BRPI0823087A2 - Resolução enantiomérica de nucleosídeos de 1,3-oxatiolano 2,4- dissubstituídos - Google Patents

Resolução enantiomérica de nucleosídeos de 1,3-oxatiolano 2,4- dissubstituídos

Info

Publication number
BRPI0823087A2
BRPI0823087A2 BRPI0823087-0A BRPI0823087A BRPI0823087A2 BR PI0823087 A2 BRPI0823087 A2 BR PI0823087A2 BR PI0823087 A BRPI0823087 A BR PI0823087A BR PI0823087 A2 BRPI0823087 A2 BR PI0823087A2
Authority
BR
Brazil
Prior art keywords
disubstituted
enantiomeric resolution
oxathiolane nucleosides
oxathiolane
nucleosides
Prior art date
Application number
BRPI0823087-0A
Other languages
English (en)
Inventor
Dan Simion
Dragos Vizitiu
Jean-Eric Lacoste
Original Assignee
Shire Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire Canada Inc filed Critical Shire Canada Inc
Publication of BRPI0823087A2 publication Critical patent/BRPI0823087A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
BRPI0823087-0A 2008-09-05 2008-09-05 Resolução enantiomérica de nucleosídeos de 1,3-oxatiolano 2,4- dissubstituídos BRPI0823087A2 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2008/002314 WO2010026439A1 (en) 2008-09-05 2008-09-05 Enantiomeric resolution of 2,4-disubstituted 1,3-oxathiolane nucleosides

Publications (1)

Publication Number Publication Date
BRPI0823087A2 true BRPI0823087A2 (pt) 2015-06-16

Family

ID=40525277

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0823087-0A BRPI0823087A2 (pt) 2008-09-05 2008-09-05 Resolução enantiomérica de nucleosídeos de 1,3-oxatiolano 2,4- dissubstituídos

Country Status (15)

Country Link
US (1) US20120184739A1 (pt)
EP (1) EP2346890B1 (pt)
JP (1) JP5690731B2 (pt)
KR (1) KR101556815B1 (pt)
CN (1) CN102203111B (pt)
AU (1) AU2008361409B2 (pt)
BR (1) BRPI0823087A2 (pt)
CA (1) CA2736163C (pt)
DK (1) DK2346890T3 (pt)
ES (1) ES2421708T3 (pt)
MX (1) MX2011002507A (pt)
NZ (1) NZ591709A (pt)
PT (1) PT2346890E (pt)
WO (1) WO2010026439A1 (pt)
ZA (1) ZA201101910B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019196107A1 (zh) * 2018-04-13 2019-10-17 深圳达闼科技控股有限公司 物质成分的检测方法及相关装置和计算机可读存储介质
CN119350115A (zh) * 2024-10-24 2025-01-24 浙江外国语学院 一种从含有β和α两种异构体的CME溶液中回收β异构体的方法
CN119350314B (zh) * 2024-10-24 2026-04-10 浙江外国语学院 一种拉米夫定中间体的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5587480A (en) * 1990-11-13 1996-12-24 Biochem Pharma, Inc. Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
FR2710337B1 (fr) * 1993-09-23 1995-12-08 Gerard Coquerel Procédé de dédoublement de deux antipodes optiques par entraînement polythermique programmé et autoensemencé.
US20040067877A1 (en) * 2002-08-01 2004-04-08 Schinazi Raymond F. 2', 3'-Dideoxynucleoside analogues for the treatment or prevention of Flaviviridae infections
US7968703B2 (en) * 2005-03-07 2011-06-28 Shire Canada Inc. Process and methods for the preparation of optically active cis-2-hydroxymethyl-4- (cytosin-1'-yl)-1,3-oxathiolane or pharmaceutically acceptable salts thereof

Also Published As

Publication number Publication date
KR101556815B1 (ko) 2015-10-01
CA2736163A1 (en) 2010-03-11
CN102203111A (zh) 2011-09-28
JP5690731B2 (ja) 2015-03-25
HK1159641A1 (en) 2012-08-03
EP2346890A1 (en) 2011-07-27
CN102203111B (zh) 2014-08-20
JP2012502016A (ja) 2012-01-26
MX2011002507A (es) 2011-07-29
EP2346890B1 (en) 2013-03-20
DK2346890T3 (da) 2013-06-24
CA2736163C (en) 2016-08-02
PT2346890E (pt) 2013-06-27
KR20110091646A (ko) 2011-08-12
NZ591709A (en) 2012-11-30
WO2010026439A1 (en) 2010-03-11
US20120184739A1 (en) 2012-07-19
AU2008361409B2 (en) 2015-02-12
ZA201101910B (en) 2011-12-28
AU2008361409A1 (en) 2010-03-11
ES2421708T3 (es) 2013-09-05

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2478 DE 03-07-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.