BRPI0819541A2 - "enzima mutante cetoácido reductoisomerase, molécula de ácido nucléico, célula recombinante e métodos para evolução e a identificação de uma enzima cetoácido reductoisomerase e para a produção de isobutanol" - Google Patents

"enzima mutante cetoácido reductoisomerase, molécula de ácido nucléico, célula recombinante e métodos para evolução e a identificação de uma enzima cetoácido reductoisomerase e para a produção de isobutanol"

Info

Publication number
BRPI0819541A2
BRPI0819541A2 BRPI0819541A BRPI0819541A BRPI0819541A2 BR PI0819541 A2 BRPI0819541 A2 BR PI0819541A2 BR PI0819541 A BRPI0819541 A BR PI0819541A BR PI0819541 A BRPI0819541 A BR PI0819541A BR PI0819541 A2 BRPI0819541 A2 BR PI0819541A2
Authority
BR
Brazil
Prior art keywords
enzyme
keto acid
acid reductoisomerase
evolution
reductoisomerase
Prior art date
Application number
BRPI0819541A
Other languages
English (en)
Inventor
P O'keefe Daniel
Liao Der-Ing
J Nelson Mark
Li Yougen
Original Assignee
Butamax Advanced Biofuels Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40385503&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0819541(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Butamax Advanced Biofuels Llc filed Critical Butamax Advanced Biofuels Llc
Publication of BRPI0819541A2 publication Critical patent/BRPI0819541A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/16—Butanols
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BRPI0819541A 2007-12-20 2008-12-18 "enzima mutante cetoácido reductoisomerase, molécula de ácido nucléico, célula recombinante e métodos para evolução e a identificação de uma enzima cetoácido reductoisomerase e para a produção de isobutanol" BRPI0819541A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1534607P 2007-12-20 2007-12-20
US10929708P 2008-10-29 2008-10-29
PCT/US2008/087429 WO2009085953A2 (en) 2007-12-20 2008-12-18 Ketol-acid reductoisomerase using nadh

Publications (1)

Publication Number Publication Date
BRPI0819541A2 true BRPI0819541A2 (pt) 2017-05-23

Family

ID=40385503

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0819541A BRPI0819541A2 (pt) 2007-12-20 2008-12-18 "enzima mutante cetoácido reductoisomerase, molécula de ácido nucléico, célula recombinante e métodos para evolução e a identificação de uma enzima cetoácido reductoisomerase e para a produção de isobutanol"

Country Status (6)

Country Link
US (3) US8129162B2 (pt)
EP (2) EP2222841B1 (pt)
BR (1) BRPI0819541A2 (pt)
CA (1) CA2709372A1 (pt)
ES (2) ES2575413T3 (pt)
WO (1) WO2009085953A2 (pt)

