MA32316B1 - Derives spiro-indoles pour le traitement de maladies parasitaires - Google Patents

Derives spiro-indoles pour le traitement de maladies parasitaires

Info

Publication number
MA32316B1
MA32316B1 MA33365A MA33365A MA32316B1 MA 32316 B1 MA32316 B1 MA 32316B1 MA 33365 A MA33365 A MA 33365A MA 33365 A MA33365 A MA 33365A MA 32316 B1 MA32316 B1 MA 32316B1
Authority
MA
Morocco
Prior art keywords
treatment
spiro
plasmodium
indole derivatives
parasitic diseases
Prior art date
Application number
MA33365A
Other languages
Arabic (ar)
English (en)
Inventor
Shi Hua Ang
Philipp Krastel
Seh Yong Leong
Liying Jocelyn Tan
Wei Lin Josephine Wong
Bryan Ks Yeung
Bin Zou
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40613087&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32316(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA32316B1 publication Critical patent/MA32316B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention concerne des composés organiques qui présentent des propriétés pharmaceutiques intéressantes. En particulier, les composés sont utiles dans le traitement et/ou la prévention d'infections telles que celles causées par plasmodium falciparum, plasmodium vivax, plasmodium malariae, plasmodium ovale, trypanosoma cruzi et des parasites du genre leishmania tels que, par exemple, leishmania donovani. L'invention concerne également des compositions pharmaceutiques contenant les composés, ainsi que des procédés pour leur préparation.
MA33365A 2008-04-29 2010-11-19 Derives spiro-indoles pour le traitement de maladies parasitaires MA32316B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08155342 2008-04-29
EP09151117 2009-01-22
PCT/EP2009/053902 WO2009132921A1 (fr) 2008-04-29 2009-04-01 Dérivés spiro-indoles pour le traitement de maladies parasitaires

Publications (1)

Publication Number Publication Date
MA32316B1 true MA32316B1 (fr) 2011-05-02

Family

ID=40613087

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33365A MA32316B1 (fr) 2008-04-29 2010-11-19 Derives spiro-indoles pour le traitement de maladies parasitaires

Country Status (30)

Country Link
US (2) US8053442B2 (fr)
EP (2) EP2722333A1 (fr)
JP (2) JP5438098B2 (fr)
KR (1) KR101390081B1 (fr)
CN (1) CN102015711B (fr)
AR (1) AR071222A1 (fr)
AU (1) AU2009242279B2 (fr)
BR (1) BRPI0911577B8 (fr)
CA (1) CA2719365C (fr)
CL (1) CL2009001007A1 (fr)
CO (1) CO6300940A2 (fr)
CY (1) CY1114874T1 (fr)
DK (1) DK2285808T3 (fr)
EA (1) EA019601B1 (fr)
EC (2) ECSP10010646A (fr)
ES (1) ES2447590T3 (fr)
HR (1) HRP20140151T1 (fr)
IL (1) IL208357A (fr)
JO (1) JO2904B1 (fr)
MA (1) MA32316B1 (fr)
MX (1) MX2010011868A (fr)
MY (2) MY156601A (fr)
NZ (1) NZ588217A (fr)
PE (1) PE20091787A1 (fr)
PL (1) PL2285808T3 (fr)
PT (1) PT2285808E (fr)
SI (1) SI2285808T1 (fr)
TW (1) TWI442921B (fr)
WO (1) WO2009132921A1 (fr)
ZA (1) ZA201006752B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102015711B (zh) * 2008-04-29 2013-05-01 诺瓦提斯公司 用于治疗寄生虫病的螺-吲哚衍生物
CN102584835B (zh) * 2011-01-17 2014-08-27 苏州大学 一种含吲哚结构的螺杂环化合物及其制备方法
CN104185634B (zh) * 2012-03-23 2017-05-03 诺华股份有限公司 制备螺旋吲哚酮和其中间体的化学工艺
EP2828256B1 (fr) * 2012-03-23 2019-07-03 Novartis AG Procédé chimique pour la préparation de spiroindolones et intermédiaires correspondants
CN104508126B (zh) 2012-03-23 2017-06-30 科德克希思公司 用于合成色胺和色胺类似物的衍生物的生物催化剂和方法
CN106232619B (zh) 2013-11-13 2022-09-09 科德克希思公司 工程化的亚胺还原酶和用于酮和胺化合物的还原胺化的方法
US10370648B2 (en) 2014-11-25 2019-08-06 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
TWI874834B (zh) 2014-12-18 2025-03-01 瑞士商赫孚孟拉羅股份公司 四氫-吡啶并[3,4-b]吲哚雌激素受體調節劑及其用途
TWI726861B (zh) * 2015-01-23 2021-05-11 英商葛蘭素史克智慧財產發展有限公司 吡唑并-嘧啶化合物、其鹽及其用途
WO2016147205A1 (fr) * 2015-03-13 2016-09-22 Council Of Scientific & Industrial Research Nouveaux 3-spirophosphoryl pyrazole-2-oxindoles substitués en tant qu'agents anti-infectieux et procédé de synthèse correspondant
US11174267B2 (en) 2015-06-12 2021-11-16 The Regents Of The University Of California Spiroindolinones and therapeutic uses thereof
JP2017024992A (ja) * 2015-07-15 2017-02-02 公益財団法人微生物化学研究会 化合物の製造方法
CR20200621A (es) 2018-06-21 2021-02-03 Hoffmann La Roche Formas sólidas de 3-((1r,3r)-1-(2,6-difluoro-4-((1-(3 fluoropropil)azetidin-3-il)amino)fenil)-3-(metil-1,3,4,9-tetrahidro-2h-pirido[3,4-b]indol-2-il)-2,2-difluoropropan-1-ol y procesos para preparar compuestos tricíclicos fusionados que comprenden un resto fenilo o piridinilo sustituido, incluidos métodos para su uso
CN110590795B (zh) * 2019-10-10 2021-01-22 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 一类多并杂环螺羟吲哚类化合物的合成方法
WO2021186348A1 (fr) * 2020-03-17 2021-09-23 The University Of Buea Dihydro-spiro[indoline-3:1'-isoquinolin]-2-ones utiles en tant qu'agents antipaludiques
CN116273188B (zh) * 2023-03-01 2024-06-25 岭南师范学院 一种负载金属的多孔有机框架材料在催化Pictet-Spengler反应中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2663935A1 (fr) * 1990-06-27 1992-01-03 Adir Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
KR100640113B1 (ko) * 1998-07-14 2006-10-31 바이엘 악티엔게젤샤프트 구충제 아르테미시닌 유도체(엔도퍼옥시드)
EE04917B1 (et) 1998-12-19 2007-10-15 Janssen Pharmaceutica N.V. Antihistamiinsed spirohendid, vahehendid ja farmatseutiline kompositsioon ning nende valmistamismeetodid ja kasutamine
US20050137220A1 (en) 2003-07-23 2005-06-23 Pharmacia Corporation Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors
AR053710A1 (es) 2005-04-11 2007-05-16 Xenon Pharmaceuticals Inc Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
DE602007006990D1 (de) 2006-12-07 2010-07-15 Hoffmann La Roche Spiropiperidinderivate als antagonisten des via-rezeptors
WO2009086303A2 (fr) * 2007-12-21 2009-07-09 University Of Rochester Procédé permettant de modifier la durée de vie d'organismes eucaryotes
TW200940542A (en) 2008-01-09 2009-10-01 Array Biopharma Inc Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
CN102015711B (zh) * 2008-04-29 2013-05-01 诺瓦提斯公司 用于治疗寄生虫病的螺-吲哚衍生物

Also Published As

Publication number Publication date
PT2285808E (pt) 2014-02-24
PL2285808T3 (pl) 2014-04-30
ECSP17068127A (es) 2017-10-31
EP2722333A1 (fr) 2014-04-23
ECSP10010646A (es) 2010-12-30
DK2285808T3 (da) 2014-02-03
PE20091787A1 (es) 2009-12-14
NZ588217A (en) 2012-10-26
CL2009001007A1 (es) 2010-06-11
BRPI0911577A8 (pt) 2018-03-06
US8053442B2 (en) 2011-11-08
JP2011518852A (ja) 2011-06-30
ZA201006752B (en) 2011-05-25
TWI442921B (zh) 2014-07-01
US20110275613A1 (en) 2011-11-10
CA2719365A1 (fr) 2009-11-05
US8399453B2 (en) 2013-03-19
AR071222A1 (es) 2010-06-02
JP2014065729A (ja) 2014-04-17
JP5438098B2 (ja) 2014-03-12
CA2719365C (fr) 2017-03-07
CN102015711A (zh) 2011-04-13
HRP20140151T1 (hr) 2014-03-28
EA201001689A1 (ru) 2011-08-30
BRPI0911577A2 (pt) 2016-01-05
CO6300940A2 (es) 2011-07-21
ES2447590T3 (es) 2014-03-12
MX2010011868A (es) 2010-11-26
EP2285808B1 (fr) 2013-11-20
KR20100135320A (ko) 2010-12-24
IL208357A (en) 2014-11-30
BRPI0911577B1 (pt) 2021-02-23
EP2285808A1 (fr) 2011-02-23
MY156601A (en) 2016-03-15
WO2009132921A1 (fr) 2009-11-05
MY152021A (en) 2014-08-15
EA019601B1 (ru) 2014-04-30
AU2009242279A1 (en) 2009-11-05
JO2904B1 (en) 2015-09-15
KR101390081B1 (ko) 2014-04-29
US20090275560A1 (en) 2009-11-05
CN102015711B (zh) 2013-05-01
BRPI0911577B8 (pt) 2021-05-25
HK1149935A1 (en) 2011-10-21
IL208357A0 (en) 2010-12-30
SI2285808T1 (sl) 2014-03-31
CY1114874T1 (el) 2016-12-14
AU2009242279B2 (en) 2012-08-30
TW200948357A (en) 2009-12-01

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