 2019-02-08 | Форум Фармасьютикалз, Инк. | Способы поддержания, лечения или улучшения когнитивной функции |
| CN104583208B (zh) | 2012-05-16 | 2016-09-28 | 杨森制药公司 | 可用于治疗(尤其是)阿尔茨海默病的取代的3,4-二氢-2H-吡啶并[1,2-a]吡嗪-1,6-二酮衍生物 |
| UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
| WO2014096212A1 (en) | 2012-12-20 | 2014-06-26 | Janssen Pharmaceutica Nv | NOVEL TRICYCLIC 3,4-DIHYDRO-2H-PYRIDO[1,2-α]PYRAZINE-1,6-DIONE DERIVATIVES AS GAMMA SECRETASE MODULATORS |
| KR102171710B1 (ko) | 2013-01-17 | 2020-10-30 | 얀센 파마슈티카 엔.브이. | 감마 세크레타제 조절 인자로서의 신규 치환 피리도-피페라지논 유도체 |
| US10372396B2 (en) * | 2013-02-21 | 2019-08-06 | Lenovo ( Singapore) Pte. Ltd. | Discovery and connection to wireless displays |
| US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
| KR102000382B1 (ko) | 2015-02-03 | 2019-07-15 | 화이자 인코포레이티드 | 신규 시클로프로파벤조푸라닐 피리도피라진디온 |
| CN117085022A (zh) * | 2017-06-02 | 2023-11-21 | Xeris药物公司 | 抗沉淀的小分子药物制剂 |
| KR20200118005A (ko) * | 2018-02-05 | 2020-10-14 | 위니베르시떼 드 스트라스부르 | 통증 치료용 화합물 및 조성물 |
| WO2020163704A1 (en) * | 2019-02-07 | 2020-08-13 | Alsatech, Inc. | Polyvalent derivatives of emoxypine |
| AU2023392783A1 (en) * | 2022-12-15 | 2025-06-19 | Sitryx Therapeutics Limited | Substituted pyridines for use in treating or preventing inflammatory diseases or diseases associated with an undesirable immune response |
| CN118459425B (zh) * | 2024-04-29 | 2025-11-14 | 南通华祥医药科技有限公司 | 一种吡咯烷-1-胺-二盐酸盐的制备方法 |
| CN121874396B (zh) * | 2026-03-20 | 2026-07-07 | 余姚市种子种苗管理站 | 一种鉴别长柄石杉与皱边石杉的分子标记引物组及其应用 |
Family Cites Families (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1101156A (en) * | 1965-09-22 | 1968-01-31 | Hickson & Welch Ltd | Triazole derivatives and their use as optical whitening agents |
| US3989816A (en) * | 1975-06-19 | 1976-11-02 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacycloheptan-2-ones |
| FR2314731A1 (fr) | 1975-06-19 | 1977-01-14 | Nelson Res & Dev | Azacycloalcan-2-ones 1-substituees et compositions pharmaceutiques contenant ces composes a titre d'excipients |
| US4508718A (en) | 1984-01-16 | 1985-04-02 | Warner-Lambert Company | Cardiotonic and antihypertensive oxadiazinone compounds |
| DE3689506D1 (de) | 1985-10-09 | 1994-02-17 | Shell Int Research | Neue Acrylsäureamide. |
| US4783463A (en) | 1985-10-23 | 1988-11-08 | Rorer Pharmaceutical Corporation | Pyridyl-pyridazinone and pyridyl-pyrazolinone compounds and their use in the treatment of congestive heart failure |
| DE3541716A1 (de) | 1985-11-26 | 1987-05-27 | Celamerck Gmbh & Co Kg | Neue acrylsaeureamide |
| FI91754C (fi) | 1986-12-02 | 1994-08-10 | Tanabe Seiyaku Co | Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi |
| FI902321A7 (fi) | 1989-05-19 | 1990-11-20 | Eisai Co Ltd | Buteenihappojohdannaiset |
| JPH03206042A (ja) * | 1990-01-06 | 1991-09-09 | Takeda Chem Ind Ltd | 降圧剤 |
| DE69126251T2 (de) | 1990-02-08 | 1997-09-25 | Eisai Co Ltd | Benzensulfonamidderivat |
| AU680870B2 (en) | 1993-04-28 | 1997-08-14 | Astellas Pharma Inc. | New heterocyclic compounds |
| GB9402807D0 (en) | 1994-02-14 | 1994-04-06 | Xenova Ltd | Pharmaceutical compounds |
| AU3577995A (en) | 1994-10-04 | 1996-04-26 | Fujisawa Pharmaceutical Co., Ltd. | Urea derivatives and their use as acat-inhibitors |
| JPH08283219A (ja) | 1995-04-07 | 1996-10-29 | Eisai Co Ltd | アラルキルアミノアルキルアミド誘導体 |
