BRPI0906972A2 - Composições de matriz extracelular. - Google Patents

Composições de matriz extracelular.

Info

Publication number
BRPI0906972A2
BRPI0906972A2 BRPI0906972-0A BRPI0906972A BRPI0906972A2 BR PI0906972 A2 BRPI0906972 A2 BR PI0906972A2 BR PI0906972 A BRPI0906972 A BR PI0906972A BR PI0906972 A2 BRPI0906972 A2 BR PI0906972A2
Authority
BR
Brazil
Prior art keywords
extracellular matrix
matrix compositions
compositions
extracellular
matrix
Prior art date
Application number
BRPI0906972-0A
Other languages
English (en)
Inventor
Gail K Naugton
Frank Ziegler
Mark Baumgartner
Kyle Nickey
Original Assignee
Histogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Histogen Inc filed Critical Histogen Inc
Publication of BRPI0906972A2 publication Critical patent/BRPI0906972A2/pt
Publication of BRPI0906972B1 publication Critical patent/BRPI0906972B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0627—Hair cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0656—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/02—Atmosphere, e.g. low oxygen conditions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/165—Vascular endothelial growth factor [VEGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cardiology (AREA)
  • Botany (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
BRPI0906972-0A 2008-01-30 2009-01-30 Métodos para produção de composições de matriz extracelular e para produção de uma proteína wnt e de um fator de crescimento endotelial vascular BRPI0906972B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US2485408P 2008-01-30 2008-01-30
US61/024,854 2008-01-30
US3436108P 2008-03-06 2008-03-06
US61/034,361 2008-03-06
US5094008P 2008-05-06 2008-05-06
US61/050,940 2008-05-06
PCT/US2009/032697 WO2009097559A1 (en) 2008-01-30 2009-01-30 Extracellular matrix compositions

Publications (2)

Publication Number Publication Date
BRPI0906972A2 true BRPI0906972A2 (pt) 2015-07-14
BRPI0906972B1 BRPI0906972B1 (pt) 2021-09-08

Family

ID=40913280

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0906972-0A BRPI0906972B1 (pt) 2008-01-30 2009-01-30 Métodos para produção de composições de matriz extracelular e para produção de uma proteína wnt e de um fator de crescimento endotelial vascular
BR122020017131-6A BR122020017131B1 (pt) 2008-01-30 2009-01-30 Métodos de produção de composição para reparo e/ou regeneração de células, para auxiliar no crescimento de células-tronco, para modificar a cicatrização de ferida, a inflamação, uma formação de cápsula fibrosa, o crescimento tecidual ou modificar o crescimento celular, para aperfeiçoamento de uma superfície cutânea, para reparo ou aumento de tecido mole, e de promoção do crescimento capilar

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR122020017131-6A BR122020017131B1 (pt) 2008-01-30 2009-01-30 Métodos de produção de composição para reparo e/ou regeneração de células, para auxiliar no crescimento de células-tronco, para modificar a cicatrização de ferida, a inflamação, uma formação de cápsula fibrosa, o crescimento tecidual ou modificar o crescimento celular, para aperfeiçoamento de uma superfície cutânea, para reparo ou aumento de tecido mole, e de promoção do crescimento capilar

Country Status (12)

Country Link
US (1) US8257947B2 (pt)
EP (1) EP2262891B1 (pt)
JP (2) JP5647007B2 (pt)
KR (1) KR101650957B1 (pt)
CN (1) CN102066558B (pt)
AP (1) AP3129A (pt)
AU (1) AU2009209022B2 (pt)
BR (2) BRPI0906972B1 (pt)
CA (1) CA2714387C (pt)
SG (2) SG10201500237TA (pt)
WO (1) WO2009097559A1 (pt)
ZA (1) ZA201006148B (pt)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8361503B2 (en) 2007-03-02 2013-01-29 University of Pittsburgh—of the Commonwealth System of Higher Education Extracellular matrix-derived gels and related methods
US9283302B2 (en) 2011-12-16 2016-03-15 Cormatrix Cardiovascular, Inc. Extracellular matrix encasement structures and methods
US20220023503A9 (en) 2007-05-10 2022-01-27 Aziyo Med, Llc Extracellular Matrix Tissue Prostheses
US8524494B2 (en) * 2008-01-30 2013-09-03 Histogen, Inc. Low oxygen tension and BFGF generates a multipotent stem cell from a fibroblast in vitro
US9290740B2 (en) * 2008-03-07 2016-03-22 Worcester Polytechnic Institute Use of basic fibroblast growth factor in the de-differentiation of animal connective tissue cells
DK2451964T3 (en) * 2009-07-10 2018-04-30 Histogen Inc Conditioned medium and extracellular matrix compositions from cells grown under hypoxic conditions
RU2418066C1 (ru) * 2010-04-26 2011-05-10 Учреждение Российской академии наук Государственный научный центр Российской Федерации-Институт медико-биологических проблем Российской академии наук (ГНЦ РФ-ИМБП РАН) Способ модификации пролиферативной активности и дифференцировочной потенции мультипотентных мезенхимальных стромальных клеток
EP2598181B1 (en) * 2010-07-31 2021-04-21 Cook Medical Technologies LLC Collagenous tissue pocket for an implantable medical device, and manufacturing method therefor
EP2903560A4 (en) * 2012-10-08 2016-05-25 Cormatrix Cardiovascular Inc METHOD AND SYSTEM FOR TREATING BIOLOGICAL TISSUE
SG11201506312TA (en) 2013-02-12 2015-09-29 Replicel Life Sciences Inc Compositions and methods for treating and repairing tendons
CN105246494B (zh) * 2013-04-19 2020-02-07 高丽大学校产学协力团 刺激毛发生长或防止毛发脱落的包括神经干细胞的提取物的组合物及其制造方法
US10533191B2 (en) 2014-01-15 2020-01-14 Serucell Corporation Therapeutic serum obtained from co-cultured cells
WO2015123477A1 (en) 2014-02-12 2015-08-20 Replicel Life Sciences Inc. Compositions and methods for treating bone, joints and cartilage
AU2015231110B2 (en) 2014-03-21 2019-03-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods for preparation of a terminally sterilized hydrogel derived from extracellular matrix
KR101633585B1 (ko) * 2014-03-31 2016-06-27 아주대학교산학협력단 표면개질된 연골세포 유래 세포외 기질막을 유효성분으로 함유하는 유착방지용 조성물
WO2015152596A1 (ko) * 2014-03-31 2015-10-08 아주대학교산학협력단 표면개질된 연골세포 유래 세포외 기질막을 유효성분으로 함유하는 유착방지용 조성물
WO2015164728A1 (en) * 2014-04-24 2015-10-29 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Fractionating extracellular matrix to modulate bioactivity and the host response
JP6718202B2 (ja) * 2014-06-20 2020-07-08 共栄化学工業株式会社 皮膚外用剤
FR3029116B1 (fr) * 2014-12-01 2018-03-30 Advanced Chitosan Solutions Biotech Procede d'obtention d'un gel de cartilage pour la reparation cartilagineuse, comprenant du chitosane et des chondrocytes
FR3032632A1 (fr) * 2015-02-12 2016-08-19 Exel Ind Pistolet de projection d'un fluide, filtre pour un tel pistolet, et procede d'extraction d'un filtre hors d'un tel pistolet
CN104941008A (zh) * 2015-05-19 2015-09-30 烟台正海生物科技股份有限公司 一种引导组织再生膜的制备方法及其应用
CN105769381B (zh) * 2015-05-26 2018-04-17 南通大学 一种用于组织损伤修复的生物补片
JP6587877B2 (ja) * 2015-09-17 2019-10-09 日本メナード化粧品株式会社 表皮幹細胞を分離するためのマーカー及び三次元培養表皮の製造方法
CN106978394B (zh) * 2017-02-23 2020-06-23 北京恒峰铭成生物科技有限公司 一种抗慢性炎症的间充质干细胞的制备方法及其应用
CA3049990A1 (en) 2017-03-02 2018-09-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Extracellular matrix (ecm) hydrogel and soluble fraction thereof for the treatment of cancer
US11718829B2 (en) 2017-07-28 2023-08-08 Breakthrough Tech Llc Methods and compositions for manufacturing extracellular matrix
CA3082896A1 (en) 2017-11-16 2019-05-23 Aivita Biomedical, Inc. Use of cell membrane-bound signaling factors
JP7151203B2 (ja) * 2018-06-19 2022-10-12 東洋インキＳｃホールディングス株式会社 細胞培養培地添加剤、細胞培養培地及び細胞凝集塊の製造方法
CA3107592A1 (en) * 2018-08-02 2020-02-06 Histogen, Inc. Conditioned medium and extracellular matrix compositions and uses thereof
JP7386539B2 (ja) * 2018-08-03 2023-11-27 株式会社細胞応用技術研究所 培養上清製剤の製造方法
CA3130744A1 (en) * 2019-02-19 2020-08-27 Direct Biologics Llc Acellular intravenous infusion including mesenchymal stem cell growth factors and exosomes
CN110607279B (zh) * 2019-10-18 2023-09-19 深圳优圣康医学检验实验室 一种原代肿瘤细胞的3d培养体系及其培养方法和应用
US12077780B2 (en) * 2020-02-14 2024-09-03 Allergan Sales, Llc Conditioned medium from cells cultured under hypoxic conditions and uses thereof
WO2022040206A1 (en) 2020-08-17 2022-02-24 Aziyo Med, Llc Depots and encasement structures for implantable devices
US20220135923A1 (en) * 2020-10-30 2022-05-05 University Of Georgia Research Foundation, Inc. Dynamic polymer surfaces for screening, enrichment, and harvesting of cells and other soft colloidal particles
US20240075189A1 (en) * 2020-12-14 2024-03-07 The Regents Of The University Of Colorado, A Body Corporate Particulate materials for tissue mimics
KR102406953B1 (ko) * 2021-05-17 2022-06-10 주식회사 에피바이오텍 신규한 모유두 세포 분리 방법
US20250163382A1 (en) * 2022-03-01 2025-05-22 National University Corporation Yokohama National University Method for producing proliferated hair follicle mesenchymal cells, and use thereof

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235312A (en) 1978-10-30 1980-11-25 Eaton Corporation Brake actuator assembly
MX163953B (es) * 1984-03-27 1992-07-03 Univ New Jersey Med Procedimiento para preparar una matriz biodegradable a base de colageno
US5032508A (en) * 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5266480A (en) * 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US5160490A (en) * 1986-04-18 1992-11-03 Marrow-Tech Incorporated Three-dimensional cell and tissue culture apparatus
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
US5091173A (en) * 1989-06-29 1992-02-25 The University Of Dundee Hair growth composition
US5204382A (en) 1992-02-28 1993-04-20 Collagen Corporation Injectable ceramic compositions and methods for their preparation and use
US6733776B1 (en) * 1992-04-02 2004-05-11 Anticancer, Inc. Method for promoting hair growth
US5830708A (en) 1995-06-06 1998-11-03 Advanced Tissue Sciences, Inc. Methods for production of a naturally secreted extracellular matrix
US6284284B1 (en) 1995-06-06 2001-09-04 Advanced Tissue Sciences, Inc. Compositions and methods for production and use of an injectable naturally secreted extracellular matrix
US5833948A (en) 1995-06-15 1998-11-10 Bracco Research S.A. Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant
US5888551A (en) * 1995-12-11 1999-03-30 University Of Miami Hair growth stimulating composition
US5866165A (en) * 1997-01-15 1999-02-02 Orquest, Inc. Collagen-polysaccharide matrix for bone and cartilage repair
US6197586B1 (en) * 1997-12-12 2001-03-06 The Regents Of The University Of California Chondrocyte-like cells useful for tissue engineering and methods
US6610540B1 (en) * 1998-11-18 2003-08-26 California Institute Of Technology Low oxygen culturing of central nervous system progenitor cells
EP2295540A1 (en) * 1998-11-19 2011-03-16 Organogenesis, Inc. Bioengineered tissue constructs and methods for producing and using them
US20030007954A1 (en) 1999-04-12 2003-01-09 Gail K. Naughton Methods for using a three-dimensional stromal tissue to promote angiogenesis
US6372494B1 (en) * 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
US6280284B1 (en) 2000-03-17 2001-08-28 Carl Winefordner Toy submarine with counter rotating propellers
ATE369144T1 (de) * 2000-03-31 2007-08-15 Gen Hospital Corp Verfahren zur steigerung des haarwuchses durch wnt polypeptid
US20020155440A1 (en) * 2000-12-19 2002-10-24 Ljubimova Julia Y. Using overexpression of laminin alpha 4 subunit as a diagnostic and prognostic indicator of malignant tumors
AU2002247044B2 (en) 2001-01-30 2006-11-16 Orthogene, Inc. Compositions and methods for the treatment and repair of defects or lesions in articular cartilage using synovial-derived tissue or cells
ITPD20010032A1 (it) * 2001-02-09 2002-08-09 Fidia Advanced Biopolymers Srl Innesti ingegnerizzati per la riparazione di difetti osteocondrali
US20050032208A1 (en) * 2003-06-18 2005-02-10 Oh Steve Kah Weng Materials and methods to produce stem cells
ES2297516T3 (es) 2003-12-02 2008-05-01 Universiteit Gent Uso de alginato polisulfatado en matrices celulares.
AU2005300263A1 (en) * 2004-03-09 2006-05-11 Jan-Eric W. Ahlfors Autogenic living scaffolds and living tissue matrices: methods and uses thereof
WO2005104766A2 (en) 2004-04-28 2005-11-10 Myocardial Therapeutics, Inc. Injection of bone marrow-derived conditioned medium for angiogenesis
US7828711B2 (en) * 2004-08-16 2010-11-09 Cardiac Pacemakers, Inc. Method and apparatus for modulating cellular growth and regeneration using ventricular assist device
US20060154365A1 (en) * 2004-08-30 2006-07-13 Anthony Ratcliffe Cultured three dimensional tissues and uses thereof
AU2005279934A1 (en) 2004-08-30 2006-03-09 Theregen, Inc. Compositions and methods of promoting hair growth
US20070072294A1 (en) * 2004-09-30 2007-03-29 Doronin Sergey V Use of human stem cells and/or factors they produce to promote adult mammalian cardiac repair through cardiomyocyte cell division
CA2662567A1 (en) * 2005-11-08 2007-05-18 Georgia Tech Research Corporation Acellularized biomaterial from embryonic stem cells

Also Published As

Publication number Publication date
BR122020017131B1 (pt) 2023-05-16
BRPI0906972B1 (pt) 2021-09-08
AU2009209022A1 (en) 2009-08-06
EP2262891A1 (en) 2010-12-22
EP2262891A4 (en) 2011-04-20
WO2009097559A1 (en) 2009-08-06
JP2011510662A (ja) 2011-04-07
US20100047305A1 (en) 2010-02-25
US8257947B2 (en) 2012-09-04
EP2262891B1 (en) 2022-09-21
CA2714387A1 (en) 2009-08-06
AP3129A (en) 2015-02-28
KR20110011599A (ko) 2011-02-08
AP2010005380A0 (en) 2010-08-31
CN102066558B (zh) 2017-02-08
SG10201906494PA (en) 2019-09-27
KR101650957B1 (ko) 2016-08-24
JP2014221070A (ja) 2014-11-27
AU2009209022B2 (en) 2014-06-12
SG10201500237TA (en) 2015-04-29
CN102066558A (zh) 2011-05-18
JP5647007B2 (ja) 2014-12-24
ZA201006148B (en) 2011-10-26
CA2714387C (en) 2018-06-19

Similar Documents

Publication Publication Date Title
BRPI0906972A2 (pt) Composições de matriz extracelular.
BRPI0915731A2 (pt) composição de graxa.
EP2381760A4 (en) CORN PROTEIN COMPOSITION
BRPI0915732A2 (pt) composição de graxa.
BRPI1010301A2 (pt) composição.
BRPI0814745A2 (pt) Composição de produto.
BRPI0907155A2 (pt) Composições pesticidas
BRPI1008939A2 (pt) 2-mercaptoquinolina-3-carboxamidas substituídas como moduladores de kncq2/3.
EP2513022A4 (en) AZEOTROPENEAN COMPOSITIONS OF CIS-1,1,1,4,4,4-HEXAFLUOR-2-BUTENE
BRPI0912634A2 (pt) Composições pesticidas
BRPI0913808A2 (pt) composição
BRPI0918430A2 (pt) 4-fenil-1h-pirazóis inseticidas.
BRPI0918637A2 (pt) composição antimicrobiana.
FR2930460B1 (fr) Distributeur de fragrance.
FR2937049B1 (fr) Composition de nettoyage.
FR2949786B1 (fr) Composition de graisse.
BRPI1011460A2 (pt) Composição desinfetante.
IT1396406B1 (it) Stantuffo.
BRPI0919048A2 (pt) Composições pesticidas
BRPI0917673A2 (pt) Combinação de herbicida-protetor compreendendo difluorometanossulfonilanilidas substituidas por dimetoxitriazinila
BRPI0916320A2 (pt) composições agrícolas
IT1393413B1 (it) Composizione pesticida.
BRPI0908923A2 (pt) composições pesticidas
FR2932490B1 (fr) Composition polyamide.
BRPI1015419A2 (pt) composição de revestimento.

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 30/01/2009, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.