BRPI1008060A2 - Agonistas e antagonistas do receptor s1p5, e métodos de uso do mesmo. - Google Patents
Agonistas e antagonistas do receptor s1p5, e métodos de uso do mesmo.Info
- Publication number
- BRPI1008060A2 BRPI1008060A2 BRPI1008060-0A BRPI1008060A BRPI1008060A2 BR PI1008060 A2 BRPI1008060 A2 BR PI1008060A2 BR PI1008060 A BRPI1008060 A BR PI1008060A BR PI1008060 A2 BRPI1008060 A2 BR PI1008060A2
- Authority
- BR
- Brazil
- Prior art keywords
- antagonists
- methods
- receptor agonists
- agonists
- receptor
- Prior art date
Links
- 102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 title 1
- 108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 title 1
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
Classifications
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- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20730109P | 2009-02-10 | 2009-02-10 | |
| PCT/US2010/023768 WO2010093704A1 (en) | 2009-02-10 | 2010-02-10 | Agonists and antagonists of the s1p5 receptor, and methods of uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1008060A2 true BRPI1008060A2 (pt) | 2015-08-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| BRPI1008060-0A BRPI1008060A2 (pt) | 2009-02-10 | 2010-02-10 | Agonistas e antagonistas do receptor s1p5, e métodos de uso do mesmo. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20100216762A1 (pt) |
| EP (1) | EP2395835A4 (pt) |
| JP (1) | JP2012517446A (pt) |
| KR (1) | KR20110117706A (pt) |
| CN (1) | CN102387704A (pt) |
| AU (1) | AU2010213794A1 (pt) |
| BR (1) | BRPI1008060A2 (pt) |
| CA (1) | CA2749960A1 (pt) |
| CL (1) | CL2011001923A1 (pt) |
| CO (1) | CO6400170A2 (pt) |
| CR (1) | CR20110421A (pt) |
| EC (1) | ECSP11011243A (pt) |
| IL (1) | IL214049A0 (pt) |
| MX (1) | MX2011008450A (pt) |
| PE (1) | PE20120578A1 (pt) |
| RU (1) | RU2011137454A (pt) |
| SG (1) | SG172982A1 (pt) |
| WO (1) | WO2010093704A1 (pt) |
| ZA (1) | ZA201105323B (pt) |
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| HRP20160890T1 (hr) | 2008-08-27 | 2016-09-23 | Arena Pharmaceuticals, Inc. | Derivati supstituirane tricikličke kiseline kao agonisti s1p1-receptora korisni u liječenju autoimunih i upalnih poremećaja |
| JP5856980B2 (ja) | 2010-01-27 | 2016-02-10 | アリーナ ファーマシューティカルズ, インコーポレイテッド | (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス |
| CN105503882B (zh) | 2010-03-03 | 2019-07-05 | 艾尼纳制药公司 | 制备s1p1受体调节剂及其晶体形式的方法 |
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| JP2014508106A (ja) * | 2010-12-03 | 2014-04-03 | アラーガン インコーポレイテッド | スフィンゴシン−1−リン酸−1受容体モジュレーターとしてのアルキンおよびアルケン誘導体 |
| US8507686B2 (en) | 2011-04-14 | 2013-08-13 | Allergan, Inc. | Substituted bicyclic methyl azetidines as sphingosine-1 phosphate receptors modulators |
| EP2697195A1 (en) | 2011-04-14 | 2014-02-19 | Allergan, Inc. | Phenyl bicyclic methyl azetidine derivatives as sphingosine-1 phosphate receptors modulators |
| JP2014525932A (ja) | 2011-08-15 | 2014-10-02 | インターミューン, インコーポレイテッド | リゾホスファチド酸レセプターアンタゴニスト |
| TWI616430B (zh) | 2012-07-27 | 2018-03-01 | 百健Ma公司 | Atx調節劑 |
| US9850206B2 (en) | 2012-11-20 | 2017-12-26 | Biogen Ma Inc. | S1P and/or ATX modulating agents |
| US8871755B2 (en) | 2013-02-12 | 2014-10-28 | Allergan, Inc. | Alkene azetidine derivatives as sphingosine 1-phosphate (S1P) receptor modulators |
| US8957061B2 (en) | 2013-02-13 | 2015-02-17 | Allergan, Inc. | Azetidine derivatives as sphingosine 1-phosphate (S1P) receptor modulators |
| US20150045341A1 (en) * | 2013-08-08 | 2015-02-12 | Allergan, Inc. | Disubstituted aryl azetidine derivatives as sphingosine-1 phosphate receptors modulators |
| CN106132928B (zh) * | 2014-02-28 | 2019-03-29 | 橘生药品工业株式会社 | 苯胺衍生物、含有所述衍生物的药物组合物及其用途 |
| PL3242666T3 (pl) | 2015-01-06 | 2025-02-17 | Arena Pharmaceuticals, Inc. | Związek do zastosowania w leczeniu dolegliwości związanych z receptorem s1p1 |
| BR112017027656B1 (pt) | 2015-06-22 | 2023-12-05 | Arena Pharmaceuticals, Inc. | Hábito cristalino de placa livre de sal de l-arginina de ácido (r)-2-(7-(4- ciclopentil-3-(trifluorometil)benzilóxi)- 1,2,3,4-tetra-hidrociclo-penta[b]indol-3- il)acético, composição farmacêutica que o compreende, seus usos e método de preparação do mesmo |
| EP3341353A1 (en) * | 2015-08-27 | 2018-07-04 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| CA3033863C (en) * | 2016-08-18 | 2021-09-14 | Memorial Sloan Kettering Cancer Center | Inhibition of sphingosine 1-phosphate receptor for treatment and prevention of lymphedema |
| MX2019009841A (es) | 2017-02-16 | 2020-01-30 | Arena Pharm Inc | Compuestos y metodos para el tratamiento de la colangitis biliar primaria. |
| MX2019009843A (es) | 2017-02-16 | 2020-01-30 | Arena Pharm Inc | Compuestos y metodos para el tratamiento de la enfermedad inflamatoria intestinal con manifestaciones extraintestinales. |
| DK3634394T3 (da) | 2017-05-15 | 2026-03-02 | Cognition Therapeutics Inc | Sammensætninger til behandling af neurogenerative sygdomme |
| WO2019016112A1 (en) * | 2017-07-17 | 2019-01-24 | AbbVie Deutschland GmbH & Co. KG | SUBSTITUTED QUINOLINE COMPOUNDS IN POSITIONS 1, 2, 3 AND 4 AS MODULATORS OF S1P |
| US11059784B2 (en) | 2017-08-09 | 2021-07-13 | Bristol-Myers Squibb Company | Oxime ether compounds |
| US11046646B2 (en) | 2017-08-09 | 2021-06-29 | Bristol-Myers Squibb Company | Alkylphenyl compounds |
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| CN112955431A (zh) | 2018-09-06 | 2021-06-11 | 艾尼纳制药公司 | 可用于治疗自身免疫性病症和炎性病症的化合物 |
| WO2020114477A1 (zh) * | 2018-12-06 | 2020-06-11 | 上海济煜医药科技有限公司 | 作为免疫调节剂的化合物及其制备方法和应用 |
| WO2020179859A1 (ja) | 2019-03-06 | 2020-09-10 | 第一三共株式会社 | ピロロピラゾール誘導体 |
| CN114460217B (zh) * | 2022-01-29 | 2023-06-30 | 杭州沐源生物医药科技有限公司 | 一种分离检测硫酸特布他林注射液及其杂质的方法 |
| AU2024331485A1 (en) * | 2023-08-31 | 2026-03-19 | Autobahn Therapeutics, Inc. | Amide prodrugs and uses thereof |
| CN119638586B (zh) * | 2023-09-15 | 2026-03-20 | 中国医学科学院药物研究所 | 一种三氟甲基环己基苄醚取代的含氮有机酸类衍生物、其制法和用途 |
| CN119638588B (zh) * | 2023-09-15 | 2026-03-20 | 中国医学科学院药物研究所 | 一种三氟甲基苄醚取代的氨基酸类衍生物、其制法和用途 |
| CN119874633B (zh) * | 2023-10-25 | 2025-10-21 | 中国石油化工股份有限公司 | 一种油田水处理缓蚀剂及其合成方法 |
| WO2025222078A1 (en) * | 2024-04-18 | 2025-10-23 | The Board Of Trustees Of The Leland Stanford Junior University | Smpd1 inhibitors and uses thereof |
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| TW200906396A (en) * | 2007-02-14 | 2009-02-16 | Janssen Pharmaceutica Nv | LTA4H modulators and uses thereof |
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2010
- 2010-02-10 PE PE2011001458A patent/PE20120578A1/es not_active Application Discontinuation
- 2010-02-10 CA CA2749960A patent/CA2749960A1/en not_active Abandoned
- 2010-02-10 AU AU2010213794A patent/AU2010213794A1/en not_active Abandoned
- 2010-02-10 MX MX2011008450A patent/MX2011008450A/es unknown
- 2010-02-10 US US12/703,615 patent/US20100216762A1/en not_active Abandoned
- 2010-02-10 WO PCT/US2010/023768 patent/WO2010093704A1/en not_active Ceased
- 2010-02-10 KR KR1020117021336A patent/KR20110117706A/ko not_active Withdrawn
- 2010-02-10 CN CN2010800161022A patent/CN102387704A/zh active Pending
- 2010-02-10 BR BRPI1008060-0A patent/BRPI1008060A2/pt not_active IP Right Cessation
- 2010-02-10 JP JP2011549346A patent/JP2012517446A/ja not_active Withdrawn
- 2010-02-10 SG SG2011050978A patent/SG172982A1/en unknown
- 2010-02-10 EP EP10741670.3A patent/EP2395835A4/en not_active Withdrawn
- 2010-02-10 RU RU2011137454/13A patent/RU2011137454A/ru unknown
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- 2011-08-02 EC EC2011011243A patent/ECSP11011243A/es unknown
- 2011-08-08 CR CR20110421A patent/CR20110421A/es not_active Application Discontinuation
- 2011-08-09 CL CL2011001923A patent/CL2011001923A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2011008450A (es) | 2011-09-01 |
| JP2012517446A (ja) | 2012-08-02 |
| WO2010093704A1 (en) | 2010-08-19 |
| ECSP11011243A (es) | 2011-09-30 |
| CR20110421A (es) | 2011-12-08 |
| CO6400170A2 (es) | 2012-03-15 |
| EP2395835A4 (en) | 2013-04-17 |
| US20100216762A1 (en) | 2010-08-26 |
| AU2010213794A1 (en) | 2011-09-01 |
| CA2749960A1 (en) | 2010-08-19 |
| SG172982A1 (en) | 2011-08-29 |
| CN102387704A (zh) | 2012-03-21 |
| RU2011137454A (ru) | 2013-03-20 |
| CL2011001923A1 (es) | 2011-11-11 |
| KR20110117706A (ko) | 2011-10-27 |
| PE20120578A1 (es) | 2012-06-17 |
| ZA201105323B (en) | 2012-03-28 |
| IL214049A0 (en) | 2011-08-31 |
| EP2395835A1 (en) | 2011-12-21 |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
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