BRPI0819661A2 - derivados de pirazol como inibidores de 5-lo - Google Patents
derivados de pirazol como inibidores de 5-loInfo
- Publication number
- BRPI0819661A2 BRPI0819661A2 BRPI0819661A BRPI0819661A BRPI0819661A2 BR PI0819661 A2 BRPI0819661 A2 BR PI0819661A2 BR PI0819661 A BRPI0819661 A BR PI0819661A BR PI0819661 A BRPI0819661 A BR PI0819661A BR PI0819661 A2 BRPI0819661 A2 BR PI0819661A2
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitors
- pyrazole derivatives
- pyrazole
- derivatives
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 150000003217 pyrazoles Chemical class 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P11/08—Bronchodilators
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
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- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US426107P | 2007-11-26 | 2007-11-26 | |
| US423607P | 2007-11-26 | 2007-11-26 | |
| US5549708P | 2008-05-23 | 2008-05-23 | |
| PCT/IB2008/054873 WO2009069044A1 (en) | 2007-11-26 | 2008-11-20 | Pyrazole derivatives as 5-lo inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0819661A2 true BRPI0819661A2 (pt) | 2019-09-24 |
Family
ID=40568336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0819661A BRPI0819661A2 (pt) | 2007-11-26 | 2008-11-20 | derivados de pirazol como inibidores de 5-lo |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US8097733B2 (pt) |
| EP (1) | EP2225229A1 (pt) |
| JP (1) | JP4718650B2 (pt) |
| KR (1) | KR20100072090A (pt) |
| CN (1) | CN101918392A (pt) |
| AP (1) | AP2010005269A0 (pt) |
| AR (1) | AR069743A1 (pt) |
| AU (1) | AU2008331199A1 (pt) |
| BR (1) | BRPI0819661A2 (pt) |
| CA (1) | CA2705729C (pt) |
| CL (1) | CL2008003495A1 (pt) |
| CO (1) | CO6280402A2 (pt) |
| CR (1) | CR11392A (pt) |
| DO (1) | DOP2010000155A (pt) |
| EA (1) | EA201000703A1 (pt) |
| EC (1) | ECSP10010200A (pt) |
| IL (1) | IL205602A0 (pt) |
| MA (1) | MA31863B1 (pt) |
| MX (1) | MX2010004604A (pt) |
| NI (1) | NI201000089A (pt) |
| PA (1) | PA8805301A1 (pt) |
| PE (1) | PE20091069A1 (pt) |
| SV (1) | SV2010003579A (pt) |
| TN (1) | TN2010000231A1 (pt) |
| TW (1) | TW200927098A (pt) |
| UY (1) | UY31487A1 (pt) |
| WO (1) | WO2009069044A1 (pt) |
| ZA (1) | ZA201002758B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009248774B2 (en) | 2008-05-23 | 2012-05-31 | Novartis Ag | Derivatives of quinolines and quinoxalines as protein tyrosine kinase inhibitors |
| WO2011137363A1 (en) * | 2010-04-30 | 2011-11-03 | Allergan, Inc. | Novel treatment for age related macular degeneration and ocular ischemic disease associated with complement activation by targeting 5-lipoxygenase |
| WO2011161615A1 (en) | 2010-06-24 | 2011-12-29 | Ranbaxy Laboratories Limited | 5-lipoxygenase inhibitors |
| MX2016001134A (es) * | 2013-07-29 | 2016-04-29 | Merck Patent Gmbh | Derivados 1,3-disustituidos de ciclopentano. |
| GB201403605D0 (en) * | 2014-02-28 | 2014-04-16 | Mologic Ltd | Monitoring inflammation status |
| BR122020001830B1 (pt) | 2015-05-18 | 2023-02-28 | Shenyang Sinochem Agrochemicals R&D Co., LTD | Compostos pirazol substituídos contendo pirimidinila, preparação e aplicação dos mesmos |
| CN111825678A (zh) * | 2020-06-05 | 2020-10-27 | 连庆泉 | 一种卡马替尼的制备方法 |
| US12569481B2 (en) | 2020-06-12 | 2026-03-10 | Vanderbilt University | Methods of treatment for gastrointestinal motility disorders |
| CN116546990B (zh) * | 2020-11-25 | 2026-05-26 | 润佳（苏州）医药科技有限公司 | Cd73抑制剂及其药学应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5254581A (en) | 1990-06-21 | 1993-10-19 | Imperial Chemical Industries Plc | Pyran derivatives and their use as inhibitors of 5-lipoxygenase |
| US5272173A (en) | 1990-11-28 | 1993-12-21 | Imperial Chemical Industries Plc | 5-lipoxygenase inhibitors |
| IE913866A1 (en) | 1990-11-28 | 1992-06-03 | Ici Plc | Aryl derivatives |
| GB9300894D0 (en) | 1992-02-07 | 1993-03-10 | Zeneca Ltd | Oxime derivatives |
| US5883106A (en) | 1994-10-18 | 1999-03-16 | Pfizer Inc. | 5-lipoxygenase inhibitors |
