BRPI0816868A8 - Processo para a preparação de derivados de 2,2-difluoroetilamina, intermediários, seu uso e seu processo de preparação - Google Patents

Processo para a preparação de derivados de 2,2-difluoroetilamina, intermediários, seu uso e seu processo de preparação

Info

Publication number
BRPI0816868A8
BRPI0816868A8 BRPI0816868A BRPI0816868A BRPI0816868A8 BR PI0816868 A8 BRPI0816868 A8 BR PI0816868A8 BR PI0816868 A BRPI0816868 A BR PI0816868A BR PI0816868 A BRPI0816868 A BR PI0816868A BR PI0816868 A8 BRPI0816868 A8 BR PI0816868A8
Authority
BR
Brazil
Prior art keywords
preparation
difluoroethylamine derivatives
intermediates
difluoroethylamine
derivatives
Prior art date
Application number
BRPI0816868A
Other languages
English (en)
Inventor
Lui Norbert
Heinrich Jens-Dietmar
Original Assignee
Bayer Cropscience Ag
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Cropscience Ag, Bayer Ip Gmbh filed Critical Bayer Cropscience Ag
Publication of BRPI0816868A2 publication Critical patent/BRPI0816868A2/pt
Publication of BRPI0816868A8 publication Critical patent/BRPI0816868A8/pt
Publication of BRPI0816868B1 publication Critical patent/BRPI0816868B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCESSO PARA A PREPARAÇÃO DE DERIVADOS DE 2,2-DIFLUOROETILAMINA ATRAVÉS DA HIDROGENAÇÃO DE IMINA. A presente invenção refere-se a um processo para a preparação de derivados de 2,2-difluoroetilamina, sendo que compostos da fórmula geral (IV) são hidrogenados para os derivados de 2,2-difluoroetilamina correspondentes da fórmula geral (II), sendo que o radical A apresenta o significado indicado na descrição.
BRPI0816868A 2007-09-18 2008-09-05 processo para a preparação de derivados de 2,2-difluoroetilamina, intermediários, seu uso e seu processo de preparação BRPI0816868B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07116641A EP2039684A1 (de) 2007-09-18 2007-09-18 Verfahren zur Herstellung von 2,2-Difluorethylamin-Derivaten durch Imin-Hydrierung
PCT/EP2008/007272 WO2009036901A1 (de) 2007-09-18 2008-09-05 Verfahren zur herstellung von 2,2-difluorethylamin-derivaten durch imin-hydrierung

Publications (3)

Publication Number Publication Date
BRPI0816868A2 BRPI0816868A2 (pt) 2015-03-17
BRPI0816868A8 true BRPI0816868A8 (pt) 2015-10-27
BRPI0816868B1 BRPI0816868B1 (pt) 2016-05-17

Family

ID=38983732

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0816868A BRPI0816868B1 (pt) 2007-09-18 2008-09-05 processo para a preparação de derivados de 2,2-difluoroetilamina, intermediários, seu uso e seu processo de preparação

Country Status (12)

Country Link
US (1) US8324393B2 (pt)
EP (2) EP2039684A1 (pt)
JP (1) JP5295248B2 (pt)
KR (1) KR101520337B1 (pt)
CN (1) CN101835754B (pt)
BR (1) BRPI0816868B1 (pt)
DK (1) DK2200984T3 (pt)
ES (1) ES2445653T3 (pt)
IL (1) IL204000A (pt)
MX (1) MX2010002453A (pt)
TW (1) TWI402245B (pt)
WO (1) WO2009036901A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2230231A1 (de) * 2009-03-16 2010-09-22 Bayer CropScience AG Verfahren zur Herstellung von 2,2-Difluorethylamin-Derivaten durch Imin-Hydrierung
EP2582673B1 (de) * 2010-06-15 2014-08-06 Bayer Intellectual Property GmbH Verfahren zur herstellung von 2,2-difluorethylamin-derivaten durch alkylierung mit 2,2- difluor-1-halogenethanen
ES2533307T3 (es) 2010-11-12 2015-04-09 Bayer Intellectual Property Gmbh Procedimiento de preparación de derivados de 2,2-difluoroetilamina partiendo de n (2,2 difluoroetil)prop-2-en-1 amina
CN103201251B (zh) * 2010-11-12 2015-12-02 拜耳知识产权有限责任公司 由苄胺化合物起始制备2,2-二氟乙胺的方法
DK2638001T3 (da) * 2010-11-12 2014-09-22 Bayer Ip Gmbh Fremgangsmåde til fremstilling af 1,2-difluorethylamin gående ud fra prop-2-en-1-amin
DK2668151T3 (en) * 2011-01-24 2017-01-30 Bayer Ip Gmbh PROCEDURE FOR PREPARING 2,2-DIFLUORETHYLAMINE WITH BASIS IN 2,2-DIFLUOR-1-CHLORETHAN
DK2841413T3 (en) * 2012-04-26 2017-10-30 Bayer Cropscience Ag METHOD FOR PREPARING N- (5-CHLOR-2-ISOPROPYLBENZYL) CYCLOPROPANAMINE
CN104379564B (zh) 2012-06-29 2016-08-24 拜耳农作物科学股份公司 通过2,2-二氟乙胺的烷基化制备2,2-二氟乙胺衍生物的方法
JP6533233B2 (ja) 2014-03-21 2019-06-19 バイエル・クロップサイエンス・アクチェンゲゼルシャフト ２，２−ジフルオロエチルアミンをアルキル化することによりｎ−［（６−クロロピリジノ−３−イル）メチル］−２，２−ジフルオロエタン−１−アミンを調製する方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2476644A1 (fr) * 1980-02-21 1981-08-28 Sarget Lab Orthoarylydeneaminophenethylamine, leur preparation et leur utilisation therapeutique
DE3314196A1 (de) 1982-07-16 1983-09-29 CIBA-GEIGY AG, 4002 Basel Heterocyclylaether
NZ205525A (en) 1982-09-29 1985-12-13 Ici Australia Ltd 5-(pyridyl)-cyclohexene-1,3-dione derivatives and herbicidal compositions
DE122006000027I2 (de) * 1989-10-06 2010-10-21 Nippon Soda Co Aminderivate
WO1992000964A1 (fr) * 1990-07-05 1992-01-23 Nippon Soda Co., Ltd. Derive d'amine
JP3149989B2 (ja) * 1992-04-28 2001-03-26 広栄化学工業株式会社 ２−クロロ−５−置換アミノメチルピリジン類の製法
JPH0616636A (ja) * 1992-06-30 1994-01-25 Ishihara Sangyo Kaisha Ltd ６−クロロ−３−ピリジルメチルアミン類の製造方法
DE4308395A1 (de) * 1993-03-17 1994-09-22 Basf Ag Verfahren zur Bekämpfung von Schädlingen
JPH08245526A (ja) * 1995-03-10 1996-09-24 Sumitomo Chem Co Ltd 光学活性なアミン類、光学活性なイミン類およびそれらの製造法
DE10221121A1 (de) * 2002-05-13 2003-12-04 Bayer Cropscience Ag N'-Cyano-N-methyl-imidamid-Derivate
CA2575139A1 (en) * 2004-08-04 2006-02-16 Merck & Co., Inc. Diastereoselective reductive amination process
JP2007284352A (ja) 2004-08-05 2007-11-01 Dai Ichi Seiyaku Co Ltd ピラゾール誘導体
DE102004047922A1 (de) * 2004-10-01 2006-04-06 Bayer Cropscience Ag Wirkstoffe für die Saatgutbehandlung
DE102006015468A1 (de) 2006-03-31 2007-10-04 Bayer Cropscience Ag Substituierte Enaminocarbonylverbindungen
DE102006015467A1 (de) * 2006-03-31 2007-10-04 Bayer Cropscience Ag Substituierte Enaminocarbonylverbindungen
DE102006033572A1 (de) * 2006-07-20 2008-01-24 Bayer Cropscience Ag N'-Cyano-N-halogenalkyl-imidamid Derivate

