MA32110B1 - Derives heterocycliques bicycliques pontes ou derives heterocyclique spiro-bicycliques de pyrazolo [1,5-a] pyrimidines, procedes pour leur preparation et leurs utilisations - Google Patents

Derives heterocycliques bicycliques pontes ou derives heterocyclique spiro-bicycliques de pyrazolo [1,5-a] pyrimidines, procedes pour leur preparation et leurs utilisations

Info

Publication number
MA32110B1
MA32110B1 MA33124A MA33124A MA32110B1 MA 32110 B1 MA32110 B1 MA 32110B1 MA 33124 A MA33124 A MA 33124A MA 33124 A MA33124 A MA 33124A MA 32110 B1 MA32110 B1 MA 32110B1
Authority
MA
Morocco
Prior art keywords
heterocyclic derivatives
bicyclic
pyrazolo
pyrimidines
spiro
Prior art date
Application number
MA33124A
Other languages
Arabic (ar)
English (en)
Inventor
Jeremy Ian Levin
Darrin William Hopper
Nancy Torres
Minu Dhanjish Dutia
Dan Maarten Berger
Xiaolun Wang
Grandi Martin Joseph Di
Chunchun Zhang
Alejandro Lee Dunnick
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of MA32110B1 publication Critical patent/MA32110B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention concerne des composés de formule a et des composés de qualité pharmaceutique de ceux-ci, qui inhibent sélectivement l'activité de raf kinase et qui sont utiles pour traiter des troubles à médiation par des raf kinases.
MA33124A 2008-02-29 2010-08-26 Derives heterocycliques bicycliques pontes ou derives heterocyclique spiro-bicycliques de pyrazolo [1,5-a] pyrimidines, procedes pour leur preparation et leurs utilisations MA32110B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6784308P 2008-02-29 2008-02-29
US11680908P 2008-11-21 2008-11-21
PCT/US2009/035422 WO2009108838A1 (fr) 2008-02-29 2009-02-27 Dérivés hétérocycliques bicycliques pontés ou hétérocycliques bicycliques spiro de pyrazolo[1,5-a]pyrimidines, leurs procédés de préparation et leurs utilisations

Publications (1)

Publication Number Publication Date
MA32110B1 true MA32110B1 (fr) 2011-02-01

Family

ID=40548843

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33124A MA32110B1 (fr) 2008-02-29 2010-08-26 Derives heterocycliques bicycliques pontes ou derives heterocyclique spiro-bicycliques de pyrazolo [1,5-a] pyrimidines, procedes pour leur preparation et leurs utilisations

Country Status (24)

Country Link
US (1) US20100029657A1 (fr)
EP (1) EP2271649A1 (fr)
JP (1) JP2011513334A (fr)
KR (1) KR20100123725A (fr)
CN (1) CN102083835A (fr)
AP (1) AP2010005363A0 (fr)
AR (1) AR070728A1 (fr)
AU (1) AU2009219175A1 (fr)
BR (1) BRPI0908403A2 (fr)
CA (1) CA2716499A1 (fr)
CO (1) CO6321261A2 (fr)
CR (1) CR11650A (fr)
DO (1) DOP2010000261A (fr)
EA (1) EA201001188A1 (fr)
EC (1) ECSP10010429A (fr)
IL (1) IL207576A0 (fr)
MA (1) MA32110B1 (fr)
MX (1) MX2010009458A (fr)
NI (1) NI201000143A (fr)
PE (1) PE20091833A1 (fr)
SV (1) SV2010003654A (fr)
TW (1) TW200951134A (fr)
WO (1) WO2009108838A1 (fr)
ZA (1) ZA201005603B (fr)

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JP2007089031A (ja) 2005-09-26 2007-04-05 Fuji Xerox Co Ltd 出力装置
EP3205644A1 (fr) 2005-12-29 2017-08-16 Celtaxsys Inc. Dérivés de diamine en tant qu'inhibiteurs d'hydrolase a4 de leucotriène
WO2011075415A1 (fr) * 2009-12-14 2011-06-23 Inspire Pharmaceuticals, Inc. Inhibiteurs de la rho-kinase bicycliques pontés, composition et utilisation
WO2011074658A1 (fr) 2009-12-18 2011-06-23 田辺三菱製薬株式会社 Nouvel agent antiplaquettaire
EP2402343A1 (fr) * 2010-06-29 2012-01-04 Basf Se Composés pyrazoliques bicycliques condenses
EP2734520B1 (fr) 2011-07-19 2016-09-14 Infinity Pharmaceuticals, Inc. Composés hétérocycliques et leurs utilisations
KR20140077963A (ko) 2011-10-20 2014-06-24 글락소스미스클라인 엘엘씨 시르투인 조절제로서의 치환된 비시클릭 아자-헤테로사이클 및 유사체
US20140288052A1 (en) * 2011-10-20 2014-09-25 GlaxoSmithKline, LLC Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators
US9408885B2 (en) 2011-12-01 2016-08-09 Vib Vzw Combinations of therapeutic agents for treating melanoma
EP2920181B1 (fr) 2012-11-16 2019-01-09 University Health Network Composés de pyrazolopyrimidine
AU2014249168B2 (en) 2013-03-12 2018-07-12 Celltaxis, Llc Methods of inhibiting leukotriene A4 hydrolase
MX2015011678A (es) 2013-03-14 2016-07-08 Celtaxsys Inc Inhibidores de leucotrieno a4 hidrolasa.
EP2968265A4 (fr) 2013-03-14 2016-12-28 Celtaxsys Inc Inhibiteurs de la leucotriène a4 hydrolase
AU2014240042C1 (en) 2013-03-14 2019-09-05 Celltaxis, Llc Inhibitors of leukotriene A4 hydrolase
US10342795B2 (en) * 2014-03-27 2019-07-09 Janssen Pharmaceutica Nv Substituted 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrimidine derivatives and 2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives as ROS1 inhibitors
EP3129376B1 (fr) 2014-03-27 2018-12-26 Janssen Pharmaceutica NV Dérivés substitués de 4,5,6,7-tétrahydro-pyrazolo[1,5-a]pyrazine et dérivés de 5,6,7,8-tétrahydro-4h-pyrazolo[1,5-a] [1,4] comme inhibiteurs de ros1
AR100448A1 (es) 2014-05-21 2016-10-05 Bayer Cropscience Ag 5-(hetero)aril-piridazinonas y su uso como herbicida
CA2992586A1 (fr) * 2015-07-16 2017-01-19 Array Biopharma, Inc. Composes substitues de pyrazolo[1,5-a]pyridines comme inhibiteurs de la kinase ret
UA125852C2 (uk) 2016-08-31 2022-06-22 Ле Лаборатуар Сервьє Інгібітори клітинних метаболічних процесів
EP3579872A1 (fr) 2017-02-10 2019-12-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés et compositions pharmaceutiques pour le traitement de cancers associés à l'activation de la voie mapk
WO2019126731A1 (fr) 2017-12-22 2019-06-27 Petra Pharma Corporation Dérivés d'aminopyridine utilisés en tant qu'inhibiteurs de la phosphatidylinositol phosphate kinase
CA3086765A1 (fr) 2017-12-28 2019-07-04 Tract Pharmaceuticals, Inc. Systemes de culture de cellules souches pour cellules souches epitheliales colonnaires, et leurs utilisations
EP3801559B1 (fr) 2018-05-31 2025-01-01 Celltaxis, LLC Procédé de réduction d'exacerbations pulmonaires chez des patients atteints d'une maladie respiratoire
CN113056264A (zh) * 2018-09-18 2021-06-29 梅塔科林公司 法尼醇x受体激动剂及其用途
TW202112767A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物
AU2021228284A1 (en) * 2020-02-28 2022-09-29 Remix Therapeutics Inc. Compounds and methods for modulating splicing
JP7664278B2 (ja) 2020-03-18 2025-04-17 オルガノボ，インク． ファルネソイドｘ受容体アゴニストの結晶質形態
CN120227340A (zh) 2020-03-18 2025-07-01 伊莱利利公司 法尼醇x受体激动剂的制剂
IL297963A (en) * 2020-05-07 2023-01-01 Adorx Therapeutics Ltd Antagonists of the adenosine a2a receptor
US20250145628A1 (en) * 2022-02-15 2025-05-08 Novo Nordisk A/S Pyrazolopyrimidines, compositions comprising them and uses thereof
WO2024088991A1 (fr) * 2022-10-26 2024-05-02 Boehringer Ingelheim International Gmbh Composés hétérocycliques capables d'activer le sting
AU2024338138A1 (en) * 2023-09-08 2026-03-19 Satellos Bioscience Inc. Ap2 associated kinase 1 inhibitors and uses thereof

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US4178449A (en) * 1978-04-17 1979-12-11 American Cyanamid Company Pyrazolo[1,5-a]pyrimidines and imidazo-[1,5-a]pyrimidines
US4236005A (en) * 1979-07-02 1980-11-25 American Cyanamid Company Imidazo[1,5-a]pyrimidines
US4281000A (en) * 1979-07-09 1981-07-28 American Cyanamid Company Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents
US4521422A (en) * 1983-06-23 1985-06-04 American Cyanamid Company Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones
US4626538A (en) * 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
US4900836A (en) * 1983-06-23 1990-02-13 American Cyanamid Company (3-amino-1H-pyrazol-4-yl) (aryl)methanones
US4654347A (en) * 1983-06-23 1987-03-31 American Cyanamid Company Aryl and heteroaryl[[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]methanones
US7550470B2 (en) * 2002-12-11 2009-06-23 Merck & Co. Inc. Substituted pyrazolo[1,5-A]pyrimidines as tyrosine kinase inhibitors
US7176210B2 (en) * 2003-02-10 2007-02-13 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
MXPA06010667A (es) * 2004-03-19 2007-07-04 Penn State Res Found Metodos combinatorios y composiciones para el tratamiento de melanoma.
US20070219186A1 (en) * 2006-03-17 2007-09-20 Wyeth Pyrazolo[1,5-A]pyrimidine derivatives and methods of use thereof

Also Published As

Publication number Publication date
TW200951134A (en) 2009-12-16
ECSP10010429A (es) 2010-09-30
US20100029657A1 (en) 2010-02-04
ZA201005603B (en) 2011-05-25
NI201000143A (es) 2011-03-09
CN102083835A (zh) 2011-06-01
DOP2010000261A (es) 2010-09-15
KR20100123725A (ko) 2010-11-24
JP2011513334A (ja) 2011-04-28
SV2010003654A (es) 2011-03-23
CR11650A (es) 2010-09-14
AP2010005363A0 (en) 2010-08-31
WO2009108838A8 (fr) 2009-11-12
CO6321261A2 (es) 2011-09-20
CA2716499A1 (fr) 2009-09-03
MX2010009458A (es) 2010-09-24
WO2009108838A1 (fr) 2009-09-03
AR070728A1 (es) 2010-04-28
AU2009219175A1 (en) 2009-09-03
IL207576A0 (en) 2010-12-30
BRPI0908403A2 (pt) 2015-08-11
EP2271649A1 (fr) 2011-01-12
EA201001188A1 (ru) 2011-04-29
PE20091833A1 (es) 2009-11-22

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