| US5804577A (en) * | 1995-09-12 | 1998-09-08 | Hoffmann-La Roche Inc. | Cephalosporin derivatives |
| EP0866705A4 (en) | 1995-10-19 | 1999-03-03 | Merck & Co Inc | FIBRINOGENIC RECEPTOR ANTAGONISTS |
| ATE215950T1 (de) | 1996-05-10 | 2002-04-15 | Icos Corp | Carbolinderivate |
| BR9710752A (pt) | 1996-07-22 | 1999-08-17 | Monsanto Co | Inbidores de metaloprotease de sulfonamida de tiol |
| US5672612A (en) | 1996-09-09 | 1997-09-30 | Pentech Pharmaceuticals, Inc. | Amorphous paroxetine composition |
| JP2001508767A (ja) | 1996-12-02 | 2001-07-03 | 藤沢薬品工業株式会社 | 5―ht拮抗作用を有するインドール―ウレア誘導体 |
| RU2189982C2 (ru) | 1997-03-31 | 2002-09-27 | Такеда Кемикал Индастриз, Лтд. | Азольные соединения, способ их получения, противогрибковая фармацевтическая композиция и способ лечения грибковой инфекции |
| JP3108997B2 (ja) | 1997-03-31 | 2000-11-13 | 武田薬品工業株式会社 | アゾール化合物、その製造法および用途 |
| IL131618A0 (en) | 1997-04-16 | 2001-01-28 | Abbott Lab | 5,7-Disubstituted aminopyrido [2,3-D] pyrimidine compounds and their use as adenosine kinase inhibitors |
| TW379224B (en) | 1997-12-02 | 2000-01-11 | Fujisawa Pharmaceutical Co | Urea derivatives |
| AU754965B2 (en) | 1997-12-31 | 2002-11-28 | University Of Kansas, The | Water soluble prodrugs of tertiary amine containing drugs and methods of making thereof |
| GB9816984D0 (en) | 1998-08-05 | 1998-09-30 | Smithkline Beecham Plc | Novel compounds |
| US6048678A (en) * | 1998-12-28 | 2000-04-11 | Eastman Kodak Company | Protective overcoat coating compositions |
| US6235728B1 (en) | 1999-02-19 | 2001-05-22 | Bristol-Myers Squibb Company | Water-soluble prodrugs of azole compounds |
| CN1348442A (zh) | 1999-02-26 | 2002-05-08 | 默克公司 | 新的磺胺化合物及其应用 |
| AU2899400A (en) | 1999-03-04 | 2000-09-21 | Nortran Pharmaceuticals Inc. | Aminocycloalkyl cinnamide compounds for arrhythmia and as analgesics and anesthetics |
| US20040087798A1 (en) | 2000-03-14 | 2004-05-06 | Akira Yamada | Novel amide compounds |
| US20010051642A1 (en) | 2000-04-17 | 2001-12-13 | Kyunghye Ahn | Method for treating Alzheimer's disease |
| AU2001254555A1 (en) | 2000-04-24 | 2001-11-07 | Merck Frosst Canada & Co | Method of treatment using phenyl and biaryl derivatives as prostaglandin E inhibitors and compounds useful therefore |
| US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
| NZ525917A (en) | 2000-12-04 | 2005-11-25 | F | Phenylethenyl or phenylethinyl derivatives as glutamate receptor antagonists and their use in treating mGLuR5 receptor mediated disorders |
| GB0108770D0 (en) | 2001-04-06 | 2001-05-30 | Eisai London Res Lab Ltd | Inhibitors |
| WO2003022273A1 (en) | 2001-09-13 | 2003-03-20 | Boehringer Ingelheim Pharmaceuticals, Inc. | Methods of treating cytokine mediated diseases |
| ATE363278T1 (de) | 2001-09-14 | 2007-06-15 | Novo Nordisk As | Neue liganden für die hisb10 zn2+ stellen des insulin-hexamers in der r-konformation |
| RU2004118719A (ru) * | 2001-11-22 | 2005-03-27 | Оно Фармасьютикал Ко., Лтд. (Jp) | Производные пиперидин-2-она и фармацевтические композиции, содержащие такие соединения в качестве активного ингредиента |
| MXPA04005427A (es) | 2001-12-10 | 2005-04-19 | Amgen Inc | Ligandos de receptor vainilloide y su uso en tratamientos. |
| DK1465861T3 (da) | 2001-12-20 | 2009-08-31 | Bristol Myers Squibb Co | Alpha-(N-sulfonamid)acetamidderivater som beta-amyloidhæmmere |
