BRPI0911577A2 - derivados espiro-indol para o tratamento de doenças parasíticas. - Google Patents

derivados espiro-indol para o tratamento de doenças parasíticas.

Info

Publication number: BRPI0911577A2
Authority: BR; Brazil
Prior art keywords: treatment; parasitic diseases; spiroindole; derivatives; spiroindole derivatives
Prior art date: 2008-04-29

Application number

BRPI0911577A

Other languages

English (en)

Inventor

Bin Zou

Bryan Ks Yeung

Liying Jocelyn Tan

Philipp Krastel

Seh Yong Leong

Shi Hua Ang

Wen Lin Josephine Wong

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-04-29

Filing date

2009-04-01

Publication date

2016-01-05

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40613087&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0911577(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-04-01 Application filed by Novartis Ag filed Critical Novartis Ag

2016-01-05 Publication of BRPI0911577A2 publication Critical patent/BRPI0911577A2/pt

2018-03-06 Publication of BRPI0911577A8 publication Critical patent/BRPI0911577A8/pt

2021-02-23 Publication of BRPI0911577B1 publication Critical patent/BRPI0911577B1/pt

2021-05-25 Publication of BRPI0911577B8 publication Critical patent/BRPI0911577B8/pt

Links

208000030852 Parasitic disease Diseases 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/20—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

BRPI0911577A 2008-04-29 2009-04-01 derivados espiro-indol, seus usos no tratamento de doenças parasíticas, e composição farmacêutica BRPI0911577B8 (pt)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
EP08155342		2008-04-29
EP08155342.2		2008-04-29
EP09151117		2009-01-22
EP09151117.0		2009-01-22
PCT/EP2009/053902 WO2009132921A1 (en)	2008-04-29	2009-04-01	Spiro-indole derivatives for the treatment of parasitic diseases

Publications (4)

Publication Number	Publication Date
BRPI0911577A2 true BRPI0911577A2 (pt)	2016-01-05
BRPI0911577A8 BRPI0911577A8 (pt)	2018-03-06
BRPI0911577B1 BRPI0911577B1 (pt)	2021-02-23
BRPI0911577B8 BRPI0911577B8 (pt)	2021-05-25

Family

ID=40613087

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0911577A BRPI0911577B8 (pt)	2008-04-29	2009-04-01	derivados espiro-indol, seus usos no tratamento de doenças parasíticas, e composição farmacêutica

Country Status (30)

