BRPI0820211A8 - Métodos de espectrometria de massa maldi para analisar um analito de aerossol, e, para a classificação de biomateriais - Google Patents
Métodos de espectrometria de massa maldi para analisar um analito de aerossol, e, para a classificação de biomateriaisInfo
- Publication number
- BRPI0820211A8 BRPI0820211A8 BRPI0820211A BRPI0820211A BRPI0820211A8 BR PI0820211 A8 BRPI0820211 A8 BR PI0820211A8 BR PI0820211 A BRPI0820211 A BR PI0820211A BR PI0820211 A BRPI0820211 A BR PI0820211A BR PI0820211 A8 BRPI0820211 A8 BR PI0820211A8
- Authority
- BR
- Brazil
- Prior art keywords
- mass spectrometry
- maldi
- maldi mass
- matrix material
- analyte
- Prior art date
Links
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 title abstract 9
- 238000004949 mass spectrometry Methods 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 5
- 239000000443 aerosol Substances 0.000 title abstract 4
- 239000012491 analyte Substances 0.000 title abstract 4
- 239000012620 biological material Substances 0.000 title abstract 2
- 239000011159 matrix material Substances 0.000 abstract 10
- 239000000203 mixture Substances 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 238000004458 analytical method Methods 0.000 abstract 2
- 239000007789 gas Substances 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 238000001906 matrix-assisted laser desorption--ionisation mass spectrometry Methods 0.000 abstract 1
- -1 methoxy, ethoxy Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0409—Sample holders or containers
- H01J49/0418—Sample holders or containers for laser desorption, e.g. matrix-assisted laser desorption/ionisation [MALDI] plates or surface enhanced laser desorption/ionisation [SELDI] plates
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
- H01J49/0445—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for introducing as a spray, a jet or an aerosol
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
MÉTODOS DE ESPECTROMETRIA DE MASSA MALDI PARA ANALISAR UM ANALITO DE AEROSSOL, E, PARA A CLASSIFICAÇÃO DE BIOMATERIAIS. A invenção é dirigida a um material para matriz para espectrometria de massa MALDI, a uma composição de matriz para espectrometria de massa MALDI, em particular para espectrometria de massa MALDI de análise de aerossol, a um método de espectrometria de massa MALDI, em particular um método de espectrometria de massa MALDI de análise de aerossol, ao uso de um composto específico como um material para matriz MALDI, e ao uso de uma composição de matriz MALDI em um método de revestimento em fase gasosa. O material para matriz da invenção compreende um 2-mercapto-4,5-dialquiltiazol de acordo com fórmula (I), em que X é escolhido de S, O ou N, e em que R1 e R2 são independentemente escolhidos dentre hidrogênio, metila, metóxi, etóxi, e propóxi, ou em que R1 e R2 são tomados juntos para formar uma estrutura de anel aromático opcionalmente substituído, opcionalmente compreendendo um ou mais heteroátomos, ou uma forma tautomérica dos mesmos. A composição de matriz preferivelmente inclui o material para matriz e um álcool. O álcool pode ser halogenado. O método MALDI MS compreende contatar o analito com o material para matriz ou uma composição de matriz; ionizando pelo menos parte do analito, e separando os componentes ionizados usando um espectrômetro de massa, por exemplo TOF-MS. Preferivelmente, bioaerossóis são contatados com o material para matriz na fase de gás.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07120550.4 | 2007-11-13 | ||
| EP07120550A EP2060919A1 (en) | 2007-11-13 | 2007-11-13 | MALDI matrix and MALDI method |
| PCT/NL2008/050721 WO2009064180A1 (en) | 2007-11-13 | 2008-11-13 | Maldi matrix and maldi method |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0820211A2 BRPI0820211A2 (pt) | 2015-06-16 |