Also Published As

Publication number Publication date
TW200922910A (en) 2009-06-01
CN101835754A (zh) 2010-09-15
EP2039684A1 (de) 2009-03-25
EP2200984A1 (de) 2010-06-30
JP2010539202A (ja) 2010-12-16
WO2009036901A1 (de) 2009-03-26
JP5295248B2 (ja) 2013-09-18
BRPI0816868A2 (pt) 2015-03-17
MX2010002453A (es) 2010-05-20
KR20100072026A (ko) 2010-06-29
KR101520337B1 (ko) 2015-05-14
IL204000A (en) 2013-11-28
DK2200984T3 (en) 2014-03-17
CN101835754B (zh) 2012-08-29
EP2200984B1 (de) 2013-12-18
US20100274021A1 (en) 2010-10-28
TWI402245B (zh) 2013-07-21
BRPI0816868B1 (pt) 2016-05-17
US8324393B2 (en) 2012-12-04
ES2445653T3 (es) 2014-03-04

Similar Documents

Publication Publication Date Title
BRPI0816868A8 (pt) Processo para a preparação de derivados de 2,2-difluoroetilamina, intermediários, seu uso e seu processo de preparação
BR112012007085B8 (pt) processos para a preparação de derivados de benzil-benzeno substituídos com glicopiranosila
BR112012032244A2 (pt) processo para preparar derivados de antranilamida com tetrazole-substituído e polimorfos cristalinos novos e derivados destes
BRPI0408347B8 (pt) derivados de pirimidina, seu uso, e composição e combinação farmacêuticas
ECSP11011470A (es) Nuevos derivados de pirimidina y sus usos en el tratamiento del cáncer y otras enfermedades
BRPI0511072B8 (pt) compostos derivados de alquinila como moduladores dos receptores de glutamato metabotróbico, seus usos e suas composições farmacêuticas
BRPI0717970C1 (pt) composto inibidor de 11betahsd1, composição farmacêutica, e, uso do composto
BRPI0816911A8 (pt) Processo para preparação de 4-aminobut-2-enolidas
BRPI0911105A2 (pt) compostos contendo um farmacóforo anti-inflamatório, composição farmacêutica, bem como seu uso
CR11623A (es) Compuestos
ECSP099750A (es) Imidazoquinolinas con propiedades inmunomoduladoras
BRPI0916995B8 (pt) compostos orgânicos, seu uso, e composição farmacêutica
BRPI0911208A2 (pt) moduladores inflamatórios antioxidantes: ácido oleanólico derivados com saturação no c-anel.
BR112014007193A2 (pt) derivados de pirazoloquinolinona, preparação dos mesmos e uso terapêutico dos mesmos
BRPI0510410A (pt) compostos orgánicos
BRPI0916069B8 (pt) composto, usos de um composto e composição farmacêutica
BRPI0719367B8 (pt) processo para a preparação de nebivolol, seus intermediários e usos
BRPI1008855B8 (pt) derivados de indol, seu uso como agentes anticâncer, seu processo para preparação e composição farmacêutica que os compreende
BR112013022671A2 (pt) processo para a preparação de aminas primárias, e, uso de um catalisador complexo
BRPI0510412A (pt) compostos orgánicos
ECSP10010192A (es) 5-[(3,3,3-trifluoro-2-hidroxi-1-arilpropil)amino]-1h-quinolin-2-onas, un proceso para su producción y su uso como agentes antiinflamatorios
UY32744A (es) Derivados de 2-carboxamida-7-piperazinil-benzofurano 774
BRPI0816830A8 (pt) Processo para a preparação de derivados de 2,2-diflúor-etilamina por hidrogenação de amida
BR112014003730A2 (pt) processo para a preparação de derivados de tietano
BR112012022949A2 (pt) processo para preparar, composição, uso.

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: BAYER INTELLECTUAL PROPERTY GMBH (DE)

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/09/2008, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 12A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2595 DE 29-09-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.