CL2008000582A1 - Compuestos ciclicos derivados de oximorfolina condensados; farmacos que comprenden a dichos compuestos; y su uso para tratar enfermedad de alzheimer, demencia senil, sindrome de down o amiloidosis. - Google Patents
Compuestos ciclicos derivados de oximorfolina condensados; farmacos que comprenden a dichos compuestos; y su uso para tratar enfermedad de alzheimer, demencia senil, sindrome de down o amiloidosis.Info
- Publication number
- CL2008000582A1 CL2008000582A1 CL200800582A CL2008000582A CL2008000582A1 CL 2008000582 A1 CL2008000582 A1 CL 2008000582A1 CL 200800582 A CL200800582 A CL 200800582A CL 2008000582 A CL2008000582 A CL 2008000582A CL 2008000582 A1 CL2008000582 A1 CL 2008000582A1
- Authority
- CL
- Chile
- Prior art keywords
- compounds
- oximorpholine
- pharmaces
- amyloidosis
- condensed
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title 2
- 150000001875 compounds Chemical class 0.000 title 2
- 201000010374 Down Syndrome Diseases 0.000 title 1
- 206010039966 Senile dementia Diseases 0.000 title 1
- 206010002022 amyloidosis Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89199707P | 2007-02-28 | 2007-02-28 | |
| JP2007049085 | 2007-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2008000582A1 true CL2008000582A1 (es) | 2008-06-27 |
Family
ID=39716667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL200800582A CL2008000582A1 (es) | 2007-02-28 | 2008-02-26 | Compuestos ciclicos derivados de oximorfolina condensados; farmacos que comprenden a dichos compuestos; y su uso para tratar enfermedad de alzheimer, demencia senil, sindrome de down o amiloidosis. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20080207900A1 (es) |
| EP (1) | EP2125829B1 (es) |
| JP (1) | JP5244096B2 (es) |
| KR (1) | KR20090116704A (es) |
| CN (1) | CN101622258B (es) |
| AU (1) | AU2008221906C1 (es) |
| CA (1) | CA2678100A1 (es) |
| CL (1) | CL2008000582A1 (es) |
| PE (1) | PE20081791A1 (es) |
| TW (1) | TW200848054A (es) |
| WO (1) | WO2008108378A2 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY149038A (en) * | 2004-05-26 | 2013-07-15 | Eisai R&D Man Co Ltd | Cinnamide compound |
| ES2529648T3 (es) * | 2007-08-31 | 2015-02-24 | Eisai R&D Management Co., Ltd. | Compuesto policíclico |
| WO2009067493A2 (en) * | 2007-11-19 | 2009-05-28 | Envivo Pharmaceuticals, Inc. | 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders |
| JP2011507909A (ja) * | 2007-12-20 | 2011-03-10 | エンビボ ファーマシューティカルズ インコーポレイテッド | 四置換ベンゼン |
| BRPI1007883A2 (pt) | 2009-02-26 | 2016-02-23 | Eisai R&D Man Co Ltd | sal, e, cristal. |
| WO2010098487A1 (en) | 2009-02-26 | 2010-09-02 | Eisai R&D Management Co., Ltd. | Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors |
| US8481731B2 (en) * | 2009-06-24 | 2013-07-09 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical composition and methods relating thereto |
| EA201200046A1 (ru) * | 2009-06-24 | 2012-08-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Новые соединения, фармацевтическая композиция и связанные с ними способы |
| MX2012010657A (es) | 2010-03-15 | 2013-02-07 | Amgen Inc | Compuestos de espiro amino-dihidrooxazina y amino-dihidrotiazina como moduladores de beta-secretasa y su uso medico. |
| EP2547685A1 (en) | 2010-03-15 | 2013-01-23 | Amgen Inc. | Spiro-tetracyclic ring compounds as beta - secretase modulators |
| WO2012019056A1 (en) | 2010-08-05 | 2012-02-09 | Amgen Inc. | Amino-iso-indole, amino-aza-iso-indole, amino-dihydroisoquinoline and amino-benzoxazine compounds as beta-secretase modulators and methods of use |
| EP2643325A1 (en) | 2010-11-23 | 2013-10-02 | Amgen Inc. | Spiro-amino-imidazolone and spiro-amino-dihydro-pyrimidinone compounds as beta-secretase modulators and methods of use |
| EP2673279A1 (en) | 2011-02-07 | 2013-12-18 | Amgen Inc. | 5-amino-oxazepine and 5-amino-thiazepane compounds as beta-secretase antagonists and methods of use |
| EP2675810A1 (en) | 2011-02-15 | 2013-12-25 | Amgen Inc. | Spiro-amino-imidazo-fused heterocyclic compounds as beta-secretase modulators and methods of use |
| EP2691393B1 (en) | 2011-03-31 | 2016-09-14 | Pfizer Inc | Novel bicyclic pyridinones |
| WO2013044092A1 (en) | 2011-09-21 | 2013-03-28 | Amgen Inc. | Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use |
| UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
| WO2014078314A1 (en) | 2012-11-15 | 2014-05-22 | Amgen Inc. | Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use |
| MX368391B (es) | 2015-02-03 | 2019-09-30 | Pfizer | Ciclopropabenzofuranil-piridopirazindionas novedosas. |
| JP7662169B2 (ja) * | 2017-11-16 | 2025-04-15 | 株式会社幹細胞&デバイス研究所 | デバイス |
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-
2008
- 2008-02-26 CL CL200800582A patent/CL2008000582A1/es unknown
- 2008-02-26 US US12/037,315 patent/US20080207900A1/en not_active Abandoned
- 2008-02-26 PE PE2008000381A patent/PE20081791A1/es not_active Application Discontinuation
- 2008-02-26 TW TW097106596A patent/TW200848054A/zh unknown
- 2008-02-27 CN CN2008800066228A patent/CN101622258B/zh not_active Expired - Fee Related
- 2008-02-27 AU AU2008221906A patent/AU2008221906C1/en not_active Ceased
- 2008-02-27 US US12/522,281 patent/US8008293B2/en not_active Expired - Fee Related
- 2008-02-27 WO PCT/JP2008/053887 patent/WO2008108378A2/en not_active Ceased
- 2008-02-27 KR KR1020097014673A patent/KR20090116704A/ko not_active Ceased
- 2008-02-27 EP EP08721307A patent/EP2125829B1/en active Active
- 2008-02-27 CA CA002678100A patent/CA2678100A1/en not_active Abandoned
- 2008-02-27 JP JP2009513504A patent/JP5244096B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20090116704A (ko) | 2009-11-11 |
| CA2678100A1 (en) | 2008-09-12 |
| AU2008221906B2 (en) | 2012-04-12 |
| US20100113773A1 (en) | 2010-05-06 |
| JP5244096B2 (ja) | 2013-07-24 |
| EP2125829B1 (en) | 2013-01-16 |
| JP2010520152A (ja) | 2010-06-10 |
| AU2008221906A1 (en) | 2008-09-12 |
| CN101622258A (zh) | 2010-01-06 |
| US20080207900A1 (en) | 2008-08-28 |
| EP2125829A2 (en) | 2009-12-02 |
| US8008293B2 (en) | 2011-08-30 |
| WO2008108378A2 (en) | 2008-09-12 |
| AU2008221906C1 (en) | 2012-12-13 |
| TW200848054A (en) | 2008-12-16 |
| CN101622258B (zh) | 2012-06-13 |
| WO2008108378A3 (en) | 2008-12-04 |
| PE20081791A1 (es) | 2009-02-07 |
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