BRPI0816116A2 - Derivados de indol 2,3-substituídos para o tratamento de infecções virais. - Google Patents
Derivados de indol 2,3-substituídos para o tratamento de infecções virais.Info
- Publication number
- BRPI0816116A2 BRPI0816116A2 BRPI0816116-0A2A BRPI0816116A BRPI0816116A2 BR PI0816116 A2 BRPI0816116 A2 BR PI0816116A2 BR PI0816116 A BRPI0816116 A BR PI0816116A BR PI0816116 A2 BRPI0816116 A2 BR PI0816116A2
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- viral infections
- substituted indol
- indol derivatives
- derivatives
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 208000036142 Viral infection Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96874507P | 2007-08-29 | 2007-08-29 | |
| PCT/US2008/010130 WO2009032116A1 (en) | 2007-08-29 | 2008-08-27 | 2, 3-substituted indole derivatives for treating viral infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0816116A2 true BRPI0816116A2 (pt) | 2015-03-03 |
Family
ID=40220015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0816116-0A2A BRPI0816116A2 (pt) | 2007-08-29 | 2008-08-27 | Derivados de indol 2,3-substituídos para o tratamento de infecções virais. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8143305B2 (pt) |
| EP (1) | EP2197842B1 (pt) |
| JP (1) | JP5272007B2 (pt) |
| KR (1) | KR20100049667A (pt) |
| CN (1) | CN101842353A (pt) |
| AR (1) | AR068107A1 (pt) |
| AU (1) | AU2008295476B2 (pt) |
| BR (1) | BRPI0816116A2 (pt) |
| CA (1) | CA2697375A1 (pt) |
| CL (1) | CL2008002538A1 (pt) |
| CO (1) | CO6321236A2 (pt) |
| EC (1) | ECSP10010002A (pt) |
| MX (1) | MX2010002319A (pt) |
| PE (1) | PE20090995A1 (pt) |
| RU (1) | RU2010111550A (pt) |
| TW (1) | TW200924751A (pt) |
| WO (1) | WO2009032116A1 (pt) |
| ZA (1) | ZA201001335B (pt) |
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| JP5211068B2 (ja) | 2006-12-22 | 2013-06-12 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｈｃｖおよび関連するウイルス疾患の治療または予防のための４，５−環インドール誘導体 |
| AU2007339382B2 (en) | 2006-12-22 | 2013-05-02 | Merck Sharp & Dohme Llc | 4,5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections |
| ATE541845T1 (de) * | 2007-08-29 | 2012-02-15 | Schering Corp | 2,3-substituierte azaindolderivate zur behandlung von virusinfektionen |
| TW200924780A (en) * | 2007-08-29 | 2009-06-16 | Schering Corp | 2-carboxy substituted indole derivatives and methods of use thereof |
| MX2010005356A (es) * | 2007-11-16 | 2010-05-27 | Schering Corp | Derivados de indol 3-heterociclico sustituidos y metodos de uso de los mismos. |
| CA2705587A1 (en) * | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-aminosulfonyl substituted indole derivatives and methods of use thereof |
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| PE20110409A1 (es) | 2008-07-23 | 2011-06-22 | Hoffmann La Roche | Compuestos heterociclicos antiviricos |
| CN102164909A (zh) | 2008-09-26 | 2011-08-24 | 弗·哈夫曼-拉罗切有限公司 | 用于治疗hcv的吡啶或吡嗪衍生物 |
| KR20120011880A (ko) | 2009-04-25 | 2012-02-08 | 에프. 호프만-라 로슈 아게 | 헤테로사이클릭 항바이러스성 화합물 |
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| TWI428332B (zh) | 2009-06-09 | 2014-03-01 | Hoffmann La Roche | 雜環抗病毒化合物 |
| BRPI1011744A2 (pt) | 2009-06-24 | 2016-03-22 | Hoffmann La Roche | composto antiviral heterocíclico. |
| AU2010297290A1 (en) | 2009-09-21 | 2012-03-15 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
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| US20050249702A1 (en) * | 2004-05-06 | 2005-11-10 | Schering Corporation | (1R,2S,5S)-N-[(1S)-3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide as inhibitor of hepatitis C virus NS3/NS4a serine protease |
| EP1604988A1 (en) | 2004-05-18 | 2005-12-14 | Sanofi-Aventis Deutschland GmbH | Pyridazinone derivatives, methods for producing them and their use as pharmaceuticals |
| WO2007084413A2 (en) | 2004-07-14 | 2007-07-26 | Ptc Therapeutics, Inc. | Methods for treating hepatitis c |
| US7153848B2 (en) | 2004-08-09 | 2006-12-26 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
| MX2007003371A (es) | 2004-09-23 | 2007-05-07 | Wyeth Corp | Derivados de carbazol y ciclopentaindol para tratar infeccion con virus de hepatitis c. |
| DE102004047272A1 (de) | 2004-09-24 | 2006-04-06 | Schering Ag | Inhibitoren der löslichen Adenylatzyklase |
| JP4149429B2 (ja) | 2004-10-26 | 2008-09-10 | 本田技研工業株式会社 | 車両の走行安全装置 |
| EP1807403A2 (en) | 2004-10-26 | 2007-07-18 | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. | Tetracyclic indole derivatives as antiviral agents |
| ZA200705872B (en) * | 2005-01-14 | 2008-09-25 | Genelabs Tecnologies Inc | Indole derivatives for treating viral infections |
| GB0518390D0 (en) | 2005-09-09 | 2005-10-19 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| US7482360B2 (en) | 2005-09-23 | 2009-01-27 | Schering Corporation | Fused tetracyclic mGluR1 antagonists as therapeutic agents |
| JP2009523732A (ja) | 2006-01-13 | 2009-06-25 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｃ型肝炎の治療方法 |
| EP1981524A2 (en) * | 2006-02-09 | 2008-10-22 | Schering Corporation | Combinations comprising hcv protease inhibitor(s) and hcv polymerase inhibitor(s), and methods of treatment related thereto |
| AU2007339382B2 (en) * | 2006-12-22 | 2013-05-02 | Merck Sharp & Dohme Llc | 4,5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections |
-
2008
- 2008-08-27 WO PCT/US2008/010130 patent/WO2009032116A1/en not_active Ceased
- 2008-08-27 AU AU2008295476A patent/AU2008295476B2/en not_active Ceased
- 2008-08-27 KR KR1020107006703A patent/KR20100049667A/ko not_active Withdrawn
- 2008-08-27 JP JP2010522925A patent/JP5272007B2/ja not_active Expired - Fee Related
- 2008-08-27 MX MX2010002319A patent/MX2010002319A/es active IP Right Grant
- 2008-08-27 EP EP08795611A patent/EP2197842B1/en active Active
- 2008-08-27 PE PE2008001454A patent/PE20090995A1/es not_active Application Discontinuation
- 2008-08-27 RU RU2010111550/04A patent/RU2010111550A/ru not_active Application Discontinuation
- 2008-08-27 US US12/675,897 patent/US8143305B2/en not_active Expired - Fee Related
- 2008-08-27 CN CN200880114487A patent/CN101842353A/zh active Pending
- 2008-08-27 AR ARP080103716A patent/AR068107A1/es unknown
- 2008-08-27 BR BRPI0816116-0A2A patent/BRPI0816116A2/pt not_active IP Right Cessation
- 2008-08-27 CA CA2697375A patent/CA2697375A1/en not_active Abandoned
- 2008-08-27 TW TW097132720A patent/TW200924751A/zh unknown
- 2008-08-28 CL CL2008002538A patent/CL2008002538A1/es unknown
-
2010
- 2010-02-24 ZA ZA2010/01335A patent/ZA201001335B/en unknown
- 2010-02-26 EC EC2010010002A patent/ECSP10010002A/es unknown
- 2010-03-25 CO CO10035485A patent/CO6321236A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20110033417A1 (en) | 2011-02-10 |
| ECSP10010002A (es) | 2010-03-31 |
| MX2010002319A (es) | 2010-03-22 |
| EP2197842A1 (en) | 2010-06-23 |
| AU2008295476B2 (en) | 2013-08-01 |
| JP5272007B2 (ja) | 2013-08-28 |
| US8143305B2 (en) | 2012-03-27 |
| CL2008002538A1 (es) | 2009-07-17 |
| CN101842353A (zh) | 2010-09-22 |
| KR20100049667A (ko) | 2010-05-12 |
| ZA201001335B (en) | 2010-12-29 |
| WO2009032116A1 (en) | 2009-03-12 |
| AU2008295476A1 (en) | 2009-03-12 |
| RU2010111550A (ru) | 2011-10-10 |
| TW200924751A (en) | 2009-06-16 |
| AR068107A1 (es) | 2009-11-04 |
| EP2197842B1 (en) | 2012-05-23 |
| JP2010537979A (ja) | 2010-12-09 |
| CO6321236A2 (es) | 2011-09-20 |
| CA2697375A1 (en) | 2009-03-12 |
| PE20090995A1 (es) | 2009-08-03 |
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