BRPI0908403A2 - Compostos derivados de pirazolo[1,5-a] piprimidinas heterocíclicos bicíclicos ou heterocíclicos espiro bicíclicos em ponte, seus métodos de preparação e usos, e composição farmacêutica - Google Patents

Compostos derivados de pirazolo[1,5-a] piprimidinas heterocíclicos bicíclicos ou heterocíclicos espiro bicíclicos em ponte, seus métodos de preparação e usos, e composição farmacêutica

Info

Publication number
BRPI0908403A2
BRPI0908403A2 BRPI0908403-7A BRPI0908403A BRPI0908403A2 BR PI0908403 A2 BRPI0908403 A2 BR PI0908403A2 BR PI0908403 A BRPI0908403 A BR PI0908403A BR PI0908403 A2 BRPI0908403 A2 BR PI0908403A2
Authority
BR
Brazil
Prior art keywords
bridged
heterocyclic
bicyclic
pyprimidines
preparation
Prior art date
Application number
BRPI0908403-7A
Other languages
English (en)
Inventor
Jeremy Ian Levin
Darrin William Hopper
Nancy Torres
Minu Dhanjish Dutia
Dan Maarten Berger
Xiaolun Wang
Martin Joseph Grandi
Chunchun Zhang
Alejandro Lee Dunnick
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of BRPI0908403A2 publication Critical patent/BRPI0908403A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BRPI0908403-7A 2008-02-29 2009-02-27 Compostos derivados de pirazolo[1,5-a] piprimidinas heterocíclicos bicíclicos ou heterocíclicos espiro bicíclicos em ponte, seus métodos de preparação e usos, e composição farmacêutica BRPI0908403A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6784308P 2008-02-29 2008-02-29
US11680908P 2008-11-21 2008-11-21
PCT/US2009/035422 WO2009108838A1 (en) 2008-02-29 2009-02-27 Bridged, bicyclic heterocyclic or spiro bicyclic heterocyclic derivatives of pyrazolo[1,5-a]pyrimidines, methods for preparation and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0908403A2 true BRPI0908403A2 (pt) 2015-08-11

Family

ID=40548843

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0908403-7A BRPI0908403A2 (pt) 2008-02-29 2009-02-27 Compostos derivados de pirazolo[1,5-a] piprimidinas heterocíclicos bicíclicos ou heterocíclicos espiro bicíclicos em ponte, seus métodos de preparação e usos, e composição farmacêutica

Country Status (24)

Country Link
US (1) US20100029657A1 (pt)
EP (1) EP2271649A1 (pt)
JP (1) JP2011513334A (pt)
KR (1) KR20100123725A (pt)
CN (1) CN102083835A (pt)
AP (1) AP2010005363A0 (pt)
AR (1) AR070728A1 (pt)
AU (1) AU2009219175A1 (pt)
BR (1) BRPI0908403A2 (pt)
CA (1) CA2716499A1 (pt)
CO (1) CO6321261A2 (pt)
CR (1) CR11650A (pt)
DO (1) DOP2010000261A (pt)
EA (1) EA201001188A1 (pt)
EC (1) ECSP10010429A (pt)
IL (1) IL207576A0 (pt)
MA (1) MA32110B1 (pt)
MX (1) MX2010009458A (pt)
NI (1) NI201000143A (pt)
PE (1) PE20091833A1 (pt)
SV (1) SV2010003654A (pt)
TW (1) TW200951134A (pt)
WO (1) WO2009108838A1 (pt)
ZA (1) ZA201005603B (pt)

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CA2781390A1 (en) 2009-12-14 2011-06-23 Inspire Pharmaceuticals, Inc. Bridged bicyclic rho kinase inhibitor compounds, composition and use
ES2574253T3 (es) 2009-12-18 2016-06-16 Mitsubishi Tanabe Pharma Corporation Nuevo agente antiplaquetario
EP2402343A1 (en) * 2010-06-29 2012-01-04 Basf Se Pyrazole-fused bicyclic compounds
CN103930422A (zh) 2011-07-19 2014-07-16 无限药品股份有限公司 杂环化合物及其用途
EP2768833A4 (en) * 2011-10-20 2015-04-15 Sirtris Pharmaceuticals Inc SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS MODULATORS OF SIRTUINS
EP2768509B1 (en) 2011-10-20 2017-03-22 Glaxosmithkline LLC Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators
US9408885B2 (en) 2011-12-01 2016-08-09 Vib Vzw Combinations of therapeutic agents for treating melanoma
EP2920181B1 (en) 2012-11-16 2019-01-09 University Health Network Pyrazolopyrimidine compounds
JP6527851B2 (ja) 2013-03-12 2019-06-05 セルタクシス，インコーポレイテッド ロイコトリエンａ４加水分解酵素を阻害する方法
AU2014239585B2 (en) 2013-03-14 2019-04-04 Celtaxsys, Inc. Inhibitors of leukotriene A4 hydrolase
AU2014239567B2 (en) 2013-03-14 2017-12-14 Celtaxsys, Inc. Inhibitors of leukotriene A4 hydrolase
EP2968264A4 (en) 2013-03-14 2016-11-02 Celtaxsys Inc INHIBITORS OF LEUCOTRIENE A4 HYDROLASE
WO2015144801A1 (en) * 2014-03-27 2015-10-01 Janssen Pharmaceutica Nv SUBSTITUTED 4,5,6,7-TETRAHYDRO-PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AND 2,3-DIHYDRO-1H-IMIDAZO[1,2-b]PYRAZOLE DERIVATIVES AS ROS1 INHIBITORS
CN106164076B (zh) * 2014-03-27 2019-03-26 詹森药业有限公司 作为ros1抑制剂的化合物
AR100448A1 (es) 2014-05-21 2016-10-05 Bayer Cropscience Ag 5-(hetero)aril-piridazinonas y su uso como herbicida
PT3322706T (pt) * 2015-07-16 2021-03-08 Array Biopharma Inc Compostos de pirazolo[1,5-a]piridina substituídos como inibidores da quinase do ret
SG11201901747VA (en) 2016-08-31 2019-03-28 Agios Pharmaceuticals Inc Inhibitors of cellular metabolic processes
EP3579872A1 (en) 2017-02-10 2019-12-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway
MX2020006587A (es) 2017-12-22 2020-12-10 Ravenna Pharmaceuticals Inc Derivados de aminopiridina como inhibidores de fosfatidilinositol fosfato cinasa.
EP3732285A1 (en) 2017-12-28 2020-11-04 Tract Pharmaceuticals, Inc. Stem cell culture systems for columnar epithelial stem cells, and uses related thereto
CA3102077A1 (en) 2018-05-31 2019-12-05 Sanjeev AHUJA Method of reducing pulmonary exacerbations in respiratory disease patients
WO2020061112A1 (en) * 2018-09-18 2020-03-26 Metacrine, Inc. Farnesoid x receptor agonists and uses thereof
TW202112767A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物
JP2023515620A (ja) * 2020-02-28 2023-04-13 リミックス セラピューティクス インコーポレイテッド スプライシングを調節するための化合物及び方法
CA3171987A1 (en) 2020-03-18 2021-09-23 Nicholas D. Smith Crystalline forms of a farnesoid x receptor agonist
US12491160B2 (en) 2020-03-18 2025-12-09 Eli Lilly And Company Formulations of a farnesoid X receptor agonist
BR112022022437A2 (pt) * 2020-05-07 2023-01-03 Adorx Therapeutics Ltd Antagonistas do receptor a2a de adenosina
US20250145628A1 (en) * 2022-02-15 2025-05-08 Novo Nordisk A/S Pyrazolopyrimidines, compositions comprising them and uses thereof
US20250122207A1 (en) * 2023-09-08 2025-04-17 Satellos Bioscience Inc. Ap2 associated kinase 1 inhibitors and uses thereof

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US4236005A (en) * 1979-07-02 1980-11-25 American Cyanamid Company Imidazo[1,5-a]pyrimidines
US4281000A (en) * 1979-07-09 1981-07-28 American Cyanamid Company Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents
US4900836A (en) * 1983-06-23 1990-02-13 American Cyanamid Company (3-amino-1H-pyrazol-4-yl) (aryl)methanones
US4626538A (en) * 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
US4654347A (en) * 1983-06-23 1987-03-31 American Cyanamid Company Aryl and heteroaryl[[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]methanones
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WO2004052315A2 (en) * 2002-12-11 2004-06-24 Merck & Co., Inc. Tyrosine kinase inhibitors
US7176210B2 (en) * 2003-02-10 2007-02-13 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
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MX2008011853A (es) * 2006-03-17 2008-09-29 Wyeth Corp Derivados de pirazolo[1,5-a]pirimidina y sus metodos de uso.

Also Published As

Publication number Publication date
PE20091833A1 (es) 2009-11-22
NI201000143A (es) 2011-03-09
ZA201005603B (en) 2011-05-25
EP2271649A1 (en) 2011-01-12
CA2716499A1 (en) 2009-09-03
WO2009108838A1 (en) 2009-09-03
SV2010003654A (es) 2011-03-23
AR070728A1 (es) 2010-04-28
AU2009219175A1 (en) 2009-09-03
MX2010009458A (es) 2010-09-24
IL207576A0 (en) 2010-12-30
KR20100123725A (ko) 2010-11-24
CN102083835A (zh) 2011-06-01
MA32110B1 (fr) 2011-02-01
ECSP10010429A (es) 2010-09-30
CR11650A (es) 2010-09-14
US20100029657A1 (en) 2010-02-04
TW200951134A (en) 2009-12-16
CO6321261A2 (es) 2011-09-20
AP2010005363A0 (en) 2010-08-31
JP2011513334A (ja) 2011-04-28
EA201001188A1 (ru) 2011-04-29
WO2009108838A8 (en) 2009-11-12
DOP2010000261A (es) 2010-09-15

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 4A, 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.