DOP2010000155A - Derivados de pirazol como inhibidores de 5-lo - Google Patents

Derivados de pirazol como inhibidores de 5-lo

Info

Publication number
DOP2010000155A
DOP2010000155A DO2010000155A DO2010000155A DOP2010000155A DO P2010000155 A DOP2010000155 A DO P2010000155A DO 2010000155 A DO2010000155 A DO 2010000155A DO 2010000155 A DO2010000155 A DO 2010000155A DO P2010000155 A DOP2010000155 A DO P2010000155A
Authority
DO
Dominican Republic
Prior art keywords
inhibitors
pirazol derivatives
pirazol
derivatives
lipoxygenase
Prior art date
Application number
DO2010000155A
Other languages
English (en)
Inventor
Matthew William Mahoney
Matthew J Graneto
Edgardo Alvira
Margaret Lanahan Grapperhaus
Kaliappan Iyanar
Todd Michael Maddux
Mark Alan Massa
Kirby Ray Sample
Michelle Ann Schmidt
Ronald Edward Seidel
Jon Gordon Selbo
Michael Brent Tollefson
Richard Alan Vonder Embse
Grace Mary Wagner
Scott Santford Woodard
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DOP2010000155A publication Critical patent/DOP2010000155A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)

Abstract

La presente se refiere a los compuestos de la formula (I) Procedimientos para su preparación, su uso como inhibidores de 5-lipoxigenasa y composiciones farmacéuticas que los contienen.
DO2010000155A 2007-11-26 2010-05-24 Derivados de pirazol como inhibidores de 5-lo DOP2010000155A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US423607P 2007-11-26 2007-11-26
US426107P 2007-11-26 2007-11-26
US5549708P 2008-05-23 2008-05-23

Publications (1)

Publication Number Publication Date
DOP2010000155A true DOP2010000155A (es) 2010-07-15

Family

ID=40568336

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2010000155A DOP2010000155A (es) 2007-11-26 2010-05-24 Derivados de pirazol como inhibidores de 5-lo

Country Status (28)

Country Link
US (1) US8097733B2 (es)
EP (1) EP2225229A1 (es)
JP (1) JP4718650B2 (es)
KR (1) KR20100072090A (es)
CN (1) CN101918392A (es)
AP (1) AP2010005269A0 (es)
AR (1) AR069743A1 (es)
AU (1) AU2008331199A1 (es)
BR (1) BRPI0819661A2 (es)
CA (1) CA2705729C (es)
CL (1) CL2008003495A1 (es)
CO (1) CO6280402A2 (es)
CR (1) CR11392A (es)
DO (1) DOP2010000155A (es)
EA (1) EA201000703A1 (es)
EC (1) ECSP10010200A (es)
IL (1) IL205602A0 (es)
MA (1) MA31863B1 (es)
MX (1) MX2010004604A (es)
NI (1) NI201000089A (es)
PA (1) PA8805301A1 (es)
PE (1) PE20091069A1 (es)
SV (1) SV2010003579A (es)
TN (1) TN2010000231A1 (es)
TW (1) TW200927098A (es)
UY (1) UY31487A1 (es)
WO (1) WO2009069044A1 (es)
ZA (1) ZA201002758B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5351254B2 (ja) 2008-05-23 2013-11-27 ノバルティス アーゲー キノキサリン−およびキノリン−カルボキシアミド誘導体
WO2011137363A1 (en) * 2010-04-30 2011-11-03 Allergan, Inc. Novel treatment for age related macular degeneration and ocular ischemic disease associated with complement activation by targeting 5-lipoxygenase
WO2011161615A1 (en) 2010-06-24 2011-12-29 Ranbaxy Laboratories Limited 5-lipoxygenase inhibitors
CA2919552C (en) * 2013-07-29 2022-03-15 Merck Patent Gmbh 1,3-disubstituted cyclopentane derivatives
GB201403605D0 (en) * 2014-02-28 2014-04-16 Mologic Ltd Monitoring inflammation status
BR122020001830B1 (pt) 2015-05-18 2023-02-28 Shenyang Sinochem Agrochemicals R&D Co., LTD Compostos pirazol substituídos contendo pirimidinila, preparação e aplicação dos mesmos
CN111825678A (zh) * 2020-06-05 2020-10-27 连庆泉 一种卡马替尼的制备方法
WO2021252951A1 (en) 2020-06-12 2021-12-16 Vanderbilt University Methods of treatment for gastrointestinal motility disorders
AU2021389685A1 (en) * 2020-11-25 2023-07-06 Risen (Suzhou) Pharma Tech Co., Ltd. Cd73 inhibitors and pharmaceutical uses thereof

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
US5254581A (en) 1990-06-21 1993-10-19 Imperial Chemical Industries Plc Pyran derivatives and their use as inhibitors of 5-lipoxygenase
US5272173A (en) 1990-11-28 1993-12-21 Imperial Chemical Industries Plc 5-lipoxygenase inhibitors
IE913866A1 (en) 1990-11-28 1992-06-03 Ici Plc Aryl derivatives
GB9300894D0 (en) 1992-02-07 1993-03-10 Zeneca Ltd Oxime derivatives
US6063928A (en) 1994-10-18 2000-05-16 Pfizer Inc 5-lipoxygenase inhibitors
US5883106A (en) 1994-10-18 1999-03-16 Pfizer Inc. 5-lipoxygenase inhibitors
SK281577B6 (sk) * 1994-10-18 2001-05-10 Pfizer Inc. Heterocyklické zlúčeniny a farmaceutický prostriedok na ich báze
JP3400392B2 (ja) * 1994-10-18 2003-04-28 ファイザー製薬株式会社 ５−リポキシゲナーゼ阻害剤及び新規医薬組成物
US6239285B1 (en) 1998-02-06 2001-05-29 Pfizer Inc Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems
WO2007087250A2 (en) 2006-01-23 2007-08-02 Amira Pharmaceuticals, Inc. Tricyclic inhibitors of 5-lipoxygenase
EP1834953A1 (en) 2006-03-14 2007-09-19 Ranbaxy Laboratories Limited Tetrahydropyrane derivatives as 5-lipoxygenase inhibitors
BRPI0718672A2 (pt) * 2006-11-27 2013-11-26 Pfizer Prod Inc Análogos de pirazol

Also Published As

Publication number Publication date
JP4718650B2 (ja) 2011-07-06
CA2705729A1 (en) 2009-06-04
ECSP10010200A (es) 2010-06-29
IL205602A0 (en) 2010-11-30
CR11392A (es) 2010-05-28
AR069743A1 (es) 2010-02-17
PE20091069A1 (es) 2009-07-19
US20090227634A1 (en) 2009-09-10
MX2010004604A (es) 2010-08-04
MA31863B1 (fr) 2010-11-01
CL2008003495A1 (es) 2010-03-12
UY31487A1 (es) 2009-07-17
AU2008331199A1 (en) 2009-06-04
CO6280402A2 (es) 2011-05-20
SV2010003579A (es) 2011-03-23
EA201000703A1 (ru) 2010-12-30
NI201000089A (es) 2010-10-05
CA2705729C (en) 2012-09-18
PA8805301A1 (es) 2009-06-23
TW200927098A (en) 2009-07-01
EP2225229A1 (en) 2010-09-08
TN2010000231A1 (fr) 2011-11-11
US8097733B2 (en) 2012-01-17
AP2010005269A0 (en) 2010-06-30
KR20100072090A (ko) 2010-06-29
JP2011504514A (ja) 2011-02-10
ZA201002758B (en) 2011-06-29
CN101918392A (zh) 2010-12-15
WO2009069044A1 (en) 2009-06-04
BRPI0819661A2 (pt) 2019-09-24

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