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US8188250B2 (en) 2008-04-28 2012-05-29 Butamax(Tm) Advanced Biofuels Llc Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans
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NZ591126A (en) 2008-09-29 2012-08-31 Butamax Tm Advanced Biofuels INCREASED HETEROLOGOUS Fe-S ENZYME ACTIIVTY IN YEAST
BRPI0914521A2 (pt) * 2008-10-27 2016-07-26 Butamax Advanced Biofuels Llc célula hospedeira microbiana recombinante, método de aumento da produção de isobutanol e método de produção de isobutanol
US20100143997A1 (en) 2008-10-31 2010-06-10 Thomas Buelter Engineered microorganisms capable of producing target compounds under anaerobic conditions
US8557562B2 (en) * 2008-12-29 2013-10-15 Butamax(Tm) Advanced Biofuels Llc Yeast with increased butanol tolerance involving filamentous growth response
US8455225B2 (en) * 2008-12-29 2013-06-04 Butamax Advanced Biofuels Llc Yeast with increased butanol tolerance involving high osmolarity/glycerol response pathway
US8795992B2 (en) * 2008-12-29 2014-08-05 Butamax Advanced Biofuels Llc Yeast with increased butanol tolerance involving cell wall integrity pathway
US8614085B2 (en) * 2009-02-27 2013-12-24 Butamax(Tm) Advanced Biofuels Llc Yeast with increased butanol tolerance involving a multidrug efflux pump gene
EP2419517A2 (en) 2009-04-13 2012-02-22 Butamax(TM) Advanced Biofuels LLC Method for producing butanol using extractive fermentation
WO2011011464A2 (en) * 2009-07-20 2011-01-27 Joule Unlimited, Inc. Constructs and methods for efficient transformation of micro-organisms for production of carbon-based products of interest
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BR112012006939A2 (pt) * 2009-09-29 2015-09-08 Butamax Tm Advanced Biofuels célula hospedeira de produção de levedura recombinante e método para a produção de um produto selecionado do grupo que consiste em 2,3-butanodiol, isobutanol, 2-butanol, 1-butanol, 2-butanona, valina, leucina, ácido lático, ácido málico, álcool, isoampilico e isoprenoides
IN2012DN02227A (pt) 2009-09-29 2015-08-21 Butamax Tm Advanced Biofuels
AU2010300722A1 (en) * 2009-09-29 2012-04-12 Butamax(Tm) Advanced Biofuels Llc Improved flux to acetolactate-derived products in lactic acid bacteria
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US20110136193A1 (en) 2009-11-23 2011-06-09 Butamax(Tm) Advanced Biofuels Llc Method for producing butanol using extractive fermentation with osmolyte addition
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US20120034666A1 (en) * 2009-11-24 2012-02-09 Gevo, Inc. Methods of increasing dihydroxy acid dehydratase activity to improve production of fuels, chemicals, and amino acids
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JP2013515507A (ja) 2009-12-29 2013-05-09 ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー 組換え宿主細胞におけるヘキソースキナーゼの発現
NZ600509A (en) 2009-12-29 2014-08-29 Butamax Tm Advanced Biofuels Alcohol dehydrogenases (adh) useful for fermentive production of lower alkyl alcohols
BR112012020589B8 (pt) 2010-02-17 2021-05-18 Butamax Tm Advanced Biofuels célula hospedeira recombinante de levedura, método para fabricar um produto, método para converter 2,3-diidroxiisovalerato em alfa-cetoisovalerato, método para aumentar a atividade específica de um polipeptídeo heterólogo, método para aumentar o fluxo em uma via biossintética e método para aumentar a atividade de uma proteína
MX2012014550A (es) 2010-06-17 2013-01-29 Butamax Tm Advanced Biofuels Cultivo de produccion de levadura para la produccion de butanol.
US9206448B2 (en) 2010-06-18 2015-12-08 Butamax Advanced Biofuels Llc Extraction solvents derived from oil for alcohol removal in extractive fermentation
US8871488B2 (en) 2010-06-18 2014-10-28 Butamax Advanced Biofuels Llc Recombinant host cells comprising phosphoketolases
JP2013533742A (ja) 2010-06-18 2013-08-29 ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー 抽出発酵におけるアルコール除去のための、油に由来する抽出溶媒
US9012190B2 (en) 2011-06-15 2015-04-21 Butamax Advanced Biofuels Llc Use of thiamine and nicotine adenine dinucleotide for butanol production
US9040263B2 (en) 2010-07-28 2015-05-26 Butamax Advanced Biofuels Llc Production of alcohol esters and in situ product removal during alcohol fermentation
CA2810244C (en) 2010-09-07 2020-10-06 Butamax(Tm) Advanced Biofuels Llc Integration of a polynucleotide encoding a polypeptide that catalyzes pyruvate to acetolactate conversion
