MA32110B1 - Derives heterocycliques bicycliques pontes ou derives heterocyclique spiro-bicycliques de pyrazolo [1,5-a] pyrimidines, procedes pour leur preparation et leurs utilisations - Google Patents

Derives heterocycliques bicycliques pontes ou derives heterocyclique spiro-bicycliques de pyrazolo [1,5-a] pyrimidines, procedes pour leur preparation et leurs utilisations

Info

Publication number
MA32110B1
MA32110B1 MA33124A MA33124A MA32110B1 MA 32110 B1 MA32110 B1 MA 32110B1 MA 33124 A MA33124 A MA 33124A MA 33124 A MA33124 A MA 33124A MA 32110 B1 MA32110 B1 MA 32110B1
Authority
MA
Morocco
Prior art keywords
heterocyclic derivatives
bicyclic
pyrazolo
pyrimidines
spiro
Prior art date
Application number
MA33124A
Other languages
Arabic (ar)
English (en)
Inventor
Jeremy Ian Levin
Darrin William Hopper
Nancy Torres
Minu Dhanjish Dutia
Dan Maarten Berger
Xiaolun Wang
Grandi Martin Joseph Di
Chunchun Zhang
Alejandro Lee Dunnick
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of MA32110B1 publication Critical patent/MA32110B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention concerne des composés de formule a et des composés de qualité pharmaceutique de ceux-ci, qui inhibent sélectivement l'activité de raf kinase et qui sont utiles pour traiter des troubles à médiation par des raf kinases.
MA33124A 2008-02-29 2010-08-26 Derives heterocycliques bicycliques pontes ou derives heterocyclique spiro-bicycliques de pyrazolo [1,5-a] pyrimidines, procedes pour leur preparation et leurs utilisations MA32110B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6784308P 2008-02-29 2008-02-29
US11680908P 2008-11-21 2008-11-21
PCT/US2009/035422 WO2009108838A1 (fr) 2008-02-29 2009-02-27 Dérivés hétérocycliques bicycliques pontés ou hétérocycliques bicycliques spiro de pyrazolo[1,5-a]pyrimidines, leurs procédés de préparation et leurs utilisations

Publications (1)

Publication Number Publication Date
MA32110B1 true MA32110B1 (fr) 2011-02-01

Family

ID=40548843

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33124A MA32110B1 (fr) 2008-02-29 2010-08-26 Derives heterocycliques bicycliques pontes ou derives heterocyclique spiro-bicycliques de pyrazolo [1,5-a] pyrimidines, procedes pour leur preparation et leurs utilisations

Country Status (24)

Country Link
US (1) US20100029657A1 (fr)
EP (1) EP2271649A1 (fr)
JP (1) JP2011513334A (fr)
KR (1) KR20100123725A (fr)
CN (1) CN102083835A (fr)
AP (1) AP2010005363A0 (fr)
AR (1) AR070728A1 (fr)
AU (1) AU2009219175A1 (fr)
BR (1) BRPI0908403A2 (fr)
CA (1) CA2716499A1 (fr)
CO (1) CO6321261A2 (fr)
CR (1) CR11650A (fr)
DO (1) DOP2010000261A (fr)
EA (1) EA201001188A1 (fr)
EC (1) ECSP10010429A (fr)
IL (1) IL207576A0 (fr)
MA (1) MA32110B1 (fr)
MX (1) MX2010009458A (fr)
NI (1) NI201000143A (fr)
PE (1) PE20091833A1 (fr)
SV (1) SV2010003654A (fr)
TW (1) TW200951134A (fr)
WO (1) WO2009108838A1 (fr)
ZA (1) ZA201005603B (fr)

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WO2011074658A1 (fr) 2009-12-18 2011-06-23 田辺三菱製薬株式会社 Nouvel agent antiplaquettaire
EP2402343A1 (fr) * 2010-06-29 2012-01-04 Basf Se Composés pyrazoliques bicycliques condenses
HK1198443A1 (en) 2011-07-19 2015-04-24 无限药品股份有限公司 Heterocyclic compounds and uses thereof
RU2014120180A (ru) * 2011-10-20 2015-11-27 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи Замещенные бициклические аза-гетероциклы и аналоги в качестве модуляторов сиртуина
JP6073343B2 (ja) 2011-10-20 2017-02-01 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ サーチュイン調節因子としての置換された二環式アザ複素環およびアナログ
US9408885B2 (en) 2011-12-01 2016-08-09 Vib Vzw Combinations of therapeutic agents for treating melanoma
CA2889919C (fr) 2012-11-16 2021-08-17 University Health Network Composes de pyrazolopyrimidine
AU2014249168B2 (en) 2013-03-12 2018-07-12 Celltaxis, Llc Methods of inhibiting leukotriene A4 hydrolase
CA2906035A1 (fr) 2013-03-14 2014-09-25 Celtaxsys, Inc. Inhibiteurs de la leucotriene a4 hydrolase
WO2014152536A2 (fr) 2013-03-14 2014-09-25 Celtaxsys, Inc. Inhibiteurs de la leucotriène a4 hydrolase
BR112015022864A8 (pt) 2013-03-14 2019-11-26 Celtaxsys Inc composto, composição farmacêutica e uso dos mesmos
US10342795B2 (en) * 2014-03-27 2019-07-09 Janssen Pharmaceutica Nv Substituted 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrimidine derivatives and 2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives as ROS1 inhibitors
ES2715676T3 (es) * 2014-03-27 2019-06-05 Janssen Pharmaceutica Nv Derivados de 4,5,6,7-tetrahidro-pirazolo[1,5-a]pirazina sustituidos y derivados de 5,6,7,8-tetrahidro-4h-pirazolo[1,5-a][1,4]diazepina como inhibidores de ros1
AR100448A1 (es) 2014-05-21 2016-10-05 Bayer Cropscience Ag 5-(hetero)aril-piridazinonas y su uso como herbicida
BR112018000808A2 (pt) * 2015-07-16 2018-09-04 Array Biopharma Inc compostos de pirazolo[1,5-a]piridina substituída como inibidores de ret cinase
JP6832430B2 (ja) 2016-08-31 2021-02-24 アジオス ファーマシューティカルズ， インコーポレイテッド 細胞代謝過程の阻害剤
WO2018146253A1 (fr) 2017-02-10 2018-08-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés et compositions pharmaceutiques pour le traitement de cancers associés à l'activation de la voie mapk
WO2019126731A1 (fr) 2017-12-22 2019-06-27 Petra Pharma Corporation Dérivés d'aminopyridine utilisés en tant qu'inhibiteurs de la phosphatidylinositol phosphate kinase
WO2019133810A1 (fr) 2017-12-28 2019-07-04 Tract Pharmaceuticals, Inc. Systèmes de culture de cellules souches pour cellules souches épithéliales colonnaires, et leurs utilisations
ES3014615T3 (en) 2018-05-31 2025-04-23 Celltaxis Llc Method of reducing pulmonary exacerbations in respiratory disease patients
US20220054469A1 (en) * 2018-09-18 2022-02-24 Metacrine, Inc. Farnesoid x receptor agonists and uses thereof
TW202112767A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物
JP7736700B2 (ja) * 2020-02-28 2025-09-09 リミックス セラピューティクス インコーポレイテッド 複素環アミド及びスプライシングを調節するためのその使用
WO2021188695A1 (fr) 2020-03-18 2021-09-23 Metacrine, Inc. Formulations d'un agoniste du récepteur farnésoïde x
IL296532A (en) 2020-03-18 2022-11-01 Metacrine Inc Crystal forms of farnesoid x receptor agonist
EP4146654A1 (fr) * 2020-05-07 2023-03-15 Adorx therapeutics Limited Antagonistes du récepteur a2a de l'adénosine
US20250145628A1 (en) * 2022-02-15 2025-05-08 Novo Nordisk A/S Pyrazolopyrimidines, compositions comprising them and uses thereof
CA3266173A1 (fr) * 2022-10-26 2024-05-02 Boehringer Ingelheim International Gmbh Composés hétérocycliques capables d'activer le sting
AU2024338138A1 (en) * 2023-09-08 2026-03-19 Satellos Bioscience Inc. Ap2 associated kinase 1 inhibitors and uses thereof

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BRPI0508970A (pt) * 2004-03-19 2007-08-21 Penn State Res Found método combinatórios e composições para o tratamento de melanoma
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Also Published As

Publication number Publication date
PE20091833A1 (es) 2009-11-22
BRPI0908403A2 (pt) 2015-08-11
CO6321261A2 (es) 2011-09-20
JP2011513334A (ja) 2011-04-28
AP2010005363A0 (en) 2010-08-31
EP2271649A1 (fr) 2011-01-12
IL207576A0 (en) 2010-12-30
AR070728A1 (es) 2010-04-28
AU2009219175A1 (en) 2009-09-03
CA2716499A1 (fr) 2009-09-03
TW200951134A (en) 2009-12-16
US20100029657A1 (en) 2010-02-04
WO2009108838A1 (fr) 2009-09-03
ECSP10010429A (es) 2010-09-30
NI201000143A (es) 2011-03-09
DOP2010000261A (es) 2010-09-15
KR20100123725A (ko) 2010-11-24
SV2010003654A (es) 2011-03-23
CN102083835A (zh) 2011-06-01
MX2010009458A (es) 2010-09-24
WO2009108838A8 (fr) 2009-11-12
ZA201005603B (en) 2011-05-25
EA201001188A1 (ru) 2011-04-29
CR11650A (es) 2010-09-14

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