MA32272B1 - Inhibiteurs de raf de pyrazole [3,4-b]pyridine - Google Patents

Inhibiteurs de raf de pyrazole [3,4-b]pyridine

Info

Publication number
MA32272B1
MA32272B1 MA33203A MA33203A MA32272B1 MA 32272 B1 MA32272 B1 MA 32272B1 MA 33203 A MA33203 A MA 33203A MA 33203 A MA33203 A MA 33203A MA 32272 B1 MA32272 B1 MA 32272B1
Authority
MA
Morocco
Prior art keywords
raf
pyrazole
pyridine
inhibitors
compounds
Prior art date
Application number
MA33203A
Other languages
Arabic (ar)
English (en)
Inventor
Meese Jason De
Kateri A Ahrendt
Alexandre J Buckmelter
Jonas Grina
Joshua D Hansen
Ellen R Laird
Paul Lunghofer
David Moreno
Brad Newhouse
Li Ren
Jeongbeob Seo
Hongqi Tian
Steven Mark Wenglowsky
Bainian Feng
Janet Gunzner
Kim Malesky
Simon Mathieu
Joachim Rudolph
Zhaoyang Wen
Wendy B Young
Original Assignee
Array Biopharma Inc
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc, Genentech Inc filed Critical Array Biopharma Inc
Publication of MA32272B1 publication Critical patent/MA32272B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention concerne des composés de formule i qui sont utiles pour l'inhibition de kinases raf. La présente invention concerne des procédés d'utilisation de composés de formule i et des stéréo-isomères, tautomères, promédicaments et sels pharmaceutiquement acceptables de ceux-ci, pour le diagnostic, la prévention ou le traitement in vitro, in situ, et in vivo de tels troubles dans des cellules de mammifère, ou des états pathologiques associés.
MA33203A 2008-02-29 2010-09-24 Inhibiteurs de raf de pyrazole [3,4-b]pyridine MA32272B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3281308P 2008-02-29 2008-02-29
PCT/US2009/035381 WO2009111279A1 (fr) 2008-02-29 2009-02-27 Inhibiteurs de raf de pyrazole[3,4-b]pyridine

Publications (1)

Publication Number Publication Date
MA32272B1 true MA32272B1 (fr) 2011-05-02

Family

ID=40677552

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33203A MA32272B1 (fr) 2008-02-29 2010-09-24 Inhibiteurs de raf de pyrazole [3,4-b]pyridine

Country Status (19)

Country Link
US (1) US8394795B2 (fr)
EP (1) EP2265610B1 (fr)
JP (1) JP2011513331A (fr)
KR (1) KR20100117686A (fr)
CN (1) CN102149712A (fr)
AR (1) AR072657A1 (fr)
AU (1) AU2009222144A1 (fr)
BR (1) BRPI0908268A2 (fr)
CA (1) CA2716952A1 (fr)
CL (1) CL2009000448A1 (fr)
CR (1) CR11690A (fr)
EC (1) ECSP10010507A (fr)
ES (1) ES2400202T3 (fr)
IL (1) IL207845A0 (fr)
MA (1) MA32272B1 (fr)
MX (1) MX2010009411A (fr)
PE (1) PE20091623A1 (fr)
TW (1) TW200940539A (fr)
WO (1) WO2009111279A1 (fr)

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US20110092479A1 (en) 2011-04-21
WO2009111279A1 (fr) 2009-09-11
CA2716952A1 (fr) 2009-09-11
JP2011513331A (ja) 2011-04-28
MX2010009411A (es) 2010-11-30
ECSP10010507A (es) 2010-10-30
IL207845A0 (en) 2010-12-30
BRPI0908268A2 (pt) 2018-10-30
US8394795B2 (en) 2013-03-12
ES2400202T3 (es) 2013-04-08
AR072657A1 (es) 2010-09-15
TW200940539A (en) 2009-10-01
CN102149712A (zh) 2011-08-10
AU2009222144A1 (en) 2009-09-11
KR20100117686A (ko) 2010-11-03
CR11690A (es) 2010-11-02

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