BRPI0819696A8 - Compostos de derivados de 2-fenil-pirimidina, composição farmacêutica e uso de um composto - Google Patents

Compostos de derivados de 2-fenil-pirimidina, composição farmacêutica e uso de um composto

Info

Publication number
BRPI0819696A8
BRPI0819696A8 BRPI0819696A BRPI0819696A BRPI0819696A8 BR PI0819696 A8 BRPI0819696 A8 BR PI0819696A8 BR PI0819696 A BRPI0819696 A BR PI0819696A BR PI0819696 A BRPI0819696 A BR PI0819696A BR PI0819696 A8 BRPI0819696 A8 BR PI0819696A8
Authority
BR
Brazil
Prior art keywords
phenyl
compound
pharmaceutical composition
pyrimidine derivatives
compounds
Prior art date
Application number
BRPI0819696A
Other languages
English (en)
Inventor
Caroff Eva
Hilpert Kurt
Hubler Francis
Meyer Emmanuel
Renneberg Dorte
Original Assignee
Actelion Pharmaceuticals Ltd
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40445499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0819696(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd, Idorsia Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of BRPI0819696A2 publication Critical patent/BRPI0819696A2/pt
Publication of BRPI0819696A8 publication Critical patent/BRPI0819696A8/pt
Publication of BRPI0819696B1 publication Critical patent/BRPI0819696B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

COMPOSTOS DE DERIVADOS DE 2-FENIL-PIRIMIDINA, COMPOSIÇÃO FARMACÊUTICA E USO DE UM COMPOSTO A invenção refere-se a derivados de 2-fenil- pirimidina que contêm um motivo de ácido fosfônico e seu uso como antagonistas de receptor P2Y12 no tratamento e/ou prevenção de doenças ou condições vasculares periféricas, viscerais, hepáticas e renal-vasculares, cardiovasculares e cerebrovasculares associadas à agregação de plaqueta, incluindo trombose em humanos e outros mamíferos.
BRPI0819696A 2007-11-29 2008-11-28 compostos de derivados de 2-fenil-pirimidina, composição farmacêutica e uso de um composto BRPI0819696B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2007054850 2007-11-29
PCT/IB2008/055002 WO2009069100A1 (en) 2007-11-29 2008-11-28 Phosphonic acid derivates and their use as p2y12 receptor antagonists

Publications (3)

Publication Number Publication Date
BRPI0819696A2 BRPI0819696A2 (pt) 2015-06-16
BRPI0819696A8 true BRPI0819696A8 (pt) 2017-12-26
BRPI0819696B1 BRPI0819696B1 (pt) 2018-10-23

Family

ID=40445499

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0819696A BRPI0819696B1 (pt) 2007-11-29 2008-11-28 compostos de derivados de 2-fenil-pirimidina, composição farmacêutica e uso de um composto

Country Status (24)

Country Link
US (1) US8518912B2 (pt)
EP (1) EP2225253B1 (pt)
JP (1) JP4729133B2 (pt)
KR (1) KR101178319B1 (pt)
CN (1) CN101868469B (pt)
AR (1) AR069494A1 (pt)
AU (1) AU2008331163B2 (pt)
BR (1) BRPI0819696B1 (pt)
CA (1) CA2706475C (pt)
CY (1) CY1113151T1 (pt)
DK (1) DK2225253T3 (pt)
ES (1) ES2388958T3 (pt)
HR (1) HRP20120735T1 (pt)
IL (1) IL205947A (pt)
MA (1) MA31983B1 (pt)
MX (1) MX2010005519A (pt)
MY (1) MY153749A (pt)
NZ (1) NZ586445A (pt)
PL (1) PL2225253T3 (pt)
PT (1) PT2225253E (pt)
RU (1) RU2483072C2 (pt)
SI (1) SI2225253T1 (pt)
TW (1) TWI361690B (pt)
WO (1) WO2009069100A1 (pt)

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TW200640877A (en) 2005-04-28 2006-12-01 Actelion Pharmaceuticals Ltd Pyrimidine derivatives
AR063258A1 (es) 2006-10-13 2009-01-14 Actelion Pharmaceuticals Ltd Derivados de 2-aminocarbonil-piridina, una composicion farmaceutica que los contiene y su uso en la preparacion de un medicamento para el tratamiento de trastornos vasculares oclusivos.
AR063518A1 (es) 2006-10-25 2009-01-28 Actelion Pharmaceuticals Ltd Derivados 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y su uso para tratar y/o prevenir enfermedades vasculares perifericas viscerales, hepaticas y renales, enfermedades cardiovasculares y enfermedades cerebrovasculares asociados con la agregacion de plaquetas, incluyendo trombosis
MY151004A (en) 2007-11-29 2014-03-31 Boehringer Ingelheim Int Derivatives of 6,7-dihydro-5h-imidazo[1,2-?]imidazole-3-carboxylic acid amides
AR071652A1 (es) * 2008-04-11 2010-07-07 Actelion Pharmaceuticals Ltd Derivados 2- fenil-piridina substituidos
AR071653A1 (es) * 2008-04-11 2010-07-07 Actelion Pharmaceuticals Ltd Derivados 2-fenil-4-ciclopropil-pirimidina
KR101694563B1 (ko) 2009-04-08 2017-01-09 액테리온 파마슈티칼 리미티드 Ａｄｐ 수용체 길항제로서 6-(3-아자-비시클로〔3.1.0〕헥스-3-일)-2-페닐-피리미딘
EP2421859B1 (en) 2009-04-22 2014-04-09 Actelion Pharmaceuticals Ltd. Thiazole derivatives and their use as p2y12 receptor antagonists
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WO2017063755A1 (en) 2015-10-12 2017-04-20 Polyphor Ag Conformationally constrained macrocyclic compounds
HUE057772T2 (hu) * 2016-09-22 2022-06-28 Idorsia Pharmaceuticals Ltd Kristályos formák
CN106749408A (zh) * 2017-02-09 2017-05-31 广东赛博科技有限公司 一种硝基噻吩芳基氧化膦p2y12受体拮抗剂及其用途
CN106831869A (zh) * 2017-02-09 2017-06-13 广东赛博科技有限公司 胺基噻吩芳基氧化膦p2y12受体拮抗剂及其用途
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CN106831867A (zh) * 2017-02-09 2017-06-13 广东赛博科技有限公司 一种腈基噻吩芳基氧化膦p2y12受体拮抗剂及其用途
CN106831870A (zh) * 2017-02-09 2017-06-13 广东赛博科技有限公司 一类腈基噻吩芳基氧化膦p2y12受体拮抗剂及其用途
CN106831868A (zh) * 2017-02-09 2017-06-13 广东赛博科技有限公司 一种胺基噻吩芳基氧化膦p2y12受体拮抗剂及其用途
CN106831866A (zh) * 2017-02-09 2017-06-13 广东赛博科技有限公司 一类烷氧噻吩芳基氧化膦p2y12受体拮抗剂及其用途
CN106831871A (zh) * 2017-02-09 2017-06-13 广东赛博科技有限公司 一类硝基噻吩芳基氧化膦p2y12受体拮抗剂及其用途
US11179390B2 (en) 2017-03-15 2021-11-23 Idorsia Pharmaceuticals Ltd Subcutaneous administration of a P2Y12 receptor antagonist
CA3082858A1 (en) * 2017-11-21 2019-05-31 Bayer Aktiengesellschaft 2-phenylpyrimidine-4-carboxamides as ahr inhibitors
US20230174562A1 (en) 2020-05-08 2023-06-08 Tonix Pharmaceuticals, Inc. Radio-and chemo-protective compounds
PT4181872T (pt) 2020-07-15 2026-01-22 Viatris Asia Pacific Pte Ltd Composição farmacêutica aquosa compreendendo um antagonista do recetor p2y12
CN112500354A (zh) * 2020-12-08 2021-03-16 烟台凯博医药科技有限公司 一种4-氯-6-环丙基嘧啶-5-胺的合成方法
JP2024524658A (ja) * 2021-07-13 2024-07-05 イドルシア・ファーマシューティカルズ・リミテッド ４－（（ｒ）－２－｛［６－（（ｓ）－３－メトキシ－ピロリジン－１－イル）－２－フェニル－ピリミジン－４－カルボニル］－アミノ｝－３－ホスホノ－プロピオニル）－ピペラジン－１－カルボン酸ブチルエステルの合成方法
JP2025509711A (ja) 2022-03-14 2025-04-11 ヴィアトリス アジア パシフィック プライヴェート リミテッド （Ｒ）－２－（（ｔｅｒｔ－ブトキシカルボニル）アミノ）－３－（ジエトキシホスホリル）プロパン酸又はそのホスホナート誘導体の合成方法

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AU2008331163A1 (en) 2009-06-04
BRPI0819696B1 (pt) 2018-10-23
ES2388958T3 (es) 2012-10-22
HRP20120735T1 (hr) 2012-10-31
WO2009069100A1 (en) 2009-06-04
JP2011505352A (ja) 2011-02-24
MA31983B1 (fr) 2011-01-03
CA2706475C (en) 2016-05-03
US20100261678A1 (en) 2010-10-14
AU2008331163B2 (en) 2014-01-30
EP2225253B1 (en) 2012-06-27
PT2225253E (pt) 2012-09-19
MX2010005519A (es) 2010-06-11
SI2225253T1 (sl) 2012-09-28
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EP2225253A1 (en) 2010-09-08
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CN101868469A (zh) 2010-10-20
KR101178319B1 (ko) 2012-09-07
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TW200922602A (en) 2009-06-01
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