| BRPI0820211A8 true BRPI0820211A8 (pt) | 2017-01-10 |
| BRPI0820211B1 BRPI0820211B1 (pt) | 2017-06-27 |
Family
ID=38786862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0820211-7A BRPI0820211B1 (pt) | 2007-11-13 | 2008-11-13 | Methods of maldi mass spectrometry to analyze an analysis of aerosol and, for the classification of biomaterials |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8409870B2 (pt) |
| EP (2) | EP2060919A1 (pt) |
| JP (1) | JP5209732B2 (pt) |
| KR (1) | KR20100106336A (pt) |
| CN (1) | CN101855556B (pt) |
| BR (1) | BRPI0820211B1 (pt) |
| CA (1) | CA2705506A1 (pt) |
| ES (1) | ES2416183T3 (pt) |
| IL (1) | IL205662A0 (pt) |
| WO (1) | WO2009064180A1 (pt) |
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| EP2416203B1 (en) * | 2009-03-31 | 2023-09-13 | Hoya Corporation | Photochromic lens manufacturing system, photochromic lens manufacturing device, photochromic lens manufacturing program, recording medium having photochromic lens manufacturing program recorded thereupon, and photochromic lens manufacturing method |
| CN102531924B (zh) * | 2010-12-27 | 2013-12-11 | 中国科学院化学研究所 | 硝酸萘乙二胺及其制备方法与应用 |
| JP5895694B2 (ja) * | 2012-05-11 | 2016-03-30 | 株式会社島津製作所 | マトリックス支援レーザ脱離イオン化質量分析用マトリックス |
| ES2998535T3 (en) * | 2014-02-07 | 2025-02-20 | European Molecular Biology Laboratory | Proteomic sample preparation using paramagnetic beads |
| CN104597113B (zh) * | 2015-01-21 | 2015-12-09 | 华中师范大学 | 一种高分辨质谱成像系统图像采集半导体薄膜、制备方法及应用 |
| WO2016142675A1 (en) | 2015-03-06 | 2016-09-15 | Micromass Uk Limited | Imaging guided ambient ionisation mass spectrometry |
| GB2551669B (en) | 2015-03-06 | 2021-04-14 | Micromass Ltd | Physically guided rapid evaporative ionisation mass spectrometry ("Reims") |
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| JP6530141B2 (ja) * | 2015-08-24 | 2019-06-12 | ゼテオ テック、 エルエルシイＺｅｔｅｏ Ｔｅｃｈ， Ｌｌｃ | 音響コータを用いたエアロゾル粒子のコーティング |
| GB201517195D0 (en) | 2015-09-29 | 2015-11-11 | Micromass Ltd | Capacitively coupled reims technique and optically transparent counter electrode |
| CN106841373B (zh) * | 2015-12-07 | 2020-03-10 | 中国科学院大连化学物理研究所 | 亚微米氧化碳球作为基质在maldi-ms中的应用 |
| CN105319262A (zh) * | 2015-12-07 | 2016-02-10 | 中国石油天然气集团公司 | 一种芳香族化合物分子组成的分析方法及其应用 |
| WO2017178833A1 (en) | 2016-04-14 | 2017-10-19 | Micromass Uk Limited | Spectrometric analysis of plants |
| WO2017190031A1 (en) * | 2016-04-28 | 2017-11-02 | Indiana University Research And Technology Corporation | Methods and compositions for resolving components of a virus preparation |
| WO2018158399A1 (en) | 2017-03-02 | 2018-09-07 | Biosparq B.V. | Diagnostic method and system for diagnosis |
| NL2018940B1 (en) | 2017-05-18 | 2018-11-28 | Biosparq B V | Maldi mass spectrometry method |
| US11668719B2 (en) | 2017-09-20 | 2023-06-06 | The Trustees Of Indiana University | Methods for resolving lipoproteins with mass spectrometry |
| US11232941B2 (en) | 2018-01-12 | 2022-01-25 | The Trustees Of Indiana University | Electrostatic linear ion trap design for charge detection mass spectrometry |
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| CN108896646A (zh) * | 2018-07-04 | 2018-11-27 | 上海海洋大学 | 亲缘关系相近的海鲜的快速分类和鉴定方法 |
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| WO2021061330A1 (en) * | 2019-09-23 | 2021-04-01 | Zeteo Tech, Inc. | Systems and methods of rapid and autonomous detection of aerosol particles |
| US12074018B2 (en) | 2019-09-23 | 2024-08-27 | Zeteo Tech, Inc. | Systems and methods of rapid and autonomous detection of aerosol particles |
| WO2021061650A1 (en) | 2019-09-25 | 2021-04-01 | The Trustees Of Indiana University | Apparatus and method for pulsed mode charge detection mass spectrometry |
| KR102849777B1 (ko) | 2019-10-10 | 2025-08-22 | 더 트러스티즈 오브 인디애나 유니버시티 | 입자들을 식별, 선택 및 정제하기 위한 시스템 및 방법 |
| CA3165106A1 (en) | 2019-12-18 | 2021-06-24 | The Trustees Of Indiana University | Mass spectrometer with charge measurement arrangement |
| EP4100991B1 (en) | 2020-02-03 | 2025-01-29 | The Trustees of Indiana University | A charge detection mass spectrometer and related method |
| US12364411B2 (en) | 2020-04-03 | 2025-07-22 | Zeteo Tech, Inc. | Diagnosis of respiratory diseases using analysis of exhaled breath and aerosols |
| EP4125569B1 (en) | 2020-04-03 | 2026-05-20 | Zeteo Tech Inc | SYSTEM FOR DIAGNOSING RESPIRATORY DISEASES USING ANALYSIS OF EXHAUSTED AIR AND AEROSOLS |
| CN112162028A (zh) * | 2020-09-29 | 2021-01-01 | 中国农业科学院农业质量标准与检测技术研究所 | 一种用于草莓组织中维生素c的质谱成像方法 |
| JP2024518022A (ja) | 2021-03-31 | 2024-04-24 | ゼテオ テック、 インク． | 充填ベッドシステムおよび方法を使用したエアロゾル化生体材料粒子の捕捉による呼吸器疾患の診断 |
| WO2024215320A1 (en) * | 2023-04-11 | 2024-10-17 | Zeteo Tech, Inc. | Systems and methods of rapid and autonomous detection of aerosol particles |
| CN120374399B (zh) * | 2025-06-26 | 2025-11-21 | 宁波华仪宁创智能科技有限公司 | 基于质谱技术的单细胞代谢组学分析方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9617852D0 (en) * | 1996-08-27 | 1996-10-09 | Univ Manchester Metropolitan | Micro-organism identification |
| NL1016887C2 (nl) * | 2000-12-15 | 2002-06-18 | Tno | Werkwijze en inrichting voor het detecteren en identificeren van bio-aÙrosoldeeltjes in de lucht. |
| DE10238069A1 (de) | 2002-08-19 | 2004-03-04 | N.V. Nutricia | MALDI-Matrix |
| US6943346B2 (en) * | 2003-08-13 | 2005-09-13 | Science & Engineering Services, Inc. | Method and apparatus for mass spectrometry analysis of aerosol particles at atmospheric pressure |
| US20060261267A1 (en) | 2005-05-20 | 2006-11-23 | Agency For Science, Technology And Research | Composite MALDI matrix material and methods of using it and kits thereof in MALDI |
-
2007
- 2007-11-13 EP EP07120550A patent/EP2060919A1/en not_active Withdrawn
-
2008
- 2008-11-13 WO PCT/NL2008/050721 patent/WO2009064180A1/en not_active Ceased
- 2008-11-13 US US12/742,093 patent/US8409870B2/en not_active Expired - Fee Related
- 2008-11-13 JP JP2010533980A patent/JP5209732B2/ja not_active Expired - Fee Related
- 2008-11-13 CA CA2705506A patent/CA2705506A1/en not_active Abandoned
- 2008-11-13 BR BRPI0820211-7A patent/BRPI0820211B1/pt not_active IP Right Cessation
- 2008-11-13 ES ES08849452T patent/ES2416183T3/es active Active
- 2008-11-13 KR KR1020107012400A patent/KR20100106336A/ko not_active Withdrawn
- 2008-11-13 CN CN200880115972.8A patent/CN101855556B/zh not_active Expired - Fee Related
- 2008-11-13 EP EP08849452A patent/EP2210110B1/en not_active Not-in-force
-
2010
- 2010-05-10 IL IL205662A patent/IL205662A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100106336A (ko) | 2010-10-01 |
| CN101855556A (zh) | 2010-10-06 |
| EP2210110A1 (en) | 2010-07-28 |
| BRPI0820211A2 (pt) | 2015-06-16 |
| JP5209732B2 (ja) | 2013-06-12 |
| CN101855556B (zh) | 2015-04-29 |
| US8409870B2 (en) | 2013-04-02 |
| WO2009064180A1 (en) | 2009-05-22 |
| JP2011503605A (ja) | 2011-01-27 |
| EP2060919A1 (en) | 2009-05-20 |
| BRPI0820211B1 (pt) | 2017-06-27 |
| CA2705506A1 (en) | 2009-05-22 |
| ES2416183T3 (es) | 2013-07-30 |
| IL205662A0 (en) | 2010-11-30 |
| EP2210110B1 (en) | 2013-03-27 |
| US20120018628A1 (en) | 2012-01-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: BIOSPARQ B.V. (NL) |
|
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] | ||
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 14A ANUIDADE. |
|
| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2696 DE 06-09-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |