BRPI0911968A2 - derivados de imidazo[2,1-b]-quinazolina e seu uso como agentes antiagregantes em plaquetas - Google Patents

derivados de imidazo[2,1-b]-quinazolina e seu uso como agentes antiagregantes em plaquetas

Info

Publication number
BRPI0911968A2
BRPI0911968A2 BRPI0911968A BRPI0911968A BRPI0911968A2 BR PI0911968 A2 BRPI0911968 A2 BR PI0911968A2 BR PI0911968 A BRPI0911968 A BR PI0911968A BR PI0911968 A BRPI0911968 A BR PI0911968A BR PI0911968 A2 BRPI0911968 A2 BR PI0911968A2
Authority
BR
Brazil
Prior art keywords
imidazo
platelets
antiplatelet agents
quinazoline derivatives
quinazoline
Prior art date
Application number
BRPI0911968A
Other languages
English (en)
Inventor
Angus Macleod
Bernard T Golding
Peter Cicala
Richard Franklin
Original Assignee
Shire Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire Llc filed Critical Shire Llc
Publication of BRPI0911968A2 publication Critical patent/BRPI0911968A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BRPI0911968A 2008-05-16 2009-05-13 derivados de imidazo[2,1-b]-quinazolina e seu uso como agentes antiagregantes em plaquetas BRPI0911968A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0808947.6A GB0808947D0 (en) 2008-05-16 2008-05-16 Substituted quinazolines
PCT/GB2009/050517 WO2009138796A2 (en) 2008-05-16 2009-05-13 Substituted quinazolines

Publications (1)

Publication Number Publication Date
BRPI0911968A2 true BRPI0911968A2 (pt) 2015-10-20

Family

ID=39596026

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0911968A BRPI0911968A2 (pt) 2008-05-16 2009-05-13 derivados de imidazo[2,1-b]-quinazolina e seu uso como agentes antiagregantes em plaquetas

Country Status (15)

Country Link
US (1) US20110152298A1 (pt)
EP (1) EP2297159B1 (pt)
JP (1) JP2011521910A (pt)
KR (1) KR20110017873A (pt)
CN (1) CN102066379A (pt)
AU (1) AU2009247797A1 (pt)
BR (1) BRPI0911968A2 (pt)
CA (1) CA2723858A1 (pt)
GB (1) GB0808947D0 (pt)
IL (1) IL209179A0 (pt)
MX (1) MX2010012540A (pt)
NZ (1) NZ589108A (pt)
RU (1) RU2010151143A (pt)
WO (1) WO2009138796A2 (pt)
ZA (1) ZA201008178B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7910597B2 (en) * 2006-11-28 2011-03-22 Shire Llc Substituted quinazolines
US8304420B2 (en) * 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
GB201017783D0 (en) * 2010-10-21 2010-12-01 Shire Llc Process for the preparation of anagrelide and analogues thereof
PL236023B1 (pl) 2015-04-28 2020-11-30 Politechnika Rzeszowska Im Ignacego Lukasiewicza Sposób wytwarzania 1-fenylo-2-(2-hydroksyetylo)-6H-imidazo[ 1,5-c]chinazolino-3,5-dionu i 1-fenylo-2-(2-hydroksypropylo)-6H- -imidazo[1,5-c]chinazolino-3,5-dionu
EP4178955A1 (en) 2020-07-11 2023-05-17 Pfizer Inc. Antiviral heteroaryl ketone derivatives
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794964A (fr) * 1972-02-04 1973-08-02 Bristol Myers Co Nouveaux agents hypotenseurs et procede pour les preparer
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
US3983120A (en) * 1974-11-06 1976-09-28 Bristol-Myers Company Process for the preparation of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones
NL7807507A (nl) * 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.
US4146718A (en) * 1978-04-10 1979-03-27 Bristol-Myers Company Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
ES2126636T3 (es) * 1992-05-19 1999-04-01 Adir Derivados del bencimidazol con actividad antidiabetica y antiagregante plaquetaria.
JP2004051594A (ja) * 2002-07-23 2004-02-19 Dai Ichi Seiyaku Co Ltd 血管新生抑制剤
US20070066619A1 (en) * 2002-10-07 2007-03-22 Artesian Therapeutics, Inc. Compounds having simultaneous ability to block L-type calcium channels and to inhibit phosphodiesterase type 3 activity
US20060030574A1 (en) * 2004-08-04 2006-02-09 Shire Holdings Ag Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
US7700608B2 (en) * 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
US8304420B2 (en) * 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count

Also Published As

Publication number Publication date
EP2297159A2 (en) 2011-03-23
KR20110017873A (ko) 2011-02-22
CA2723858A1 (en) 2009-11-19
CN102066379A (zh) 2011-05-18
WO2009138796A2 (en) 2009-11-19
EP2297159B1 (en) 2012-08-15
MX2010012540A (es) 2011-02-25
ZA201008178B (en) 2013-04-24
US20110152298A1 (en) 2011-06-23
RU2010151143A (ru) 2012-06-27
AU2009247797A1 (en) 2009-11-19
GB0808947D0 (en) 2008-06-25
IL209179A0 (en) 2011-01-31
NZ589108A (en) 2012-08-31
WO2009138796A3 (en) 2010-01-07
JP2011521910A (ja) 2011-07-28

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.