BRPI0821114A2 - Composto, uso de um composto e método para tratar qualquer mamífero afetado por câncer - Google Patents

Composto, uso de um composto e método para tratar qualquer mamífero afetado por câncer

Info

Publication number: BRPI0821114A2
Authority: BR; Brazil
Prior art keywords: compound; cancer; treat; affected mammal; mammal
Prior art date: 2007-12-20

Application number

BRPI0821114-0A

Other languages

English (en)

Inventor

Alberto Rodrígues Vicente

María Garranzo García-Ibarrola

Carmen Murcia Pérez

Francisco Sánchez Sancho

María Del Carmen Cuevas Marchante

Cristina Mateo Urbano

Isabel Digón Juárez

Original Assignee

Pharma Mar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-20

Filing date

2008-12-19

Publication date

2015-06-16

2008-12-19 Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa

2015-06-16 Publication of BRPI0821114A2 publication Critical patent/BRPI0821114A2/pt

2021-09-08 Publication of BRPI0821114B1 publication Critical patent/BRPI0821114B1/pt

2021-11-09 Publication of BRPI0821114B8 publication Critical patent/BRPI0821114B8/pt

Links

150000001875 compounds Chemical class 0.000 title abstract 3
206010028980 Neoplasm Diseases 0.000 title abstract 2
201000011510 cancer Diseases 0.000 title abstract 2
241000124008 Mammalia Species 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pyrane Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Dermatology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)
Compounds Of Unknown Constitution (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Steroid Compounds (AREA)

BRPI0821114A 2007-12-20 2008-12-19 Composto antitumoral, composição farmacêutica, uso de um composto antitumoral, uso de uma composição farmacêutica, e processo para a preparação do referido composto BRPI0821114B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP07123882.8		2007-12-20
EP07123882		2007-12-20
PCT/EP2008/068065 WO2009080769A1 (en)	2007-12-20	2008-12-19	Antitumoral compounds

Publications (3)

Publication Number	Publication Date
BRPI0821114A2 true BRPI0821114A2 (pt)	2015-06-16
BRPI0821114B1 BRPI0821114B1 (pt)	2021-09-08
BRPI0821114B8 BRPI0821114B8 (pt)	2021-11-09

Family

ID=40580474

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
BRPI0821116A BRPI0821116B8 (pt)	2007-12-20	2008-12-19	composto, composição farmacêutica que o contem, uso deste e processo para a preparação do mesmo
BRPI0821114A BRPI0821114B8 (pt)	2007-12-20	2008-12-19	Composto antitumoral, composição farmacêutica, uso de um composto antitumoral, uso de uma composição farmacêutica, e processo para a preparação do referido composto

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
BRPI0821116A BRPI0821116B8 (pt)	2007-12-20	2008-12-19	composto, composição farmacêutica que o contem, uso deste e processo para a preparação do mesmo

Country Status (26)

Country	Link
US (4)	US8710264B2 (pt)
EP (3)	EP2231633B1 (pt)
JP (3)	JP5727228B2 (pt)
KR (3)	KR101639772B1 (pt)
CN (4)	CN101903367B (pt)
AT (1)	ATE549313T1 (pt)
AU (2)	AU2008341670B2 (pt)
BR (2)	BRPI0821116B8 (pt)
CA (2)	CA2710087C (pt)
CY (1)	CY1117245T1 (pt)
DK (2)	DK2231633T3 (pt)
ES (3)	ES2578606T3 (pt)
HR (2)	HRP20120464T1 (pt)
IL (3)	IL206396A (pt)
MX (2)	MX2010006795A (pt)
MY (3)	MY155342A (pt)
NZ (3)	NZ586012A (pt)
PL (2)	PL2231590T3 (pt)
PT (2)	PT2231590E (pt)
RS (2)	RS52343B (pt)
RU (3)	RU2489429C2 (pt)
SG (2)	SG170778A1 (pt)
SI (2)	SI2231633T1 (pt)
UA (3)	UA106967C2 (pt)
WO (2)	WO2009080769A1 (pt)
ZA (3)	ZA201004017B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BRPI0821116B8 (pt)	2007-12-20	2021-05-25	Pharma Mar Sa	composto, composição farmacêutica que o contem, uso deste e processo para a preparação do mesmo
US9856196B2 (en)	2012-01-05	2018-01-02	Kao Corporation	Agent for reduction of sensory irritation
EA029361B1 (ru)	2013-04-16	2018-03-30	Идорсиа Фармасьютиклз Лтд	Антибактериальные биароматические производные
GB201309807D0 (en) *	2013-05-31	2013-07-17	Pharma Mar Sau	Antibody drug conjugates
CN108467378A (zh) *	2017-02-23	2018-08-31	复旦大学	一种二氢吡喃酮类化合物及其制备方法和用途
US11332480B2 (en)	2017-04-27	2022-05-17	Pharma Mar, S.A.	Antitumoral compounds

Family Cites Families (20)

* Cited by examiner, † Cited by third party
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US5142056A (en) *	1989-05-23	1992-08-25	Abbott Laboratories	Retroviral protease inhibiting compounds
US4855086A (en) *	1982-10-15	1989-08-08	Burroughs Wellcome Co.	Novel pesticides, preparation and use
JPS61109717A (ja) *	1984-11-02	1986-05-28	Teruhiko Beppu	抗腫瘍剤
CA2098702A1 (en) *	1990-12-28	1992-06-29	James C. Powers	Peptide ketoamides, ketoacids, and ketoesters
JPH0539283A (ja) *	1991-01-31	1993-02-19	Suntory Ltd	新規物質Ｓ−５９９１７ａ及びその製造方法
ZA938019B (en)	1992-11-13	1995-04-28	Upjohn Co	Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses
US5523456A (en) *	1994-09-29	1996-06-04	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
US5681847A (en) *	1995-12-05	1997-10-28	Harbor Branch Oceanographic Institution, Inc.	Methods of using discodermolide compounds
US5834506A (en)	1996-11-01	1998-11-10	Warner-Lambert Company	Dihydropyrones with improved antiviral activity
US5840974A (en) *	1996-12-04	1998-11-24	Britisch Biotech Pharmaceuticals, Ltd.	Metalloproteinase inhibitors
US6380400B1 (en)	1998-09-11	2002-04-30	Victor Fedij	Methods of making dihydropyrone HIV protease inhibitors
NZ510013A (en)	1998-09-11	2003-11-28	Warner Lambert Co	Dihydropyrones with selected heterocycles replacing the phenyls bearing polar substituents used as HIV protease inhibitors
WO2001074355A1 (en) *	2000-04-04	2001-10-11	Novartis Ag	Method for treating cells resistant to antineoplastic agents
NZ550185A (en) *	2002-03-04	2008-10-31	Merck Hdac Res Llc	Methods of inducing terminal differentiation Methods of inducing terminal differentiation
CN1856486A (zh) *	2003-07-25	2006-11-01	诺瓦提斯公司	取代的内酰胺和它们作为抗癌剂的用途
US7446196B2 (en)	2004-06-03	2008-11-04	Kosan Biosciences, Incorporated	Leptomycin compounds
RU2006142690A (ru) *	2004-06-03	2008-06-10	Козан Байосайенсиз Инкорпорейтед (Us)	Соединения лептомицина
WO2007014423A1 (en) *	2005-08-02	2007-02-08	Medvet Science Pty, Ltd.	Exercise apparatus
ATE522514T1 (de)	2006-06-16	2011-09-15	Pharma Mar Sa	Dihydropyran-2-onverbindungen mit antitumorwirkung
BRPI0821116B8 (pt)	2007-12-20	2021-05-25	Pharma Mar Sa	composto, composição farmacêutica que o contem, uso deste e processo para a preparação do mesmo