Country	Link
US (2)	US8053442B2 (pt)
EP (2)	EP2722333A1 (pt)
JP (2)	JP5438098B2 (pt)
KR (1)	KR101390081B1 (pt)
CN (1)	CN102015711B (pt)
AR (1)	AR071222A1 (pt)
AU (1)	AU2009242279B2 (pt)
BR (1)	BRPI0911577B8 (pt)
CA (1)	CA2719365C (pt)
CL (1)	CL2009001007A1 (pt)
CO (1)	CO6300940A2 (pt)
CY (1)	CY1114874T1 (pt)
DK (1)	DK2285808T3 (pt)
EA (1)	EA019601B1 (pt)
EC (2)	ECSP10010646A (pt)
ES (1)	ES2447590T3 (pt)
HR (1)	HRP20140151T1 (pt)
IL (1)	IL208357A (pt)
JO (1)	JO2904B1 (pt)
MA (1)	MA32316B1 (pt)
MX (1)	MX2010011868A (pt)
MY (2)	MY156601A (pt)
NZ (1)	NZ588217A (pt)
PE (1)	PE20091787A1 (pt)
PL (1)	PL2285808T3 (pt)
PT (1)	PT2285808E (pt)
SI (1)	SI2285808T1 (pt)
TW (1)	TWI442921B (pt)
WO (1)	WO2009132921A1 (pt)
ZA (1)	ZA201006752B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN102015711B (zh) *	2008-04-29	2013-05-01	诺瓦提斯公司	用于治疗寄生虫病的螺-吲哚衍生物
CN102584835B (zh) *	2011-01-17	2014-08-27	苏州大学	一种含吲哚结构的螺杂环化合物及其制备方法
CN104185634B (zh) *	2012-03-23	2017-05-03	诺华股份有限公司	制备螺旋吲哚酮和其中间体的化学工艺
EP2828256B1 (en) *	2012-03-23	2019-07-03	Novartis AG	Chemical process for preparing spiroindolones and intermediates thereof
CN104508126B (zh)	2012-03-23	2017-06-30	科德克希思公司	用于合成色胺和色胺类似物的衍生物的生物催化剂和方法
CN106232619B (zh)	2013-11-13	2022-09-09	科德克希思公司	工程化的亚胺还原酶和用于酮和胺化合物的还原胺化的方法
US10370648B2 (en)	2014-11-25	2019-08-06	Codexis, Inc.	Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
TWI874834B (zh)	2014-12-18	2025-03-01	瑞士商赫孚孟拉羅股份公司	四氫-吡啶并[3,4-b]吲哚雌激素受體調節劑及其用途
TWI726861B (zh) *	2015-01-23	2021-05-11	英商葛蘭素史克智慧財產發展有限公司	吡唑并-嘧啶化合物、其鹽及其用途
WO2016147205A1 (en) *	2015-03-13	2016-09-22	Council Of Scientific & Industrial Research	Novel substituted 3-spirophosphoryl pyrazole-2-oxindoles as anti-infectives and process for the synthesis thereof
US11174267B2 (en)	2015-06-12	2021-11-16	The Regents Of The University Of California	Spiroindolinones and therapeutic uses thereof
JP2017024992A (ja) *	2015-07-15	2017-02-02	公益財団法人微生物化学研究会	化合物の製造方法
CR20200621A (es)	2018-06-21	2021-02-03	Hoffmann La Roche	Formas sólidas de 3-((1r,3r)-1-(2,6-difluoro-4-((1-(3 fluoropropil)azetidin-3-il)amino)fenil)-3-(metil-1,3,4,9-tetrahidro-2h-pirido[3,4-b]indol-2-il)-2,2-difluoropropan-1-ol y procesos para preparar compuestos tricíclicos fusionados que comprenden un resto fenilo o piridinilo sustituido, incluidos métodos para su uso
CN110590795B (zh) *	2019-10-10	2021-01-22	贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室)	一类多并杂环螺羟吲哚类化合物的合成方法
WO2021186348A1 (en) *	2020-03-17	2021-09-23	The University Of Buea	Dihydro-spiro[indoline-3:1'-isoquinolin]-2-ones as antimalarial agents
CN116273188B (zh) *	2023-03-01	2024-06-25	岭南师范学院	一种负载金属的多孔有机框架材料在催化Pictet-Spengler反应中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2663935A1 (fr) *	1990-06-27	1992-01-03	Adir	Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
KR100640113B1 (ko) *	1998-07-14	2006-10-31	바이엘 악티엔게젤샤프트	구충제 아르테미시닌 유도체(엔도퍼옥시드)
EE04917B1 (et)	1998-12-19	2007-10-15	Janssen Pharmaceutica N.V.	Antihistamiinsed spirohendid, vahehendid ja farmatseutiline kompositsioon ning nende valmistamismeetodid ja kasutamine
US20050137220A1 (en)	2003-07-23	2005-06-23	Pharmacia Corporation	Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors
AR053710A1 (es)	2005-04-11	2007-05-16	Xenon Pharmaceuticals Inc	Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
DE602007006990D1 (de)	2006-12-07	2010-07-15	Hoffmann La Roche	Spiropiperidinderivate als antagonisten des via-rezeptors
WO2009086303A2 (en) *	2007-12-21	2009-07-09	University Of Rochester	Method for altering the lifespan of eukaryotic organisms
TW200940542A (en)	2008-01-09	2009-10-01	Array Biopharma Inc	Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
CN102015711B (zh) *	2008-04-29	2013-05-01	诺瓦提斯公司	用于治疗寄生虫病的螺-吲哚衍生物

