BRPI0906433A2 - indole-3-carboxamidas cíclicas, sua preparação e seu uso como farmacêutico - Google Patents
indole-3-carboxamidas cíclicas, sua preparação e seu uso como farmacêuticoInfo
- Publication number
- BRPI0906433A2 BRPI0906433A2 BRPI0906433A BRPI0906433A BRPI0906433A2 BR PI0906433 A2 BRPI0906433 A2 BR PI0906433A2 BR PI0906433 A BRPI0906433 A BR PI0906433A BR PI0906433 A BRPI0906433 A BR PI0906433A BR PI0906433 A2 BRPI0906433 A2 BR PI0906433A2
- Authority
- BR
- Brazil
- Prior art keywords
- carboxamides
- pharmaceutical
- preparation
- cyclic indole
- indole
- Prior art date
Links
- -1 cyclic indole-3-carboxamides Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08290093 | 2008-01-31 | ||
| PCT/EP2009/000281 WO2009095163A2 (en) | 2008-01-31 | 2009-01-17 | Cyclic indole-3-carboxamides, their preparation and their use as pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0906433A2 true BRPI0906433A2 (pt) | 2019-09-24 |
Family
ID=39596523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0906433A BRPI0906433A2 (pt) | 2008-01-31 | 2009-01-17 | indole-3-carboxamidas cíclicas, sua preparação e seu uso como farmacêutico |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8211885B2 (pt) |
| EP (1) | EP2247575B1 (pt) |
| JP (1) | JP5727794B2 (pt) |
| KR (1) | KR20100121610A (pt) |
| CN (1) | CN101981006B (pt) |
| AR (1) | AR070290A1 (pt) |
| AU (1) | AU2009210297B2 (pt) |
| BR (1) | BRPI0906433A2 (pt) |
| CA (1) | CA2712854C (pt) |
| IL (1) | IL207204A (pt) |
| MX (1) | MX2010007660A (pt) |
| MY (1) | MY153611A (pt) |
| RU (1) | RU2485102C2 (pt) |
| TW (1) | TWI447112B (pt) |
| WO (1) | WO2009095163A2 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR077428A1 (es) * | 2009-07-29 | 2011-08-24 | Sanofi Aventis | (aza) indolizinacarboxamidas ciclicas su preparacion y su uso como agentes farmaceuticos |
| JP2012211085A (ja) * | 2009-08-12 | 2012-11-01 | Kyowa Hakko Kirin Co Ltd | ヘッジホッグシグナル阻害剤 |
| US12428415B2 (en) | 2018-10-02 | 2025-09-30 | Disc Medicine, Inc. | Matriptase 2 inhibitors and uses thereof |
| EP4221701A1 (en) * | 2020-09-30 | 2023-08-09 | FL2022-001, Inc. | Hsd17b13 inhibitors and uses thereof |
| US20250163077A1 (en) * | 2022-02-18 | 2025-05-22 | Insilico Medicine Ip Limited | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (pkmyt1) inhibitors and uses thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2557341A1 (de) * | 1975-12-19 | 1977-06-30 | Hoechst Ag | Basisch substituierte indolderivate und verfahren zu ihrer herstellung |
| RU2026287C1 (ru) * | 1991-06-28 | 1995-01-09 | Центр по химии лекарственных трав | Производные пирролин-2-она-4 или индолинона-3, обладающие антигипертензивной активностью, и способ их получения |
| ATE159524T1 (de) * | 1992-05-13 | 1997-11-15 | Syntex Inc | Substituierte indole als angiotensin ii antagonisten |
| EP0716077A1 (de) * | 1994-12-08 | 1996-06-12 | Ciba-Geigy Ag | Aromatisch substituierte Omega-Aminoalkansäureamide und Alkansäurediamide und ihre Verwendung als Renininhibitoren |
| KR20010041346A (ko) | 1998-02-25 | 2001-05-15 | 브루스 엠. 에이센, 토마스 제이 데스로저 | 포스포리파제 ａ2 억제제 |
| NZ506329A (en) | 1998-02-25 | 2004-01-30 | Inst Genetics Llc | Inhibitors of phospholipase enzymes |
| US6500853B1 (en) * | 1998-02-28 | 2002-12-31 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| EP1156045A4 (en) * | 1999-01-28 | 2002-04-17 | Nippon Shinyaku Co Ltd | AMID DERIVATIVES AND DRUG COMPOSITIONS |
| EP1243268A4 (en) | 1999-12-14 | 2003-05-21 | Nippon Shinyaku Co Ltd | MEDICINAL COMPOSITION |
| WO2003037862A1 (en) | 2001-10-30 | 2003-05-08 | Nippon Shinyaku Co., Ltd. | Amide derivatives and drugs |
| CN1870991A (zh) * | 2003-09-04 | 2006-11-29 | 安万特药物公司 | 作为多聚(adp－核糖)聚合酶(parp)抑制剂的被取代的吲哚类化合物 |
| EP1773880A4 (en) | 2004-06-08 | 2009-09-09 | Novartis Vaccines & Diagnostic | ENV POLYPEPTIDE COMPLEXES AND METHOD FOR THEIR USE |
| AP2007004047A0 (en) | 2005-01-20 | 2007-06-30 | Pfizer Ltd | Substituted triazole derivatives as oxtocin antagonists |
| US20100121048A1 (en) * | 2006-02-16 | 2010-05-13 | Takanobu Kuroita | Cyclic Amine Compound and Use Thereof for the Prophylaxis or Treatment of Hypertension |
-
2009
- 2009-01-17 EP EP09706006.5A patent/EP2247575B1/en not_active Not-in-force
- 2009-01-17 JP JP2010544615A patent/JP5727794B2/ja not_active Expired - Fee Related
- 2009-01-17 KR KR1020107017058A patent/KR20100121610A/ko not_active Abandoned
- 2009-01-17 BR BRPI0906433A patent/BRPI0906433A2/pt not_active IP Right Cessation
- 2009-01-17 AU AU2009210297A patent/AU2009210297B2/en not_active Ceased
- 2009-01-17 WO PCT/EP2009/000281 patent/WO2009095163A2/en not_active Ceased
- 2009-01-17 MY MYPI2010003203A patent/MY153611A/en unknown
- 2009-01-17 MX MX2010007660A patent/MX2010007660A/es active IP Right Grant
- 2009-01-17 RU RU2010136324/04A patent/RU2485102C2/ru not_active IP Right Cessation
- 2009-01-17 CA CA2712854A patent/CA2712854C/en not_active Expired - Fee Related
- 2009-01-17 CN CN2009801105421A patent/CN101981006B/zh not_active Expired - Fee Related
- 2009-01-22 TW TW098102341A patent/TWI447112B/zh not_active IP Right Cessation
- 2009-01-29 AR ARP090100278A patent/AR070290A1/es unknown
-
2010
- 2010-07-25 IL IL207204A patent/IL207204A/en not_active IP Right Cessation
- 2010-07-28 US US12/845,317 patent/US8211885B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL207204A (en) | 2014-06-30 |
| JP5727794B2 (ja) | 2015-06-03 |
| CA2712854C (en) | 2016-02-23 |
| WO2009095163A2 (en) | 2009-08-06 |
| WO2009095163A3 (en) | 2009-12-10 |
| CN101981006B (zh) | 2013-08-28 |
| EP2247575B1 (en) | 2016-03-23 |
| KR20100121610A (ko) | 2010-11-18 |
| TWI447112B (zh) | 2014-08-01 |
| US20110039830A1 (en) | 2011-02-17 |
| EP2247575A2 (en) | 2010-11-10 |
| RU2010136324A (ru) | 2012-03-10 |
| IL207204A0 (en) | 2010-12-30 |
| RU2485102C2 (ru) | 2013-06-20 |
| AR070290A1 (es) | 2010-03-25 |
| AU2009210297B2 (en) | 2013-11-21 |
| HK1149013A1 (en) | 2011-09-23 |
| CA2712854A1 (en) | 2009-08-06 |
| JP2011510942A (ja) | 2011-04-07 |
| MY153611A (en) | 2015-02-27 |
| CN101981006A (zh) | 2011-02-23 |
| AU2009210297A1 (en) | 2009-08-06 |
| US8211885B2 (en) | 2012-07-03 |
| TW200944515A (en) | 2009-11-01 |
| MX2010007660A (es) | 2010-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |