BRPI0816116A2 - Derivados de indol 2,3-substituídos para o tratamento de infecções virais. - Google Patents
Derivados de indol 2,3-substituídos para o tratamento de infecções virais.Info
- Publication number
- BRPI0816116A2 BRPI0816116A2 BRPI0816116-0A2A BRPI0816116A BRPI0816116A2 BR PI0816116 A2 BRPI0816116 A2 BR PI0816116A2 BR PI0816116 A BRPI0816116 A BR PI0816116A BR PI0816116 A2 BRPI0816116 A2 BR PI0816116A2
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- viral infections
- substituted indol
- indol derivatives
- derivatives
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 208000036142 Viral infection Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96874507P | 2007-08-29 | 2007-08-29 | |
| PCT/US2008/010130 WO2009032116A1 (en) | 2007-08-29 | 2008-08-27 | 2, 3-substituted indole derivatives for treating viral infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0816116A2 true BRPI0816116A2 (pt) | 2015-03-03 |
Family
ID=40220015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0816116-0A2A BRPI0816116A2 (pt) | 2007-08-29 | 2008-08-27 | Derivados de indol 2,3-substituídos para o tratamento de infecções virais. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8143305B2 (pt) |
| EP (1) | EP2197842B1 (pt) |
| JP (1) | JP5272007B2 (pt) |
| KR (1) | KR20100049667A (pt) |
| CN (1) | CN101842353A (pt) |
| AR (1) | AR068107A1 (pt) |
| AU (1) | AU2008295476B2 (pt) |
| BR (1) | BRPI0816116A2 (pt) |
| CA (1) | CA2697375A1 (pt) |
| CL (1) | CL2008002538A1 (pt) |
| CO (1) | CO6321236A2 (pt) |
| EC (1) | ECSP10010002A (pt) |
| MX (1) | MX2010002319A (pt) |
| PE (1) | PE20090995A1 (pt) |
| RU (1) | RU2010111550A (pt) |
| TW (1) | TW200924751A (pt) |
| WO (1) | WO2009032116A1 (pt) |
| ZA (1) | ZA201001335B (pt) |
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| EP2408761B1 (en) * | 2007-08-29 | 2014-01-01 | Merck Sharp & Dohme Corp. | Substituted indole derivatives and methods of use thereof |
| ATE541845T1 (de) * | 2007-08-29 | 2012-02-15 | Schering Corp | 2,3-substituierte azaindolderivate zur behandlung von virusinfektionen |
| US8377928B2 (en) * | 2007-11-16 | 2013-02-19 | Merck Sharp & Dohme Corp. | 3-aminosulfonyl substituted indole derivatives and methods of use thereof |
| MX2010005356A (es) * | 2007-11-16 | 2010-05-27 | Schering Corp | Derivados de indol 3-heterociclico sustituidos y metodos de uso de los mismos. |
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| EP2307372B1 (en) | 2008-07-23 | 2012-04-25 | F. Hoffmann-La Roche AG | Heterocyclic antiviral compounds |
| CN102164909A (zh) | 2008-09-26 | 2011-08-24 | 弗·哈夫曼-拉罗切有限公司 | 用于治疗hcv的吡啶或吡嗪衍生物 |
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| GB0323845D0 (en) | 2003-10-10 | 2003-11-12 | Angeletti P Ist Richerche Bio | Chemical compounds,compositions and uses |
| AR046833A1 (es) * | 2003-11-10 | 2005-12-28 | Schering Corp | Anticuerpos anti-interleuquina-10 |
| DE602005021760D1 (de) | 2004-02-27 | 2010-07-22 | Schering Corp | Schwefelverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus |
| US20070219212A1 (en) | 2004-03-01 | 2007-09-20 | Condon Stephen M | Pyranouidole Derivatives and the Use Thereof for the Treatment of Hepatitis C Virus Infection or Disease |
| AR049635A1 (es) * | 2004-05-06 | 2006-08-23 | Schering Corp | (1r,2s,5s)-n-((1s)-3-amino-1-(ciclobutilmetil)-2,3-dioxopropil)-3-((2s)-2-((((1,1-dimetiletil)amino)carbonil)amino)-3,3-dimetil-1-oxobutil)-6,6-dimetil-3-azabiciclo(3.1.0)hexan-2-carboxamida como inhibidor de la ns3/ns4a serina proteasa del virus de la hepatitis c |
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| WO2007084413A2 (en) | 2004-07-14 | 2007-07-26 | Ptc Therapeutics, Inc. | Methods for treating hepatitis c |
| US7153848B2 (en) | 2004-08-09 | 2006-12-26 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
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-
2008
- 2008-08-27 WO PCT/US2008/010130 patent/WO2009032116A1/en not_active Ceased
- 2008-08-27 PE PE2008001454A patent/PE20090995A1/es not_active Application Discontinuation
- 2008-08-27 EP EP08795611A patent/EP2197842B1/en active Active
- 2008-08-27 KR KR1020107006703A patent/KR20100049667A/ko not_active Withdrawn
- 2008-08-27 CN CN200880114487A patent/CN101842353A/zh active Pending
- 2008-08-27 BR BRPI0816116-0A2A patent/BRPI0816116A2/pt not_active IP Right Cessation
- 2008-08-27 TW TW097132720A patent/TW200924751A/zh unknown
- 2008-08-27 AR ARP080103716A patent/AR068107A1/es unknown
- 2008-08-27 MX MX2010002319A patent/MX2010002319A/es active IP Right Grant
- 2008-08-27 CA CA2697375A patent/CA2697375A1/en not_active Abandoned
- 2008-08-27 AU AU2008295476A patent/AU2008295476B2/en not_active Ceased
- 2008-08-27 RU RU2010111550/04A patent/RU2010111550A/ru not_active Application Discontinuation
- 2008-08-27 JP JP2010522925A patent/JP5272007B2/ja not_active Expired - Fee Related
- 2008-08-27 US US12/675,897 patent/US8143305B2/en not_active Expired - Fee Related
- 2008-08-28 CL CL2008002538A patent/CL2008002538A1/es unknown
-
2010
- 2010-02-24 ZA ZA2010/01335A patent/ZA201001335B/en unknown
- 2010-02-26 EC EC2010010002A patent/ECSP10010002A/es unknown
- 2010-03-25 CO CO10035485A patent/CO6321236A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US8143305B2 (en) | 2012-03-27 |
| ZA201001335B (en) | 2010-12-29 |
| ECSP10010002A (es) | 2010-03-31 |
| KR20100049667A (ko) | 2010-05-12 |
| EP2197842B1 (en) | 2012-05-23 |
| CL2008002538A1 (es) | 2009-07-17 |
| TW200924751A (en) | 2009-06-16 |
| CN101842353A (zh) | 2010-09-22 |
| CO6321236A2 (es) | 2011-09-20 |
| AU2008295476A1 (en) | 2009-03-12 |
| US20110033417A1 (en) | 2011-02-10 |
| PE20090995A1 (es) | 2009-08-03 |
| MX2010002319A (es) | 2010-03-22 |
| JP2010537979A (ja) | 2010-12-09 |
| JP5272007B2 (ja) | 2013-08-28 |
| AR068107A1 (es) | 2009-11-04 |
| WO2009032116A1 (en) | 2009-03-12 |
| RU2010111550A (ru) | 2011-10-10 |
| CA2697375A1 (en) | 2009-03-12 |
| EP2197842A1 (en) | 2010-06-23 |
| AU2008295476B2 (en) | 2013-08-01 |
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