| JP2003206280A (ja) | 2001-12-28 | 2003-07-22 | Takeda Chem Ind Ltd | ビアリール化合物およびその用途 |
| EP1509505A2 (en) | 2002-01-23 | 2005-03-02 | Arena Pharmaceuticals, Inc. | SMALL MOLECULE MODULATORS OF THE 5−HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO |
| AU2003225668A1 (en) | 2002-03-01 | 2003-09-16 | Pintex Pharmaceutical, Inc. | Pin1-modulating compounds and methods of use thereof |
| GB0207436D0 (en) | 2002-03-28 | 2002-05-08 | Glaxo Group Ltd | Novel compounds |
| TW200307667A (en) * | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
| JP2005531574A (ja) | 2002-05-22 | 2005-10-20 | アムジエン・インコーポレーテツド | 痛みの治療にバニロイド受容体リガンドとして使用するためのアミノ−ピリジン、−ピリジンおよびピリダジン誘導体 |
| PT1511710E (pt) | 2002-05-31 | 2014-02-26 | Proteotech Inc | Compostos, composições e métodos para o tratamento de doenças da amiloide e sinucleínopatias tais como doença de alzheimer, diabetes do tipo 2, e doença de parkinson |
| AU2003247758A1 (en) | 2002-06-27 | 2004-01-19 | Elan Pharmaceuticals, Inc. | Methods for treating alzheimer's disease using hydroxyethylene compounds containing a heterocyclic amide bond isostere |
| AU2003249937A1 (en) | 2002-07-12 | 2004-02-02 | Sanofi-Aventis Deutschland Gmbh | Heterocyclically substituted benzoylureas, method for their production and their use as medicaments |
| US6900354B2 (en) | 2002-07-15 | 2005-05-31 | Hoffman-La Roche Inc. | 3-phenyl-propionamido, 3-phenyl-acrylamido and 3-phenyl-propynamido derivatives |
| AU2004210711B2 (en) | 2003-02-12 | 2010-07-08 | Transtech Pharma, Inc. | Substituted azole derivatives as therapeutic agents |
| CN1795165A (zh) | 2003-04-01 | 2006-06-28 | 普拉斯化学品有限公司 | 无定形辛伐他汀钙及其制备方法 |
| CN1787822A (zh) * | 2003-05-14 | 2006-06-14 | 托里派因斯疗法公司 | 化合物及其在调节淀粉样蛋白β中的用途 |
| CN102584813B (zh) * | 2003-05-14 | 2016-07-06 | Ngc药物公司 | 化合物及其在调节淀粉样蛋白β中的用途 |
| WO2005020921A2 (en) | 2003-08-29 | 2005-03-10 | Exelixis, Inc. | C-kit modulators and methods of use |
| AP2331A (en) | 2003-12-22 | 2011-12-05 | Pfizer | Triazole derivatives as vasopressin antagonists. |
| WO2005080346A1 (en) | 2004-02-12 | 2005-09-01 | Transtech Pharma, Inc. | Substituted azole derivatives, compositions, and methods of use |
| WO2005087768A1 (en) | 2004-03-09 | 2005-09-22 | Merck & Co., Inc. | Hiv integrase inhibitors |
| EP2261218B1 (en) * | 2004-05-26 | 2013-04-03 | Eisai R&D Management Co., Ltd. | Imidazole compound for use as an intermediate in the production of cinnamide compounds |
| US20080261952A1 (en) | 2004-08-16 | 2008-10-23 | Jason Bloxham | Aryl Urea Derivatives for Treating Obesity |
| KR20070083781A (ko) | 2004-10-26 | 2007-08-24 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 신나미드 화합물의 비정질체 |
| US20060241038A1 (en) | 2005-04-20 | 2006-10-26 | Eisai Co., Ltd. | Therapeutic agent for Abeta related disorders |
| WO2007034282A2 (en) | 2005-09-19 | 2007-03-29 | Pfizer Products Inc. | Diaryl-imidazole compounds condensed with a heterocycle as c3a receptor antagonists |
| CA2628047A1 (en) | 2005-11-18 | 2007-05-24 | Eisai R & D Management Co., Ltd. | Process for production of cinnamide derivative |
| EP1953151A4 (en) | 2005-11-18 | 2010-06-02 | Eisai R&D Man Co Ltd | SALTS FROM A CYNNAMIDE COMPOUND OR SOLVATE THEREOF |
| TWI386207B (zh) | 2005-11-24 | 2013-02-21 | Eisai R&D Man Co Ltd | 味啉類型之肉桂醯胺化合物 |
