BRPI0911622B8 - derivados de benzoxepina e benzociclo-heptano, seu processo de preparação, seu uso e composição farmacêutica que os compreende - Google Patents

derivados de benzoxepina e benzociclo-heptano, seu processo de preparação, seu uso e composição farmacêutica que os compreende

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Publication number
BRPI0911622B8
BRPI0911622B8 BRPI0911622A BRPI0911622A BRPI0911622B8 BR PI0911622 B8 BRPI0911622 B8 BR PI0911622B8 BR PI0911622 A BRPI0911622 A BR PI0911622A BR PI0911622 A BRPI0911622 A BR PI0911622A BR PI0911622 B8 BRPI0911622 B8 BR PI0911622B8
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BR
Brazil
Prior art keywords
benzoxepine
pharmaceutical composition
preparation process
benzocycloheptane
derivatives
Prior art date
Application number
BRPI0911622A
Other languages
English (en)
Inventor
Philippe Poncelet Alain
Schoentjes Bruno
Theodorus Maria Linders Joannes
Georges Pierre-Olivier Doyon Julien
Meerpoel Lieven
August Laurentius Ver Donck Luc
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0911622A2 publication Critical patent/BRPI0911622A2/pt
Publication of BRPI0911622B1 publication Critical patent/BRPI0911622B1/pt
Publication of BRPI0911622B8 publication Critical patent/BRPI0911622B8/pt

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    • C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
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    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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    • C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered

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  • Pyrane Compounds (AREA)

Abstract

derivados de benzoxepina e benzociclo-heptano. a presente invenção refere-se a um composto da fórmula (i) incluindo qualquer sua forma estereoquimicamente isomérica, em que o substituintes são como definidos no relatório e nas reivindicações; um seu n-óxido, um seu solvato ou seu sal farmaceuticamente aceitável; com a condição de que o composto seja outro que não ou um seu fal farmaceuticamente aceitável. os compostos reivindicados são úteis para o tratamento de uma doença, cujo tratamento é afetado, é mediado ou é facilitado por ativação do receptor de ghs1a-r. a invenção também refere-se a suas composições farmacêuticas e processos para a sua preparação.
BRPI0911622A 2008-04-28 2009-04-27 derivados de benzoxepina e benzociclo-heptano, seu processo de preparação, seu uso e composição farmacêutica que os compreende BRPI0911622B8 (pt)

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EP08155261.4 2008-04-28
EP08155261 2008-04-28
PCT/EP2009/055034 WO2009133052A1 (en) 2008-04-28 2009-04-27 Benzocycloheptane and benzoxepine derivatives

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BR (1) BRPI0911622B8 (pt)
CA (1) CA2722122C (pt)
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ES2433215T3 (es) * 2008-04-28 2013-12-10 Janssen Pharmaceutica, N.V. Derivados de benzocicloheptano y benzoxepina
US9643947B2 (en) 2013-08-28 2017-05-09 Northwestern University 7-membered fused heterocycles and methods of their synthesis
CA2951026A1 (en) * 2014-06-02 2015-12-10 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof

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FR2319332A1 (fr) * 1975-07-28 1977-02-25 Roussel Uclaf Nouveaux derives de l'aminobenzocycloheptene et leurs sels, procede de preparation et application a titre de medicaments desdits produits
US4736031A (en) * 1985-06-10 1988-04-05 Takeda Chemical Industries, Ltd. 2-(piperazinylalkyl)-1-benzothiepin, 1-benzoxepin, and 1,5-benzodioxepin derivatives
DE19755480A1 (de) 1997-12-13 1999-06-24 Gruenenthal Gmbh Substituierte heterocyclische Benzocycloalkene und ihre Verwendung als analgetisch wirksame Substanzen
EP1057485B1 (en) 1998-01-14 2005-05-11 Nippon Shinyaku Co., Ltd. Potassium channel activators
AU2003254902A1 (en) 2002-08-09 2004-02-25 Kaken Pharmaceutical Co., Ltd. Myocardial cell protecting agents
WO2008143835A1 (en) 2007-05-15 2008-11-27 Yale University Ghrelin protects substantia nigra dopamine neurons
ES2433215T3 (es) * 2008-04-28 2013-12-10 Janssen Pharmaceutica, N.V. Derivados de benzocicloheptano y benzoxepina

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MX2010011767A (es) 2010-11-30
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ES2433215T3 (es) 2013-12-10
BRPI0911622B1 (pt) 2021-05-11
US8703973B2 (en) 2014-04-22
US9040725B2 (en) 2015-05-26
US20120322796A1 (en) 2012-12-20
EP2297089A1 (en) 2011-03-23
AU2009242219B2 (en) 2013-03-21
JP5754811B2 (ja) 2015-07-29
AU2009242219A1 (en) 2009-11-05
JP2011522783A (ja) 2011-08-04
RU2496769C2 (ru) 2013-10-27
BRPI0911622A2 (pt) 2015-10-13
CN102076654A (zh) 2011-05-25
CN102076654B (zh) 2014-07-23
US8278466B2 (en) 2012-10-02
CA2722122A1 (en) 2009-11-05
US20140187557A1 (en) 2014-07-03
RU2010148433A (ru) 2012-06-10
CA2722122C (en) 2017-01-03
EP2297089B1 (en) 2013-07-31
US20110046139A1 (en) 2011-02-24

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