| US6063928A (en) | 1994-10-18 | 2000-05-16 | Pfizer Inc | 5-lipoxygenase inhibitors |
| SK281577B6 (sk) * | 1994-10-18 | 2001-05-10 | Pfizer Inc. | Heterocyklické zlúčeniny a farmaceutický prostriedok na ich báze |
| JP3400392B2 (ja) * | 1994-10-18 | 2003-04-28 | ファイザー製薬株式会社 | ５−リポキシゲナーゼ阻害剤及び新規医薬組成物 |
| US6239285B1 (en) | 1998-02-06 | 2001-05-29 | Pfizer Inc | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems |
| CA2636043A1 (en) | 2006-01-23 | 2007-08-02 | Amira Pharmaceuticals, Inc. | Tricyclic inhibitors of 5-lipoxygenase |
| EP1834953A1 (en) | 2006-03-14 | 2007-09-19 | Ranbaxy Laboratories Limited | Tetrahydropyrane derivatives as 5-lipoxygenase inhibitors |
| JP4469924B2 (ja) * | 2006-11-27 | 2010-06-02 | ファイザー・プロダクツ・インク | ピラゾール類似体 |
-
2008
- 2008-11-20 CN CN2008801178682A patent/CN101918392A/zh active Pending
- 2008-11-20 JP JP2010535484A patent/JP4718650B2/ja not_active Expired - Fee Related
- 2008-11-20 KR KR1020107011376A patent/KR20100072090A/ko not_active Ceased
- 2008-11-20 EA EA201000703A patent/EA201000703A1/ru unknown
- 2008-11-20 AP AP2010005269A patent/AP2010005269A0/en unknown
- 2008-11-20 CA CA2705729A patent/CA2705729C/en not_active Expired - Fee Related
- 2008-11-20 MX MX2010004604A patent/MX2010004604A/es not_active Application Discontinuation
- 2008-11-20 EP EP08853504A patent/EP2225229A1/en not_active Withdrawn
- 2008-11-20 WO PCT/IB2008/054873 patent/WO2009069044A1/en not_active Ceased
- 2008-11-20 AU AU2008331199A patent/AU2008331199A1/en not_active Abandoned
- 2008-11-20 BR BRPI0819661A patent/BRPI0819661A2/pt not_active IP Right Cessation
- 2008-11-24 CL CL2008003495A patent/CL2008003495A1/es unknown
- 2008-11-24 US US12/276,779 patent/US8097733B2/en not_active Expired - Fee Related
- 2008-11-25 TW TW097145472A patent/TW200927098A/zh unknown
- 2008-11-25 PE PE2008001974A patent/PE20091069A1/es not_active Application Discontinuation
- 2008-11-25 UY UY31487A patent/UY31487A1/es not_active Application Discontinuation
- 2008-11-26 PA PA20088805301A patent/PA8805301A1/es unknown
- 2008-11-26 AR ARP080105131A patent/AR069743A1/es not_active Application Discontinuation
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2010
- 2010-04-20 ZA ZA2010/02758A patent/ZA201002758B/en unknown
- 2010-04-26 CR CR11392A patent/CR11392A/es not_active Application Discontinuation
- 2010-05-06 IL IL205602A patent/IL205602A0/en unknown
- 2010-05-21 TN TN2010000231A patent/TN2010000231A1/fr unknown
- 2010-05-24 DO DO2010000155A patent/DOP2010000155A/es unknown
- 2010-05-25 NI NI201000089A patent/NI201000089A/es unknown
- 2010-05-26 MA MA32869A patent/MA31863B1/fr unknown
- 2010-05-26 SV SV2010003579A patent/SV2010003579A/es not_active Application Discontinuation
- 2010-05-26 EC EC2010010200A patent/ECSP10010200A/es unknown
- 2010-05-26 CO CO10063358A patent/CO6280402A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PA8805301A1 (es) | 2009-06-23 |
| PE20091069A1 (es) | 2009-07-19 |
| ECSP10010200A (es) | 2010-06-29 |
| US20090227634A1 (en) | 2009-09-10 |
| MX2010004604A (es) | 2010-08-04 |
| IL205602A0 (en) | 2010-11-30 |
| KR20100072090A (ko) | 2010-06-29 |
| CO6280402A2 (es) | 2011-05-20 |
| CN101918392A (zh) | 2010-12-15 |
| JP4718650B2 (ja) | 2011-07-06 |
| ZA201002758B (en) | 2011-06-29 |
| AU2008331199A1 (en) | 2009-06-04 |
| CR11392A (es) | 2010-05-28 |
| AP2010005269A0 (en) | 2010-06-30 |
| SV2010003579A (es) | 2011-03-23 |
| UY31487A1 (es) | 2009-07-17 |
| DOP2010000155A (es) | 2010-07-15 |
| JP2011504514A (ja) | 2011-02-10 |
| WO2009069044A1 (en) | 2009-06-04 |
| TN2010000231A1 (fr) | 2011-11-11 |
| CL2008003495A1 (es) | 2010-03-12 |
| CA2705729C (en) | 2012-09-18 |
| CA2705729A1 (en) | 2009-06-04 |
| MA31863B1 (fr) | 2010-11-01 |
| AR069743A1 (es) | 2010-02-17 |
| EP2225229A1 (en) | 2010-09-08 |
| EA201000703A1 (ru) | 2010-12-30 |
| TW200927098A (en) | 2009-07-01 |
| US8097733B2 (en) | 2012-01-17 |
| NI201000089A (es) | 2010-10-05 |
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Legal Events
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |