BRPI0907061A2 - Derivados de 2-aminoquinolina úteis como inibidores de beta-secretase (base) - Google Patents
Derivados de 2-aminoquinolina úteis como inibidores de beta-secretase (base)Info
- Publication number
- BRPI0907061A2 BRPI0907061A2 BRPI0907061-3A BRPI0907061A BRPI0907061A2 BR PI0907061 A2 BRPI0907061 A2 BR PI0907061A2 BR PI0907061 A BRPI0907061 A BR PI0907061A BR PI0907061 A2 BRPI0907061 A2 BR PI0907061A2
- Authority
- BR
- Brazil
- Prior art keywords
- beta
- base
- derivatives useful
- secretase inhibitors
- aminoquinoline derivatives
- Prior art date
Links
- 150000005013 2-aminoquinolines Chemical class 0.000 title 1
- 239000002439 beta secretase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2424408P | 2008-01-29 | 2008-01-29 | |
| PCT/US2009/032393 WO2009097401A1 (en) | 2008-01-29 | 2009-01-29 | 2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0907061A2 true BRPI0907061A2 (pt) | 2015-07-07 |
Family
ID=40488089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0907061-3A BRPI0907061A2 (pt) | 2008-01-29 | 2009-01-29 | Derivados de 2-aminoquinolina úteis como inibidores de beta-secretase (base) |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7786116B2 (pt) |
| EP (1) | EP2240472B1 (pt) |
| JP (1) | JP2011510993A (pt) |
| KR (1) | KR20100118983A (pt) |
| CN (1) | CN101970429B (pt) |
| AU (1) | AU2009209147B2 (pt) |
| BR (1) | BRPI0907061A2 (pt) |
| CA (1) | CA2714008A1 (pt) |
| ES (1) | ES2397682T3 (pt) |
| IL (1) | IL207100A (pt) |
| MX (1) | MX2010008243A (pt) |
| NZ (1) | NZ586830A (pt) |
| RU (1) | RU2010136050A (pt) |
| WO (1) | WO2009097401A1 (pt) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US8383637B2 (en) * | 2004-08-06 | 2013-02-26 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
| US8436006B2 (en) * | 2004-08-06 | 2013-05-07 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
| US8426429B2 (en) * | 2004-08-06 | 2013-04-23 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
| WO2006138265A2 (en) | 2005-06-14 | 2006-12-28 | Schering Corporation | Heterocyclic aspartyl protease inhibitors, preparation and use thereof |
| PE20070135A1 (es) | 2005-06-14 | 2007-03-09 | Schering Corp | Compuestos heterociclicos como inhibidores de aspartil proteasas |
| CA2628074C (en) | 2005-10-25 | 2014-01-14 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivative |
| US7776882B2 (en) * | 2006-02-06 | 2010-08-17 | Baxter Ellen W | 2-amino-3,4-dihydro-quinoline derivatives useful as inhibitors of β-secretase (BACE) |
| US7868022B2 (en) * | 2006-02-06 | 2011-01-11 | Janssen Pharmaceutica Nv | 2-amino-quinoline derivatives useful as inhibitors of β-secretase (BACE) |
| US7932261B2 (en) * | 2006-02-06 | 2011-04-26 | Janssen Pharmaceutica Nv | Macrocycle derivatives useful as inhibitors of β-secretase (BACE) |
| PE20080155A1 (es) | 2006-06-12 | 2008-03-10 | Schering Corp | Compuestos heterociclicos como inhibidores de aspartil-proteasa |
| US8653067B2 (en) | 2007-04-24 | 2014-02-18 | Shionogi & Co., Ltd. | Pharmaceutical composition for treating Alzheimer's disease |
| JP5383484B2 (ja) | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | 環式基で置換されたアミノジヒドロチアジン誘導体 |
| WO2009097278A1 (en) * | 2008-01-28 | 2009-08-06 | Janssen Pharmaceutica N.V. | 6-SUBSTITUTED-THIO-2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE) |
| CA2723222C (en) | 2008-04-22 | 2013-04-02 | Schering Corporation | Phenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as bace-1 inhibitors, compositions, and their use |
| KR101324426B1 (ko) | 2008-06-13 | 2013-10-31 | 시오노기세야쿠 가부시키가이샤 | β 세크레타제 저해 작용을 갖는 황 함유 복소환 유도체 |
| CN102186841A (zh) | 2008-10-22 | 2011-09-14 | 盐野义制药株式会社 | 具有bace1抑制活性的2-氨基嘧啶-4-酮及2-氨基吡啶衍生物 |
| WO2011063233A1 (en) * | 2009-11-23 | 2011-05-26 | Amgen Inc. | Amino heteroaryl compounds as beta-secretase modulators and methods of use |
| EP2504330A1 (en) | 2009-11-23 | 2012-10-03 | Amgen Inc. | Amino heteroaryl compounds as beta-secretase modulators and methods of use |
| MX2012006491A (es) | 2009-12-11 | 2012-07-03 | Shionogi & Co | Derivados de oxazina. |
| CA2788363A1 (en) * | 2010-01-19 | 2011-07-28 | Amgen Inc. | Amino heteroaryl compounds as beta-secretase modulators and methods of use |
| US8198300B2 (en) | 2010-04-29 | 2012-06-12 | Universidad De Chile | Method for preventing tau protein aggregation and treating Alzheimer's disease with a quinoline derivative compound |
| JP5816630B2 (ja) | 2010-10-29 | 2015-11-18 | 塩野義製薬株式会社 | ナフチリジン誘導体 |
| EP2634188A4 (en) | 2010-10-29 | 2014-05-07 | Shionogi & Co | FUSIONED AMINODIHYDROPYRIMIDINE DERIVATIVE |
| US8883779B2 (en) | 2011-04-26 | 2014-11-11 | Shinogi & Co., Ltd. | Oxazine derivatives and a pharmaceutical composition for inhibiting BACE1 containing them |
| GB201212871D0 (en) | 2012-07-20 | 2012-09-05 | Eisai Ltd | Novel compounds |
| EP2912035A4 (en) | 2012-10-24 | 2016-06-15 | Shionogi & Co | DERIVATIVES OF DIHYDROOXAZINE OR OXAZEPINE HAVING BACE1 INHIBITING ACTIVITY |
| MX2015014688A (es) | 2013-04-22 | 2016-02-19 | Abbvie Inc | Tiazoles y usos de los mismos. |
| US11344543B2 (en) * | 2017-07-14 | 2022-05-31 | Innate Tumor Immunity, Inc. | NLRP3 modulators |
| CN112263583B (zh) * | 2020-11-23 | 2021-10-22 | 诸城市精神卫生中心 | 一种治疗帕金森疾病的药物及其制备方法 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4001237A (en) * | 1976-02-18 | 1977-01-04 | Bristol-Myers Company | Oxazole, isoxazole, thiazole and isothiazole amides |
| NZ197420A (en) * | 1980-07-01 | 1984-04-27 | Ici Australia Ltd | -(quinazolin-(2-or 4-)(oxy,ylthio or amino)phen(oxy or ylthio)alkanoic acid derivatives |
| US5684153A (en) * | 1984-08-16 | 1997-11-04 | Beecham Group Plc | Process for the preparation of purine derivatives |
| US4761416A (en) * | 1986-07-25 | 1988-08-02 | Syntex (U.S.A.) Inc. | N-N-disubstituted-ω-[2-amino-3-(carbonylmethyl)-3, 4-dihydroquinazolinyl]oxyalkylamides and related compounds |
| US4739056A (en) * | 1986-11-26 | 1988-04-19 | Syntex (U.S.A.) Inc. | N-N-disubstituted-omega-(2-amino-3-(carbonylmethyl)-3,4-dihydroquinazolinyl)oxy-alkylamides and related compounds |
| JPH0730046B2 (ja) | 1987-02-10 | 1995-04-05 | 第一製薬株式会社 | キナゾリン酢酸誘導体 |
| NZ234186A (en) | 1989-07-07 | 1991-10-25 | Janssen Pharmaceutica Nv | Imidazo quinazolin-one derivatives and pharmaceutical compositions |
| JP2726950B2 (ja) | 1990-04-27 | 1998-03-11 | 富士写真フイルム株式会社 | カラー画像形成方法 |
| ES2217250T3 (es) * | 1990-06-15 | 2004-11-01 | Scios Inc. | Mamifero transgenico, no humano que muestra la patologia de formacion amiloides de la enfermedad de alzheimer. |
| ES2236682T5 (es) * | 1991-01-21 | 2011-03-31 | Elan Pharmaceuticals, Inc. | Ensayo y modelo para la enfermedad de alzheimer. |
| US5672805A (en) * | 1991-07-18 | 1997-09-30 | The Regents Of The University Of California | Transgenic mice expressing the neurotoxic C-terminus of β-amyloid precursor protein |
| AU2765992A (en) * | 1991-10-03 | 1993-05-03 | Indiana University Foundation | Method for screening for alzheimer's disease |
| AU671093B2 (en) * | 1992-01-07 | 1996-08-15 | Elan Pharmaceuticals, Inc. | Transgenic animal models for alzheimer's disease |
| SE511886C2 (sv) * | 1992-01-31 | 1999-12-13 | Svedala Arbra Ab | Sätt att styra en gyratorisk kross |
| US5604102A (en) * | 1992-04-15 | 1997-02-18 | Athena Neurosciences, Inc. | Methods of screening for β-amyloid peptide production inhibitors |
| US5958883A (en) * | 1992-09-23 | 1999-09-28 | Board Of Regents Of The University Of Washington Office Of Technology | Animal models of human amyloidoses |