| US20070117839A1 (en) | 2005-11-24 | 2007-05-24 | Eisai R&D Management Co., Ltd. | Two cyclic cinnamide compound |
| TWI370130B (en) | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
| GEP20115139B (en) * | 2006-03-09 | 2011-01-10 | Eisai R&D Man Co Ltd | Polycyclic cinnamide derivative |
| TWI378091B (en) * | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
| SA07280403B1 (ar) * | 2006-07-28 | 2010-12-01 | إيساي أر أند دي منجمنت كو. ليمتد | ملح رباعي لمركب سيناميد |
| WO2008097538A1 (en) | 2007-02-08 | 2008-08-14 | Merck & Co., Inc. | Therapeutic agents |
| TW200848054A (en) * | 2007-02-28 | 2008-12-16 | Eisai R&D Man Co Ltd | Two cyclic oxomorpholine derivatives |
| WO2008137102A2 (en) | 2007-05-04 | 2008-11-13 | Torreypines Therapeutics, Inc. | Methods of modulating amyloid beta and compounds useful therefor |
| MX2009012177A (es) | 2007-05-07 | 2009-11-23 | Schering Corp | Moduladores de gamma-secretasa. |
| CN101675045B (zh) | 2007-05-11 | 2012-11-28 | 弗·哈夫曼-拉罗切有限公司 | 作为β-淀粉样蛋白调节剂的杂芳基苯胺 |
| WO2008156580A1 (en) | 2007-06-13 | 2008-12-24 | Merck & Co., Inc. | Triazole derivatives for treating alzheimer's disease and related conditions |
| CA2695543A1 (en) | 2007-08-06 | 2009-02-12 | Schering Corporation | Gamma secretase modulators |
| US7935815B2 (en) * | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
| AR068121A1 (es) | 2007-08-31 | 2009-11-04 | Eisai R&D Man Co Ltd | Compuestos multiciclicos para tratar enfermedades neurodegenerativas |
| MX2010006243A (es) | 2007-12-06 | 2010-08-31 | Schering Corp | Moduladores de gamma secretasa. |
| WO2009126311A1 (en) * | 2008-04-11 | 2009-10-15 | The University Of Texas, M.D. Anderson Cancer Center | Radiosensitization of tumors with indazolpyrrolotriazines for radiotherapy |
| CN102137855A (zh) | 2008-08-27 | 2011-07-27 | 卫材R&D管理有限公司 | 制备某些肉桂酰胺化合物的方法 |
| PT2401256E (pt) | 2009-02-26 | 2013-05-13 | Boehringer Ingelheim Int | Compostos como antagonistas da bradicinina b1 |
| UY32464A (es) | 2009-02-26 | 2010-09-30 | Glaxo Group Ltd | Nuevos compuestos de indazol |
| BRPI1007883A2 (pt) | 2009-02-26 | 2016-02-23 | Eisai R&D Man Co Ltd | sal, e, cristal. |
| JP2012051806A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | イミダゾリルピラジン誘導体 |
| JPWO2010098466A1 (ja) | 2009-02-27 | 2012-09-06 | Hoya株式会社 | 成形型およびプラスチックレンズの製造方法 |
| WO2011006903A1 (en) * | 2009-07-15 | 2011-01-20 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc | Substituted triazole and imidazole derivatives as gamma secretase modulators |
| US8381014B2 (en) * | 2010-05-06 | 2013-02-19 | International Business Machines Corporation | Node controller first failure error management for a distributed system |
-
2008
- 2008-08-28 AR ARP080103739A patent/AR068121A1/es unknown
- 2008-08-28 BR BRPI0815773A patent/BRPI0815773A2/pt not_active IP Right Cessation
- 2008-08-28 PE PE2008001455A patent/PE20090674A1/es not_active Application Discontinuation
- 2008-08-28 TW TW097132893A patent/TW200916469A/zh unknown
- 2008-08-28 EP EP08828870.9A patent/EP2181992B8/en active Active
- 2008-08-28 KR KR1020107005314A patent/KR20100055456A/ko not_active Abandoned
- 2008-08-28 EP EP12191398.2A patent/EP2559693B1/en active Active
- 2008-08-28 CA CA2694401A patent/CA2694401C/en not_active Expired - Fee Related
- 2008-08-28 MX MX2010002098A patent/MX2010002098A/es active IP Right Grant
- 2008-08-28 MY MYPI20100422 patent/MY150507A/en unknown
- 2008-08-28 JP JP2009530168A patent/JP5433418B2/ja not_active Expired - Fee Related
- 2008-08-28 NZ NZ583515A patent/NZ583515A/en not_active IP Right Cessation
- 2008-08-28 US US12/671,873 patent/US9453000B2/en not_active Expired - Fee Related
- 2008-08-28 ES ES12191398.2T patent/ES2529648T3/es active Active
- 2008-08-28 AU AU2008292390A patent/AU2008292390B2/en not_active Ceased
- 2008-08-28 CN CN200880104785XA patent/CN101815713B/zh not_active Expired - Fee Related
- 2008-08-28 CL CL2008002542A patent/CL2008002542A1/es unknown
- 2008-08-28 WO PCT/JP2008/065365 patent/WO2009028588A1/ja not_active Ceased
-
2010
- 2010-01-21 ZA ZA2010/00474A patent/ZA201000474B/en unknown
- 2010-02-08 IL IL203778A patent/IL203778A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TW200916469A (en) | 2009-04-16 |
| CA2694401C (en) | 2012-12-04 |
| EP2181992A1 (en) | 2010-05-05 |
| EP2559693B1 (en) | 2014-11-26 |
| CN101815713B (zh) | 2013-09-11 |
| JP5433418B2 (ja) | 2014-03-05 |
| MX2010002098A (es) | 2010-03-30 |
| EP2181992B1 (en) | 2013-05-01 |
| NZ583515A (en) | 2011-05-27 |
| CA2694401A1 (en) | 2009-03-05 |
| US9453000B2 (en) | 2016-09-27 |
| ZA201000474B (en) | 2011-05-25 |
| IL203778A (en) | 2013-11-28 |
| PE20090674A1 (es) | 2009-06-19 |
| ES2529648T3 (es) | 2015-02-24 |
| AR068121A1 (es) | 2009-11-04 |
| MY150507A (en) | 2014-01-30 |
| EP2181992B8 (en) | 2013-06-26 |
| WO2009028588A1 (ja) | 2009-03-05 |
| EP2559693A1 (en) | 2013-02-20 |
| KR20100055456A (ko) | 2010-05-26 |
| CN101815713A (zh) | 2010-08-25 |
| US20110009619A1 (en) | 2011-01-13 |
| EP2181992A4 (en) | 2011-09-14 |
| AU2008292390A1 (en) | 2009-03-05 |
| AU2008292390B2 (en) | 2013-04-04 |
| JPWO2009028588A1 (ja) | 2010-12-02 |
| CL2008002542A1 (es) | 2009-01-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2007002783S1 (es) | Inhalador multidosis. | |
| BRPI1010772A2 (pt) | composto,e, composição farmacêutica. | |
| BRPI0813235A2 (pt) | Combinação anti-helmíntica. | |
| BRPI0816408A2 (pt) | Fungicidas. | |
| FR2909857B1 (fr) | Endovalve. | |
| HRP20151058T1 (xx) | Ariloazol-2-il-cijanoetilamino-spojevi, postupak njihove proizvodnje i postupak njihove uporabe | |
| ATE513831T1 (de) | Pyridinä3,4-büpyrazinone | |
| BRPI0816970A2 (pt) | 1,3-dissubstituídas-4-fenil-1h-piridin-2-onas | |
| BRPI0814736A2 (pt) | inalador. | |
| DK2205562T3 (da) | 1,1,1-trifluor-2-hydroxy-3-phenylpropanderivater | |
| BRPI0807078A2 (pt) | Composto, e, formulação farmacêutica | |
| EP2023715A4 (en) | Indoleamine-2,3-dioxygenase 2 | |
| FR2900034B1 (fr) | Poudrier. | |
| BRPI0809684A2 (pt) | Embalagem, e embalagem | |
| FR2905564B1 (fr) | Fourrages. | |
| NL1032915A1 (nl) | Katheterpunt. | |
| FR2912872B1 (fr) | Tondeuse autoportee. | |
| FR2923713B1 (fr) | Composition reductrice epaissie. | |
| FR2915500B1 (fr) | Garde-corps. | |
| FI7604U1 (fi) | Tuntoelin | |
| FR2909834B1 (fr) | Andaineuse transversale. | |
| ITCE20060002A1 (it) | Patok. | |
| ES1061965Y (es) | Tractocamion polivalente. | |
| CL2008000712S1 (es) | Inhalador. | |
| ITPA20070017A1 (it) | Ciottola. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: dismissal - article 86 of industrial property law | ||
| B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |