BRPI0821116A2 - Composto, composição farmacêutica que o contem, uso deste e método para tratar qualquer mamífero afetado por câncer - Google Patents

Composto, composição farmacêutica que o contem, uso deste e método para tratar qualquer mamífero afetado por câncer

Info

Publication number: BRPI0821116A2
Authority: BR; Brazil
Prior art keywords: cancer; compound; treating; pharmaceutical composition; composition containing
Prior art date: 2007-12-20

Application number

BRPI0821116-7A

Other languages

English (en)

Inventor

Alberto Rodríguez Vicente

Carmen Murcia Pérez

Francisco Sánchez Sancho

María Del Carmen Cuevas Marchante

María Garranzo García-Ibarrola

Cristina Mateo Urbano

Isabel Digón Juárez

Original Assignee

Pharma Mar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-20

Filing date

2008-12-19

Publication date

2015-08-11

2008-12-19 Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa

2015-08-11 Publication of BRPI0821116A2 publication Critical patent/BRPI0821116A2/pt

2020-02-18 Publication of BRPI0821116B1 publication Critical patent/BRPI0821116B1/pt

2021-05-25 Publication of BRPI0821116B8 publication Critical patent/BRPI0821116B8/pt

Links

206010028980 Neoplasm Diseases 0.000 title abstract 2
201000011510 cancer Diseases 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title abstract 2
241000124008 Mammalia Species 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pyrane Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)
Dermatology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Compounds Of Unknown Constitution (AREA)
Steroid Compounds (AREA)

BRPI0821116A 2007-12-20 2008-12-19 composto, composição farmacêutica que o contem, uso deste e processo para a preparação do mesmo BRPI0821116B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP07123882.8		2007-12-20
EP07123882		2007-12-20
PCT/EP2008/068049 WO2009080761A1 (en)	2007-12-20	2008-12-19	Antitumoral compounds

Publications (3)

Publication Number	Publication Date
BRPI0821116A2 true BRPI0821116A2 (pt)	2015-08-11
BRPI0821116B1 BRPI0821116B1 (pt)	2020-02-18
BRPI0821116B8 BRPI0821116B8 (pt)	2021-05-25

Family

ID=40580474

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
BRPI0821114A BRPI0821114B8 (pt)	2007-12-20	2008-12-19	Composto antitumoral, composição farmacêutica, uso de um composto antitumoral, uso de uma composição farmacêutica, e processo para a preparação do referido composto
BRPI0821116A BRPI0821116B8 (pt)	2007-12-20	2008-12-19	composto, composição farmacêutica que o contem, uso deste e processo para a preparação do mesmo

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
BRPI0821114A BRPI0821114B8 (pt)	2007-12-20	2008-12-19	Composto antitumoral, composição farmacêutica, uso de um composto antitumoral, uso de uma composição farmacêutica, e processo para a preparação do referido composto

Country Status (26)

Country	Link
US (4)	US8710264B2 (pt)
EP (3)	EP2597091B1 (pt)
JP (3)	JP5727228B2 (pt)
KR (3)	KR101541436B1 (pt)
CN (4)	CN102174058A (pt)
AT (1)	ATE549313T1 (pt)
AU (2)	AU2008341670B2 (pt)
BR (2)	BRPI0821114B8 (pt)
CA (2)	CA2715203C (pt)
CY (1)	CY1117245T1 (pt)
DK (2)	DK2231590T3 (pt)
ES (3)	ES2442140T3 (pt)
HR (2)	HRP20120464T1 (pt)
IL (3)	IL206397A (pt)
MX (2)	MX2010006796A (pt)
MY (3)	MY148651A (pt)
NZ (3)	NZ586013A (pt)
PL (2)	PL2231590T3 (pt)
PT (2)	PT2231590E (pt)
RS (2)	RS53140B (pt)
RU (3)	RU2493147C2 (pt)
SG (2)	SG170778A1 (pt)
SI (2)	SI2231590T1 (pt)
UA (3)	UA104281C2 (pt)
WO (2)	WO2009080769A1 (pt)
ZA (3)	ZA201004018B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5727228B2 (ja)	2007-12-20	2015-06-03	ファルマ・マール・ソシエダード・アノニマ	抗腫瘍化合物
WO2013103155A1 (en) *	2012-01-05	2013-07-11	Kao Corporation	Agent for reduction of sensory irritation
BR112015026261A8 (pt)	2013-04-16	2017-12-26	Actelion Pharmaceuticals Ltd	Derivados biaromáticos antibacterianos
GB201309807D0 (en) *	2013-05-31	2013-07-17	Pharma Mar Sau	Antibody drug conjugates
CN108467378A (zh) *	2017-02-23	2018-08-31	复旦大学	一种二氢吡喃酮类化合物及其制备方法和用途
SI4101855T1 (sl)	2017-04-27	2024-03-29	Pharma Mar S.A.	Protitumorske spojine

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US5142056A (en) *	1989-05-23	1992-08-25	Abbott Laboratories	Retroviral protease inhibiting compounds
US4855086A (en)	1982-10-15	1989-08-08	Burroughs Wellcome Co.	Novel pesticides, preparation and use
JPS61109717A (ja) *	1984-11-02	1986-05-28	Teruhiko Beppu	抗腫瘍剤
JPH06504547A (ja) *	1990-12-28	1994-05-26	ジョージア・テック・リサーチ・コーポレーション	ペプチドケトアミド、ケト酸およびケトエステル
JPH0539283A (ja) *	1991-01-31	1993-02-19	Suntory Ltd	新規物質Ｓ−５９９１７ａ及びその製造方法
ZA938019B (en)	1992-11-13	1995-04-28	Upjohn Co	Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses
US5523456A (en) *	1994-09-29	1996-06-04	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
US5681847A (en) *	1995-12-05	1997-10-28	Harbor Branch Oceanographic Institution, Inc.	Methods of using discodermolide compounds
US5834506A (en)	1996-11-01	1998-11-10	Warner-Lambert Company	Dihydropyrones with improved antiviral activity
US5840974A (en) *	1996-12-04	1998-11-24	Britisch Biotech Pharmaceuticals, Ltd.	Metalloproteinase inhibitors
BR9913598A (pt)	1998-09-11	2001-05-29	Warner Lambert Co	Inibidores de protease de hiv
US6380400B1 (en)	1998-09-11	2002-04-30	Victor Fedij	Methods of making dihydropyrone HIV protease inhibitors
EP1274422A1 (en) *	2000-04-04	2003-01-15	Novartis AG	Method for treating cells resistant to antineoplastic agents
EP1487426B1 (en) *	2002-03-04	2012-08-22	Sloan-kettering Institute For Cancer Research	Methods of inducing terminal differentiation
AU2004263287B2 (en)	2003-07-25	2009-02-12	Novartis Ag	Substituted lactams and their use as anti-cancer agents
RU2006142690A (ru) *	2004-06-03	2008-06-10	Козан Байосайенсиз Инкорпорейтед (Us)	Соединения лептомицина
US7446196B2 (en) *	2004-06-03	2008-11-04	Kosan Biosciences, Incorporated	Leptomycin compounds
WO2007014423A1 (en) *	2005-08-02	2007-02-08	Medvet Science Pty, Ltd.	Exercise apparatus
CN101679340B (zh)	2006-06-16	2013-06-05	马尔药品公司	抗肿瘤二氢吡喃-2-酮化合物
JP5727228B2 (ja)	2007-12-20	2015-06-03	ファルマ・マール・ソシエダード・アノニマ	抗腫瘍化合物

2008
- 2008-12-19 JP JP2010538769A patent/JP5727228B2/ja not_active Expired - Fee Related
- 2008-12-19 CN CN2011100568656A patent/CN102174058A/zh active Pending
- 2008-12-19 RU RU2010130180/04A patent/RU2493147C2/ru active
- 2008-12-19 RU RU2013112003/04A patent/RU2528393C9/ru active
- 2008-12-19 CA CA2715203A patent/CA2715203C/en active Active
- 2008-12-19 AU AU2008341670A patent/AU2008341670B2/en not_active Ceased
- 2008-12-19 MX MX2010006796A patent/MX2010006796A/es active IP Right Grant
- 2008-12-19 HR HRP20120464AT patent/HRP20120464T1/hr unknown
- 2008-12-19 EP EP13154647.5A patent/EP2597091B1/en active Active
- 2008-12-19 EP EP08865009A patent/EP2231590B9/en active Active
- 2008-12-19 JP JP2010538765A patent/JP5529038B2/ja not_active Expired - Fee Related
- 2008-12-19 WO PCT/EP2008/068065 patent/WO2009080769A1/en not_active Ceased
- 2008-12-19 ES ES08864895.1T patent/ES2442140T3/es active Active
- 2008-12-19 SI SI200830644T patent/SI2231590T1/sl unknown
- 2008-12-19 BR BRPI0821114A patent/BRPI0821114B8/pt not_active IP Right Cessation
- 2008-12-19 DK DK08865009.8T patent/DK2231590T3/da active
- 2008-12-19 US US12/746,966 patent/US8710264B2/en active Active
- 2008-12-19 MY MYPI2010002590A patent/MY148651A/en unknown
- 2008-12-19 SG SG201102163-1A patent/SG170778A1/en unknown
- 2008-12-19 ES ES08865009T patent/ES2384420T3/es active Active
- 2008-12-19 NZ NZ586013A patent/NZ586013A/en not_active IP Right Cessation
- 2008-12-19 WO PCT/EP2008/068049 patent/WO2009080761A1/en not_active Ceased
- 2008-12-19 MX MX2010006795A patent/MX2010006795A/es active IP Right Grant
- 2008-12-19 PT PT08865009T patent/PT2231590E/pt unknown
- 2008-12-19 KR KR1020107015965A patent/KR101541436B1/ko not_active Expired - Fee Related
- 2008-12-19 US US12/746,974 patent/US9187445B2/en active Active
- 2008-12-19 UA UAA201009035A patent/UA104281C2/ru unknown
- 2008-12-19 SG SG201102164-9A patent/SG170779A1/en unknown
- 2008-12-19 PL PL08865009T patent/PL2231590T3/pl unknown
- 2008-12-19 PT PT88648951T patent/PT2231633E/pt unknown
- 2008-12-19 HR HRP20140015AT patent/HRP20140015T1/hr unknown
- 2008-12-19 SI SI200831122T patent/SI2231633T1/sl unknown
- 2008-12-19 EP EP08864895.1A patent/EP2231633B1/en active Active
- 2008-12-19 RS RS20140007A patent/RS53140B/sr unknown
- 2008-12-19 CN CN201110073931.0A patent/CN102190643B/zh not_active Expired - Fee Related
- 2008-12-19 UA UAA201406894A patent/UA119963C2/uk unknown
- 2008-12-19 ES ES13154647.5T patent/ES2578606T3/es active Active
- 2008-12-19 CN CN200880121840.6A patent/CN101903367B/zh not_active Expired - Fee Related
- 2008-12-19 KR KR1020157016575A patent/KR101639772B1/ko not_active Expired - Fee Related
- 2008-12-19 MY MYPI2010002591A patent/MY155342A/en unknown
- 2008-12-19 NZ NZ586012A patent/NZ586012A/en not_active IP Right Cessation
- 2008-12-19 UA UAA201009034A patent/UA106967C2/uk unknown
- 2008-12-19 NZ NZ597526A patent/NZ597526A/en not_active IP Right Cessation
- 2008-12-19 CA CA2710087A patent/CA2710087C/en active Active
- 2008-12-19 AT AT08865009T patent/ATE549313T1/de active
- 2008-12-19 DK DK08864895.1T patent/DK2231633T3/da active
- 2008-12-19 PL PL08864895T patent/PL2231633T3/pl unknown
- 2008-12-19 CN CN2008801218410A patent/CN101903337B/zh not_active Expired - Fee Related
- 2008-12-19 MY MYPI2014002392A patent/MY164533A/en unknown
- 2008-12-19 RS RS20120242A patent/RS52343B/sr unknown
- 2008-12-19 RU RU2010130253/04A patent/RU2489429C2/ru active
- 2008-12-19 KR KR1020107015968A patent/KR101579553B1/ko not_active Expired - Fee Related
- 2008-12-19 AU AU2008341671A patent/AU2008341671B2/en not_active Ceased
- 2008-12-19 BR BRPI0821116A patent/BRPI0821116B8/pt not_active IP Right Cessation
2010
- 2010-06-04 ZA ZA2010/04018A patent/ZA201004018B/en unknown
- 2010-06-04 ZA ZA2010/04017A patent/ZA201004017B/en unknown
- 2010-06-15 IL IL206397A patent/IL206397A/en active IP Right Grant
- 2010-06-15 IL IL206396A patent/IL206396A/en active IP Right Grant
2011
- 2011-08-31 ZA ZA2011/06371A patent/ZA201106371B/en unknown
2013
- 2013-11-24 IL IL229594A patent/IL229594A/en active IP Right Grant
2014
- 2014-01-27 CY CY20141100069T patent/CY1117245T1/el unknown
- 2014-04-10 JP JP2014080887A patent/JP5860088B2/ja not_active Expired - Fee Related
2015
- 2015-08-12 US US14/824,690 patent/US9750759B2/en not_active Expired - Fee Related
- 2015-08-12 US US14/824,699 patent/US9827257B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN101903367A (zh)	2010-12-01
RU2528393C1 (ru)	2014-09-20
ZA201004018B (en)	2011-12-28
HK1147998A1 (en)	2011-08-26
AU2008341671B2 (en)	2012-07-26
DK2231633T3 (da)	2014-01-20
HRP20140015T1 (hr)	2014-02-14
IL229594A (en)	2016-02-29
PL2231633T3 (pl)	2014-03-31
CA2715203C (en)	2015-09-08
JP2011506575A (ja)	2011-03-03
KR101541436B1 (ko)	2015-08-03
RU2010130253A (ru)	2012-01-27
IL206396A (en)	2014-05-28
CN101903367B (zh)	2015-08-05
MX2010006796A (es)	2010-10-26
BRPI0821116B1 (pt)	2020-02-18
SG170779A1 (en)	2011-05-30
EP2231633B1 (en)	2013-10-30
AU2008341670A1 (en)	2009-07-02
ZA201004017B (en)	2011-12-28
US20110034549A1 (en)	2011-02-10
EP2597091A1 (en)	2013-05-29
WO2009080761A1 (en)	2009-07-02
AU2008341670B2 (en)	2012-04-19
JP5529038B2 (ja)	2014-06-25
EP2231590A1 (en)	2010-09-29
KR20100125226A (ko)	2010-11-30
UA104281C2 (ru)	2014-01-27
MY155342A (en)	2015-10-15
HK1147990A1 (en)	2011-08-26
PL2231590T3 (pl)	2012-09-28
RU2010130180A (ru)	2012-01-27
MY164533A (en)	2017-12-29
US20150344454A1 (en)	2015-12-03
PT2231633E (pt)	2014-01-20
WO2009080769A1 (en)	2009-07-02
UA119963C2 (uk)	2019-09-10
PT2231590E (pt)	2012-06-25
UA106967C2 (uk)	2014-11-10
EP2231633A1 (en)	2010-09-29
RS53140B (sr)	2014-06-30
US20150342972A1 (en)	2015-12-03
US20120041063A2 (en)	2012-02-16
EP2231590B1 (en)	2012-03-14
MX2010006795A (es)	2010-10-26
RU2493147C2 (ru)	2013-09-20
SI2231633T1 (sl)	2014-02-28
ATE549313T1 (de)	2012-03-15
DK2231590T3 (da)	2012-07-09
SI2231590T1 (sl)	2012-10-30
RS52343B (sr)	2012-12-31
ES2578606T3 (es)	2016-07-28
KR101579553B1 (ko)	2015-12-22
US8710264B2 (en)	2014-04-29
JP5860088B2 (ja)	2016-02-16
CA2710087A1 (en)	2009-07-02
IL206397A0 (en)	2010-12-30
IL206397A (en)	2014-01-30
CY1117245T1 (el)	2017-04-05
BRPI0821114A2 (pt)	2015-06-16
JP2014133752A (ja)	2014-07-24
NZ586012A (en)	2011-11-25
US20100280108A1 (en)	2010-11-04
ES2442140T3 (es)	2014-02-25
RU2013112003A (ru)	2014-08-20
HRP20120464T1 (hr)	2012-07-31
BRPI0821116B8 (pt)	2021-05-25
ZA201106371B (en)	2013-05-29
CN101903337B (zh)	2013-12-18
JP5727228B2 (ja)	2015-06-03
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