ECSP17068127A - Derivados de espiro-indol para el tratamiento de enfermedades parasitarias - Google Patents

Derivados de espiro-indol para el tratamiento de enfermedades parasitarias

Info

Publication number
ECSP17068127A
ECSP17068127A ECIEPI201768127A ECPI201768127A ECSP17068127A EC SP17068127 A ECSP17068127 A EC SP17068127A EC IEPI201768127 A ECIEPI201768127 A EC IEPI201768127A EC PI201768127 A ECPI201768127 A EC PI201768127A EC SP17068127 A ECSP17068127 A EC SP17068127A
Authority
EC
Ecuador
Prior art keywords
treatment
plasmodium
spiro
parasitic diseases
compounds
Prior art date
Application number
ECIEPI201768127A
Other languages
English (en)
Inventor
Liying Jocelyn Tan
Wei Lin Josephine Wong
Philipp Krastel
Bin Zou
Bryan Ks Yeung
Seh Yong Leong
Shi Hua Ang
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40613087&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP17068127(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP17068127A publication Critical patent/ECSP17068127A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención se refiere a compuestos orgánicos, los cuales tienen propiedades farmacéuticas interesantes. En particular, los compuestos son útiles en el tratamiento y/o la prevención de infecciones tales como aquéllas causadas por Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, Trypanosoma cruzi y parásitos del género Leishmania, tales como, por ejemplo, Leishmania donovani. La invención también se refiere a composiciones farmacéuticas que contienen los compuestos, así como a los procesos para su preparación.
ECIEPI201768127A 2008-04-29 2017-10-13 Derivados de espiro-indol para el tratamiento de enfermedades parasitarias ECSP17068127A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08155342 2008-04-29
EP09151117 2009-01-22

Publications (1)

Publication Number Publication Date
ECSP17068127A true ECSP17068127A (es) 2017-10-31

Family

ID=40613087

Family Applications (2)

Application Number Title Priority Date Filing Date
EC2010010646A ECSP10010646A (es) 2008-04-29 2010-11-29 Derivados de espiro-indol para el tratamiento de enfermedades parasitarias
ECIEPI201768127A ECSP17068127A (es) 2008-04-29 2017-10-13 Derivados de espiro-indol para el tratamiento de enfermedades parasitarias

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EC2010010646A ECSP10010646A (es) 2008-04-29 2010-11-29 Derivados de espiro-indol para el tratamiento de enfermedades parasitarias

Country Status (30)

Country Link
US (2) US8053442B2 (es)
EP (2) EP2722333A1 (es)
JP (2) JP5438098B2 (es)
KR (1) KR101390081B1 (es)
CN (1) CN102015711B (es)
AR (1) AR071222A1 (es)
AU (1) AU2009242279B2 (es)
BR (1) BRPI0911577B8 (es)
CA (1) CA2719365C (es)
CL (1) CL2009001007A1 (es)
CO (1) CO6300940A2 (es)
CY (1) CY1114874T1 (es)
DK (1) DK2285808T3 (es)
EA (1) EA019601B1 (es)
EC (2) ECSP10010646A (es)
ES (1) ES2447590T3 (es)
HR (1) HRP20140151T1 (es)
IL (1) IL208357A (es)
JO (1) JO2904B1 (es)
MA (1) MA32316B1 (es)
MX (1) MX2010011868A (es)
MY (2) MY152021A (es)
NZ (1) NZ588217A (es)
PE (1) PE20091787A1 (es)
PL (1) PL2285808T3 (es)
PT (1) PT2285808E (es)
SI (1) SI2285808T1 (es)
TW (1) TWI442921B (es)
WO (1) WO2009132921A1 (es)
ZA (1) ZA201006752B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2722333A1 (en) * 2008-04-29 2014-04-23 Novartis AG Spiro-indole derivatives for the treatment of parasitic diseases.
CN102584835B (zh) * 2011-01-17 2014-08-27 苏州大学 一种含吲哚结构的螺杂环化合物及其制备方法
CN104185634B (zh) * 2012-03-23 2017-05-03 诺华股份有限公司 制备螺旋吲哚酮和其中间体的化学工艺
CA2866222C (en) * 2012-03-23 2022-01-11 Novartis Ag Chemical process for preparing spiroindolones and intermediates thereof
DK2828385T3 (en) 2012-03-23 2018-03-12 Codexis Inc BIOCATALIZATORS AND METHODS FOR SYNTHETIZING DERIVATIVES AND TRYPTAMIN AND TRYPTAMINE ANALOGS
US9822346B2 (en) 2013-11-13 2017-11-21 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
JP6719463B2 (ja) 2014-11-25 2020-07-15 コデクシス， インコーポレイテッド ケトン化合物およびアミン化合物の還元的アミノ化のための操作されたイミンレダクターゼおよび方法
CN112375078B (zh) 2014-12-18 2023-12-19 豪夫迈·罗氏有限公司 四氢-吡啶并[3,4-b]吲哚雌激素受体调节剂及其用途
EP3247713B1 (en) * 2015-01-23 2019-08-28 GlaxoSmithKline Intellectual Property Development Limited Pyrazolo[3,4-d]pyrimidin derivative and its use for the treatment of leishmaniasis
WO2016147205A1 (en) * 2015-03-13 2016-09-22 Council Of Scientific & Industrial Research Novel substituted 3-spirophosphoryl pyrazole-2-oxindoles as anti-infectives and process for the synthesis thereof
WO2016201440A1 (en) * 2015-06-12 2016-12-15 The Regents Of The University Of California Spiroindolinones and therapeutic uses thereof
JP2017024992A (ja) * 2015-07-15 2017-02-02 公益財団法人微生物化学研究会 化合物の製造方法
IL278063B2 (en) 2018-06-21 2025-08-01 Hoffmann La Roche Solid forms of 3-((1r,3r)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2h-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use
CN110590795B (zh) * 2019-10-10 2021-01-22 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 一类多并杂环螺羟吲哚类化合物的合成方法
US20230132973A1 (en) * 2020-03-17 2023-05-04 The University Of Buea DIHYDRO-SPIRO[INDOLINE-3:1'-iSOQUINOLIN]-2-ONES AS ANTIMALARIAL AGENTS
CN116273188B (zh) * 2023-03-01 2024-06-25 岭南师范学院 一种负载金属的多孔有机框架材料在催化Pictet-Spengler反应中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2663935A1 (fr) * 1990-06-27 1992-01-03 Adir Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
RU2236413C2 (ru) * 1998-07-14 2004-09-20 Байер Акциенгезельшафт Производные артемизинина, способ их получения, фармацевтическая композиция на их основе и способ лечения
WO2000037470A1 (en) 1998-12-19 2000-06-29 Janssen Pharmaceutica N.V. Antihistaminic spiro compounds
US20050137220A1 (en) * 2003-07-23 2005-06-23 Pharmacia Corporation Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors
MY145694A (en) 2005-04-11 2012-03-30 Xenon Pharmaceuticals Inc Spiroheterocyclic compounds and their uses as therapeutic agents
KR101050568B1 (ko) 2006-12-07 2011-07-19 에프. 호프만-라 로슈 아게 Ｖ1ａ 수용체 길항제로서의 스피로-피페리딘 유도체
US8642660B2 (en) * 2007-12-21 2014-02-04 The University Of Rochester Method for altering the lifespan of eukaryotic organisms
US8324221B2 (en) 2008-01-09 2012-12-04 Array Biopharma Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
EP2722333A1 (en) * 2008-04-29 2014-04-23 Novartis AG Spiro-indole derivatives for the treatment of parasitic diseases.