| AU702293B2 (en) * | 1993-10-27 | 1999-02-18 | Athena Neurosciences, Inc. | Transgenic animals harboring APP allele having Swedish mutation |
| JPH07132033A (ja) * | 1993-11-12 | 1995-05-23 | Hoechst Japan Ltd | アルツハイマー病モデルトランスジェニック動物 |
| US5877399A (en) * | 1994-01-27 | 1999-03-02 | Johns Hopkins University | Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease |
| WO1996006927A1 (en) * | 1994-09-01 | 1996-03-07 | Merck & Co., Inc. | Transgenic animal expressing a familial form of human amyloid precursor protein |
| US6071903A (en) * | 1998-01-27 | 2000-06-06 | American Cyanamid Company | 2,3,4,5-tetrahydro-1H-[1,4]-benzodiazepine-3-hydroxyamic acids |
| ATE356117T1 (de) * | 1999-01-22 | 2007-03-15 | Kirin Brewery | Derivate des n-((chinolinyl)oxy)-phenyl)- harnstoffs und des n-((chinazolinyl)oxy)-phenyl)- harnstoffs mit antitumor aktivität |
| EP1235815A1 (en) | 1999-11-22 | 2002-09-04 | Warner-Lambert Company | Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes |
| US20040087548A1 (en) * | 2001-02-27 | 2004-05-06 | Salvati Mark E. | Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
| EP1395257A1 (en) | 2001-06-12 | 2004-03-10 | Elan Pharmaceuticals, Inc. | Macrocycles useful in the treatment of alzheimer's disease |
| JP4450628B2 (ja) * | 2002-03-22 | 2010-04-14 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ファルネシルトランスフェラーゼインヒビターとして使用するためのベンジルイミダゾリル置換２−キノリンおよびキナゾリン誘導体 |
| WO2004058686A1 (en) | 2002-04-30 | 2004-07-15 | Elan Pharmaceuticals, Inc. | Hydroxypropyl amides for the treatment of alzheimer’s disease |
| CA2497979A1 (en) | 2002-09-06 | 2004-03-18 | Elan Pharmaceuticals, Inc. | 1, 3-diamino-2-hydroxypropane prodrug derivatives |
| EP1407774A1 (en) | 2002-09-10 | 2004-04-14 | LION Bioscience AG | 2-Amino-4-quinazolinones as LXR nuclear receptor binding compounds |
| GB0325830D0 (en) | 2003-11-05 | 2003-12-10 | Novartis Ag | Organic compounds |
| DE602005023887D1 (de) * | 2004-08-06 | 2010-11-11 | Janssen Pharmaceutica Nv | Als b-sekretase (bace)-hemmer nützliche 2-amino-chinazolinderivate |
| EP1776350B1 (en) * | 2004-08-06 | 2013-01-23 | Janssen Pharmaceutica NV | NOVEL 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF ß-SECRETASE ( BACE ) |
| US8426429B2 (en) * | 2004-08-06 | 2013-04-23 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
| US8383637B2 (en) * | 2004-08-06 | 2013-02-26 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
| US8436006B2 (en) | 2004-08-06 | 2013-05-07 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
| US20060074105A1 (en) * | 2004-09-20 | 2006-04-06 | Serenex, Inc. | Substituted quinoline and quinazoline inhibitors of quinone reductase 2 |
| CN101106989A (zh) * | 2005-01-19 | 2008-01-16 | 默克公司 | 作为β-分泌酶有效抑制剂用于治疗阿尔茨海默氏病的、具有取代的杂环的叔碳胺 |
| CA2594946A1 (en) | 2005-01-19 | 2006-07-27 | Merck & Co., Inc | Tertiary carbinamines having substituted heterocycles, which are active as inhibitors of beta-secretase, for the treatment of alzheimer's disease |
| EP1966198B1 (en) | 2005-10-25 | 2011-03-16 | Janssen Pharmaceutica NV | 2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives useful as inhibitors of beta-secretase (bace) |
| US7776882B2 (en) * | 2006-02-06 | 2010-08-17 | Baxter Ellen W | 2-amino-3,4-dihydro-quinoline derivatives useful as inhibitors of β-secretase (BACE) |
| US7868022B2 (en) * | 2006-02-06 | 2011-01-11 | Janssen Pharmaceutica Nv | 2-amino-quinoline derivatives useful as inhibitors of β-secretase (BACE) |
| WO2009097278A1 (en) * | 2008-01-28 | 2009-08-06 | Janssen Pharmaceutica N.V. | 6-SUBSTITUTED-THIO-2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE) |
-
2009
- 2009-01-29 EP EP09705822A patent/EP2240472B1/en not_active Not-in-force
- 2009-01-29 BR BRPI0907061-3A patent/BRPI0907061A2/pt not_active IP Right Cessation
- 2009-01-29 CA CA2714008A patent/CA2714008A1/en not_active Abandoned
- 2009-01-29 RU RU2010136050/04A patent/RU2010136050A/ru not_active Application Discontinuation
- 2009-01-29 AU AU2009209147A patent/AU2009209147B2/en not_active Ceased
- 2009-01-29 US US12/362,020 patent/US7786116B2/en active Active
- 2009-01-29 JP JP2010545148A patent/JP2011510993A/ja active Pending
- 2009-01-29 ES ES09705822T patent/ES2397682T3/es active Active
- 2009-01-29 MX MX2010008243A patent/MX2010008243A/es active IP Right Grant
- 2009-01-29 KR KR1020107018024A patent/KR20100118983A/ko not_active Withdrawn
- 2009-01-29 NZ NZ586830A patent/NZ586830A/en not_active IP Right Cessation
- 2009-01-29 WO PCT/US2009/032393 patent/WO2009097401A1/en not_active Ceased
- 2009-01-29 CN CN200980103364XA patent/CN101970429B/zh not_active Expired - Fee Related
-
2010
- 2010-07-20 IL IL207100A patent/IL207100A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MX2010008243A (es) | 2010-11-30 |
| KR20100118983A (ko) | 2010-11-08 |
| CN101970429B (zh) | 2013-05-29 |
| ES2397682T3 (es) | 2013-03-08 |
| CA2714008A1 (en) | 2009-08-06 |
| CN101970429A (zh) | 2011-02-09 |
| NZ586830A (en) | 2012-02-24 |
| IL207100A0 (en) | 2010-12-30 |
| EP2240472B1 (en) | 2012-11-21 |
| US7786116B2 (en) | 2010-08-31 |
| IL207100A (en) | 2013-10-31 |
| WO2009097401A1 (en) | 2009-08-06 |
| US20090227581A1 (en) | 2009-09-10 |
| AU2009209147B2 (en) | 2013-03-14 |
| JP2011510993A (ja) | 2011-04-07 |
| EP2240472A1 (en) | 2010-10-20 |
| RU2010136050A (ru) | 2012-03-10 |
| AU2009209147A1 (en) | 2009-08-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0907061A2 (pt) | Derivados de 2-aminoquinolina úteis como inibidores de beta-secretase (base) | |
| CY2020023I2 (el) | Αναστολεiς βητα-λακταμασων | |
| CY2021001I2 (el) | Παραγωγα ετεροκυκλικου αμιδιου χρησιμα ως μικροβιοκτονα | |
| BRPI0906625A2 (pt) | Derivados de tio-2-amino-quinolina-6-substituída úteis como inibidores da beta-secretase (bace) | |
| BRPI0920135A2 (pt) | imidazopiridazinacarbonitrilos úteis como inibidores de quinase | |
| BRPI0812825A2 (pt) | Derivados ftalazinona como inibidores de parp-1 | |
| BRPI0913879A2 (pt) | fenilpirazinonas como inibidores de quinase | |
| HRP20150477T1 (xx) | Postupci dobivanja derivata kinazolona | |
| BRPI0814797A2 (pt) | Inibidores dna-pk | |
| DK2308877T3 (da) | Imidazopyridin-2-on-derivater | |
| ATE549340T1 (de) | Spiroindolinon-derivate als mdm2-p53 inhibitoren | |
| EP2296526A4 (en) | EXTENSIBLE ARTICULATED PROBE DEVICE | |
| BRPI0811639A2 (pt) | Cicloaquilaminas fenil substituídas como inibidores da recaptação de monoamina | |
| BRPI0811761A2 (pt) | Derivados de quinolinas como inibidores das p13 cinases | |
| BRPI0911444A2 (pt) | benzoimidazóis como inibidores de prolil hidroxilase | |
| BRPI0915064A2 (pt) | derivados de qunoxalinadiona | |
| BRPI0912234A2 (pt) | derivados de salinosporamida como inibidores de proteassomas | |
| BRPI0913832A2 (pt) | derivados de pirrolopiridinilpirimidin-2-ilamina | |
| BRPI0811044A2 (pt) | 2-morfolin-4-il-pirimidinas como inibidores de p13k. | |
| BRPI0918564A2 (pt) | inibidores | |
| BRPI0912475A2 (pt) | compostos como inibidores de quinase | |
| CR10879A (es) | Cyclized derivatives as eg-5 inhibitors | |
| DK2275414T3 (da) | Cyclopentylacrylamidderivat | |
| BRPI0925050A2 (pt) | Compostos heterocíclicos como inibidores de mek | |
| BRPI1012852A2 (pt) | derivados de benzoxazolona como inibidores da sintase de aldoesterona |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2363 DE 19-04-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |