BRPI0908403A2 - Compostos derivados de pirazolo[1,5-a] piprimidinas heterocíclicos bicíclicos ou heterocíclicos espiro bicíclicos em ponte, seus métodos de preparação e usos, e composição farmacêutica - Google Patents

Compostos derivados de pirazolo[1,5-a] piprimidinas heterocíclicos bicíclicos ou heterocíclicos espiro bicíclicos em ponte, seus métodos de preparação e usos, e composição farmacêutica

Info

Publication number
BRPI0908403A2
BRPI0908403A2 BRPI0908403-7A BRPI0908403A BRPI0908403A2 BR PI0908403 A2 BRPI0908403 A2 BR PI0908403A2 BR PI0908403 A BRPI0908403 A BR PI0908403A BR PI0908403 A2 BRPI0908403 A2 BR PI0908403A2
Authority
BR
Brazil
Prior art keywords
bridged
heterocyclic
bicyclic
pyprimidines
preparation
Prior art date
Application number
BRPI0908403-7A
Other languages
English (en)
Inventor
Jeremy Ian Levin
Darrin William Hopper
Nancy Torres
Minu Dhanjish Dutia
Dan Maarten Berger
Xiaolun Wang
Martin Joseph Grandi
Chunchun Zhang
Alejandro Lee Dunnick
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of BRPI0908403A2 publication Critical patent/BRPI0908403A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BRPI0908403-7A 2008-02-29 2009-02-27 Compostos derivados de pirazolo[1,5-a] piprimidinas heterocíclicos bicíclicos ou heterocíclicos espiro bicíclicos em ponte, seus métodos de preparação e usos, e composição farmacêutica BRPI0908403A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6784308P 2008-02-29 2008-02-29
US11680908P 2008-11-21 2008-11-21
PCT/US2009/035422 WO2009108838A1 (en) 2008-02-29 2009-02-27 Bridged, bicyclic heterocyclic or spiro bicyclic heterocyclic derivatives of pyrazolo[1,5-a]pyrimidines, methods for preparation and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0908403A2 true BRPI0908403A2 (pt) 2015-08-11

Family

ID=40548843

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0908403-7A BRPI0908403A2 (pt) 2008-02-29 2009-02-27 Compostos derivados de pirazolo[1,5-a] piprimidinas heterocíclicos bicíclicos ou heterocíclicos espiro bicíclicos em ponte, seus métodos de preparação e usos, e composição farmacêutica

Country Status (24)

Country Link
US (1) US20100029657A1 (pt)
EP (1) EP2271649A1 (pt)
JP (1) JP2011513334A (pt)
KR (1) KR20100123725A (pt)
CN (1) CN102083835A (pt)
AP (1) AP2010005363A0 (pt)
AR (1) AR070728A1 (pt)
AU (1) AU2009219175A1 (pt)
BR (1) BRPI0908403A2 (pt)
CA (1) CA2716499A1 (pt)
CO (1) CO6321261A2 (pt)
CR (1) CR11650A (pt)
DO (1) DOP2010000261A (pt)
EA (1) EA201001188A1 (pt)
EC (1) ECSP10010429A (pt)
IL (1) IL207576A0 (pt)
MA (1) MA32110B1 (pt)
MX (1) MX2010009458A (pt)
NI (1) NI201000143A (pt)
PE (1) PE20091833A1 (pt)
SV (1) SV2010003654A (pt)
TW (1) TW200951134A (pt)
WO (1) WO2009108838A1 (pt)
ZA (1) ZA201005603B (pt)

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US8476295B2 (en) 2009-12-14 2013-07-02 Inspire Bridged bicyclic RHO kinase inhibitor compounds, composition and use
WO2011074658A1 (ja) 2009-12-18 2011-06-23 田辺三菱製薬株式会社 新規抗血小板薬
EP2402343A1 (en) * 2010-06-29 2012-01-04 Basf Se Pyrazole-fused bicyclic compounds
HK1198443A1 (en) 2011-07-19 2015-04-24 无限药品股份有限公司 Heterocyclic compounds and uses thereof
RU2014120180A (ru) * 2011-10-20 2015-11-27 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи Замещенные бициклические аза-гетероциклы и аналоги в качестве модуляторов сиртуина
JP6073343B2 (ja) 2011-10-20 2017-02-01 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ サーチュイン調節因子としての置換された二環式アザ複素環およびアナログ
US9408885B2 (en) 2011-12-01 2016-08-09 Vib Vzw Combinations of therapeutic agents for treating melanoma
CA2889919C (en) 2012-11-16 2021-08-17 University Health Network Pyrazolopyrimidine compounds
AU2014249168B2 (en) 2013-03-12 2018-07-12 Celltaxis, Llc Methods of inhibiting leukotriene A4 hydrolase
CA2906035A1 (en) 2013-03-14 2014-09-25 Celtaxsys, Inc. Inhibitors of leukotriene a4 hydrolase
WO2014152536A2 (en) 2013-03-14 2014-09-25 Celtaxsys, Inc. Inhibitors of leukotriene a4 hydrolase
BR112015022864A8 (pt) 2013-03-14 2019-11-26 Celtaxsys Inc composto, composição farmacêutica e uso dos mesmos
US10342795B2 (en) * 2014-03-27 2019-07-09 Janssen Pharmaceutica Nv Substituted 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrimidine derivatives and 2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives as ROS1 inhibitors
ES2715676T3 (es) * 2014-03-27 2019-06-05 Janssen Pharmaceutica Nv Derivados de 4,5,6,7-tetrahidro-pirazolo[1,5-a]pirazina sustituidos y derivados de 5,6,7,8-tetrahidro-4h-pirazolo[1,5-a][1,4]diazepina como inhibidores de ros1
AR100448A1 (es) 2014-05-21 2016-10-05 Bayer Cropscience Ag 5-(hetero)aril-piridazinonas y su uso como herbicida
BR112018000808A2 (pt) * 2015-07-16 2018-09-04 Array Biopharma Inc compostos de pirazolo[1,5-a]piridina substituída como inibidores de ret cinase
JP6832430B2 (ja) 2016-08-31 2021-02-24 アジオス ファーマシューティカルズ， インコーポレイテッド 細胞代謝過程の阻害剤
WO2018146253A1 (en) 2017-02-10 2018-08-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway
WO2019126731A1 (en) 2017-12-22 2019-06-27 Petra Pharma Corporation Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors
WO2019133810A1 (en) 2017-12-28 2019-07-04 Tract Pharmaceuticals, Inc. Stem cell culture systems for columnar epithelial stem cells, and uses related thereto
ES3014615T3 (en) 2018-05-31 2025-04-23 Celltaxis Llc Method of reducing pulmonary exacerbations in respiratory disease patients
US20220054469A1 (en) * 2018-09-18 2022-02-24 Metacrine, Inc. Farnesoid x receptor agonists and uses thereof
TW202112767A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物
JP7736700B2 (ja) * 2020-02-28 2025-09-09 リミックス セラピューティクス インコーポレイテッド 複素環アミド及びスプライシングを調節するためのその使用
WO2021188695A1 (en) 2020-03-18 2021-09-23 Metacrine, Inc. Formulations of a farnesoid x receptor agonist
IL296532A (en) 2020-03-18 2022-11-01 Metacrine Inc Crystal forms of farnesoid x receptor agonist
EP4146654A1 (en) * 2020-05-07 2023-03-15 Adorx therapeutics Limited Antagonists of the adenosine a2a receptor
US20250145628A1 (en) * 2022-02-15 2025-05-08 Novo Nordisk A/S Pyrazolopyrimidines, compositions comprising them and uses thereof
CA3266173A1 (en) * 2022-10-26 2024-05-02 Boehringer Ingelheim International Gmbh HETEROCYCLIC COMPOUNDS CAPABLE OF ACTIVATING STING
AU2024338138A1 (en) * 2023-09-08 2026-03-19 Satellos Bioscience Inc. Ap2 associated kinase 1 inhibitors and uses thereof

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US4178449A (en) * 1978-04-17 1979-12-11 American Cyanamid Company Pyrazolo[1,5-a]pyrimidines and imidazo-[1,5-a]pyrimidines
US4236005A (en) * 1979-07-02 1980-11-25 American Cyanamid Company Imidazo[1,5-a]pyrimidines
US4281000A (en) * 1979-07-09 1981-07-28 American Cyanamid Company Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents
US4654347A (en) * 1983-06-23 1987-03-31 American Cyanamid Company Aryl and heteroaryl[[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]methanones
US4900836A (en) * 1983-06-23 1990-02-13 American Cyanamid Company (3-amino-1H-pyrazol-4-yl) (aryl)methanones
US4521422A (en) * 1983-06-23 1985-06-04 American Cyanamid Company Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones
US4626538A (en) * 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
US7550470B2 (en) * 2002-12-11 2009-06-23 Merck & Co. Inc. Substituted pyrazolo[1,5-A]pyrimidines as tyrosine kinase inhibitors
US7176210B2 (en) * 2003-02-10 2007-02-13 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
BRPI0508970A (pt) * 2004-03-19 2007-08-21 Penn State Res Found método combinatórios e composições para o tratamento de melanoma
JP2009530296A (ja) * 2006-03-17 2009-08-27 ワイス ピラゾロ［１，５−ａ］ピリミジン誘導体およびその使用方法

Also Published As

Publication number Publication date
PE20091833A1 (es) 2009-11-22
MA32110B1 (fr) 2011-02-01
CO6321261A2 (es) 2011-09-20
JP2011513334A (ja) 2011-04-28
AP2010005363A0 (en) 2010-08-31
EP2271649A1 (en) 2011-01-12
IL207576A0 (en) 2010-12-30
AR070728A1 (es) 2010-04-28
AU2009219175A1 (en) 2009-09-03
CA2716499A1 (en) 2009-09-03
TW200951134A (en) 2009-12-16
US20100029657A1 (en) 2010-02-04
WO2009108838A1 (en) 2009-09-03
ECSP10010429A (es) 2010-09-30
NI201000143A (es) 2011-03-09
DOP2010000261A (es) 2010-09-15
KR20100123725A (ko) 2010-11-24
SV2010003654A (es) 2011-03-23
CN102083835A (zh) 2011-06-01
MX2010009458A (es) 2010-09-24
WO2009108838A8 (en) 2009-11-12
ZA201005603B (en) 2011-05-25
EA201001188A1 (ru) 2011-04-29
CR11650A (es) 2010-09-14

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 4A, 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.