BRPI0908268A2 - compostos do inibidor de raf e seus métodos de uso - Google Patents
compostos do inibidor de raf e seus métodos de usoInfo
- Publication number
- BRPI0908268A2 BRPI0908268A2 BRPI0908268A BRPI0908268A BRPI0908268A2 BR PI0908268 A2 BRPI0908268 A2 BR PI0908268A2 BR PI0908268 A BRPI0908268 A BR PI0908268A BR PI0908268 A BRPI0908268 A BR PI0908268A BR PI0908268 A2 BRPI0908268 A2 BR PI0908268A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- inhibitor compounds
- raf inhibitor
- raf
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3281308P | 2008-02-29 | 2008-02-29 | |
| PCT/US2009/035381 WO2009111279A1 (en) | 2008-02-29 | 2009-02-27 | Pyrazole [3, 4-b] pyridine raf inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0908268A2 true BRPI0908268A2 (pt) | 2018-10-30 |
Family
ID=40677552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0908268A BRPI0908268A2 (pt) | 2008-02-29 | 2009-02-27 | compostos do inibidor de raf e seus métodos de uso |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8394795B2 (pt) |
| EP (1) | EP2265610B1 (pt) |
| JP (1) | JP2011513331A (pt) |
| KR (1) | KR20100117686A (pt) |
| CN (1) | CN102149712A (pt) |
| AR (1) | AR072657A1 (pt) |
| AU (1) | AU2009222144A1 (pt) |
| BR (1) | BRPI0908268A2 (pt) |
| CA (1) | CA2716952A1 (pt) |
| CL (1) | CL2009000448A1 (pt) |
| CR (1) | CR11690A (pt) |
| EC (1) | ECSP10010507A (pt) |
| ES (1) | ES2400202T3 (pt) |
| IL (1) | IL207845A0 (pt) |
| MA (1) | MA32272B1 (pt) |
| MX (1) | MX2010009411A (pt) |
| PE (1) | PE20091623A1 (pt) |
| TW (1) | TW200940539A (pt) |
| WO (1) | WO2009111279A1 (pt) |
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| MX2010009410A (es) * | 2008-02-29 | 2010-11-30 | Array Biopharma Inc | Compuestos del inhibidor de raf y métodos de uso de los mismos. |
| EA031116B1 (ru) | 2009-04-03 | 2018-11-30 | Ф. Хоффманн-Ля Рош Аг | КРИСТАЛЛИЧЕСКИЕ ПОЛИМОРФНЫЕ ФОРМЫ {3-[5-(4-ХЛОРФЕНИЛ)-1H-ПИРРОЛО[2,3-b]ПИРИДИН-3-КАРБОНИЛ]-2,4-ДИФТОРФЕНИЛ}АМИДА ПРОПАН-1-СУЛЬФОНОВОЙ КИСЛОТЫ |
| US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
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| SG178561A1 (en) * | 2009-08-28 | 2012-03-29 | Array Biopharma Inc | 1h-pyrazolo [ 3, 4-b] pyridine compounds for inhibiting raf kinase |
| UA105813C2 (uk) | 2009-11-06 | 2014-06-25 | Плексікон, Інк. | Сполуки-інгібітори кіназ та фармацевтична композиція (варіанти) |
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| PL2672967T3 (pl) | 2011-02-07 | 2019-04-30 | Plexxikon Inc | Związki i sposoby modulacji kinaz i wskazania ku temu |
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| EA026924B1 (ru) | 2011-08-01 | 2017-05-31 | Дженентек, Инк. | Способы лечения рака с использованием антагонистов, связывающихся с осью pd-1, и ингибиторов mek |
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| CN102491974B (zh) * | 2011-12-12 | 2013-08-07 | 南京药石药物研发有限公司 | 1-（2-氟苄基）-1H-吡唑并[3，4-b]吡啶-3-甲脒盐酸盐的合成方法 |
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| CN121154828A (zh) | 2015-11-19 | 2025-12-19 | 豪夫迈·罗氏有限公司 | 使用b-raf抑制剂和免疫检查点抑制剂治疗癌症的方法 |
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| CN111295577A (zh) * | 2017-11-01 | 2020-06-16 | 小利兰·斯坦福大学托管委员会 | 分析物检测方法 |
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| BR112021018168B1 (pt) | 2019-03-21 | 2023-11-28 | Onxeo | Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer |
| CN110627691B (zh) * | 2019-08-20 | 2022-03-25 | 中船(邯郸)派瑞特种气体股份有限公司 | 一种制备n-苯基-双(全氟烷基磺酰)亚胺的方法 |
| CA3159348A1 (en) | 2019-11-08 | 2021-05-14 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
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-
2009
- 2009-02-27 CL CL2009000448A patent/CL2009000448A1/es unknown
- 2009-02-27 BR BRPI0908268A patent/BRPI0908268A2/pt not_active IP Right Cessation
- 2009-02-27 PE PE2009000310A patent/PE20091623A1/es not_active Application Discontinuation
- 2009-02-27 WO PCT/US2009/035381 patent/WO2009111279A1/en not_active Ceased
- 2009-02-27 AR ARP090100688A patent/AR072657A1/es unknown
- 2009-02-27 KR KR1020107021611A patent/KR20100117686A/ko not_active Withdrawn
- 2009-02-27 CA CA2716952A patent/CA2716952A1/en not_active Abandoned
- 2009-02-27 JP JP2010548886A patent/JP2011513331A/ja not_active Withdrawn
- 2009-02-27 AU AU2009222144A patent/AU2009222144A1/en not_active Abandoned
- 2009-02-27 EP EP09718306A patent/EP2265610B1/en active Active
- 2009-02-27 ES ES09718306T patent/ES2400202T3/es active Active
- 2009-02-27 MX MX2010009411A patent/MX2010009411A/es not_active Application Discontinuation
- 2009-02-27 US US12/920,050 patent/US8394795B2/en not_active Expired - Fee Related
- 2009-02-27 CN CN2009801155134A patent/CN102149712A/zh active Pending
- 2009-02-27 TW TW098106512A patent/TW200940539A/zh unknown
-
2010
- 2010-08-29 IL IL207845A patent/IL207845A0/en unknown
- 2010-09-24 MA MA33203A patent/MA32272B1/fr unknown
- 2010-09-27 CR CR11690A patent/CR11690A/es unknown
- 2010-09-28 EC EC2010010507A patent/ECSP10010507A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PE20091623A1 (es) | 2009-11-19 |
| US8394795B2 (en) | 2013-03-12 |
| JP2011513331A (ja) | 2011-04-28 |
| CA2716952A1 (en) | 2009-09-11 |
| AU2009222144A1 (en) | 2009-09-11 |
| CL2009000448A1 (es) | 2009-11-27 |
| IL207845A0 (en) | 2010-12-30 |
| CN102149712A (zh) | 2011-08-10 |
| EP2265610A1 (en) | 2010-12-29 |
| EP2265610B1 (en) | 2012-12-12 |
| MX2010009411A (es) | 2010-11-30 |
| ES2400202T3 (es) | 2013-04-08 |
| ECSP10010507A (es) | 2010-10-30 |
| CR11690A (es) | 2010-11-02 |
| KR20100117686A (ko) | 2010-11-03 |
| AR072657A1 (es) | 2010-09-15 |
| TW200940539A (en) | 2009-10-01 |
| US20110092479A1 (en) | 2011-04-21 |
| MA32272B1 (fr) | 2011-05-02 |
| WO2009111279A1 (en) | 2009-09-11 |
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