2009
- 2009-04-01 CN CN2009801149364A patent/CN102015711B/zh active Active
- 2009-04-01 BR BRPI0911577A patent/BRPI0911577B8/pt active IP Right Grant
- 2009-04-01 MX MX2010011868A patent/MX2010011868A/es active IP Right Grant
- 2009-04-01 DK DK09737965.5T patent/DK2285808T3/da active
- 2009-04-01 EA EA201001689A patent/EA019601B1/ru not_active IP Right Cessation
- 2009-04-01 JP JP2011506638A patent/JP5438098B2/ja active Active
- 2009-04-01 PT PT97379655T patent/PT2285808E/pt unknown
- 2009-04-01 HR HRP20140151AT patent/HRP20140151T1/hr unknown
- 2009-04-01 SI SI200930847T patent/SI2285808T1/sl unknown
- 2009-04-01 EP EP13185962.1A patent/EP2722333A1/en not_active Withdrawn
- 2009-04-01 MY MYPI2013001071A patent/MY156601A/en unknown
- 2009-04-01 KR KR1020107026548A patent/KR101390081B1/ko active Active
- 2009-04-01 MY MYPI20104473 patent/MY152021A/en unknown
- 2009-04-01 AU AU2009242279A patent/AU2009242279B2/en active Active
- 2009-04-01 WO PCT/EP2009/053902 patent/WO2009132921A1/en not_active Ceased
- 2009-04-01 PL PL09737965T patent/PL2285808T3/pl unknown
- 2009-04-01 ES ES09737965.5T patent/ES2447590T3/es active Active
- 2009-04-01 EP EP09737965.5A patent/EP2285808B1/en active Active
- 2009-04-01 CA CA2719365A patent/CA2719365C/en active Active
- 2009-04-01 NZ NZ588217A patent/NZ588217A/xx unknown
- 2009-04-27 US US12/430,625 patent/US8053442B2/en active Active
- 2009-04-27 AR ARP090101487A patent/AR071222A1/es active IP Right Grant
- 2009-04-28 JO JO2009149A patent/JO2904B1/en active
- 2009-04-28 PE PE2009000577A patent/PE20091787A1/es active IP Right Grant
- 2009-04-28 TW TW098114086A patent/TWI442921B/zh active
- 2009-04-28 CL CL2009001007A patent/CL2009001007A1/es unknown
2010
- 2010-09-21 IL IL208357A patent/IL208357A/en active IP Right Grant
- 2010-09-21 ZA ZA2010/06752A patent/ZA201006752B/en unknown
- 2010-11-19 MA MA33365A patent/MA32316B1/fr unknown
- 2010-11-25 CO CO10148514A patent/CO6300940A2/es active IP Right Grant
- 2010-11-29 EC EC2010010646A patent/ECSP10010646A/es unknown
2011
- 2011-07-19 US US13/186,035 patent/US8399453B2/en active Active
2013
- 2013-12-12 JP JP2013257004A patent/JP2014065729A/ja active Pending
2014
- 2014-02-20 CY CY20141100135T patent/CY1114874T1/el unknown
2017
- 2017-10-13 EC ECIEPI201768127A patent/ECSP17068127A/es unknown

Also Published As

Publication number	Publication date
PT2285808E (pt)	2014-02-24
PL2285808T3 (pl)	2014-04-30
ECSP17068127A (es)	2017-10-31
EP2722333A1 (en)	2014-04-23
ECSP10010646A (es)	2010-12-30
DK2285808T3 (da)	2014-02-03
PE20091787A1 (es)	2009-12-14
NZ588217A (en)	2012-10-26
CL2009001007A1 (es)	2010-06-11
BRPI0911577A8 (pt)	2018-03-06
US8053442B2 (en)	2011-11-08
JP2011518852A (ja)	2011-06-30
ZA201006752B (en)	2011-05-25
TWI442921B (zh)	2014-07-01
US20110275613A1 (en)	2011-11-10
CA2719365A1 (en)	2009-11-05
US8399453B2 (en)	2013-03-19
AR071222A1 (es)	2010-06-02
JP2014065729A (ja)	2014-04-17
JP5438098B2 (ja)	2014-03-12
CA2719365C (en)	2017-03-07
CN102015711A (zh)	2011-04-13
MA32316B1 (fr)	2011-05-02
HRP20140151T1 (hr)	2014-03-28
EA201001689A1 (ru)	2011-08-30
CO6300940A2 (es)	2011-07-21
ES2447590T3 (es)	2014-03-12
MX2010011868A (es)	2010-11-26
EP2285808B1 (en)	2013-11-20
KR20100135320A (ko)	2010-12-24
IL208357A (en)	2014-11-30
BRPI0911577B1 (pt)	2021-02-23
EP2285808A1 (en)	2011-02-23
MY156601A (en)	2016-03-15
WO2009132921A1 (en)	2009-11-05
MY152021A (en)	2014-08-15
EA019601B1 (ru)	2014-04-30
AU2009242279A1 (en)	2009-11-05
JO2904B1 (en)	2015-09-15
KR101390081B1 (ko)	2014-04-29
US20090275560A1 (en)	2009-11-05
CN102015711B (zh)	2013-05-01
BRPI0911577B8 (pt)	2021-05-25
HK1149935A1 (en)	2011-10-21
IL208357A0 (en)	2010-12-30
SI2285808T1 (sl)	2014-03-31
CY1114874T1 (el)	2016-12-14
AU2009242279B2 (en)	2012-08-30
TW200948357A (en)	2009-12-01

Legal Events

Date	Code	Title	Description
2018-03-06	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2020-05-05	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2020-05-12	B06U	Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
2020-09-24	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2021-01-05	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2021-02-23	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/02/2021, OBSERVADAS AS CONDICOES LEGAIS.
2021-05-25	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/04/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

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