US20130040340A1 (en) 2011-02-07 2013-02-14 E. I. Du Pont De Nemours And Company Production of alcohol esters in situ using alcohols and fatty acids produced by microorganisms
US8765425B2 (en) 2011-03-23 2014-07-01 Butamax Advanced Biofuels Llc In situ expression of lipase for enzymatic production of alcohol esters during fermentation
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WO2012129555A2 (en) * 2011-03-24 2012-09-27 Butamax (Tm) Advanced Biofuels Llc Host cells and methods for production of isobutanol
US20140295512A1 (en) * 2011-06-16 2014-10-02 California Institute Of Technology Ketol-Acid Reductoisomerases With Improved Performance Properties
EP2721163B1 (en) 2011-06-17 2016-12-21 Butamax Advanced Biofuels LLC Co-products from biofuel production processes and methods of making
AU2012286640B2 (en) 2011-07-28 2016-09-01 Butamax Advanced Biofuels Llc Keto-isovalerate decarboxylase enzymes and methods of use thereof
JP5803563B2 (ja) 2011-10-24 2015-11-04 トヨタ自動車株式会社 イソブタノールの製造方法
EP2788096A2 (en) 2011-12-09 2014-10-15 Butamax Advanced Biofuels LLC Process to remove product alcohols from fermentation broth
JP2015503351A (ja) 2011-12-30 2015-02-02 ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー ブタノール生産のための遺伝的スイッチ
CA2861613A1 (en) 2011-12-30 2013-07-04 Butamax Advanced Biofuels Llc Fermentative production of alcohols
CA2868153A1 (en) 2012-03-23 2013-09-26 Butamax Advanced Biofuels Llc Acetate supplemention of medium for butanologens
CN104619835B (zh) 2012-05-11 2018-06-19 布特马斯先进生物燃料有限责任公司 酮醇酸还原异构酶及其使用方法
US20140024064A1 (en) 2012-07-23 2014-01-23 Butamax(Tm) Advanced Biofuels Llc Processes and systems for the production of fermentative alcohols
AU2013305714A1 (en) 2012-08-22 2015-02-05 Butamax Advanced Biofuels Llc Production of fermentation products
WO2014043288A1 (en) 2012-09-12 2014-03-20 Butamax Advanced Biofuels Llc Processes and systems for the production of fermentation products
WO2014047421A1 (en) 2012-09-21 2014-03-27 Butamax(Tm) Advanced Biofuels Llc Production of renewable hydrocarbon compositions
CA2886157A1 (en) 2012-09-26 2014-04-03 Butamax Advanced Biofuels Llc Polypeptides with ketol-acid reductoisomerase activity
WO2014052735A1 (en) 2012-09-28 2014-04-03 Butamax Advanced Biofuels Llc Production of fermentation products
US9273330B2 (en) 2012-10-03 2016-03-01 Butamax Advanced Biofuels Llc Butanol tolerance in microorganisms
CA2887574A1 (en) 2012-10-11 2014-04-17 Butamax Advanced Biofuels Llc Processes and systems for the production of fermentation products
US9650624B2 (en) 2012-12-28 2017-05-16 Butamax Advanced Biofuels Llc DHAD variants for butanol production
WO2014105840A1 (en) 2012-12-31 2014-07-03 Butamax Advanced Biofuels Llc Fermentative production of alcohols
WO2014159309A1 (en) 2013-03-12 2014-10-02 Butamax Advanced Biofuels Llc Processes and systems for the production of alcohols
AU2014244216A1 (en) 2013-03-14 2015-09-24 E.I. Du Pont De Nemours And Company Glycerol 3- phosphate dehydrogenase for butanol production
US9771602B2 (en) 2013-03-15 2017-09-26 Butamax Advanced Biofuels Llc Competitive growth and/or production advantage for butanologen microorganism
US9156760B2 (en) 2013-03-15 2015-10-13 Butamax Advanced Biofuels Llc Method for production of butanol using extractive fermentation
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JP5845210B2 (ja) * 2013-06-13 2016-01-20 トヨタ自動車株式会社 組換え酵母、及びそれを用いたエタノールの製造方法
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KR101960501B1 (ko) * 2017-09-15 2019-03-21 고려대학교 산학협력단 Ｎａｄｈ 친화적인 신규 케톨산 리덕토아이소머라제
GB201916020D0 (en) 2019-11-04 2019-12-18 Univ Of Essex Enterprise Limited Crispr-mediated identification of biotinylated proteins and chromatin regions
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CN119639703B (zh) * 2024-11-29 2025-09-23 江南大学 一种生产1,4-环己烷二甲胺的重组菌及多酶级联生产1,4-环己烷二甲胺的方法

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Also Published As

Publication number Publication date
CA2709372A1 (en) 2009-07-09
US20120115197A1 (en) 2012-05-10
EP2222841B1 (en) 2015-08-26
WO2009085953A3 (en) 2009-09-03
US8129162B2 (en) 2012-03-06
EP2222841A2 (en) 2010-09-01
ES2553726T3 (es) 2015-12-11
US8222017B2 (en) 2012-07-17
US20130072394A1 (en) 2013-03-21
US20090163376A1 (en) 2009-06-25
EP2677028A1 (en) 2013-12-25
ES2575413T3 (es) 2016-06-28
EP2677028B1 (en) 2016-03-09
US8895307B2 (en) 2014-11-25
WO2009085953A2 (en) 2009-07-09

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