Also Published As

Publication number Publication date
MX2010011868A (es) 2010-11-26
SI2285808T1 (sl) 2014-03-31
US20110275613A1 (en) 2011-11-10
CN102015711B (zh) 2013-05-01
JP2014065729A (ja) 2014-04-17
EA019601B1 (ru) 2014-04-30
PE20091787A1 (es) 2009-12-14
MA32316B1 (fr) 2011-05-02
JO2904B1 (en) 2015-09-15
ZA201006752B (en) 2011-05-25
US20090275560A1 (en) 2009-11-05
KR101390081B1 (ko) 2014-04-29
US8053442B2 (en) 2011-11-08
JP5438098B2 (ja) 2014-03-12
NZ588217A (en) 2012-10-26
IL208357A (en) 2014-11-30
HRP20140151T1 (hr) 2014-03-28
BRPI0911577A8 (pt) 2018-03-06
BRPI0911577B8 (pt) 2021-05-25
PT2285808E (pt) 2014-02-24
US8399453B2 (en) 2013-03-19
CN102015711A (zh) 2011-04-13
TW200948357A (en) 2009-12-01
ES2447590T3 (es) 2014-03-12
DK2285808T3 (da) 2014-02-03
EP2722333A1 (en) 2014-04-23
BRPI0911577B1 (pt) 2021-02-23
HK1149935A1 (en) 2011-10-21
CA2719365A1 (en) 2009-11-05
PL2285808T3 (pl) 2014-04-30
ECSP10010646A (es) 2010-12-30
JP2011518852A (ja) 2011-06-30
MY156601A (en) 2016-03-15
TWI442921B (zh) 2014-07-01
CY1114874T1 (el) 2016-12-14
EP2285808A1 (en) 2011-02-23
AU2009242279A1 (en) 2009-11-05
AU2009242279B2 (en) 2012-08-30
WO2009132921A1 (en) 2009-11-05
MY152021A (en) 2014-08-15
CL2009001007A1 (es) 2010-06-11
IL208357A0 (en) 2010-12-30
AR071222A1 (es) 2010-06-02
CA2719365C (en) 2017-03-07
KR20100135320A (ko) 2010-12-24
EP2285808B1 (en) 2013-11-20
EA201001689A1 (ru) 2011-08-30
BRPI0911577A2 (pt) 2016-01-05
CO6300940A2 (es) 2011-07-21

Similar Documents

Publication Publication Date Title
ECSP17068127A (es) Derivados de espiro-indol para el tratamiento de enfermedades parasitarias
ECSP077894A (es) Antagonistas de npy, preparación y usos
UY35146A (es) Compuestos y composiciones para el tratamiento de enfermedades parasitarias
EA201200098A1 (ru) Конденсированные имидазолы и содержащие их композиции, предназначенные для лечения паразитарных заболеваний, таких как, например, малярия
SMT201600055B (it) Composizione farmaceutica per il trattamento o la prevenzione del glaucoma
DOP2014000115A (es) Uso de 4-fenil-piridinas sustituidas para la fabricación de medicamentos útiles en el tratamiento de enfermedades relacionadas con el receptor de nk1
ECSP14017584A (es) Compuestos inhibidores de raf
CO6331340A2 (es) Pirrolo-pirimidinas y pirrolo piridinas
UY32848A (es) Compuestos heterocíclicos de oxima
UY30220A1 (es) Compuestos de tetrahidropiridotienopirimidina y metodos para su empleo
NI201300070A (es) Ureas asimétricas y usos médicos de las mismas
MX339644B (es) Sales de xantilio 3,6-disustituidas.
CO6321288A2 (es) Sales de compuestos inhibidores de vih
CU24011B1 (es) Piperidinas 2-fenil-5-(1,2,4-oxadiazol-5-il) sustituidas
MX2012003001A (es) Proceso para la produccion de intermediarios de artemisina.
UY32016A (es) Compuesto de 1,6-dihidro-2h-3-oxa-6-aza-as-indaceno
PL2515646T3 (pl) Kompozycje zawierające flawonoidy cytrusowe i określone kationowe środki powierzchniowo czynne do leczenia wszawic spowodowanych przez wszy głowowe
TH93138B (th) อนุพันธ์สไปโร-อินโดลสำหรับการบำบัดโรคจากเชื้อปรสิตสาขาวิทยาการที่เกี่ยวข้องกับการประดิษฐ์
TN2010000458A1 (en) Spiro indole derivatives for the treatment of parasitic diseases
TH106774A (th) อนุพันธ์สไปโร-อินโดลสำหรับการบำบัดโรคจากเชื้อปรสิตสาขาวิทยาการที่เกี่ยวข้องกับการประดิษฐ์
UY36469A (es) Nuevo compuesto de tiotriazol
TH149183B (th) การใช้เฟอร์โรควินในการรักษาหรือป้องกันมาลาเรีย
CU20100147A7 (es) Pirrolo-pirimidinas y pirrolo-piridinas
UY36636A (es) Compuesto derivado de butanamida con actividad antiparasitaria
CU20100011A7 (es) Compuestos orgánicos