2008
- 2008-12-19 BR BRPI0821116A patent/BRPI0821116B8/pt not_active IP Right Cessation
- 2008-12-19 NZ NZ586012A patent/NZ586012A/en not_active IP Right Cessation
- 2008-12-19 RU RU2010130253/04A patent/RU2489429C2/ru active
- 2008-12-19 JP JP2010538769A patent/JP5727228B2/ja not_active Expired - Fee Related
- 2008-12-19 NZ NZ586013A patent/NZ586013A/en not_active IP Right Cessation
- 2008-12-19 WO PCT/EP2008/068065 patent/WO2009080769A1/en not_active Ceased
- 2008-12-19 PL PL08865009T patent/PL2231590T3/pl unknown
- 2008-12-19 KR KR1020157016575A patent/KR101639772B1/ko not_active Expired - Fee Related
- 2008-12-19 UA UAA201009034A patent/UA106967C2/uk unknown
- 2008-12-19 PT PT08865009T patent/PT2231590E/pt unknown
- 2008-12-19 PL PL08864895T patent/PL2231633T3/pl unknown
- 2008-12-19 AU AU2008341670A patent/AU2008341670B2/en not_active Ceased
- 2008-12-19 CA CA2710087A patent/CA2710087C/en active Active
- 2008-12-19 UA UAA201406894A patent/UA119963C2/uk unknown
- 2008-12-19 NZ NZ597526A patent/NZ597526A/en not_active IP Right Cessation
- 2008-12-19 CN CN200880121840.6A patent/CN101903367B/zh not_active Expired - Fee Related
- 2008-12-19 UA UAA201009035A patent/UA104281C2/ru unknown
- 2008-12-19 RU RU2010130180/04A patent/RU2493147C2/ru active
- 2008-12-19 SI SI200831122T patent/SI2231633T1/sl unknown
- 2008-12-19 AU AU2008341671A patent/AU2008341671B2/en not_active Ceased
- 2008-12-19 CN CN201110073931.0A patent/CN102190643B/zh not_active Expired - Fee Related
- 2008-12-19 DK DK08864895.1T patent/DK2231633T3/da active
- 2008-12-19 HR HRP20120464AT patent/HRP20120464T1/hr unknown
- 2008-12-19 AT AT08865009T patent/ATE549313T1/de active
- 2008-12-19 KR KR1020107015965A patent/KR101541436B1/ko not_active Expired - Fee Related
- 2008-12-19 RU RU2013112003/04A patent/RU2528393C9/ru active
- 2008-12-19 SG SG201102163-1A patent/SG170778A1/en unknown
- 2008-12-19 RS RS20120242A patent/RS52343B/sr unknown
- 2008-12-19 RS RS20140007A patent/RS53140B/sr unknown
- 2008-12-19 EP EP08864895.1A patent/EP2231633B1/en active Active
- 2008-12-19 MY MYPI2010002591A patent/MY155342A/en unknown
- 2008-12-19 WO PCT/EP2008/068049 patent/WO2009080761A1/en not_active Ceased
- 2008-12-19 EP EP13154647.5A patent/EP2597091B1/en active Active
- 2008-12-19 US US12/746,966 patent/US8710264B2/en active Active
- 2008-12-19 ES ES13154647.5T patent/ES2578606T3/es active Active
- 2008-12-19 DK DK08865009.8T patent/DK2231590T3/da active
- 2008-12-19 ES ES08864895.1T patent/ES2442140T3/es active Active
- 2008-12-19 MX MX2010006795A patent/MX2010006795A/es active IP Right Grant
- 2008-12-19 KR KR1020107015968A patent/KR101579553B1/ko not_active Expired - Fee Related
- 2008-12-19 ES ES08865009T patent/ES2384420T3/es active Active
- 2008-12-19 BR BRPI0821114A patent/BRPI0821114B8/pt not_active IP Right Cessation
- 2008-12-19 CN CN2011100568656A patent/CN102174058A/zh active Pending
- 2008-12-19 SG SG201102164-9A patent/SG170779A1/en unknown
- 2008-12-19 SI SI200830644T patent/SI2231590T1/sl unknown
- 2008-12-19 CN CN2008801218410A patent/CN101903337B/zh not_active Expired - Fee Related
- 2008-12-19 MY MYPI2010002590A patent/MY148651A/en unknown
- 2008-12-19 CA CA2715203A patent/CA2715203C/en active Active
- 2008-12-19 EP EP08865009A patent/EP2231590B9/en active Active
- 2008-12-19 US US12/746,974 patent/US9187445B2/en active Active
- 2008-12-19 JP JP2010538765A patent/JP5529038B2/ja not_active Expired - Fee Related
- 2008-12-19 MX MX2010006796A patent/MX2010006796A/es active IP Right Grant
- 2008-12-19 HR HRP20140015AT patent/HRP20140015T1/hr unknown
- 2008-12-19 PT PT88648951T patent/PT2231633E/pt unknown
- 2008-12-19 MY MYPI2014002392A patent/MY164533A/en unknown
2010
- 2010-06-04 ZA ZA2010/04017A patent/ZA201004017B/en unknown
- 2010-06-04 ZA ZA2010/04018A patent/ZA201004018B/en unknown
- 2010-06-15 IL IL206396A patent/IL206396A/en active IP Right Grant
- 2010-06-15 IL IL206397A patent/IL206397A/en active IP Right Grant
2011
- 2011-08-31 ZA ZA2011/06371A patent/ZA201106371B/en unknown
2013
- 2013-11-24 IL IL229594A patent/IL229594A/en active IP Right Grant
2014
- 2014-01-27 CY CY20141100069T patent/CY1117245T1/el unknown
- 2014-04-10 JP JP2014080887A patent/JP5860088B2/ja not_active Expired - Fee Related
2015
- 2015-08-12 US US14/824,690 patent/US9750759B2/en not_active Expired - Fee Related
- 2015-08-12 US US14/824,699 patent/US9827257B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
SI2231590T1 (sl)	2012-10-30
JP2011506575A (ja)	2011-03-03
EP2231633B1 (en)	2013-10-30
NZ597526A (en)	2012-06-29
ATE549313T1 (de)	2012-03-15
HRP20140015T1 (hr)	2014-02-14
CA2710087A1 (en)	2009-07-02
NZ586012A (en)	2011-11-25
US20100280108A1 (en)	2010-11-04
UA119963C2 (uk)	2019-09-10
CN101903337A (zh)	2010-12-01
EP2231633A1 (en)	2010-09-29
CN102190643A (zh)	2011-09-21
US20150342972A1 (en)	2015-12-03
EP2231590B1 (en)	2012-03-14
ZA201004018B (en)	2011-12-28
US20150344454A1 (en)	2015-12-03
CA2710087C (en)	2015-06-02
IL229594A0 (en)	2014-01-30
IL206396A (en)	2014-05-28
US20110034549A1 (en)	2011-02-10
ES2578606T3 (es)	2016-07-28
DK2231633T3 (da)	2014-01-20
PT2231633E (pt)	2014-01-20
WO2009080769A1 (en)	2009-07-02
JP5727228B2 (ja)	2015-06-03
IL206397A (en)	2014-01-30
US20120041063A2 (en)	2012-02-16
RU2489429C2 (ru)	2013-08-10
KR101579553B1 (ko)	2015-12-22
AU2008341671A1 (en)	2009-07-02
RU2013112003A (ru)	2014-08-20
JP5529038B2 (ja)	2014-06-25
DK2231590T3 (da)	2012-07-09
HK1147990A1 (en)	2011-08-26
US9827257B2 (en)	2017-11-28
CA2715203A1 (en)	2009-07-02
KR101639772B1 (ko)	2016-07-15
US9187445B2 (en)	2015-11-17
JP2014133752A (ja)	2014-07-24
IL206397A0 (en)	2010-12-30
KR20100125226A (ko)	2010-11-30
RU2528393C1 (ru)	2014-09-20
UA106967C2 (uk)	2014-11-10
IL229594A (en)	2016-02-29
HK1180678A1 (en)	2013-10-25
AU2008341670A1 (en)	2009-07-02
AU2008341670B2 (en)	2012-04-19
CN101903367A (zh)	2010-12-01
KR20100100979A (ko)	2010-09-15
SG170778A1 (en)	2011-05-30
BRPI0821114B1 (pt)	2021-09-08
PT2231590E (pt)	2012-06-25
SI2231633T1 (sl)	2014-02-28
BRPI0821114B8 (pt)	2021-11-09
MX2010006795A (es)	2010-10-26
BRPI0821116B1 (pt)	2020-02-18
EP2231590B9 (en)	2012-08-15
CN102174058A (zh)	2011-09-07
MY164533A (en)	2017-12-29
CA2715203C (en)	2015-09-08
JP2011506578A (ja)	2011-03-03
ZA201106371B (en)	2013-05-29
EP2597091A1 (en)	2013-05-29
BRPI0821116A2 (pt)	2015-08-11
MX2010006796A (es)	2010-10-26
BRPI0821116B8 (pt)	2021-05-25
KR101541436B1 (ko)	2015-08-03
JP5860088B2 (ja)	2016-02-16
RU2493147C2 (ru)	2013-09-20
MY148651A (en)	2013-05-15
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